Cyanidioschyzon merolae Genome Project

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CMT216C (492 aa)
by blastp 2.2.10 [Oct-19-2004] against nr [Apr-30-2005] (XML result)

		Hypothetical protein C34F6.8 [Caenorhabditis elegans]
		isocitrate dehydrogenase (NADP+) [Solanum tuberosum]
		Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
		Hypothetical protein CBG17397 [Caenorhabditis briggsae]
		isocitrate dehydrogenase (NADP+) [Nicotiana tabacum]
		isocitrate dehydrogenase [Cucumis sativus]
		NADP-isocitrate dehydrogenase [Eucalyptus globulus]
		NADPH-specific isocitrate dehydrogenase
		isocitrate dehydrogenase (NADP) (EC 1.1.1.42) - soybean
		Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
		NADP-specific isocitrate dehydrogenase [Lupinus albus]
		NADP-dependent isocitrate dehydrogenase [Glycine max]
		NADP specific isocitrate dehydrogenase [Daucus carota]
		isocitrate dehydrogenase (NADP+) [Apium graveolens]
		NADP specific isocitrate dehydrogenase [Arabidopsis thaliana]
		COG0538: Isocitrate dehydrogenases [Rhodospirillum rubrum]
		Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
		NADP-isocitrate dehydrogenase [Citrus limon]
		isocitrate dehydrogenase (NADP+) [Nicotiana tabacum]
		NADP-dependent isocitrate dehydrogenase I [Pisum sativum]
		Isocitrate dehydrogenase [NADP], chloroplast precursor (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
		unnamed protein product [Yarrowia lipolytica CLIB99]
		NADP-specific isocitrate dehydrogenase [Lupinus albus]
		isocitrate dehydrogenase (NADP+) [Nicotiana tabacum]
		Chain B, Crystal Structure Of Nadp-Dependent Isocitrate Dehydrogenase From Porcine Heart Mitochondria
		NADP-dependent isocitrate dehydrogenase [Prunus persica]
		ENSANGP00000016660 [Anopheles gambiae str. PEST]
		hypothetical protein [Gallus gallus]
		isocitrate dehydrogenase (NADP) (EC 1.1.1.42), mitochondrial - pig
		unnamed protein product [Tetraodon nigroviridis]
		NADP-specific isocitrate dehydrogenase [Lupinus albus]
		Isocitrate dehydrogenase [NADP], mitochondrial precursor (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) (CtIDP1)
		isocitrate dehydrogenase [Oryza sativa (japonica cultivar-group)]
		isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
		At1g65930/F12P19_10 [Arabidopsis thaliana]
		NADP-specific isocitrate dehydrogenase [Oryza sativa (japonica cultivar-group)]
		Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
		unnamed protein product [Tetraodon nigroviridis]
		isocitrate dehydrogenase (NAD+) [Solanum tuberosum]
		Isocitrate dehydrogenase 2 (NADP+), mitochondrial, precursor [Homo sapiens]
		isocitrate dehydrogenase (NADP+) [Homo sapiens]
		similar to NADP-specific isocitrate dehydrogenase [Arabidopsis thaliana]
		PREDICTED: similar to isocitrate dehydrogenase (NADP+) [Canis familiaris]
		hypothetical LOC361596 [Rattus norvegicus]
		isocitrate dehydrogenase (NADP+) [Bos taurus]
		MGC64442 protein [Xenopus laevis]
		isocitrate dehydrogenase [Arabidopsis thaliana]
		isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor variant [Homo sapiens]
		isocitrate dehydrogenase, putative [Arabidopsis thaliana]
		isocitrate dehydrogenase-like protein [Arabidopsis thaliana]
		NADP specific isocitrate dehydrogenase [Daucus carota]
		NADP-dependent isocitrate dehydrogenase [Sinorhizobium meliloti]
		Isocitrate dehydrogenase 1 (NADP+), soluble [Danio rerio]
		isocitrate dehydrogenase-like protein [Arabidopsis thaliana]
		PROBABLE ISOCITRATE DEHYDROGENASE [NADP] PROTEIN [Sinorhizobium meliloti]
		unnamed protein product [Debaryomyces hansenii CBS767]
		hypothetical protein CaO19.5211 [Candida albicans SC5314]
		COG0538: Isocitrate dehydrogenases [Magnetospirillum magnetotacticum MS-1]
		unnamed protein product [Debaryomyces hansenii CBS767]
		hypothetical protein FG10347.1 [Gibberella zeae PH-1]
		COG0538: Isocitrate dehydrogenases [Mesorhizobium sp. BNC1]
		isocitrate dehydrogenase, NADP-dependent [Caulobacter crescentus CB15]
		MGC69505 protein [Xenopus tropicalis]
		isocitrate dehydrogenase [Toxoplasma gondii]
		COG0538: Isocitrate dehydrogenases [Cytophaga hutchinsonii]
		isocitrate dehydrogenase, NADP-dependent [Brucella abortus biovar 1 str. 9-941]
		OSJNBa0043L24.16 [Oryza sativa (japonica cultivar-group)]
		unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
		Isocitrate dehydrogenase [NADP] peroxisomal (Oxalosuccinate decarboxylase) (IDH) (PS-NADP-IDH) (CtIDP2)
		LOC494713 protein [Xenopus laevis]
		unnamed protein product [Tetraodon nigroviridis]
		isocitrate dehydrogenase (NADP) (EC 1.1.1.42) - alfalfa
		isocitrate dehydrogenase, NADP-dependent [Brucella suis 1330]
		NADP-dependent isocitrate dehydrogenase [Oryza sativa (japonica cultivar-group)]
		probable isocitrate dehydrogenase [Gloeobacter violaceus PCC 7421]
		AAL022Wp [Ashbya gossypii ATCC 10895]
		hypothetical protein MG07268.4 [Magnaporthe grisea 70-15]
		Hypothetical protein CBG21657 [Caenorhabditis briggsae]
		isocitrate dehydrogenase
		Hypothetical protein F59B8.2 [Caenorhabditis elegans]
		Idp2p: isocitrate dehydrogenase [Saccharomyces cerevisiae]
		cytosolic NADP-dependent isocitrate dehydrogenase [Microtus mexicanus]
		cytosolic NADP-dependent isocitrate dehydrogenase [Microtus ochrogaster]
		NADP-dependent isocitrate dehydrogenase [Rhodopseudomonas palustris CGA009]
		hypothetical protein CaO19.3733 [Candida albicans SC5314]
		PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial [Pan troglodytes]
		isocitrate dehydrogenase [Erythrobacter litoralis HTCC2594]
		isocitrate dehydrogenase (NADP) [Bdellovibrio bacteriovorus HD100]
		NADP-dependent isocitrate dehydrogenase [Homo sapiens]
		PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD1 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) [Mycobacterium tuberculosis H37Rv]
		isocitrate dehydrogenase [Rhizobium leguminosarum bv. viciae]
		hypothetical protein [Homo sapiens]
		PREDICTED: similar to cytosolic NADP-dependent isocitrate dehydrogenase [Gallus gallus]
		NADP-dependent isocitrate dehydrogenase [Mesorhizobium loti MAFF303099]
		isocitrate dehydrogenase 1 (NADP+), soluble [Rattus norvegicus]
		isocitrate dehydrogenase
		isocitrate dehydrogenase
		IDH1 [Homo sapiens]
		IDH1 protein [Homo sapiens]
		hypothetical protein [Neurospora crassa]
		isocitrate dehydrogenase (NADP), mitochondrial precursor [Plasmodium falciparum 3D7]
		Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
		COG0538: Isocitrate dehydrogenases [Novosphingobium aromaticivorans DSM 12444]
		similar to Rattus norvegicus (Rat). Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) [Dictyostelium discoideum]
		isocitrate dehydrogenase [Crassostrea gigas]
		hypothetical protein [Homo sapiens]
		IDH1 [Homo sapiens]
		cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
		cytosolic NADP+-dependent isocitrate dehydrogenase [Bos taurus]
		isocitrate dehydrogenase [NADP] [Bradyrhizobium japonicum USDA 110]
		unnamed protein product [Mus musculus]
		NADP-dependent isocitrate dehydrogenase [Mus musculus]
		isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus]
		SPAC6G10.08 [Schizosaccharomyces pombe]
		hypothetical protein AGR_C_3429 [Agrobacterium tumefaciens str. C58]
		COG0538: Isocitrate dehydrogenases [Rhodobacter sphaeroides 2.4.1]
		isocitrate dehydrogenase, NADP-dependent [Plasmodium yoelii yoelii]
		NADP-dependent isocitrate dehydrogenase precursor [Aspergillus niger]
		hypothetical protein [Pongo pygmaeus]
		peroxisomal NADP-dependent isocitrate dehydrogenase [Aspergillus nidulans]
		ENSANGP00000020939 [Anopheles gambiae str. PEST]
		hypothetical protein [Pongo pygmaeus]
		isocitrate dehydrogenase [Leifsonia xyli subsp. xyli str. CTCB07]
		unnamed protein product [Candida glabrata CBS138]
		similar to Sus scrofa (Pig). Isocitrate dehydrogenase [NADP], mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) (ICD-M) (Fragment) [Dictyostelium discoideum]
		isocitrate dehydrogenase [NADP] [Bifidobacterium longum NCC2705]
		Icd1 [Mycobacterium avium subsp. paratuberculosis str. k10]
		AER061Cp [Ashbya gossypii ATCC 10895]
		COG0538: Isocitrate dehydrogenases [Thermobifida fusca]
		COG0538: Isocitrate dehydrogenases [Bifidobacterium longum DJO10A]
		COG0538: Isocitrate dehydrogenases [Rhodobacter sphaeroides 2.4.1]
		hypothetical protein UM06111.1 [Ustilago maydis 521]
		GA20156-PA [Drosophila pseudoobscura]
		unnamed protein product [Candida glabrata CBS138]
		mitochondrial NADP-dependent isocitrate dehydrogenase [Aspergillus nidulans]
		isocitrate dehydrogenase (NADP), mitochondrial precursor, putative [Plasmodium berghei]
		hypothetical protein CNBB1650 [Cryptococcus neoformans var. neoformans B-3501A]
		hypothetical protein CNBB1650 [Cryptococcus neoformans var. neoformans B-3501A]
		putative isocitrate/isopropylmalate dehydrogenase [Nocardia farcinica IFM 10152]
		unnamed protein product [Saccharomyces cerevisiae]
		isocitrate dehydrogenase [NADP], mitochondrial precursor, putative [Trypanosoma brucei]
		IDP1 [Saccharomyces cerevisiae]
		unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
		putative NADP-isocitrate dehydrogenase [Oryza sativa (japonica cultivar-group)]
		CG7176-PD, isoform D [Drosophila melanogaster]
		CG7176-PE, isoform E [Drosophila melanogaster]
		CG7176-PC, isoform C [Drosophila melanogaster]
		CG7176-PB, isoform B [Drosophila melanogaster]
		NADP-dependent isocitrate dehydrogenase [Bartonella henselae str. Houston-1]
		unnamed protein product [Candida glabrata CBS138]
		NADP-dependent isocitrate dehydrogenase [Bartonella quintana str. Toulouse]
		IDHP_ASPNG ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL PRECURSOR (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) [Aspergillus nidulans FGSC A4]
		isocitrate dehydrogenase
		isocitrate dehydrogenase
		COG0538: Isocitrate dehydrogenases [Clostridium thermocellum ATCC 27405]
		Isocitrate dehydrogenases [Thermoanaerobacter tengcongensis MB4]
		isocitrate dehydrogenase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
		isocitrate dehydrogenase [Thermotoga maritima MSB8]
		COG0538: Isocitrate dehydrogenases [Desulfitobacterium hafniense DCB-2]
		COG0538: Isocitrate dehydrogenases [Magnetospirillum magnetotacticum MS-1]
		isocitrate dehydrogenase (NADP+) [Piromyces sp. E2]
		MGC69225 protein [Xenopus tropicalis]
		probable isocitrate dehydrogenase [Desulfotalea psychrophila LSv54]
		isocitrate dehydrogenase, NADP-dependent, putative [Plasmodium yoelii yoelii]
		isocitrate dehydrogenase (NADP), mitochondrial precursor, putative [Plasmodium chabaudi]
		hypothetical protein CaO19.11218 [Candida albicans SC5314]
		isocitrate dehydrogenase (NADP+) [Eucalyptus globulus subsp. bicostata]
		isocitrate dehydrogenase [Beta vulgaris]
		isocitrate dehydrogenase [Kluyveromyces lactis]
		hypothetical protein PC302184.00.0 [Plasmodium chabaudi]
		PREDICTED: similar to cytosolic NADP+-dependent isocitrate dehydrogenase [Canis familiaris]
		COG0538: Isocitrate dehydrogenases [Magnetospirillum magnetotacticum MS-1]
		unknown [Schistosoma japonicum]
		PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) [Pan troglodytes]
		putative cytosolic NADP-dependent isocitrate dehydrogenase [Homo sapiens]
		NADP-dependent isocitrate dehydrogenase [Periplaneta americana]
		hypothetical protein CaO19.11217 [Candida albicans SC5314]
		NADP-dependent isocitrate dehydrogenase [Capsicum annuum]
		hypothetical protein PC000375.04.0 [Plasmodium chabaudi]
		NADP-dependent isocitrate dehydrogenase [Prunus persica]
		PREDICTED: similar to cytosolic NADP+-dependent isocitrate dehydrogenase [Canis familiaris]
		NADP specific isocitrate dehydrogenase like protein [Arabidopsis thaliana]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Rubrobacter xylanophilus DSM 9941]
		3-isopropylmalate dehydrogenase [Symbiobacterium thermophilum IAM 14863]
		NADP+-specific isocitrate dehydrogenase [Homo sapiens]
		COG0538: Isocitrate dehydrogenases [Magnetospirillum magnetotacticum MS-1]
		NADP-isocitrate dehydrogenase [Haloferax volcanii]
		3-isopropylmalate dehydrogenase [Bradyrhizobium japonicum USDA 110]
		3-isopropylmalate dehydrogenase (beta-IPM dehydrogenase) [Haemophilus influenzae Rd KW20]
		probable isocitrate dehydrogenase (NADP) [Parachlamydia sp. UWE25]
		isocitrate dehydrogenase [Haloarcula marismortui ATCC 43049]
		putative Isocitrate/isopropylmalatedehydrogenase [Photobacterium profundum SS9]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Haemophilus influenzae R2846]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Novosphingobium aromaticivorans DSM 12444]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Haemophilus influenzae 86-028NP]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Rhodobacter sphaeroides 2.4.1]
		3-isopropylmalate dehydrogenase [Aquifex aeolicus VF5]
		3-isopropylmalate dehydrogenase 2 [Pyrococcus furiosus DSM 3638]
		LeuB protein [Mannheimia succiniciproducens MBEL55E]
		3-isopropylmalate dehydrogenase [Bacillus halodurans C-125]
		PREDICTED: similar to isocitrate dehydrogenase 2 (NADP+), mitochondrial, partial [Gallus gallus]
		3-isopropylmalate dehydrogenase [Campylobacter coli RM2228]
		3-isopropylmalate dehydrogenase [Silicibacter pomeroyi DSS-3]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Rickettsia akari str. Hartford]
		3-isopropylmalate dehydrogenase [Caulobacter crescentus CB15]
		hypothetical protein UM04873.1 [Ustilago maydis 521]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Haemophilus influenzae R2866]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Silicibacter sp. TM1040]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Rubrobacter xylanophilus DSM 9941]
		LeuB [Pasteurella multocida subsp. multocida str. Pm70]
		ADL214Cp [Ashbya gossypii ATCC 10895]
		isocitrate dehydrogenase [Symbiobacterium thermophilum IAM 14863]
		LeuB [Bacillus licheniformis ATCC 14580]
		3-isopropylmalate dehydrogenase [Bacillus licheniformis ATCC 14580]
		unnamed protein product [Saccharomyces cerevisiae]
		3-isopropylmalate dehydrogenase [Shewanella oneidensis MR-1]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Rickettsia rickettsii]
		isocitrate dehydrogenase [EC:1.1.1.42] [Rickettsia conorii str. Malish 7]
		unnamed protein product [Candida glabrata CBS138]
		Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
		3-isopropylmalate dehydrogenase [Buchnera aphidicola]
		unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
		Isocitrate/isopropylmalate dehydrogenase, LeuB [Wolbachia endosymbiont strain TRS of Brugia malayi]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Microbulbifer degradans 2-40]
		Chain H, The Structure Of The Mutant, S225a And E251l, Of 3- Isopropylmalate Dehydrogenase From Bacillus Coagulans
		3-isopropylmalate dehydrogenase [Bacillus clausii KSM-K16]
		Isocitrate/isopropylmalate dehydrogenase [Vibrio vulnificus CMCP6]
		hypothetical protein CNBD2460 [Cryptococcus neoformans var. neoformans B-3501A]
		3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
		ISOPROPYLMALATE DEHYDROGENASE [Wolinella succinogenes DSM 1740]
		3-isopropylmalate dehydrogenase [Geobacillus kaustophilus HTA426]
		3-isopropylmalate dehydrogenase (EC 1.1.1.85) - Neisseria lactamica (fragment)
		isopropylmalate dehydrogenase [Buchnera aphidicola]
		COG0473: Isocitrate/isopropylmalate dehydrogenase [Magnetococcus sp. MC-1]
		COG0538: Isocitrate dehydrogenases [Streptococcus suis 89/1591]
		3-isopropylmalate dehydrogenase [Neisseria meningitidis MC58]
		3-isopropylmalate dehydrogenase [Vibrio parahaemolyticus RIMD 2210633]
		3-isopropylmalate dehydrogenase [Bordetella parapertussis 12822]
		isocitrate dehydrogenase, NAD-dependent, putative [Methylococcus capsulatus str. Bath]
		LeuB [Neisseria gonorrhoeae FA 1090]
		3-isopropylmalate dehydrogenase [Vibrio vulnificus YJ016]
		3-isopropylmalate dehydrogenase [Bordetella bronchiseptica RB50]
		3-isopropylmalate dehydrogenase [Bordetella pertussis Tohama I]
		3-isopropylmalate dehydrogenase [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67]
		3-isopropylmalate dehydrogenase [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]
		3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
		3-isopropylmalate dehydrogenase [Escherichia coli CFT073]
		3-isopropylmalate dehydrogenase [Escherichia coli O157:H7]
		3-isopropylmalate dehydrogenase [Escherichia coli O157:H7 EDL933]
		3-isopropylmalate dehydrogenase [Shigella flexneri 2a str. 301]
		3-isopropylmaltate dehydrogenase [Buchnera aphidicola]
		3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)

emb|CAB03943.1| Hypothetical protein C34F6.8 [Caenorhabditis elegans]
ref|NP_509875.1| isocitrate dehydrogenase (49.0 kD) (XL835) [Caenorhabditis elegans]
pir||T19733 hypothetical protein C34F6.8 - Caenorhabditis elegans
(435 aa)

Score: 560 bits (1443), Expect: 3.97179e-158
Length: 414, Idn/Pos/Gap = 254/318/4 (61%/76%/0%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V NP+V+LDGDE  R+IW  IKNKLILPYL+LDI Y+DLGL  RD T+D VT++AA 
Sbjct:  26 KIKVDNPVVDLDGDEMTRIIWKEIKNKLILPYLDLDIKYYDLGLEYRDETNDQVTIDAAH  85

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A+ +H   +K ATITPDEAR++EF+LK+M+ SPNGT+RN+L GTVFREPIL +NIPRLVP
Sbjct:  86 AILEHSVGIKCATITPDEARIKEFNLKKMWLSPNGTIRNILGGTVFREPILCKNIPRLVP 145

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW QPI I RH FGDQYK  DL +P    ++L V    G     + VH        GGV 
Sbjct: 146 GWTQPITIGRHAFGDQYKCTDLVIPSGSTLQLLVNKPDG----SKDVHNVYDFKKSGGVG 201

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           L M+NTDESI+ FA SCF++AL ++ P+YLSTKNTILK YDGR++DIFQ++YE+ Y   F
Sbjct: 202 LAMYNTDESIKGFAHSCFQYALMKQWPLYLSTKNTILKKYDGRFKDIFQDIYEKKYEADF 261

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               +WYEHRLIDD VAQALKSSGGF+WACKNYDGDVQSDI+AQGYGSLGLMSSVL+ PD
Sbjct: 262 KNNKIWYEHRLIDDQVAQALKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMSSVLMCPD 321

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GKT+ AEAAHGTVTRH+R HQ+G  TSTN +ASI AW RGL HR  LD    +  F+  L
Sbjct: 322 GKTIEAEAAHGTVTRHYREHQKGNSTSTNPIASIFAWTRGLHHRGVLDNNEALKTFSLTL 381

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQE 483
           E++CI+T+ +GKMTKDLSI ++GT++G+++  YL TE+F+ A+  ++   M Q+
Sbjct: 382 EKACIDTVEEGKMTKDLSICIHGTKKGTEKGAYLITEDFLSAIDTKMAELMRQD 435

emb|CAA53300.1| isocitrate dehydrogenase (NADP+) [Solanum tuberosum]
pir||T07402 probable isocitrate dehydrogenase (NADP) (EC 1.1.1.42) ICDH-1, cytosol - potato (fragment)
(438 aa)

Score: 560 bits (1442), Expect: 5.31881e-158
Length: 421, Idn/Pos/Gap = 263/325/8 (62%/77%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI V+NPIVE+DGDE  RVIW  IK+KLILP+L LDI YF LGLP RDATDD VT+E
Sbjct:  24 AFQKITVQNPIVEMDGDEMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRDATDDKVTVE  83

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q+++ A+K ATITPDEARV+EF+LK M+ SPNGT+RN+LNGTVFREPI+ +NIPR
Sbjct:  84 SAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIMCKNIPR 143

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQY+A D  +  A +++L  +     E    +V+ F   T  G
Sbjct: 144 LVPGWTKPICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTEFEVYNF---TGAG 200

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDES+R+FA +    A ++K P+YLSTKNTILK YDGR++DIFQE+YE +++
Sbjct: 201 GVALSMYNTDESVRSFAEASMNMAFQKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWK 260

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 261 SKYEEAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 320

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW RGLAHRATLD    +  F 
Sbjct: 321 CPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNNERLLDFT 380

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSK--RENYLNTEEFIDAVQQRLDVHMLQEH 484
           E LE +CI  +  GKMTKDL++ +     GSK  RE+YLNTEEFIDAV   L   +L+  
Sbjct: 381 EKLEAACIGAVESGKMTKDLALIII---HGSKLSREHYLNTEEFIDAVADELKARLLKAK 437

Query: 485 A 485
           A
Sbjct: 438 A 438

sp|P50217|IDHC_SOLTU Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
pir||S47013 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) - potato
prf||2111437A isocitrate dehydrogenase
(416 aa)

Score: 558 bits (1438), Expect: 1.20485e-157
Length: 421, Idn/Pos/Gap = 263/325/8 (62%/77%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI V+NPIVE+DGDE  RVIW  IK+KLILP+L LDI YF LGLP RDATDD VT+E
Sbjct:   2 AFQKITVQNPIVEMDGDEMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRDATDDKVTVE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q+++ A+K ATITPDEARV+EF+LK M+ SPNGT+RN+LNGTVFREPI+ +NIPR
Sbjct:  62 SAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIMCKNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQY+A D  +  A +++L  +     E    +V+ F   T  G
Sbjct: 122 LVPGWTKPICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTEFEVYNF---TGAG 178

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDES+R+FA +    A ++K P+YLSTKNTILK YDGR++DIFQE+YE +++
Sbjct: 179 GVALSMYNTDESVRSFAEASMNMAFQKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWK 238

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 239 SKYEEAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 298

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW RGLAHRATLD    +  F 
Sbjct: 299 CPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNNERLLDFT 358

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSK--RENYLNTEEFIDAVQQRLDVHMLQEH 484
           E LE +CI  +  GKMTKDL++ +     GSK  RE+YLNTEEFIDAV   L   +L+  
Sbjct: 359 EKLEAACIGAVESGKMTKDLALIII---HGSKLSREHYLNTEEFIDAVADELKARLLKAK 415

Query: 485 A 485
           A
Sbjct: 416 A 416

emb|CAE70680.1| Hypothetical protein CBG17397 [Caenorhabditis briggsae]
(435 aa)

Score: 558 bits (1437), Expect: 1.62698e-157
Length: 407, Idn/Pos/Gap = 251/318/4 (61%/78%/0%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V+NP+V+LDGDE  R+IW  IK+KLI PYL+LDI Y+DLGL  RD T+D VT++AA 
Sbjct:  26 KIKVKNPVVDLDGDEMTRIIWKEIKDKLIFPYLDLDIKYYDLGLEYRDDTNDQVTVDAAH  85

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A+ ++   +K ATITPDEARV+EF LK+M+ SPNGT+RN+L GTVFREPIL +NIPRLVP
Sbjct:  86 AILEYSVGIKCATITPDEARVKEFKLKKMWLSPNGTIRNILGGTVFREPILCKNIPRLVP 145

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW +PI I RH FGDQYK  DL +P    +EL V +A G     + +H+     + GGV 
Sbjct: 146 GWTEPITIGRHAFGDQYKCTDLVIPEGSTLELVVNNADG----SKDIHKVFDFKNSGGVG 201

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           L M+NTDESI+ FA SCF+++L +K P+YLSTKNTILK YDGR++DIFQ++YER Y   F
Sbjct: 202 LAMYNTDESIKGFAHSCFQYSLMKKWPLYLSTKNTILKKYDGRFKDIFQDIYERKYEAEF 261

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               +WYEHRLIDD VAQALKSSGGF+WACKNYDGDVQSDI+AQGYGSLGLMSSVL+ PD
Sbjct: 262 KNNKIWYEHRLIDDQVAQALKSSGGFVWACKNYDGDVQSDIVAQGYGSLGLMSSVLMCPD 321

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GKT+ AEAAHGTVTRH+R HQ+G  TSTN +ASI AW RGL HR  LD    +  F+  L
Sbjct: 322 GKTMEAEAAHGTVTRHYREHQKGNSTSTNPIASIFAWTRGLHHRGVLDENEALKTFSLTL 381

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E++CI+T+ +GKMTKDLSI ++GT++G+++  YL TE+F+ A+  ++
Sbjct: 382 EKACIDTVEEGKMTKDLSICIHGTKKGTEKGAYLITEDFLAAIDTKM 428

emb|CAA54912.1| isocitrate dehydrogenase (NADP+) [Nicotiana tabacum]
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
pir||S65065 isocitrate dehydrogenase (NADP) (EC 1.1.1.42), cytosolic - common tobacco
(415 aa)

Score: 556 bits (1433), Expect: 5.6876e-157
Length: 418, Idn/Pos/Gap = 258/324/5 (61%/77%/1%)

Query:  68 FSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEA 127
           F KI+V NPIVE+DGDE  RVIW  IK+KLI P+L LDI YFDLGLP RDATDD VT+E+
Sbjct:   3 FDKIKVENPIVEMDGDEMTRVIWKSIKDKLICPFLELDIKYFDLGLPHRDATDDKVTVES  62

Query: 128 ARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRL 187
           A A Q+++ A+K ATITPDEARV+EF+LK M+ SPNGT+RN+LNGTVFREPI+ +NIPRL
Sbjct:  63 AEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIMCKNIPRL 122

Query: 188 VPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGG 247
           VPGW +PI I RH FGDQY+A D  +  A +++L  +     E    +V+ F   T  GG
Sbjct: 123 VPGWTKPICIGRHAFGDQYRATDTVIQGAGKLKLVFVPEGTDEKTEFEVYNF---TGAGG 179

Query: 248 VALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRE 307
           VAL M+NTDES+R+FA +    A ++K P+YLSTKNTILK YDGR++DIFQE+YE +++ 
Sbjct: 180 VALSMYNTDESVRSFAEASMNMAYQKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKS 239

Query: 308 RFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLT 367
           ++  A +WYEHRLIDDM A ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+ 
Sbjct: 240 KYEEAGIWYEHRLIDDMAAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVC 299

Query: 368 PDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAE 427
           PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW RGLAHRATLD    +  F E
Sbjct: 300 PDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNNERLLDFTE 359

Query: 428 ALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQEHA 485
            LE +CI  +  GKMTKDL++ ++G++    R++YLNTEEFIDAV   L   +L+  A
Sbjct: 360 KLEAACIGAVESGKMTKDLALIIHGSKL--SRDHYLNTEEFIDAVADELKARLLKAKA 415

emb|CAD24779.1| isocitrate dehydrogenase [Cucumis sativus]
(410 aa)

Score: 554 bits (1428), Expect: 1.75437e-156
Length: 416, Idn/Pos/Gap = 261/323/8 (62%/77%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V NPIVE+DGDE  RVIW  IKNKLI P+L LDI YFDLGLP RDATDD VT+E
Sbjct:   2 AFQKIKVANPIVEMDGDEMTRVIWESIKNKLIFPFLELDIKYFDLGLPHRDATDDKVTIE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDEARV+EF LK+M+ SPNGT+RN+LNGTVFREPIL +N+PR
Sbjct:  62 SAEATLKYNVAIKCATITPDEARVKEFGLKQMWRSPNGTIRNILNGTVFREPILCKNVPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQY+A D  +    +++L     +G E +  +V  F   T  G
Sbjct: 122 LVPGWTKPICIGRHAFGDQYRATDTVIRGPGKLKLVF---EGQETQEIEVFNF---TGAG 175

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESIR+FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 176 GVALAMYNTDESIRSFAEASMATAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYESQWK 235

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            +F  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 236 SKFEAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 295

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRHFR+HQ+G ETSTNS+ASI AW+RGLAHRA LD    +  F 
Sbjct: 296 CPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDDNASLLEFT 355

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           E LE + I+T+  GKMTKDL++ ++G++    R+ YLNTEEFIDAV + L   +L+
Sbjct: 356 EKLELAYIDTVESGKMTKDLALILHGSKL--SRDQYLNTEEFIDAVAEELKSRLLK 409

gb|AAB39248.1| NADP-isocitrate dehydrogenase [Eucalyptus globulus]
(416 aa)

Score: 553 bits (1426), Expect: 3.3633e-156
Length: 414, Idn/Pos/Gap = 258/320/5 (62%/77%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
            F KI+V NPIVE+DGDE  RV W  IK+KLI P+L LDI YFDLGLP RDATDD VT+E
Sbjct:   2 GFEKIKVENPIVEMDGDEMTRVFWKSIKDKLIFPFLELDIKYFDLGLPHRDATDDKVTIE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDEAR++EF LK+M+ SPNGT+RN+LNGTVFREPI+ +NIPR
Sbjct:  62 SAEATLKYNVAIKCATITPDEARMKEFTLKQMWKSPNGTIRNILNGTVFREPIMCKNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQYKA D  +  A +++L  +     E    +V+ F   T  G
Sbjct: 122 LVPGWSKPICIGRHAFGDQYKATDTVIKGAGKLKLVFVPEGTDEKTELEVYNF---TGAG 178

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESIR+FA +    A ++K P+YLSTKNTILK YDGR++DIFQE+YE +++
Sbjct: 179 GVALSMYNTDESIRSFAEASMNTAYQKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWK 238

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            +F  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 239 SKFEAAGIWYEHRLIDDMVAYALKSDGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 298

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW+RGLAHRA LD    +  FA
Sbjct: 299 CPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRAKLDNNAKLLDFA 358

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E LE +CI T+  GKMTKDL++ ++G +    R+ YLNTEEFIDAV   L   +
Sbjct: 359 EKLEAACIGTVESGKMTKDLALLIHGPK--FTRDQYLNTEEFIDAVAVELKARL 410

gb|AAA33978.1| NADPH-specific isocitrate dehydrogenase
(441 aa)

Score: 551 bits (1419), Expect: 1.98885e-155
Length: 441, Idn/Pos/Gap = 268/330/9 (60%/74%/2%)

Query:  43 GHCFPKFLRRTTGRSLCANMSNVP--AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILP 100
           G CF   +   T  S  + +  +   AF KI+V NPIVE+DGDE  RVIW  IK+KLILP
Sbjct:   5 GLCFSLLISHLTFYSSQSQIRTLAMAAFQKIKVANPIVEMDGDEMTRVIWKSIKDKLILP  64

Query: 101 YLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYP 160
           +L LDI Y+DLGLP RD TDD VT+E+A A  +++ A+K ATITPDEARV+EF LK M+ 
Sbjct:  65 FLELDIKYYDLGLPYRDETDDKVTIESAEATLKYNVAIKCATITPDEARVKEFGLKSMWK 124

Query: 161 SPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVE 220
           SPNGT+RN+LNGTVFREPIL +NIPRLVPGW + I I RH FGDQY+A D  +  A +++
Sbjct: 125 SPNGTIRNILNGTVFREPILCKNIPRLVPGWTKAICIGRHAFGDQYRATDTVIKGAGKLK 184

Query: 221 LR-VLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYL 279
           L  V + QG E E  +V  F   T  GGV+L M+NTDESIR+FA +    AL +K P+YL
Sbjct: 185 LVFVPEGQGEETEF-EVFNF---TGEGGVSLAMYNTDESIRSFAEASMATALEKKWPLYL 240

Query: 280 STKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWAC 339
           STKNTILK YDGR++DIFQE+YE  ++ +F  A +WYEHRLIDDMVA ALKS GG++WAC
Sbjct: 241 STKNTILKKYDGRFKDIFQEVYEASWKSKFEAAGIWYEHRLIDDMVAYALKSEGGYVWAC 300

Query: 340 KNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNS 399
           KNYDGDVQSD +AQG+GSLGLM+SVL+ PDGKT+ AEAAHGTVTRHFR+HQ+G ETSTNS
Sbjct: 301 KNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNS 360

Query: 400 VASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKR 459
           +ASI AW RGLAHRA LD    +  F E LE +CI  +  GKMTKDL++ ++G++    R
Sbjct: 361 IASIFAWTRGLAHRAKLDDNAKLLDFTEKLEAACIGVVEAGKMTKDLALILHGSKL--SR 418

Query: 460 ENYLNTEEFIDAVQQRLDVHM 480
           E+YLNTEEFIDAV   L   +
Sbjct: 419 EHYLNTEEFIDAVAAELSARL 439

pir||S33612 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) - soybean
(451 aa)

Score: 550 bits (1418), Expect: 3.06924e-155
Length: 441, Idn/Pos/Gap = 268/330/9 (60%/74%/2%)

Query:  43 GHCFPKFLRRTTGRSLCANMSNVP--AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILP 100
           G CF   +   T  S  + +  +   AF KI+V NPIVE+DGDE  RVIW  IK+KLILP
Sbjct:  15 GLCFSLLISHLTFYSSQSQIRTLAMAAFQKIKVANPIVEMDGDEMTRVIWKSIKDKLILP  74

Query: 101 YLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYP 160
           +L LDI Y+DLGLP RD TDD VT+E+A A  +++ A+K ATITPDEARV+EF LK M+ 
Sbjct:  75 FLELDIKYYDLGLPYRDETDDKVTIESAEATLKYNVAIKCATITPDEARVKEFGLKSMWK 134

Query: 161 SPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVE 220
           SPNGT+RN+LNGTVFREPIL +NIPRLVPGW + I I RH FGDQY+A D  +  A +++
Sbjct: 135 SPNGTIRNILNGTVFREPILCKNIPRLVPGWTKAICIGRHAFGDQYRATDTVIKGAGKLK 194

Query: 221 LR-VLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYL 279
           L  V + QG E E  +V  F   T  GGV+L M+NTDESIR+FA +    AL +K P+YL
Sbjct: 195 LVFVPEGQGEETEF-EVFNF---TGEGGVSLAMYNTDESIRSFAEASMATALEKKWPLYL 250

Query: 280 STKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWAC 339
           STKNTILK YDGR++DIFQE+YE  ++ +F  A +WYEHRLIDDMVA ALKS GG++WAC
Sbjct: 251 STKNTILKKYDGRFKDIFQEVYEASWKSKFEAAGIWYEHRLIDDMVAYALKSEGGYVWAC 310

Query: 340 KNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNS 399
           KNYDGDVQSD +AQG+GSLGLM+SVL+ PDGKT+ AEAAHGTVTRHFR+HQ+G ETSTNS
Sbjct: 311 KNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNS 370

Query: 400 VASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKR 459
           +ASI AW RGLAHRA LD    +  F E LE +CI  +  GKMTKDL++ ++G++    R
Sbjct: 371 IASIFAWTRGLAHRAKLDDNAKLLDFTEKLEAACIGVVEAGKMTKDLALILHGSKL--SR 428

Query: 460 ENYLNTEEFIDAVQQRLDVHM 480
           E+YLNTEEFIDAV   L   +
Sbjct: 429 EHYLNTEEFIDAVAAELSARL 449

sp|Q06197|IDHC_SOYBN Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
(413 aa)

Score: 550 bits (1417), Expect: 3.81282e-155
Length: 415, Idn/Pos/Gap = 263/321/7 (63%/77%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V NPIVE+DGDE  RVIW  IK+KLILP+L LDI Y+DLGLP RD TDD VT+E
Sbjct:   3 AFQKIKVANPIVEMDGDEMTRVIWKSIKDKLILPFLELDIKYYDLGLPYRDETDDKVTIE  62

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDEARV+EF LK M+ SPNGT+RN+LNGTVFREPIL +NIPR
Sbjct:  63 SAEATLKYNVAIKCATITPDEARVKEFGLKSMWKSPNGTIRNILNGTVFREPILCKNIPR 122

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELR-VLDAQGMELERRQVHQFASSTDG 245
           LVPGW + I I RH FGDQY+A D  +  A +++L  V + QG E E  +V  F   T  
Sbjct: 123 LVPGWTKAICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGQGEETEF-EVFNF---TGE 178

Query: 246 GGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDY 305
           GGV+L M+NTDESIR+FA +    AL +K P+YLSTKNTILK YDGR++DIFQE+YE  +
Sbjct: 179 GGVSLAMYNTDESIRSFAEASMATALEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASW 238

Query: 306 RERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVL 365
           + +F  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL
Sbjct: 239 KSKFEAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVL 298

Query: 366 LTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHF 425
           + PDGKT+ AEAAHGTVTRHFR+HQ+G ETSTNS+ASI AW RGLAHRA LD    +  F
Sbjct: 299 VCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNAKLLDF 358

Query: 426 AEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
            E LE +CI  +  GKMTKDL++ ++G++    RE+YLNTEEFIDAV   L   +
Sbjct: 359 TEKLEAACIGVVEAGKMTKDLALILHGSKL--SREHYLNTEEFIDAVAAELSARL 411

dbj|BAC77064.1| NADP-specific isocitrate dehydrogenase [Lupinus albus]
(412 aa)

Score: 548 bits (1412), Expect: 1.58814e-154
Length: 410, Idn/Pos/Gap = 258/315/5 (62%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI V NPIVE+DGDE  RVIW  IK+KLILP+L LDI Y+DLGLP RD TDD VT+E
Sbjct:   2 AFQKINVANPIVEMDGDEMTRVIWKSIKDKLILPFLELDIKYYDLGLPYRDETDDKVTVE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDEARV+EF LK+M+ SPNGT+RN+LNGTVFREPIL +NIPR
Sbjct:  62 SAEATLKYNVAIKCATITPDEARVKEFGLKQMWKSPNGTIRNILNGTVFREPILCKNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQYKA D  +  A +++L  +     E    +V+ F   T  G
Sbjct: 122 LVPGWNKPICIGRHAFGDQYKATDAVIKGAGKLKLVFVPEGQSEATELEVYNF---TGEG 178

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVA  M+NTDESIR FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 179 GVAQAMYNTDESIRAFADASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWK 238

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F  A +WYEHRLIDDMVA A+KS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 239 SNFEAAGIWYEHRLIDDMVAYAVKSDGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 298

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRHFR+HQ+G ETSTNS+ASI AW+RGLAHRA LD    +  F 
Sbjct: 299 CPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDDNAKLLDFT 358

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           + LE +CI  +  GKMTKDL++ ++G++    RE+YLNTEEFIDAV   L
Sbjct: 359 KKLEEACIGAVESGKMTKDLALIIHGSKL--SREHYLNTEEFIDAVANEL 406

gb|AAC64182.1| NADP-dependent isocitrate dehydrogenase [Glycine max]
(416 aa)

Score: 548 bits (1411), Expect: 1.69777e-154
Length: 414, Idn/Pos/Gap = 256/319/5 (61%/77%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
            F KIRV NPIVE+DGDE  RVIW LIK+KLI PYL LDI YFDLGLP RDAT+D VT+E
Sbjct:   2 GFQKIRVGNPIVEMDGDEMTRVIWKLIKDKLIFPYLELDIKYFDLGLPHRDATNDRVTIE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDEARV+EF+LK+M+ SPNGT+RN+LNGTVFREPI+ +NIPR
Sbjct:  62 SAEATLKYNVAIKCATITPDEARVKEFNLKQMWRSPNGTIRNILNGTVFREPIICKNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LV GW +PI I RH FGDQY+A D  +    +++L    +    ++  +V+ F   T  G
Sbjct: 122 LVSGWTKPICIGRHAFGDQYRATDTVIKGPGKLKLVFAPSGNEGIKELEVYNF---TGAG 178

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           G+AL M+NTDESIR FA +   FA ++K P+YLSTKNTILK YDGR++DIFQE+++  + 
Sbjct: 179 GIALSMYNTDESIRAFAEASMNFAYQKKWPLYLSTKNTILKKYDGRFKDIFQEVFDTQWN 238

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            +F  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 239 HKFKAAGIWYEHRLIDDMVAYALKSDGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 298

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW+RGLAHR  LDG   +  F 
Sbjct: 299 CPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRPKLDGNARLLDFT 358

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E LE +CI T+  GKMTKDL++ V+G +    R  YLNTEEFIDAV + L   +
Sbjct: 359 EKLEAACIGTVELGKMTKDLALLVHGPK--VSRSQYLNTEEFIDAVAEELRTRL 410

dbj|BAA34112.1| NADP specific isocitrate dehydrogenase [Daucus carota]
(412 aa)

Score: 548 bits (1411), Expect: 2.09156e-154
Length: 414, Idn/Pos/Gap = 254/320/5 (61%/77%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V NPIVE+DGDE  RV W  IK+KLI P++ LDI YFDLGLP RDATDD VT+E
Sbjct:   2 AFQKIKVANPIVEMDGDEMTRVFWKSIKDKLIFPFVELDIKYFDLGLPHRDATDDKVTVE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDEARV+EF LK+M+ SPNGT+RN+LNGTVFREPI+ +NIP+
Sbjct:  62 SAEATLKYNVAIKCATITPDEARVKEFGLKQMWKSPNGTIRNILNGTVFREPIICKNIPK 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           L+PGW +PI I RH FGDQY+A D  +    +++L  +     E    +V+ F   T  G
Sbjct: 122 LIPGWTKPICIGRHAFGDQYRATDAVIQGPGKLKLVFVPEGKEEKTELEVYNF---TGAG 178

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESIR+FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 179 GVALSMYNTDESIRSFAEASMATAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWK 238

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 239 SKYDAAGIWYEHRLIDDMVAYALKSDGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 298

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW+RGLAHRA LD    +  FA
Sbjct: 299 CPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRAKLDDNAALLSFA 358

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E LE +C+ T+  GKMTKDL++ ++G++    RE+YLNTEEFIDAV   L   +
Sbjct: 359 EKLEAACVGTVESGKMTKDLALILHGSKL--SREHYLNTEEFIDAVASDLKARL 410

emb|CAA73139.1| isocitrate dehydrogenase (NADP+) [Apium graveolens]
(412 aa)

Score: 546 bits (1408), Expect: 4.18054e-154
Length: 414, Idn/Pos/Gap = 254/320/5 (61%/77%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V NPIVE+DGDE  RV W  IK+KLI P++ LDI YFDLGLP RDATDD VT+E
Sbjct:   2 AFQKIKVANPIVEMDGDEMTRVFWKSIKDKLIFPFVELDIKYFDLGLPHRDATDDKVTVE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDEARVEEF LK+M+ SPNGT+RN+LNGTVFREPI+ +NIP+
Sbjct:  62 SAEATLKYNVAIKCATITPDEARVEEFGLKQMWKSPNGTIRNILNGTVFREPIICKNIPK 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           L+PGW +PI I RH FGDQY+A D  +    +++L  +     E    +V+ F   T  G
Sbjct: 122 LIPGWTKPICIGRHAFGDQYRATDAVIKGPGKLKLVFVPEGKEEKTELEVYNF---TGAG 178

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESIR+FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 179 GVALSMYNTDESIRSFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWK 238

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 239 SKYEAAGIWYEHRLIDDMVAYALKSDGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 298

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW+RGLAHRA LD    +  FA
Sbjct: 299 CPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRAKLDDNAALLSFA 358

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E LE +C+ T+  G+MTKDL++ ++G++    RE+YLNTEEFIDAV   L   +
Sbjct: 359 EKLEAACVGTVEAGRMTKDLALILHGSKL--SREHYLNTEEFIDAVADDLKARL 410

gb|AAD25614.1| NADP specific isocitrate dehydrogenase [Arabidopsis thaliana]
ref|NP_175836.1| isocitrate dehydrogenase, putative / NADP+ isocitrate dehydrogenase, putative [Arabidopsis thaliana]
gb|AAK06592.1| NADP-specific isocitrate dehydrogenase [Arabidopsis thaliana]
pir||A96585 NADP specific isocitrate dehydrogenase [imported] - Arabidopsis thaliana
(416 aa)

Score: 546 bits (1407), Expect: 4.93975e-154
Length: 414, Idn/Pos/Gap = 254/317/6 (61%/76%/1%)

Query:  68 FSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEA 127
           F KI+V NP+VE+DGDE  RVIW  IK+KLI P+L LDI YFDLGLP RD TDD VT+E 
Sbjct:   3 FEKIKVINPVVEMDGDEMTRVIWKFIKDKLIFPFLELDIKYFDLGLPNRDFTDDKVTIET  62

Query: 128 ARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRL 187
           A A  +++ A+K ATITPDEARV EF LK+M+ SPNGT+RN+LNGTVFREPI+  NIPRL
Sbjct:  63 AEATLKYNVAIKCATITPDEARVREFGLKKMWRSPNGTIRNILNGTVFREPIICRNIPRL 122

Query: 188 VPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGG 247
           VPGW +PI I RH FGDQY+A DL V    +++L    +   +    +V  F     GGG
Sbjct: 123 VPGWTKPICIGRHAFGDQYRATDLIVNEPGKLKLVFEPSGSSQKTEFEVFNFT----GGG 178

Query: 248 VALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRE 307
           VAL M+NTDESIR FA S    A ++K P+YLSTKNTILK+YDGR++DIFQE+YE ++R 
Sbjct: 179 VALAMYNTDESIRAFAESSMYTAYQKKWPLYLSTKNTILKIYDGRFKDIFQEVYEANWRS 238

Query: 308 RFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLT 367
           ++  A +WYEHRLIDDMVA A+KS GG++WACKNYDGDVQSD +AQGYGSLG+M+SVL+ 
Sbjct: 239 KYEAAGIWYEHRLIDDMVAYAMKSEGGYVWACKNYDGDVQSDFLAQGYGSLGMMTSVLVC 298

Query: 368 PDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAE 427
           PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW+RGLAHRA LD    +  + E
Sbjct: 299 PDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRAKLDSNAALLSYTE 358

Query: 428 ALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHML 481
            LE +C+ T+  GKMTKDL++ ++G +   +R+ Y+NTEEFIDAV   L   +L
Sbjct: 359 KLEAACMGTVESGKMTKDLALLIHGAK--VRRDQYVNTEEFIDAVAWELKRRLL 410

ref|ZP_00268160.1| COG0538: Isocitrate dehydrogenases [Rhodospirillum rubrum]
(405 aa)

Score: 546 bits (1407), Expect: 5.59835e-154
Length: 412, Idn/Pos/Gap = 251/314/10 (60%/76%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           SKI V+NPIVELDGDE  R+IW  IK KLILPYL++D++Y+DLG+  RD T+D +T+EAA
Sbjct:   2 SKITVKNPIVELDGDEMTRIIWQFIKEKLILPYLDVDLLYYDLGVEKRDETEDRITIEAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A+++HH  VK ATITPDEARVEEF LK+M+ SPNGT+RN+L+GTVFREPI+ +N+PRLV
Sbjct:  62 NAIKKHHVGVKCATITPDEARVEEFGLKKMWKSPNGTIRNILDGTVFREPIICKNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW QPIVI RH FGDQYKA D  VP A  + +      G   +  +V +F     G GV
Sbjct: 122 PGWTQPIVIGRHAFGDQYKATDFIVPGAGTLTMSFKPEDGGPAQEYEVFKFP----GAGV 177

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+GM+N D+SIR FAR+C  + + R  P+YLSTKNTILK YDGR++D+FQE+++ ++ ER
Sbjct: 178 AMGMYNLDDSIRGFARACLNYGILRNWPVYLSTKNTILKAYDGRFKDLFQEVFDAEFAER 237

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    + YEHRLIDDMVA  +K SGGF+WACKNYDGDVQSD +AQG+GSLGLM+SVL+TP
Sbjct: 238 FKAKGITYEHRLIDDMVACCMKWSGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTP 297

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DG+T+ AEAAHGTVTRH+RLHQ+GKETSTN +ASI AW RGL  R   DGTPDV  FAEA
Sbjct: 298 DGETVEAEAAHGTVTRHYRLHQKGKETSTNPIASIFAWTRGLKFRGEFDGTPDVVQFAEA 357

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           LER C+ET+  G MTKDL+I + G +Q      +L T +F+D +   L   M
Sbjct: 358 LERVCVETVEAGFMTKDLAILI-GPDQ-----PWLTTTQFLDKLDATLKAEM 403

gb|AAH63967.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
gb|AAH48041.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
ref|NP_955858.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Danio rerio]
(449 aa)

Score: 546 bits (1407), Expect: 5.88575e-154
Length: 411, Idn/Pos/Gap = 244/316/4 (59%/76%/0%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLIL  +N+D+ Y+DLGLP RD TDD VT++
Sbjct:  38 ADKRIQVAQPVVEMDGDEMTRIIWEFIKEKLILTNVNVDLKYYDLGLPYRDQTDDQVTID  97

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A ++++ AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPR
Sbjct:  98 SAIATKKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 157

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW Q I I RH FGDQYKA D  V    + ++    A G + +  +V+ F     GG
Sbjct: 158 LVPGWTQAITIGRHAFGDQYKATDFVVNQPGKFKMVFTPADGSKNKEWEVYDFP----GG 213

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           G  +GM+NTDESI  FA SCF++A+++K P+Y+STKNTILK YDGR++DIFQ+++E++Y+
Sbjct: 214 GCGMGMYNTDESITGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKNYK 273

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F +  +WYEHRLIDDMVAQ LKSSG F+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 274 PEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 333

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG PD+  F+
Sbjct: 334 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPDLIKFS 393

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           + LER C+ET+  G MTKDL+  ++G       E+Y+NT +F+DA++  LD
Sbjct: 394 QTLERVCVETVESGVMTKDLAGCIHGLANCKLNEHYVNTTDFLDAIKTNLD 444

gb|AAD51361.1| NADP-isocitrate dehydrogenase [Citrus limon]
(414 aa)

Score: 545 bits (1404), Expect: 1.32219e-153
Length: 410, Idn/Pos/Gap = 252/320/5 (61%/78%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V NPIVE+DGDE  RV W  IK+KLI P+L LDI YFDLGLP RDATDD VT+E
Sbjct:   2 AFQKIKVANPIVEMDGDEMTRVFWKSIKDKLIFPFLELDIKYFDLGLPNRDATDDKVTVE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDEARV+EF LK+M+ SPNGT+RN+LNGTVFREPI+ +N+PR
Sbjct:  62 SAEATLKYNVAIKCATITPDEARVKEFVLKQMWKSPNGTIRNILNGTVFREPIICKNVPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           L+PGW +PI I RH FGDQY+A D  +    +++L  +     E    +V+ F   T  G
Sbjct: 122 LIPGWTKPICIGRHAFGDQYRATDTVIQGPGKLKLVFVPEGKDEKTELEVYNF---TGEG 178

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESIR+FA +    A ++K P+YLSTKNTILK YDG+++DIFQE+YE +++
Sbjct: 179 GVALSMYNTDESIRSFAEASMNTAYQKKWPLYLSTKNTILKNYDGKFKDIFQEVYEANWK 238

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            +F  A +WYEHRLIDDMVA ALKS GG++WACK+YDG+VQSD +AQG+GSLGLM+SVL+
Sbjct: 239 SKFEAAGIWYEHRLIDDMVAYALKSEGGYVWACKDYDGNVQSDFLAQGFGSLGLMTSVLV 298

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW+RGLAHRA LD    +  F 
Sbjct: 299 CPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRAKLDNNARLLDFT 358

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E LE +C+ T+  GKMTKDL++ ++G++    RE+YLNTEEFIDAV   L
Sbjct: 359 EKLEAACVGTVESGKMTKDLALIIHGSKM--TREHYLNTEEFIDAVADDL 406

emb|CAA65504.1| isocitrate dehydrogenase (NADP+) [Nicotiana tabacum]
pir||T04356 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) precursor, mitochondrial - common tobacco
(470 aa)

Score: 544 bits (1402), Expect: 1.94081e-153
Length: 416, Idn/Pos/Gap = 258/317/6 (62%/76%/1%)

Query:  61 NMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATD 120
           + ++  A SKIRV NPIVE+DGDE  RVIW +IK KLI PYL LD  Y+DLG+  RDATD
Sbjct:  51 SFASTTASSKIRVENPIVEMDGDEMTRVIWTMIKEKLIYPYLELDTKYYDLGILNRDATD 110

Query: 121 DGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPIL 180
           D VT+E+A A  +++ AVK ATITPDE RV+EF LK M+ SPN T+RN+LNGTVFREPIL
Sbjct: 111 DQVTVESAEATLKYNVAVKCATITPDETRVKEFGLKSMWRSPNATIRNILNGTVFREPIL 170

Query: 181 VENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFA 240
            +N+PR+VPGWK+PI I RH FGDQY+A D  +    ++++      G       V+ F 
Sbjct: 171 CKNVPRIVPGWKKPICIGRHAFGDQYRATDAVINGPGKLKMVFEPENGEAPTELDVYDF- 229

Query: 241 SSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQEL 300
               G GVAL M+N D+SIR FA S    A  +K P+YLSTKNTILK YDGR++DIF+E+
Sbjct: 230 ---KGPGVALAMYNVDQSIRAFAESSMSMAFSKKWPLYLSTKNTILKKYDGRFKDIFEEV 286

Query: 301 YERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGL 360
           YE  ++++F   ++WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD++AQG+GSLGL
Sbjct: 287 YEEKWKQQFEEHSIWYEHRLIDDMVAYALKSGGGYVWACKNYDGDVQSDLLAQGFGSLGL 346

Query: 361 MSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTP 420
           M+SVLL+ DGKTL AEAAHGTVTRHFRLHQ+G+ETSTNSVASI AWARGL HRA LDG  
Sbjct: 347 MTSVLLSSDGKTLEAEAAHGTVTRHFRLHQKGQETSTNSVASIFAWARGLGHRAQLDGNQ 406

Query: 421 DVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
            ++ F  ALE +C+ TI  GKMTKDL+I V+G +    RE+YLNTEEFID V Q+L
Sbjct: 407 KLSEFVHALEAACVGTIESGKMTKDLAILVHGPK--VSREHYLNTEEFIDPVAQKL 460

gb|AAU44341.1| NADP-dependent isocitrate dehydrogenase I [Pisum sativum]
gb|AAS49171.1| NADP-dependent isocitrate dehydrogenase [Pisum sativum]
(412 aa)

Score: 544 bits (1401), Expect: 2.70975e-153
Length: 410, Idn/Pos/Gap = 254/315/5 (61%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V +PIVE+DGDE  RVIW  IK+KLI P+L LDI YFDLGLP RD TDD VT+E
Sbjct:   2 AFQKIKVASPIVEMDGDEMTRVIWKSIKDKLIFPFLELDIKYFDLGLPHRDQTDDKVTVE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDEARVEEF LK M+ SPNGT+RN+LNGTVFREPI+ +N+PR
Sbjct:  62 SAEATLKYNVAIKCATITPDEARVEEFGLKSMWRSPNGTIRNILNGTVFREPIICKNVPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           L+PGW +PI I RH FGDQY+A D  +    ++++  +     E    +V+ F   T  G
Sbjct: 122 LIPGWTKPICIGRHAFGDQYRATDAVIKGPGKLKMVFVPEGKGETTDLEVYNF---TGEG 178

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESIR+FA +    AL +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 179 GVALAMYNTDESIRSFAEASMATALEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWK 238

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 239 SKYEAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 298

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRHFR+HQ+G ETSTN +ASI AW RGLAHRA LD    +    
Sbjct: 299 CPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNGIASIFAWTRGLAHRAKLDDNAKLLELT 358

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E LE +CI  +  GKMTKDL++ ++G++   KRE+YLNTEEFIDAV   L
Sbjct: 359 EKLEAACIGAVESGKMTKDLALILHGSQL--KREHYLNTEEFIDAVAAEL 406

sp|Q40345|IDHP_MEDSA Isocitrate dehydrogenase [NADP], chloroplast precursor (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
pir||T09619 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) precursor - alfalfa (fragment)
gb|AAA32656.1| isocitrate dehydrogenase
(433 aa)

Score: 543 bits (1400), Expect: 3.04551e-153
Length: 411, Idn/Pos/Gap = 256/318/7 (62%/77%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
            F KI+V NPIVE+DGDE  R+IW  IK+KLI P++ LDI YFDLGLP RD T+D VT+E
Sbjct:  23 GFQKIKVANPIVEMDGDEMTRIIWKYIKDKLIFPFVELDIKYFDLGLPYRDETNDKVTVE  82

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDEARV+EF LK M+ SPNGT+RN+LNGTVFREPI+ +NIPR
Sbjct:  83 SAEATLKYNVAIKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPIICKNIPR 142

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELR-VLDAQGMELERRQVHQFASSTDG 245
           L+PGW +PI I RH FGDQY+A D  +    +++L  V + QG E    +V+ F   T  
Sbjct: 143 LIPGWTKPICIGRHAFGDQYRATDSVIKGPGKLKLVFVPEGQG-ETTDLEVYNF---TGE 198

Query: 246 GGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDY 305
           GGVAL M+NTDESIR+FA +    AL +K P+YLSTKNTILK YDGR++DIFQE+YE  +
Sbjct: 199 GGVALAMYNTDESIRSFAEASMAVALEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEAGW 258

Query: 306 RERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVL 365
           + ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL
Sbjct: 259 KSKYEAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVL 318

Query: 366 LTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHF 425
           + PDGKT+ AEAAHGTVTRHFR+HQ+G ETSTNS+ASI AW RGLAHRA LD    +  F
Sbjct: 319 VCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNATLLDF 378

Query: 426 AEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
            E LE +CI  +  GKMTKDL++ ++G++    RE+YLNTEEFIDAV   L
Sbjct: 379 TEKLEAACIGVVESGKMTKDLALILHGSKL--SREHYLNTEEFIDAVAAEL 427

emb|CAG77785.1| unnamed protein product [Yarrowia lipolytica CLIB99]
ref|XP_504978.1| hypothetical protein [Yarrowia lipolytica]
(440 aa)

Score: 543 bits (1400), Expect: 3.31052e-153
Length: 437, Idn/Pos/Gap = 260/331/14 (59%/75%/3%)

Query:  46 FPKFLRRTTGR--SLCANMSNVPA---FSKIRVRNPIVELDGDEQARVIWHLIKNKLILP 100
            P  L   T R  +L   MS        +KI+V+NPIVELDGDE  R+IW  IK+KLILP
Sbjct:   7 LPAMLTPATTRLLALSKTMSTTATRGLSTKIKVKNPIVELDGDEMTRIIWKSIKDKLILP  66

Query: 101 YLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYP 160
           YL++D+ Y+DLG+  RD T+D VT++AA A++++   VK ATITPDEARV+EF LK+M+ 
Sbjct:  67 YLDIDLKYYDLGIEYRDQTNDQVTIDAAEAIKKYQVGVKCATITPDEARVKEFGLKKMWL 126

Query: 161 SPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVE 220
           SPNGT+RN+L GTVFREPI++  +PRLVPGWK+PI+I RH  GDQYKAQD  +P A  + 
Sbjct: 127 SPNGTIRNILGGTVFREPIVIPAVPRLVPGWKEPIIIGRHAHGDQYKAQDAVIPGAGELT 186

Query: 221 LRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLS 280
           L    A G + +  +V+ +    D  GVA+ M+NTDESI  FA S F  AL++KLP+Y+S
Sbjct: 187 LNFKPANGGDEQVIKVYTY----DAPGVAMAMYNTDESITGFAYSSFNLALQKKLPLYMS 242

Query: 281 TKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACK 340
           TKNTILK YDGR++DIFQE+Y+++Y+++F  A +WYEHRLIDDMVAQ +KS GGF+ A K
Sbjct: 243 TKNTILKKYDGRFKDIFQEIYDKEYKDKFDAAGIWYEHRLIDDMVAQMIKSKGGFIMALK 302

Query: 341 NYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSV 400
           NYDGDVQSDI+AQG+GSLGLM+SVL+TPDGKT  +EAAHGTVTRH+R HQQGKETSTNS+
Sbjct: 303 NYDGDVQSDIVAQGFGSLGLMTSVLVTPDGKTFESEAAHGTVTRHYRQHQQGKETSTNSI 362

Query: 401 ASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI-LDGKMTKDLSIAVYGTEQGSKR 459
           ASI AW RGL  R  LD TP+V  FAEALE++ ++T+  DG MTKDL++A   T+    R
Sbjct: 363 ASIFAWTRGLIQRGILDETPEVTKFAEALEKATVDTVDKDGIMTKDLALAGGKTD----R 418

Query: 460 ENYLNTEEFIDAVQQRL 476
            +Y+ TEEFIDAV  RL
Sbjct: 419 SSYVLTEEFIDAVANRL 435

dbj|BAC77063.1| NADP-specific isocitrate dehydrogenase [Lupinus albus]
(412 aa)

Score: 543 bits (1399), Expect: 4.54563e-153
Length: 414, Idn/Pos/Gap = 254/316/5 (61%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI V NPIVE+DGDE  RVIW  IK+KLI P+L LDI Y+DLGLP RD TDD VT+E
Sbjct:   2 AFQKINVANPIVEMDGDEMTRVIWKSIKDKLIFPFLELDIKYYDLGLPYRDETDDKVTVE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDE RV+EF LK+M+ SPNGT+RN+LNGTVFREPIL +NIPR
Sbjct:  62 SAEATLKYNVAIKCATITPDEGRVKEFGLKQMWRSPNGTIRNILNGTVFREPILCKNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           L+PGW +PI I RH FGDQY+A D  +  A +++L  +     E    +V+ F   T  G
Sbjct: 122 LLPGWNKPICIGRHAFGDQYRATDSVIKGAGKLKLVFVPEGQSEATELEVYNF---TGEG 178

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESIR FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 179 GVALAMYNTDESIRAFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWK 238

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            +F  A +WYEHRLIDDMVA A+KS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 239 SKFEAAGIWYEHRLIDDMVAYAVKSDGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 298

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ +EAAHGTVTRHFR+HQ+G ETSTNS+ASI AW+RGLAHRA LD    +  F 
Sbjct: 299 CPDGKTIESEAAHGTVTRHFRVHQKGGETSTNSIASIFAWSRGLAHRAKLDDNAKLLDFT 358

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           + LE +CI  +  GKMTKDL++ ++G++    RE+YLNTEEFIDAV   L   +
Sbjct: 359 QKLEAACIGAVESGKMTKDLALILHGSKL--SREHYLNTEEFIDAVANELKARL 410

emb|CAA65503.1| isocitrate dehydrogenase (NADP+) [Nicotiana tabacum]
pir||T04355 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) precursor, mitochondrial - common tobacco
(482 aa)

Score: 543 bits (1398), Expect: 5.19485e-153
Length: 416, Idn/Pos/Gap = 258/317/6 (62%/76%/1%)

Query:  61 NMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATD 120
           + ++  A SKIRV NPIVE+DGDE  RVIW +IK KLI PYL LD  Y+DLG+  RDATD
Sbjct:  63 SFASTTASSKIRVENPIVEMDGDEMTRVIWTMIKEKLIYPYLELDTKYYDLGILNRDATD 122

Query: 121 DGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPIL 180
           D VT+E+A A  +++ AVK ATITPDE RV+EF LK M+ SPN T+RN+LNGTVFREPIL
Sbjct: 123 DQVTVESAEATLKYNVAVKCATITPDETRVKEFGLKSMWRSPNATIRNILNGTVFREPIL 182

Query: 181 VENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFA 240
            +N+PR+VPGWK+PI I RH FGDQY+A D  +    ++++      G       V+ F 
Sbjct: 183 CKNVPRIVPGWKKPICIGRHAFGDQYRATDAVINGPGKLKMVFEPENGEAPTELDVYDF- 241

Query: 241 SSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQEL 300
               G GVAL M+N D+SIR FA S    A  +K P+YLSTKNTILK YDGR++DIF+E+
Sbjct: 242 ---KGPGVALAMYNVDQSIRAFAESSMSMAFSKKWPLYLSTKNTILKKYDGRFKDIFEEV 298

Query: 301 YERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGL 360
           YE  ++++F   ++WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD++AQG+GSLGL
Sbjct: 299 YEEKWKQQFEEHSIWYEHRLIDDMVAYALKSGGGYVWACKNYDGDVQSDLLAQGFGSLGL 358

Query: 361 MSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTP 420
           M+SVLL+ DGKTL AEAAHGTVTRHFRLHQ+G+ETSTNSVASI AWARGL HRA LDG  
Sbjct: 359 MTSVLLSSDGKTLEAEAAHGTVTRHFRLHQKGQETSTNSVASIFAWARGLGHRAQLDGNQ 418

Query: 421 DVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
            ++ F  ALE +C+ TI  GKMTKDL+I V+G +    RE+YLNTEEFID V Q+L
Sbjct: 419 KLSEFVHALEAACVGTIESGKMTKDLAILVHGPK--VSREHYLNTEEFIDPVAQKL 472

pdb|1LWD|B Chain B, Crystal Structure Of Nadp-Dependent Isocitrate Dehydrogenase From Porcine Heart Mitochondria
pdb|1LWD|A Chain A, Crystal Structure Of Nadp-Dependent Isocitrate Dehydrogenase From Porcine Heart Mitochondria
(413 aa)

Score: 542 bits (1396), Expect: 9.08567e-153
Length: 411, Idn/Pos/Gap = 243/314/4 (59%/76%/0%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFDLGLP RD T+D VT++
Sbjct:   1 ADQRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTID  60

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPR
Sbjct:  61 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 120

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH  GDQYKA D  V  A   ++      G   ++ +V+ F +    G
Sbjct: 121 LVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPA----G 176

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++A+++K P+Y+STKNTILK YDGR++DIFQE++E+ Y+
Sbjct: 177 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYK 236

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F +  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 237 TDFDKYKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 296

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+  FA
Sbjct: 297 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 356

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           + LE+ C+ET+  G MTKDL+  ++G       E++LNT +F+D ++  LD
Sbjct: 357 QTLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLD 407

gb|AAL11503.1| NADP-dependent isocitrate dehydrogenase [Prunus persica]
(414 aa)

Score: 541 bits (1395), Expect: 1.18663e-152
Length: 410, Idn/Pos/Gap = 254/315/5 (61%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V NPIVE+DGDE  RV W  IK+KLILP+L LDI YFDLGLP RDATDD VT+E
Sbjct:   2 AFQKIKVANPIVEMDGDEMTRVFWKSIKDKLILPFLELDIKYFDLGLPHRDATDDKVTVE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDE RV+EF+LK M+ SPNGT+RN+LNGTVFREPIL +NIPR
Sbjct:  62 SAEATLKYNVAIKCATITPDEGRVKEFNLKSMWRSPNGTIRNILNGTVFREPILCKNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           L+PGW +PI I RH FGDQY+A D  +    +++L  +     E    +V+ F   T  G
Sbjct: 122 LIPGWTKPICIGRHAFGDQYRATDAVIKGPGKLKLVFVPDGKDEKTELEVYNF---TGEG 178

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESIR FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 179 GVALAMYNTDESIRAFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEAKWK 238

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 239 SQYEAAGIWYEHRLIDDMVAYALKSDGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 298

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW RGLAHRA LD    +  F 
Sbjct: 299 CPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNAKLLDFT 358

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           + LE +CI T+  GKMTKDL++ ++G +    R +YLNTEEFI+AV + L
Sbjct: 359 QKLEEACIGTVESGKMTKDLALIIHGPKLA--RNHYLNTEEFIEAVAEEL 406

gb|EAA08466.3| ENSANGP00000016660 [Anopheles gambiae str. PEST]
ref|XP_312860.2| ENSANGP00000016660 [Anopheles gambiae str. PEST]
(407 aa)

Score: 541 bits (1395), Expect: 1.30069e-152
Length: 409, Idn/Pos/Gap = 246/325/6 (60%/79%/1%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           ++I+   PIVE+DGDE  R+IW  IK+KLI PY+ ++ +Y+DLGLP RD T+D VT++AA
Sbjct:   1 TRIQAVKPIVEMDGDEMTRIIWQFIKDKLIFPYVKVEALYYDLGLPYRDQTNDQVTIDAA  60

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A+ +H+  +K ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFREPI+  NIPR+V
Sbjct:  61 HAMLKHNVGIKCATITPDEQRVEEFKLKKMWLSPNGTIRNILGGTVFREPIICNNIPRIV 120

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PIVI RH  GDQYKAQD  V     V++ V   +   +E  Q++++ S     GV
Sbjct: 121 PGWTKPIVIGRHAHGDQYKAQDYVVRKPGTVKM-VYTGEDGTVEEIQLYKYTSP----GV 175

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           AL M+NTDESI  FA S F+ AL ++ P+YLSTKNTILK YDGR++DIFQE+YE+DY+++
Sbjct: 176 ALAMYNTDESISAFAHSSFQVALGKRWPLYLSTKNTILKRYDGRFKDIFQEIYEKDYKKQ 235

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F  A +WYEHRLIDDMVAQALKSSG F+WACKNYDGDVQSDI+AQGYGSLGLM+SVL+ P
Sbjct: 236 FEEAKIWYEHRLIDDMVAQALKSSGEFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCP 295

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ +EAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HRA LD TP++A F++A
Sbjct: 296 DGKTVESEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRAKLDNTPELARFSKA 355

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           LE++C++T+  GKMTKDL++ ++G+ +  K   YLNT++F++A+ ++L+
Sbjct: 356 LEKACVDTVESGKMTKDLALCIHGS-RNLKDSMYLNTQDFLEAISEQLE 403

emb|CAG31511.1| hypothetical protein [Gallus gallus]
(452 aa)

Score: 540 bits (1392), Expect: 3.17617e-152
Length: 408, Idn/Pos/Gap = 242/313/4 (59%/76%/0%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           +I+V NP+VE+DGDE  R+IW  IK KLILP +++ + YFDLGLP RD TDD VT+++A 
Sbjct:  43 RIKVANPVVEMDGDEMTRIIWAFIKEKLILPNVDVQLKYFDLGLPHRDKTDDQVTIDSAL 102

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A +++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPRLVP
Sbjct: 103 ATKKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVP 162

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW QPI I RH  GDQYKA D  V  +   ++      G  ++  +V  F     GGGV 
Sbjct: 163 GWTQPITIGRHAHGDQYKATDFVVNKSGTFKMVFTPKDGSGVKEWEVFNFP----GGGVG 218

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           +GM+NTDESI  FA SCF++A+++K P+Y+STKNTILK YDGR++DIFQE++++ Y+  F
Sbjct: 219 MGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTEF 278

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
            +  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+ PD
Sbjct: 279 DKLKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPD 338

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LD  P++  FA+ L
Sbjct: 339 GKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDSNPELIKFAQTL 398

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           E+ C+ET+  G MTKDL+  ++G       E+++NT +F+DA++  LD
Sbjct: 399 EKVCVETVESGTMTKDLAGCIHGLANVKLNEHFVNTTDFLDAIKNTLD 446

pir||A43294 isocitrate dehydrogenase (NADP) (EC 1.1.1.42), mitochondrial - pig
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) (ICD-M)
gb|AAA31089.1| NADPH-specific isocitrate dehydrogenase
(421 aa)

Score: 540 bits (1391), Expect: 3.7218e-152
Length: 411, Idn/Pos/Gap = 243/314/4 (59%/76%/0%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFDLGLP RD T+D VT++
Sbjct:   9 ADQRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTID  68

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPR
Sbjct:  69 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 128

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH  GDQYKA D  V  A   ++      G   ++ +V+ F +    G
Sbjct: 129 LVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFPA----G 184

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++A+++K P+Y+STKNTILK YDGR++DIFQE++E+ Y+
Sbjct: 185 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYK 244

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F +  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 245 TDFDKYKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 304

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+  FA
Sbjct: 305 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 364

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           + LE+ C+ET+  G MTKDL+  ++G       E++LNT +F+D ++  LD
Sbjct: 365 QTLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLD 415

emb|CAG02362.1| unnamed protein product [Tetraodon nigroviridis]
(438 aa)

Score: 540 bits (1390), Expect: 5.37271e-152
Length: 437, Idn/Pos/Gap = 248/318/30 (56%/72%/6%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNK--------------------------LILP 100
           A  +I+V  P+VE+DGDE  R+IW  IK K                          LILP
Sbjct:   1 ATERIKVEQPVVEMDGDEMTRIIWEFIKEKVLKSSKRCRFFGGPAWFFPSPCVRPQLILP  60

Query: 101 YLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYP 160
            +++++ YFDLGLP RD TDD VT+++A A ++++ AVK ATITPDEARVEEF+LK+M+ 
Sbjct:  61 NVDVELKYFDLGLPYRDQTDDQVTIDSALATKKYNVAVKCATITPDEARVEEFNLKKMWK 120

Query: 161 SPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVE 220
           SPNGT+RN+L GTVFREPIL +NIPRLVPGW QPI I RH FGDQY+A D  V    + +
Sbjct: 121 SPNGTIRNILGGTVFREPILCKNIPRLVPGWTQPITIGRHAFGDQYRATDFTVNQPGKFK 180

Query: 221 LRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLS 280
           +    A G + +  +V+ F S    GG  +GM+NTDESI  FA SCF++A+++K P+Y+S
Sbjct: 181 IIFAPADGGQQKEWEVYDFKS----GGCGMGMYNTDESIWGFAHSCFQYAIQKKWPLYMS 236

Query: 281 TKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACK 340
           TKNTILK YDGR++DIFQ++YE+DY+  F +  +WYEHRLIDDMVAQ LKSSG F+WACK
Sbjct: 237 TKNTILKAYDGRFKDIFQDIYEKDYQAEFEKLKIWYEHRLIDDMVAQVLKSSGAFVWACK 296

Query: 341 NYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSV 400
           NYDGDVQSDI+AQG+GSLGLM+SVL+ PDGKT+ AEAAHGTVTRH+R HQ+GK TSTN +
Sbjct: 297 NYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQRGKPTSTNPI 356

Query: 401 ASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRE 460
           ASI AW RGL HR  LDG PD+  F + LER C+ET+  G MTKDL+  ++G       E
Sbjct: 357 ASIFAWTRGLEHRGKLDGNPDLIRFCQTLERVCVETVESGVMTKDLAGCIHGLANCKLNE 416

Query: 461 NYLNTEEFIDAVQQRLD 477
           +Y+NT +F+DA++  LD
Sbjct: 417 HYVNTTDFLDAIRTNLD 433

dbj|BAC77065.1| NADP-specific isocitrate dehydrogenase [Lupinus albus]
(485 aa)

Score: 539 bits (1389), Expect: 7.25512e-152
Length: 421, Idn/Pos/Gap = 257/316/7 (61%/75%/1%)

Query:  66 PAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTL 125
           P F +++V NPIVE+DGDE  R+IW +IK+KLI PYL+L+I YFDLG+  RDATDD VT+
Sbjct:  70 PNFHRLQVLNPIVEMDGDEMTRIIWKMIKDKLIFPYLDLNIKYFDLGVENRDATDDRVTV 129

Query: 126 EAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIP 185
           E+A A  +++ AVK ATITPDE RV+EF LK M+ SPNGT+RN+LNGTVFREPI+  NIP
Sbjct: 130 ESAEATLKYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPIICRNIP 189

Query: 186 RLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDG 245
           R+VPGWK+PI I RH FGDQY+A D  +    +++L  +   G       V+ F     G
Sbjct: 190 RIVPGWKKPICIGRHAFGDQYRATDAIIKGPGKLKLVFVPEDGEAPTELDVYDF----KG 245

Query: 246 GGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDY 305
            GVAL M+N DESIR FA S    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  +
Sbjct: 246 PGVALAMYNIDESIRAFAESSMSLAFAKKWPLYLSTKNTILKKYDGRFKDIFQEVYEERW 305

Query: 306 RERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVL 365
           R+ F   ++WYEHRLIDDMVA A+KS GG++WACKNYDGDVQSD++AQG+GSLGLM+SVL
Sbjct: 306 RQNFEEHSIWYEHRLIDDMVAYAVKSEGGYVWACKNYDGDVQSDLLAQGFGSLGLMTSVL 365

Query: 366 LTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHF 425
           L+ DGKTL AEAAHGTVTRHFRLHQ+G+ETSTNS+ASI AW RGL HRA LD    +  F
Sbjct: 366 LSSDGKTLEAEAAHGTVTRHFRLHQKGQETSTNSIASIFAWTRGLEHRAKLDNNEKLRDF 425

Query: 426 AEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQEHA 485
              LE +C+ET+  GKMTKDL++ ++G +    RE YLNTEEFIDAV   L    LQE  
Sbjct: 426 TYKLEAACVETVESGKMTKDLALLIHGPK--VSREYYLNTEEFIDAVAHNLK-RKLQETP 482

Query: 486 A 486
           A
Sbjct: 483 A 483

sp|O13285|IDH1_CANTR Isocitrate dehydrogenase [NADP], mitochondrial precursor (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) (CtIDP1)
dbj|BAA22945.1| mitochondrial NADP-linked isocitrate dehydrogenase [Candida tropicalis]
(430 aa)

Score: 538 bits (1387), Expect: 1.03863e-151
Length: 429, Idn/Pos/Gap = 257/326/14 (59%/75%/3%)

Query:  49 FLRRTTGRSLCANMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVY 108
            LR+  G S  A +++     KI+V+NPIVELDGDE  R+IW  IK++LILPYL++D+ Y
Sbjct:  13 LLRQLRGFSTSATLAD-----KIKVKNPIVELDGDEMTRIIWQKIKDQLILPYLDVDLKY  67

Query: 109 FDLGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRN 168
           +DLG+  RDATDD +T++AA A++++   VK ATITPDEARV+EFHLK+M+ SPNGT+RN
Sbjct:  68 YDLGIESRDATDDQITIDAANAIKEYGVGVKCATITPDEARVKEFHLKKMWLSPNGTIRN 127

Query: 169 VLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQG 228
           +L GTVFRE I++  IPRL+PGW++PIVI RH FGDQYKA DL +    R+ELR   A G
Sbjct: 128 ILGGTVFRESIIIPCIPRLIPGWEKPIVIGRHAFGDQYKATDLVINEPGRLELRFTPASG 187

Query: 229 MELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKV 288
            E + ++V+ +     G GV L M+NTDESI  FA + F+ AL + LP+Y+STKNTILK 
Sbjct: 188 GEAQTQKVYDYT----GPGVGLAMYNTDESITGFAHASFKMALAKGLPLYMSTKNTILKK 243

Query: 289 YDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQS 348
           YDGR++DIFQ++YE+DY   F +  LWYEHRLIDDMVAQ +KS GGF+ A KNYDGDVQS
Sbjct: 244 YDGRFKDIFQQIYEQDYAAEFEKQGLWYEHRLIDDMVAQMIKSKGGFVMALKNYDGDVQS 303

Query: 349 DIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWAR 408
           DI+AQG+GSLGLM+S L+TPDGK   AEAAHGTVTRH+R HQQGKETSTNS+ASI AW R
Sbjct: 304 DIVAQGFGSLGLMTSALMTPDGKAYEAEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTR 363

Query: 409 GLAHRATLDGTPDVAHFAEALERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEE 467
           GLA R  LD TPDV  FA  LE++ I+T+ +D  MTKDL++A+  T+    R  Y+ T E
Sbjct: 364 GLAQRGKLDETPDVVDFASKLEQATIDTVEVDRIMTKDLALAMGKTD----RSAYVTTTE 419

Query: 468 FIDAVQQRL 476
           F+DAV  RL
Sbjct: 420 FLDAVADRL 428

gb|AAU44104.1| isocitrate dehydrogenase [Oryza sativa (japonica cultivar-group)]
gb|AAD37810.1| NADP-specific isocitrate dehydrogenase [Oryza sativa]
(412 aa)

Score: 538 bits (1387), Expect: 1.25836e-151
Length: 410, Idn/Pos/Gap = 256/315/6 (62%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A +KI+V NPIVE+DGDE  RV W  IK+KLI P+L LDI YFDLGLP RD TDD VT+E
Sbjct:   2 ASTKIKVANPIVEMDGDEMTRVFWKSIKDKLIFPFLELDIKYFDLGLPYRDQTDDKVTVE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           AA A  +++ A+K ATITPDEARV+EF LK M+ SPNGT+RN+LNGTVFREPI+ +NIPR
Sbjct:  62 AAEATLKYNVAIKCATITPDEARVKEFSLKSMWKSPNGTIRNILNGTVFREPIICKNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQY+A D  +    +++L V + +  E+E  +V  F   T  G
Sbjct: 122 LVPGWTKPICIGRHAFGDQYRATDAVIKGPGKLKL-VYEGKDEEIEL-EVFNF---TGAG 176

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVA  M+NTDESIR+FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 177 GVAQSMYNTDESIRSFAEASMATAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEAQWK 236

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            +F  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 237 SKFEAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 296

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW RGLAHRA LD    +  F 
Sbjct: 297 CPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNARLLDFT 356

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           + LE +CI  +  GKMTKDL++ V+G+   + R +YLNTEEFIDAV   L
Sbjct: 357 QKLEAACIGAVESGKMTKDLALLVHGSSNVT-RSHYLNTEEFIDAVADEL 405

ref|NP_766599.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
gb|AAG43538.1| NADP+-specific isocitrate dehydrogenase [Mus musculus]
(452 aa)

Score: 538 bits (1386), Expect: 1.32296e-151
Length: 411, Idn/Pos/Gap = 243/313/4 (59%/76%/0%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFDLGLP RD T+D VT++
Sbjct:  40 AEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTID  99

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPR
Sbjct: 100 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 159

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH  GDQYKA D  V  A   +L      G   +  +V+ F +    G
Sbjct: 160 LVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPA----G 215

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++++++K P+YLSTKNTILK YDGR++DIFQE++++ Y+
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYK 275

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F R  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 276 TDFDRNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 335

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+  FA
Sbjct: 336 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 395

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           + LE+ C++T+  G MTKDL+  ++G       E++LNT +F+D ++  LD
Sbjct: 396 QTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 446

gb|AAM19856.1| At1g65930/F12P19_10 [Arabidopsis thaliana]
gb|AAO00760.1| isocitrate dehydrogenase, putative [Arabidopsis thaliana]
ref|NP_176768.1| isocitrate dehydrogenase, putative / NADP+ isocitrate dehydrogenase, putative [Arabidopsis thaliana]
gb|AAL31907.1| At1g65930/F12P19_10 [Arabidopsis thaliana]
gb|AAF06054.1| Strong similarity to gb|AF155333 NADP-specific isocitrate dehydrogenase from Oryza sativa.  ESTs gb|R30474, gb|H36712, gb|T22563, gb|N97293, gb|T43729, gb|Z17440, gb|Z34193, gb|Z46528, gb|T14072, gb|T42413, gb|AA389759, gb|N38098, gb|T43337, gb|N96032, gb|N96031 and gb|Z38038 come from this gene. [Arabidopsis thaliana]
gb|AAK73989.1| At1g65930/F12P19_10 [Arabidopsis thaliana]
pir||F96683 hypothetical protein F12P19.10 [imported] - Arabidopsis thaliana
(410 aa)

Score: 538 bits (1385), Expect: 1.78648e-151
Length: 410, Idn/Pos/Gap = 251/312/7 (61%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V NPIVE+DGDE  RVIW  IK+KLI P++ LDI YFDLGLP RDATDD VT+E
Sbjct:   2 AFEKIKVANPIVEMDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A ++++ A+K ATITPDE RV EF LK+M+ SPNGT+RN+LNGTVFREPI+ +N+P+
Sbjct:  62 SAEATKKYNVAIKCATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPK 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQY+A D  +    ++ +      G      +V  F   T  G
Sbjct: 122 LVPGWTKPICIGRHAFGDQYRATDAVIKGPGKLTMTFEGKDGKT--ETEVFTF---TGEG 176

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVA+ M+NTDESIR FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 177 GVAMAMYNTDESIRAFADASMNTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWK 236

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 237 SKYDAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 296

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRHFR+HQ+G ETSTNS+ASI AW RGLAHRA LD    +  F 
Sbjct: 297 CPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNAKLLDFT 356

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E LE +C+ T+  GKMTKDL++ ++G++    R+ YLNTEEFIDAV   L
Sbjct: 357 EKLEAACVGTVESGKMTKDLALIIHGSKL--SRDTYLNTEEFIDAVAAEL 404

ref|NP_917313.1| NADP-specific isocitrate dehydrogenase [Oryza sativa (japonica cultivar-group)]
gb|AAD37809.1| NADP-specific isocitrate dehydrogenase [Oryza sativa]
dbj|BAD72316.1| putative NADP-specific isocitrate dehydrogenase [Oryza sativa (japonica cultivar-group)]
dbj|BAB90451.1| putative NADP-specific isocitrate dehydrogenase [Oryza sativa (japonica cultivar-group)]
(412 aa)

Score: 537 bits (1384), Expect: 2.20084e-151
Length: 412, Idn/Pos/Gap = 256/318/10 (62%/77%/2%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V NPIVE+DGDE  R+ W  IK+KLI P+L+LDI Y+DLG+  RDATDD VT+E
Sbjct:   2 AFEKIKVANPIVEMDGDEMTRIFWQSIKDKLIFPFLDLDIKYYDLGVLHRDATDDKVTVE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           AA A  +++ A+K ATITPDEARV+EF+LK+M+ SPNGT+RN++NGTVFREPI+ +N+PR
Sbjct:  62 AAEATLKYNVAIKCATITPDEARVKEFNLKQMWKSPNGTIRNIINGTVFREPIICKNVPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQD--LRVPPACRVELRVLDAQGMELERRQVHQFASSTD 244
           LVPGW +PI I RH FGDQY+A D  L+ P   ++     D Q ++LE   V  F   T 
Sbjct: 122 LVPGWTKPICIGRHAFGDQYRATDAVLKGPGKLKLVFEGKDEQ-IDLE---VFNF---TG 174

Query: 245 GGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERD 304
            GGVAL M+NTDESIR FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  
Sbjct: 175 AGGVALSMYNTDESIRAFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEAG 234

Query: 305 YRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSV 364
           ++ +F  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SV
Sbjct: 235 WKSKFEAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSV 294

Query: 365 LLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAH 424
           L+ PDGKT+ AEAAHGTVTRHFR+HQ+G ETSTNS+ASI AW RGLAHRA LD    +  
Sbjct: 295 LVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNARLLD 354

Query: 425 FAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           FA  LE +C+ T+  GKMTKDL++ ++G+   + R +YLNTEEFIDAV   L
Sbjct: 355 FALKLEAACVGTVESGKMTKDLALLIHGSSNVT-RSHYLNTEEFIDAVAAEL 405

gb|AAH60030.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial [Mus musculus]
dbj|BAC40149.1| unnamed protein product [Mus musculus]
(452 aa)

Score: 537 bits (1384), Expect: 2.2946e-151
Length: 411, Idn/Pos/Gap = 242/313/4 (58%/76%/0%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFDLGLP RD T+D VT++
Sbjct:  40 AEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTID  99

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPR
Sbjct: 100 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 159

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH  GDQYKA D  V  A   +L      G   +  +V+ F +    G
Sbjct: 160 LVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKDGSSAKEWEVYNFPA----G 215

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++++++K P+YLSTKNTILK YDGR++DIFQE++++ Y+
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYK 275

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F +  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 276 TDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 335

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+  FA
Sbjct: 336 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 395

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           + LE+ C++T+  G MTKDL+  ++G       E++LNT +F+D ++  LD
Sbjct: 396 QTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 446

emb|CAG13105.1| unnamed protein product [Tetraodon nigroviridis]
(415 aa)

Score: 537 bits (1383), Expect: 2.97194e-151
Length: 408, Idn/Pos/Gap = 240/310/4 (58%/75%/0%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           +I+V  P+VE+DGDE  R+IW  IK KLIL  +++++ YFDLGLP RD TDD VT+++A 
Sbjct:   7 RIKVAQPVVEMDGDEMTRIIWEFIKEKLILTNVDVELKYFDLGLPYRDQTDDQVTIDSAL  66

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A +++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+  NIPRLVP
Sbjct:  67 ATKKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICRNIPRLVP 126

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW QPI I RH FGDQY+A D  V    + ++    A G   +  +V+ F +    GG  
Sbjct: 127 GWTQPITIGRHAFGDQYRATDFVVDKPGKFKIVFSPADGSSAKEWEVYDFPA----GGCG 182

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           +GM+NTDESI  FA SCF++A+ +K P+Y+STKNTILK YDGR++DIFQ+++E+ Y+  F
Sbjct: 183 MGMYNTDESITGFAHSCFQYAIGKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKHYKPEF 242

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
            +  +WYEHRLIDDMVAQ LKSSG F+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+ PD
Sbjct: 243 DKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPD 302

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+  F++ L
Sbjct: 303 GKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNNDLIKFSQTL 362

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           ER C+ET+  G MTKDL+  ++G       E+Y+NT +F+DA++  LD
Sbjct: 363 ERVCVETVESGTMTKDLAGCIHGLPNVKLNEHYVNTTDFLDAIRTNLD 410

emb|CAA63220.1| isocitrate dehydrogenase (NAD+) [Solanum tuberosum]
(470 aa)

Score: 537 bits (1383), Expect: 2.99684e-151
Length: 430, Idn/Pos/Gap = 260/320/11 (60%/74%/2%)

Query:  59 CANMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDA 118
           C   S+ P  SKIRV+NPIVE+DGDE  RVIW +IK+KLI PYL LD  Y+DLG+  RDA
Sbjct:  51 CFASSSGPT-SKIRVQNPIVEMDGDEMTRVIWKMIKDKLIYPYLELDTKYYDLGILNRDA 109

Query: 119 TDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREP 178
           TDD VT+E+A A  +++ AVK ATITPDE RV+EF LK M+ SPNGT+RN+LNGTVFREP
Sbjct: 110 TDDQVTVESAEATLKYNVAVKCATITPDETRVKEFGLKSMWKSPNGTIRNILNGTVFREP 169

Query: 179 ILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQ 238
           IL  NIPR+VPGWK+PI I RH FGDQY+A D  +    ++++  +   G       V+ 
Sbjct: 170 ILCTNIPRIVPGWKKPICIGRHAFGDQYRATDRIINGPGKLKMVFVPENGESPMELDVYD 229

Query: 239 FASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQ 298
           F     G G+AL M+N D+SIR FA S    A  +K P+YLSTKNTILK YDGR++DIFQ
Sbjct: 230 F----KGPGIALAMYNVDQSIRAFAESSMSMAFSKKWPLYLSTKNTILKKYDGRFKDIFQ 285

Query: 299 ELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSL 358
           E+YE  ++++F   ++WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD++AQG+GSL
Sbjct: 286 EVYEEKWKQQFEEHSIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDLLAQGFGSL 345

Query: 359 GLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDG 418
           GLM+S+LL+ DGKTL AEAAHGTVT HFRLHQ+G+ETSTNSVASI AW +GL HRA LDG
Sbjct: 346 GLMTSILLSSDGKTLEAEAAHGTVTIHFRLHQKGQETSTNSVASIFAWTKGLGHRAQLDG 405

Query: 419 TPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDV 478
              +  F   LE SCI TI  GKMT +L+I  +G++    RE YLNTEEFIDAV Q+L  
Sbjct: 406 NQKLLEFVHTLEASCIGTIESGKMT-NLAILAHGSK--VSREFYLNTEEFIDAVAQKLQE 462

Query: 479 HMLQEHAAAP 488
            +   HA+ P
Sbjct: 463 KL---HASVP 469

gb|AAH71828.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial, precursor [Homo sapiens]
gb|AAH09244.1| Isocitrate dehydrogenase 2 (NADP+), mitochondrial, precursor [Homo sapiens]
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) (ICD-M)
ref|NP_002159.2| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor [Homo sapiens]
(452 aa)

Score: 537 bits (1383), Expect: 3.28492e-151
Length: 411, Idn/Pos/Gap = 242/313/4 (58%/76%/0%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFDLGLP RD TDD VT++
Sbjct:  40 ADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTID  99

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPR
Sbjct: 100 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 159

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH  GDQYKA D     A   ++      G  ++  +V+ F +    G
Sbjct: 160 LVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPA----G 215

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++A+++K P+Y+STKNTILK YDGR++DIFQE++++ Y+
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYK 275

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F +  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 276 TDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 335

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+  FA
Sbjct: 336 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 395

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           + LE+ C+ET+  G MTKDL+  ++G       E++LNT +F+D ++  LD
Sbjct: 396 QMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 446

emb|CAA49208.1| isocitrate dehydrogenase (NADP+) [Homo sapiens]
(452 aa)

Score: 536 bits (1382), Expect: 4.36243e-151
Length: 411, Idn/Pos/Gap = 242/313/4 (58%/76%/0%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFDLGLP RD TDD VT++
Sbjct:  40 ADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTID  99

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPR
Sbjct: 100 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 159

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH  GDQYKA D     A   ++      G  ++  +V+ F +    G
Sbjct: 160 LVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPA----G 215

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++A+++K P+Y+STKNTILK YDGR++DIFQE++++ Y+
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYK 275

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F +  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 276 TDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 335

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+  FA
Sbjct: 336 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 395

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           + LE+ C+ET+  G MTKDL+  ++G       E++LNT +F+D ++  LD
Sbjct: 396 QMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTMDFLDTIKSNLD 446

gb|AAM13090.1| similar to NADP-specific isocitrate dehydrogenase [Arabidopsis thaliana]
(410 aa)

Score: 536 bits (1382), Expect: 4.78176e-151
Length: 410, Idn/Pos/Gap = 250/312/7 (60%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V NPIVE+DGDE  RVIW  IK+KLI P++ LDI YFDLGLP RDATDD VT+E
Sbjct:   2 AFEKIKVANPIVEMDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A ++++ A+K ATITPDE RV EF LK+M+ SPNGT+RN+LNGTVFREPI+ +N+P+
Sbjct:  62 SAEATKKYNVAIKCATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPK 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQY+A D  +    ++ +      G      +V  F   T  G
Sbjct: 122 LVPGWTKPICIGRHAFGDQYRATDAVIKGPGKLTMTFEGKDGKT--ETEVFTF---TGEG 176

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVA+ M+NTDESIR FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 177 GVAMAMYNTDESIRAFADASMNTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWK 236

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 237 SKYDAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 296

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRHFR+HQ+G ETSTNS+ASI AW RGLAHRA LD    +  F 
Sbjct: 297 CPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNAKLLDFT 356

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E LE +C+ T+  GKMTKDL++ ++G++    R+ YLNTE+FIDAV   L
Sbjct: 357 EKLEAACVGTVESGKMTKDLALIIHGSKL--SRDTYLNTEDFIDAVAAEL 404

ref|XP_536192.1| PREDICTED: similar to isocitrate dehydrogenase (NADP+) [Canis familiaris]
(474 aa)

Score: 536 bits (1381), Expect: 5.4193e-151
Length: 418, Idn/Pos/Gap = 245/316/11 (58%/75%/2%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFDLGLP RD T+D VT++
Sbjct:  56 ADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTID 115

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPR
Sbjct: 116 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 175

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH  GDQYKA D  V  A   ++      G   +  +V+ F     GG
Sbjct: 176 LVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIIFSPKDGSGAKEWEVYNFP----GG 231

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++A+++K P+Y+STKNTILK YDGR++DIFQE++E+ Y+
Sbjct: 232 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYK 291

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F +  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 292 TDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 351

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+  FA
Sbjct: 352 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 411

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQ------GSK-RENYLNTEEFIDAVQQRLD 477
           + LE+ C++T+  G MTKDL+  ++G  +      G K  E++LNT +F+D ++  LD
Sbjct: 412 QTLEKVCVQTVESGAMTKDLAGCIHGLSKCVACGRGVKLNEHFLNTSDFLDTIKNNLD 469

ref|NP_001014183.1| hypothetical LOC361596 [Rattus norvegicus]
gb|AAH76398.1| Hypothetical LOC361596 [Rattus norvegicus]
(452 aa)

Score: 536 bits (1381), Expect: 5.60322e-151
Length: 411, Idn/Pos/Gap = 241/313/4 (58%/76%/0%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFDLGLP RD T+D VT++
Sbjct:  40 AEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTID  99

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPR
Sbjct: 100 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 159

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH  GDQYKA D  V  A   +L      G   +  +V+ F +    G
Sbjct: 160 LVPGWTKPITIGRHAHGDQYKATDFVVDRAGMFKLVFTPKDGSGAKEWEVYNFPA----G 215

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++++++K P+YLSTKNTI+K YDGR++DIFQE++++ Y+
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTIMKAYDGRFKDIFQEIFDKHYK 275

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F +  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 276 TDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 335

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+  FA
Sbjct: 336 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 395

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           + LE+ C++T+  G MTKDL+  ++G       E++LNT +F+D ++  LD
Sbjct: 396 QTLEKVCVQTVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 446

emb|CAA49207.1| isocitrate dehydrogenase (NADP+) [Bos taurus]
pir||S33859 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) precursor, mitochondrial - bovine
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) (ICD-M)
ref|NP_786984.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial [Bos taurus]
(452 aa)

Score: 536 bits (1381), Expect: 5.99e-151
Length: 433, Idn/Pos/Gap = 248/322/9 (57%/74%/2%)

Query:  56 RSLCA-NMSNVP----AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFD 110
           R+L A N+   P    A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFD
Sbjct:  24 RALTAPNLQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFD  83

Query: 111 LGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVL 170
           LGLP RD T+D VT+++A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L
Sbjct:  84 LGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNIL 143

Query: 171 NGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGME 230
            GTVFREPI+ +NIPRLVPGW +PI I RH  GDQYKA D  V  A   ++      G  
Sbjct: 144 GGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKVVFTPKDGSG 203

Query: 231 LERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYD 290
            +  +V+ F +    GGV +GM+NTDESI  FA SCF++A+++K P+Y+STKNTILK YD
Sbjct: 204 PKEWEVYNFPA----GGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYD 259

Query: 291 GRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDI 350
           GR++DIFQ ++E+ Y+  F +  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI
Sbjct: 260 GRFKDIFQAIFEKHYKTEFDKHKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDI 319

Query: 351 IAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGL 410
           +AQG+GSLGLM+SVL+ PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL
Sbjct: 320 LAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGL 379

Query: 411 AHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFID 470
            HR  LDG  D+  FA+ LE+ C+ET+  G MTKDL+  ++G       E++LNT +F+D
Sbjct: 380 EHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLD 439

Query: 471 AVQQRLDVHMLQE 483
            ++  LD  + Q+
Sbjct: 440 TIKSNLDRALGQQ 452

gb|AAH54241.1| MGC64442 protein [Xenopus laevis]
(454 aa)

Score: 536 bits (1380), Expect: 6.67627e-151
Length: 412, Idn/Pos/Gap = 244/315/5 (59%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V NP+VE+DGDE  R+IW  IK KLIL  +++++ YFDLGLP RD TDD VT++
Sbjct:  41 ADKRIKVANPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYFDLGLPYRDQTDDQVTID 100

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPR
Sbjct: 101 SALATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTVRNILGGTVFREPIICKNIPR 160

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW Q I I RH  GDQYKA D  V  A   ++    A G   +  +V +F +    G
Sbjct: 161 LVPGWTQAITIGRHAHGDQYKATDFVVDQAGTFKMVFTPANGTATKEWEVFKFPA----G 216

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++A+++K P+Y+STKNTILK YDGR++DIFQ+++E+ Y+
Sbjct: 217 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQDIFEKHYK 276

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F +  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+AQG+GSLGLMSSVL+
Sbjct: 277 PDFDKVKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMSSVLV 336

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+ +F+
Sbjct: 337 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLINFS 396

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSK-RENYLNTEEFIDAVQQRLD 477
             LE+ C+ET+  G MTKDL+  ++G     +  E+Y+NT +F+DA++  LD
Sbjct: 397 LKLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNEHYVNTTDFLDAIKNNLD 448

emb|CAD24782.1| isocitrate dehydrogenase [Arabidopsis thaliana]
(410 aa)

Score: 536 bits (1380), Expect: 6.96069e-151
Length: 410, Idn/Pos/Gap = 250/313/7 (60%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V NPIVE+DGDE  RVIW  IK+KLI P++ LDI YFDLGLP RDATDD VT+E
Sbjct:   2 AFEKIKVANPIVEMDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A ++++ A+K ATITPDE RV EF LK+M+ SPNGT+RN+LNGTVFREPI+ +N+P+
Sbjct:  62 SAEATKKYNVAIKCATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPK 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQY+A D  +    ++ +      G      +V  F   T  G
Sbjct: 122 LVPGWTKPICIGRHAFGDQYRATDAVIKGPGKLTMTFEGKDGKT--ETEVFTF---TGEG 176

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVA+ M+NTDESIR FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 177 GVAMVMYNTDESIRAFADASMNTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWK 236

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD++AQG+GSLGLM+SVL+
Sbjct: 237 SKYDAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDLLAQGFGSLGLMTSVLV 296

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGK++ AEAAHGTVTRHFR+HQ+G ETSTNS+ASI AW RGLAHRA LD    +  F 
Sbjct: 297 CPDGKSIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNAKLLDFT 356

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E LE +C+ T+  GKMTKDL++ ++G++    R+ YLNTEEFIDAV   L
Sbjct: 357 EKLEAACVGTVESGKMTKDLALIIHGSKL--SRDTYLNTEEFIDAVAAEL 404

dbj|BAD96636.1| isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor variant [Homo sapiens]
(452 aa)

Score: 536 bits (1380), Expect: 7.62979e-151
Length: 411, Idn/Pos/Gap = 242/312/4 (58%/75%/0%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFDLGLP RD TDD VT++
Sbjct:  40 ADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTID  99

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPR
Sbjct: 100 SALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 159

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH  GDQYKA D     A   ++      G  ++  +V+ F +    G
Sbjct: 160 LVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPA----G 215

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++A+++K P+Y+STKNTILK YDGR++DIFQE++++ Y 
Sbjct: 216 GVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYE 275

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F +  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 276 TDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 335

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+  FA
Sbjct: 336 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFA 395

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           + LE+ C+ET+  G MTKDL+  ++G       E++LNT +F+D ++  LD
Sbjct: 396 QMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 446

gb|AAM65674.1| isocitrate dehydrogenase, putative [Arabidopsis thaliana]
(410 aa)

Score: 535 bits (1379), Expect: 9.63772e-151
Length: 410, Idn/Pos/Gap = 250/311/7 (60%/75%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V NPIVE+DGDE  RVIW  IK+KLI P++ LDI YFDLGLP RDATDD VT+E
Sbjct:   2 AFEKIKVANPIVEMDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A ++++ A+K ATITPDE RV EF LK+M+ SPNGT+RN+LNGTVFREPI+ +N+P+
Sbjct:  62 SAEATKKYNVAIKCATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPK 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQY+A D  +    ++ +      G      +V  F   T  G
Sbjct: 122 LVPGWTKPICIGRHAFGDQYRATDAVIKGPGKLTMTFEGKDGKT--ETEVFTF---TGEG 176

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVA+ M+NTDESIR FA +    A  +K P+YLSTKNTILK YDGR++DIFQE+YE  ++
Sbjct: 177 GVAMAMYNTDESIRAFADASMNTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWK 236

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 237 SKYDAAGIWYEHRLIDDMVAYALKSKGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 296

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRHFR+HQ+  ETSTNS+ASI AW RGLAHRA LD    +  F 
Sbjct: 297 CPDGKTIEAEAAHGTVTRHFRVHQKAGETSTNSIASIFAWTRGLAHRAKLDDNAKLLDFT 356

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E LE +C+ T+  GKMTKDL++ ++G++    R+ YLNTEEFIDAV   L
Sbjct: 357 EKLEAACVGTVESGKMTKDLALIIHGSKL--SRDTYLNTEEFIDAVAAEL 404

gb|AAN15595.1| isocitrate dehydrogenase-like protein [Arabidopsis thaliana]
gb|AAM20534.1| isocitrate dehydrogenase-like protein [Arabidopsis thaliana]
ref|NP_196963.2| isocitrate dehydrogenase, putative / NADP+ isocitrate dehydrogenase, putative [Arabidopsis thaliana]
(485 aa)

Score: 535 bits (1377), Expect: 1.52502e-150
Length: 407, Idn/Pos/Gap = 249/315/6 (61%/77%/1%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           +I+V+NPIVE+DGDE  RVIW +IK KLILPYL+LDI YFDLG+  RDATDD VT+E+A 
Sbjct:  75 RIQVQNPIVEMDGDEMTRVIWSMIKEKLILPYLDLDIKYFDLGILNRDATDDKVTVESAE 134

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A  +++ A+K ATITPDE RV+EF LK M+ SPNGT+RN+L+GTVFREPI+  NIPRLVP
Sbjct: 135 AALKYNVAIKCATITPDEGRVKEFGLKSMWRSPNGTIRNILDGTVFREPIMCSNIPRLVP 194

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW++PI I RH FGDQY+A D  +    ++++  +   G       V+ F     G GVA
Sbjct: 195 GWEKPICIGRHAFGDQYRATDTVIKGPGKLKMVFVPEDGNAPVELDVYDF----KGPGVA 250

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           L M+N DESIR FA S    AL +K P+YLSTKNTILK YDGR++DIFQE+YE +++++F
Sbjct: 251 LAMYNVDESIRAFAESSMAMALTKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKQKF 310

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
              ++WYEHRLIDDMVA A+KS GG++WACKNYDGDVQSD++AQG+GSLGLM+SVLL+ D
Sbjct: 311 EEHSIWYEHRLIDDMVAYAVKSEGGYVWACKNYDGDVQSDLLAQGFGSLGLMTSVLLSAD 370

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GKTL +EAAHGTVTRHFRLHQ+G+ETSTNS+ASI AW RGL HRA LD    +  F + L
Sbjct: 371 GKTLESEAAHGTVTRHFRLHQKGQETSTNSIASIFAWTRGLEHRAKLDKNEKLMDFVKKL 430

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E SC+ T+  GKMTKDL++ ++G +    R+ +LNTEEFIDAV  +L
Sbjct: 431 ESSCVNTVETGKMTKDLALLIHGPK--VSRDLFLNTEEFIDAVASKL 475

dbj|BAA34113.1| NADP specific isocitrate dehydrogenase [Daucus carota]
(416 aa)

Score: 534 bits (1376), Expect: 2.05933e-150
Length: 410, Idn/Pos/Gap = 251/313/5 (61%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  KI+V NPIVE+DGDE  RV W  IK KLI P+L+LDI YFDLGLP RDATDD VT+E
Sbjct:   2 AMQKIKVLNPIVEMDGDEMTRVFWKSIKEKLIFPFLDLDIKYFDLGLPNRDATDDRVTIE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDE R++EF+LK+M+ SPNGT+RN+LNGTVFREPI+ +NIPR
Sbjct:  62 SAEATLKYNVAIKCATITPDETRLKEFNLKQMWKSPNGTIRNILNGTVFREPIICKNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LV GW +PI I RH FGDQY+A DL V    ++++  +     E    +V  F   T  G
Sbjct: 122 LVQGWNKPICIGRHAFGDQYRATDLVVQGPGKLKMVFVPDGQSEKTELEVFNF---TGAG 178

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESI  FA +    A +++ P+YLSTKNTILK YDGR++DIFQE+YE++++
Sbjct: 179 GVALSMYNTDESIHAFAEASMNTAYQKRWPLYLSTKNTILKKYDGRFKDIFQEVYEKEWK 238

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            +F    +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+
Sbjct: 239 SKFESVGIWYEHRLIDDMVAYALKSDGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLV 298

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW+RGLAHRA LD    +  F 
Sbjct: 299 CPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWSRGLAHRAKLDDNALLLDFT 358

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E LE +CI T+  GKMTKDL+I +YG+     + +YLNTE FIDAV   L
Sbjct: 359 EKLEAACIGTVERGKMTKDLAILLYGSR--VTKAHYLNTEGFIDAVAAEL 406

gb|AAF73472.1| NADP-dependent isocitrate dehydrogenase [Sinorhizobium meliloti]
(404 aa)

Score: 534 bits (1376), Expect: 2.39305e-150
Length: 408, Idn/Pos/Gap = 240/315/11 (58%/77%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+VELDGD+  R+IW  IK+KLI PYL+LD+ Y+DLG+  RDATDD VT++AA
Sbjct:   2 AKIKVANPVVELDGDQMTRIIWQFIKDKLIHPYLDLDLEYYDLGVENRDATDDQVTIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A+++H   VK ATITPDE RVEEF LK+M+ SPNGT+RN+L G +FREPI+ +N+PRLV
Sbjct:  62 NAIKKHGVGVKCATITPDEGRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PI++ RH FGDQY+A D + P   ++ ++ +   G  +E            G GV
Sbjct: 122 PGWTKPIIVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDGQTIEHD-----VYDAPGAGV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           AL M+N DESI  FAR+ F + L+RK+P+YLSTKNTILK YDGR++DIFQ+++E ++ ++
Sbjct: 177 ALAMYNLDESITEFARASFNYGLQRKVPVYLSTKNTILKAYDGRFKDIFQKVFEEEFADQ 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    LWYEHRLIDDMVA ALK SGG++WACKNYDGDVQSDI+AQG+GSLGLM+SVL+TP
Sbjct: 237 FKAEKLWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ AEAAHGTVTRH+R HQ+G+ETSTNS+ASI AW RGLAHRA LDG  ++A F+E 
Sbjct: 297 DGKTVEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDGNTELAKFSET 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LER C++T+  G MTKDL++ + G +Q      +L+T  F+D + + L
Sbjct: 357 LERVCVDTVESGFMTKDLALLI-GPDQ-----PWLSTTGFLDKIDENL 398

gb|AAH46894.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Danio rerio]
ref|NP_958907.1| isocitrate dehydrogenase 1 (NADP+), soluble [Danio rerio]
(429 aa)

Score: 534 bits (1375), Expect: 2.87522e-150
Length: 404, Idn/Pos/Gap = 249/308/4 (61%/76%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  RVIW LIK KLI PYL LD+  +DLG+  RDATDD VT+EAA AV++++ 
Sbjct:  24 VVEMQGDEMTRVIWELIKEKLIFPYLELDLHSYDLGMENRDATDDKVTVEAAEAVRRYNV  83

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            +K ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLVPGW +PI+
Sbjct:  84 GIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNIPRLVPGWIKPII 143

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH  GDQYKA D  VP    VE+      G E  +  VH F  +   GGVALGM+NTD
Sbjct: 144 IGRHAHGDQYKATDFVVPGPGTVEMTYKPKNGGETLKFVVHDFEGT---GGVALGMYNTD 200

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SIR+FA S F+  L +  PMYLSTKNTILK YDGR++DIFQE+Y+++Y+ ++    +WY
Sbjct: 201 KSIRDFAHSSFQMGLNKGWPMYLSTKNTILKKYDGRFKDIFQEIYDKEYKAKYEAMGIWY 260

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDG+T+ AE
Sbjct: 261 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGRTVEAE 320

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R+HQQGKETSTN +ASI AW RGL HRA LD   ++  FAEALE  C+ET
Sbjct: 321 AAHGTVTRHYRMHQQGKETSTNPIASIFAWTRGLLHRAELDKNAELRVFAEALEVVCVET 380

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           I  G MTKDL+I + G   G  R +YLNT EF+D + + L + +
Sbjct: 381 IEAGFMTKDLAICIKGM-SGVTRSDYLNTFEFLDKLAENLKIKL 423

emb|CAB87626.1| isocitrate dehydrogenase-like protein [Arabidopsis thaliana]
pir||T48632 isocitrate dehydrogenase-like protein - Arabidopsis thaliana
(465 aa)

Score: 533 bits (1374), Expect: 3.28587e-150
Length: 408, Idn/Pos/Gap = 251/318/10 (61%/77%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           +I+V+NPIVE+DGDE  RVIW +IK KLILPYL+LDI YFDLG+  RDATDD VT+E+A 
Sbjct:  57 RIQVQNPIVEMDGDEMTRVIWSMIKEKLILPYLDLDIKYFDLGILNRDATDDKVTVESAE 116

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A  +++ A+K ATITPDE RV+EF LK M+ SPNGT+RN+L+GTVFREPI+  NIPRLVP
Sbjct: 117 AALKYNVAIKCATITPDEGRVKEFGLKSMWRSPNGTIRNILDGTVFREPIMCSNIPRLVP 176

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQG-MELERRQVHQFASSTDGGGV 248
           GW++PI I RH FGDQY+A D  +    ++++   D    +EL+   V+ F     G GV
Sbjct: 177 GWEKPICIGRHAFGDQYRATDTVIKGPGKLKMVFEDGNAPVELD---VYDF----KGPGV 229

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           AL M+N DESIR FA S    AL +K P+YLSTKNTILK YDGR++DIFQE+YE +++++
Sbjct: 230 ALAMYNVDESIRAFAESSMAMALTKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKQK 289

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F   ++WYEHRLIDDMVA A+KS GG++WACKNYDGDVQSD++AQG+GSLGLM+SVLL+ 
Sbjct: 290 FEEHSIWYEHRLIDDMVAYAVKSEGGYVWACKNYDGDVQSDLLAQGFGSLGLMTSVLLSA 349

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKTL +EAAHGTVTRHFRLHQ+G+ETSTNS+ASI AW RGL HRA LD    +  F + 
Sbjct: 350 DGKTLESEAAHGTVTRHFRLHQKGQETSTNSIASIFAWTRGLEHRAKLDKNEKLMDFVKK 409

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LE SC+ T+  GKMTKDL++ ++G +    R+ +LNTEEFIDAV  +L
Sbjct: 410 LESSCVNTVETGKMTKDLALLIHGPK--VSRDLFLNTEEFIDAVASKL 455

emb|CAC46371.1| PROBABLE ISOCITRATE DEHYDROGENASE [NADP] PROTEIN [Sinorhizobium meliloti]
ref|NP_385898.1| PROBABLE ISOCITRATE DEHYDROGENASE [NADP] PROTEIN [Sinorhizobium meliloti 1021]
(404 aa)

Score: 533 bits (1373), Expect: 4.90439e-150
Length: 408, Idn/Pos/Gap = 240/314/11 (58%/76%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+VELDGDE  R+IW  IK+KLI PYL+LD+ Y+DLG+  RDATDD VT++AA
Sbjct:   2 AKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLDLEYYDLGVENRDATDDQVTIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A+++H   VK ATITPDE RVEEF LK+M+ SPNGT+RN+L G +FREPI+ +N+PRLV
Sbjct:  62 NAIKKHGVGVKCATITPDEGRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PI++ RH FGDQY+A D + P   ++ ++ +   G  +E            G GV
Sbjct: 122 PGWTKPIIVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDGQTIEHD-----VYDAPGAGV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           AL M+N DESI  FAR+ F + L+RK+P+YLSTKNTILK YDGR++DIFQ++++ ++  +
Sbjct: 177 ALAMYNLDESITEFARASFNYGLQRKVPVYLSTKNTILKAYDGRFKDIFQKVFDEEFAAQ 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    LWYEHRLIDDMVA ALK SGG++WACKNYDGDVQSDI+AQG+GSLGLM+SVL+TP
Sbjct: 237 FKAEKLWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ AEAAHGTVTRH+R HQ+G+ETSTNS+ASI AW RGLAHRA LDG  ++A F+E 
Sbjct: 297 DGKTVEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDGNAELAKFSET 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LER C++T+  G MTKDL++ + G +Q      +L+T  F+D + + L
Sbjct: 357 LERVCVDTVESGFMTKDLALLI-GPDQ-----PWLSTTGFLDKIDENL 398

emb|CAG88011.1| unnamed protein product [Debaryomyces hansenii CBS767]
ref|XP_459772.1| unnamed protein product [Debaryomyces hansenii]
(431 aa)

Score: 533 bits (1372), Expect: 5.89258e-150
Length: 422, Idn/Pos/Gap = 253/320/12 (59%/75%/2%)

Query:  56 RSLCANMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPV 115
           RS  +++ N+    KI+V+NPIVELDGDE  R+IW  IK+KLI PYL++D+ Y+DLG+  
Sbjct:  15 RSFSSSLINL---DKIKVKNPIVELDGDEMTRIIWQRIKDKLINPYLDVDLKYYDLGIES  71

Query: 116 RDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVF 175
           RD TDD +T++AA A++++   VK ATITPDE+RVEEF+LK+M+ SPNGT+RN+L GTVF
Sbjct:  72 RDKTDDQITIDAANAIKEYGVGVKCATITPDESRVEEFNLKKMWLSPNGTIRNILGGTVF 131

Query: 176 REPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQ 235
           RE I++  IPRLVPGWK+PIVI RH  GDQYKA DL +    ++E+      G   E R 
Sbjct: 132 REAIIIPRIPRLVPGWKEPIVIGRHAHGDQYKATDLVINEPGKLEMTFTPENGGAPETRT 191

Query: 236 VHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRD 295
           V+ +     G GV L M+NTDESI  FA S F+ AL +KLP+YLSTKNTILK YDGR++D
Sbjct: 192 VYDY----KGPGVGLAMYNTDESIIGFAHSSFKMALTKKLPLYLSTKNTILKKYDGRFKD 247

Query: 296 IFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGY 355
           IF E+YE  Y++ F    +WYEHRLIDDMVAQ +KS GGF+ A KNYDGDVQSDI+AQG+
Sbjct: 248 IFHEIYESTYKKEFETNNIWYEHRLIDDMVAQMIKSKGGFVMALKNYDGDVQSDIVAQGF 307

Query: 356 GSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRAT 415
           GSLGLM+SVL+TPDGKT  +EAAHGTVTRHFR HQQGKETSTNS+ASI AW RG+A R  
Sbjct: 308 GSLGLMTSVLMTPDGKTFESEAAHGTVTRHFRQHQQGKETSTNSIASIFAWTRGIAQRGR 367

Query: 416 LDGTPDVAHFAEALERSCIETIL-DGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQ 474
           LD TPDV  FAE +E++  +T+  DG MTKDL++A+  T+    RE+Y+ T EF+DAV  
Sbjct: 368 LDDTPDVVKFAEIVEKATFDTVQEDGIMTKDLALALGRTD----RESYVTTTEFLDAVSD 423

Query: 475 RL 476
           +L
Sbjct: 424 KL 425

gb|EAK91676.1| hypothetical protein CaO19.5211 [Candida albicans SC5314]
gb|EAK91661.1| hypothetical protein CaO19.12678 [Candida albicans SC5314]
(433 aa)

Score: 533 bits (1372), Expect: 5.94195e-150
Length: 415, Idn/Pos/Gap = 249/316/9 (60%/76%/2%)

Query:  63 SNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDG 122
           S      KI+V+NPIVELDGDE  R+IW  IK++LILPYL++++ Y+DLG+  RDAT+D 
Sbjct:  25 STASILDKIKVKNPIVELDGDEMTRIIWQKIKDQLILPYLDVNLKYYDLGIESRDATNDQ  84

Query: 123 VTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVE 182
           +T++AA A+++H   VK ATITPDEARV+EF+LK+M+ SPNGT+RN+L GTVFRE I++ 
Sbjct:  85 ITIDAANAIKEHGVGVKCATITPDEARVKEFNLKKMWLSPNGTIRNILGGTVFRESIIIP 144

Query: 183 NIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASS 242
            IPRL+PGWK+PIVI RH FGDQYKA DL +    ++ELR     G E +  +V+ +   
Sbjct: 145 CIPRLIPGWKEPIVIGRHAFGDQYKATDLVISEPGKLELRFTPENGGETQTHKVYDYT-- 202

Query: 243 TDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYE 302
             G GV L M+NTDESI  FAR+ F  AL + LP+Y+STKNTILK YDGR++DIFQ++YE
Sbjct: 203 --GPGVGLAMYNTDESISGFARASFNMALSKNLPLYMSTKNTILKKYDGRFKDIFQDIYE 260

Query: 303 RDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMS 362
            +Y   F +  LWYEHRLIDDMVAQ +KS GGF+ A KNYDGDVQSDI+AQG+GSLGLM+
Sbjct: 261 NEYASEFEKKGLWYEHRLIDDMVAQMIKSKGGFVMALKNYDGDVQSDIVAQGFGSLGLMT 320

Query: 363 SVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDV 422
           S L+TPDGK   AEAAHGTVTRH+R HQQGKETSTNS+ASI AW RGLA R  LD TP+V
Sbjct: 321 SALMTPDGKAYEAEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLAQRGRLDETPEV 380

Query: 423 AHFAEALERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
             FA+ LE++ I+T+ +D  MTKDL++A+  T+    R  Y+ T EF+DAV  RL
Sbjct: 381 VDFADKLEKATIDTVEVDRIMTKDLALAMGKTD----RSAYVTTTEFLDAVADRL 431

ref|ZP_00056387.1| COG0538: Isocitrate dehydrogenases [Magnetospirillum magnetotacticum MS-1]
(405 aa)

Score: 532 bits (1371), Expect: 9.01802e-150
Length: 411, Idn/Pos/Gap = 242/317/11 (58%/77%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V NPIVELDGDE  R+IW  IK+KLILPYL++D+ Y+DLG+  RD TDD VT+EA+ 
Sbjct:   3 KIKVANPIVELDGDEMTRIIWKFIKDKLILPYLDVDLKYYDLGIEYRDKTDDKVTVEASE  62

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   VK ATITPDEARV+EF+LK+M+ SPNGT+RN+L+GTVFREPI+ +N+PRLVP
Sbjct:  63 AIKKYGVGVKCATITPDEARVKEFNLKKMWKSPNGTIRNILDGTVFREPIICKNVPRLVP 122

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW +PIVI RH FGDQYKA D  VP   ++ ++ +   G  +E  +V  F     G GVA
Sbjct: 123 GWTKPIVIGRHAFGDQYKATDFTVPGPGKLTIKFVGTNGETIEH-EVFDFP----GAGVA 177

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           +GM+N DESI  FAR+C  +  ++K P+YLSTKNTILK YDGR++DIFQE+YE++++  +
Sbjct: 178 MGMYNLDESIYGFARACLNYGRQKKWPVYLSTKNTILKAYDGRFKDIFQEVYEKEFKADY 237

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
            +  + YEHRLIDDMVA ALK SG F+WACKNYDGDVQSD +AQG+GSLGLM+SVL++PD
Sbjct: 238 DKLGITYEHRLIDDMVASALKWSGEFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMSPD 297

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GK + AEAAHGTVTRH+R HQ+GKETSTN +ASI AW RGL +RA  D TP+VA+FA+AL
Sbjct: 298 GKVVEAEAAHGTVTRHYREHQKGKETSTNPIASIFAWTRGLFYRAQFDNTPEVANFAQAL 357

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E  C+ET+  G MTKDL+I +         +++L T++F+D + + L   M
Sbjct: 358 EEVCVETVESGFMTKDLAILI------GPGQSWLTTQQFLDKLDENLKKRM 402

emb|CAG88573.1| unnamed protein product [Debaryomyces hansenii CBS767]
ref|XP_460289.1| unnamed protein product [Debaryomyces hansenii]
(410 aa)

Score: 532 bits (1370), Expect: 9.2466e-150
Length: 415, Idn/Pos/Gap = 250/318/9 (60%/76%/2%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
            F+KI+V  PIVE+DGDE  R+IW  IK+KLI PYL++D+ Y+DLG+  R+ TDD VT +
Sbjct:   2 GFNKIKVDQPIVEMDGDEMTRIIWKFIKDKLIFPYLDVDLKYYDLGIEYRNQTDDKVTTD  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           AA A+ ++   VK ATITPDEARVEEF LK+M+ SPNGTLRN+L GTVFREPI+++NIPR
Sbjct:  62 AAEAILKYQVGVKCATITPDEARVEEFKLKKMWLSPNGTLRNILGGTVFREPIVIDNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           +VP W+ PI+I RH FGDQYKA D+ +P A ++EL    A G   E   V+ +    D  
Sbjct: 122 IVPQWESPIIIGRHAFGDQYKATDVVIPKAGQLELVFKPADGSATEVYPVYNY----DAP 177

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NT++SI +FA S F+ AL RKL ++ STKNTILK YDGR++DIF++LYE+ Y+
Sbjct: 178 GVALAMYNTEKSITDFAESSFKMALDRKLILFSSTKNTILKKYDGRFKDIFEDLYEKKYK 237

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
           ++F  A +WYEHRLIDDMVAQ LKS GG++ A KNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 238 KQFEEAGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVQSDIVAQGFGSLGLMTSVLM 297

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
           TPDGK   AEAAHGTVTRH+R HQQGKETSTNS+ASI AW RG+  R  LD   DV  F 
Sbjct: 298 TPDGKAFEAEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGIIQRGKLDNNADVVKFG 357

Query: 427 EALERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E+LE++ I+T+ LD  MTKDL++A   TE    R +Y+ TEEFIDAV +RL+ ++
Sbjct: 358 ESLEKATIDTVALDNVMTKDLALAQGKTE----RSSYVTTEEFIDAVAKRLNKNL 408

gb|EAA67324.1| hypothetical protein FG10347.1 [Gibberella zeae PH-1]
ref|XP_390523.1| hypothetical protein FG10347.1 [Gibberella zeae PH-1]
(445 aa)

Score: 532 bits (1370), Expect: 1.12028e-149
Length: 408, Idn/Pos/Gap = 246/319/9 (60%/78%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V+NP+VELDGDE  R+IW +IK+K I PYL++D+ Y+DLGL  RD T+D VT++AA 
Sbjct:  38 KIKVKNPVVELDGDEMTRIIWQVIKDKFIHPYLDIDLKYYDLGLEYRDETNDQVTIDAAE  97

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   VK ATITPDEARVEEF LK+M+ SPNGT+RN L GTVFREPI++  IPRLVP
Sbjct:  98 AIKKYSVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNALGGTVFREPIVIPRIPRLVP 157

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GWK+PI+I RH FGDQY+A+D  +P   ++ + V   +G + E  +V QF    +GGGVA
Sbjct: 158 GWKKPIIIGRHAFGDQYRAKDAVLPGPGKLSM-VYTPEGGQPEEIEVFQF---KEGGGVA 213

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
              +NTDESI  FA + F+ A+ ++LP+Y+STKNTILK YDGR++DIFQE+YE  Y++ F
Sbjct: 214 QTQYNTDESITGFAHASFKLAIDKELPLYMSTKNTILKKYDGRFKDIFQEIYETTYKKEF 273

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               +WYEHRLIDDMVAQ +KSSGG++ A KNYDGDVQSDI+AQG+GSLGLM+SVL+TPD
Sbjct: 274 EAKKIWYEHRLIDDMVAQMIKSSGGYIMALKNYDGDVQSDIVAQGFGSLGLMTSVLITPD 333

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GKT  +EAAHGTVTRH+R HQ+G ETSTN +ASI AW RGL  R  LD TPDV  FAE L
Sbjct: 334 GKTFESEAAHGTVTRHYREHQKGNETSTNPIASIFAWTRGLIQRGKLDDTPDVVAFAEGL 393

Query: 430 ERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E++CI+T+ +DG MTKDL++A   +E    R++Y  T E++DAV++RL
Sbjct: 394 EQACIDTVDIDGIMTKDLALATGKSE----RKDYATTNEYLDAVERRL 437

ref|ZP_00194333.1| COG0538: Isocitrate dehydrogenases [Mesorhizobium sp. BNC1]
(404 aa)

Score: 531 bits (1369), Expect: 1.39168e-149
Length: 412, Idn/Pos/Gap = 241/317/11 (58%/76%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+VELDGDE  R+IW LIK+KLI PYL++D+ Y+DLG+  RD TDD +T++AA
Sbjct:   2 AKIKVDNPVVELDGDEMTRIIWQLIKDKLIHPYLDIDLKYYDLGIQKRDETDDQITIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
           +A++++   VK ATITPDEARVEEF LK+M+ SPNGT+RN+L G +FREPI+  N+PRLV
Sbjct:  62 KAIKKYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICRNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PIV+ RH FGDQY+A D + P   ++ ++ +   G  +E    H+   +  G GV
Sbjct: 122 PGWTKPIVVGRHAFGDQYRATDFKFPGKGKLSIKFVGEDGEVIE----HEVFDAP-GSGV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ M+N D+SIR+FAR+ F + L+R  P+YLSTKNTILK YDGR++DIFQE+YE ++   
Sbjct: 177 AMAMYNLDDSIRDFARASFNYGLQRGFPVYLSTKNTILKAYDGRFKDIFQEIYETEFEAA 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    LWYEHRLIDDMVA +LK SGG++WACKNYDGDVQSDI+AQG+GSLGLM+SVL+TP
Sbjct: 237 FKERKLWYEHRLIDDMVAASLKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ AEAAHGTVTRH+R HQ+G+ETSTNS+ASI AW RGLAHRA LDG  ++  FAE 
Sbjct: 297 DGKTVEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDGNAELKKFAET 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           LER C++T+  G MTKDL++ + G +Q      +L+T  F+D + + L   M
Sbjct: 357 LERVCVDTVEAGHMTKDLALLI-GPDQ-----PWLSTTGFLDKIDENLQKAM 402

ref|NP_421325.1| isocitrate dehydrogenase, NADP-dependent [Caulobacter crescentus CB15]
gb|AAK24493.1| isocitrate dehydrogenase, NADP-dependent [Caulobacter crescentus CB15]
pir||A87562 isocitrate dehydrogenase, NADP-dependent [imported] - Caulobacter crescentus
(403 aa)

Score: 531 bits (1368), Expect: 1.59045e-149
Length: 412, Idn/Pos/Gap = 244/315/11 (59%/76%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+V++DGDE  R+IW LIK+KLI PYL+L++ Y+DL +  RDATDD VT++AA
Sbjct:   2 AKIKVANPVVDMDGDEMTRIIWKLIKDKLIFPYLDLELDYYDLSVENRDATDDQVTIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A ++H  AVK ATITPDE RVEEF LK+M+ SPNGT+RN+L G +FREPI+ +N+PRLV
Sbjct:  62 NATKKHGVAVKCATITPDEQRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICQNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW QPI++ RH FGDQY+A D + P    + ++ +   G  +E    H+   + D G V
Sbjct: 122 PGWTQPIIVGRHAFGDQYRATDFKFPGKGTLSIKFVGEDGQTIE----HEVFKAPDAG-V 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ M+N DESIR+FA + F + L R  P+YLSTKNTILK YDGR++DIFQE+Y+ +Y E+
Sbjct: 177 AMAMYNLDESIRDFAHASFAYGLNRGYPVYLSTKNTILKAYDGRFKDIFQEIYDAEYAEK 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F  A + YEHRLIDDMVA ALK SGG++WACKNYDGDVQSDI+AQG+GSLGLM+SVL+TP
Sbjct: 237 FKAAGIHYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ AEAAHGTVTRH+R HQ+G+ TSTNS+ASI AW RGLAHRA LD   D+A+FA  
Sbjct: 297 DGKTVEAEAAHGTVTRHYRQHQKGESTSTNSIASIFAWTRGLAHRAKLDDNQDLANFAAT 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           LE+ CI+T+  G MTKDL++ V G +QG     +L TE F+D + + L   M
Sbjct: 357 LEKVCIDTVESGYMTKDLALLV-GDKQG-----WLTTEGFLDKIDENLKKAM 402

gb|AAH74545.1| MGC69505 protein [Xenopus tropicalis]
ref|NP_001004799.1| MGC69505 protein [Xenopus tropicalis]
(455 aa)

Score: 531 bits (1367), Expect: 2.18382e-149
Length: 412, Idn/Pos/Gap = 241/314/5 (58%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V NP+VE+DGDE  R+IW  IK KLIL  +++++ YFDLGLP RD T+D VT++
Sbjct:  42 ADKRIKVANPVVEMDGDEMTRIIWEFIKEKLILSNVDVELKYFDLGLPYRDQTNDQVTID 101

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFR+PI+ +NIPR
Sbjct: 102 SALATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFRDPIICKNIPR 161

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW Q I I RH  GDQYKA D  V  A   +L    A G   +  +V  F +    G
Sbjct: 162 LVPGWTQAITIGRHAHGDQYKATDFVVDQAGTFKLVFAPANGTATKEWEVFNFPA----G 217

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++++++K P+YLSTKNTILK YDGR++DIFQ+++E+ Y+
Sbjct: 218 GVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQDIFEKHYK 277

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F +  +WYEHRLIDDMVAQ LKS+GGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 278 PEFDKLKIWYEHRLIDDMVAQVLKSTGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLV 337

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +ASI AW RGL HR  LDG  D+ +F+
Sbjct: 338 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLINFS 397

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSK-RENYLNTEEFIDAVQQRLD 477
             LE+ C+ET+  G MTKDL+  ++G     +  E+Y+NT +F+DA++  LD
Sbjct: 398 LTLEKVCVETVESGIMTKDLAGCIHGGMSNVRLNEHYVNTTDFLDAIKNNLD 449

gb|AAV33246.1| isocitrate dehydrogenase [Toxoplasma gondii]
(594 aa)

Score: 531 bits (1367), Expect: 2.43402e-149
Length: 433, Idn/Pos/Gap = 244/325/6 (56%/75%/1%)

Query:  52 RTTGRSLCANMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDL 111
           R+   S    M+ +  F +I+V  P+VE+DGDE ARVIW +IK KLILPYL++ ++Y+DL
Sbjct: 163 RSNALSQTGIMNKMSGFQRIKVDQPVVEMDGDEMARVIWAMIKEKLILPYLDIPLMYYDL 222

Query: 112 GLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLN 171
            +  RD TDD VT++AA A+++H   VK ATITPDE RV+EF+LK+M+ SPN T+RN L+
Sbjct: 223 SIQHRDKTDDQVTIDAALAIKRHGVGVKCATITPDEQRVKEFNLKKMWKSPNATIRNTLD 282

Query: 172 GTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMEL 231
           GT+FR PIL++N+PRLVP W +PI+I RH   DQYKA D  V    R  +  + A     
Sbjct: 283 GTIFRAPILMKNVPRLVPSWTKPIIIGRHAHADQYKALDFTVDKPGRFVMSFIPADKSNP 342

Query: 232 ERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDG 291
           E  +V++F     GGGVALGM+NTD SI+ FA SCF++AL +K+P+YLSTKNT+LK YDG
Sbjct: 343 EVHEVYEF----KGGGVALGMYNTDASIKGFAHSCFQYALDQKMPLYLSTKNTVLKKYDG 398

Query: 292 RWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDII 351
           R++DIFQ +YE++Y+++F  A LWYEHRLIDDMVAQA+KSSGGF+WACKNYDGDVQSD++
Sbjct: 399 RFKDIFQTIYEKEYKQKFEEAGLWYEHRLIDDMVAQAIKSSGGFVWACKNYDGDVQSDVV 458

Query: 352 AQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLA 411
           AQGYGSLGLM+SVL+ PDGKT+ AEAAHGTVTRH+R +Q+G +TSTN +ASI AW R L 
Sbjct: 459 AQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRQYQKGIKTSTNPIASIYAWTRSLG 518

Query: 412 HRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDA 471
           HRA LD    +  F EALE +C+ET+  G MTKDL++A+ G +   +  +YL TE+F+D 
Sbjct: 519 HRAKLDNNQKLKEFVEALEDACVETVEAGFMTKDLALAIKGDKLTDR--DYLCTEDFMDK 576

Query: 472 VQQRLDVHMLQEH 484
           + +  +  +L+  
Sbjct: 577 LARVAERKLLERQ 589

ref|ZP_00309338.1| COG0538: Isocitrate dehydrogenases [Cytophaga hutchinsonii]
(410 aa)

Score: 530 bits (1364), Expect: 4.66626e-149
Length: 411, Idn/Pos/Gap = 242/313/6 (58%/76%/1%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V NP+VELDGDE  R+IW  IK+KLILPYL+LDI Y+DLG+  RDAT+D VT+++A 
Sbjct:   4 KIKVANPVVELDGDEMTRIIWKFIKDKLILPYLDLDIKYYDLGMENRDATNDQVTIDSAE  63

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   +K ATITPDE RVEEF LK+M+ SPNGT+RN+L+GTVFREPI+  N+PRLVP
Sbjct:  64 AIKKYSVGIKCATITPDEQRVEEFKLKQMWKSPNGTIRNILDGTVFREPIVCTNVPRLVP 123

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            W  PIV+ RH FGDQYKA D  VP   ++ ++     G  +E  +V+QF     G GVA
Sbjct: 124 NWTAPIVVGRHAFGDQYKATDFVVPGKGKLTIKFEGEDGKVIEH-EVYQF----KGPGVA 178

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           +GM+NT+ESIR FA SCF  AL +K P+YLSTKNTILK YDGR++DIF+E+Y++DY+ +F
Sbjct: 179 MGMYNTEESIRGFAYSCFNMALSKKWPLYLSTKNTILKKYDGRFKDIFEEIYQKDYKSKF 238

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
             A + YEHRLIDDMVA ALK +G F+WACKNYDGDVQSD +AQG+GSLGLM+SVL+TPD
Sbjct: 239 EAAGIVYEHRLIDDMVASALKWNGNFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVTPD 298

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           G T+ AEAAHGTVTRH+R HQ GK TSTN +ASI AW RGL  R   DG  ++ +F + L
Sbjct: 299 GSTMEAEAAHGTVTRHYRDHQAGKPTSTNPIASIFAWTRGLEFRGKKDGNQELVNFCQTL 358

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E+ C+ T+  GKMTKDL++ ++G +     E+YL TEEF+ A+   L + +
Sbjct: 359 EKVCVATVESGKMTKDLAVCIHGNKV-KHGEHYLYTEEFLAAIDDNLKIAL 408

ref|YP_221903.1| isocitrate dehydrogenase, NADP-dependent [Brucella abortus biovar 1 str. 9-941]
gb|AAX74542.1| isocitrate dehydrogenase, NADP-dependent [Brucella abortus biovar 1 str. 9-941]
gb|AAL51972.1| ISOCITRATE DEHYDROGENASE (NADP) [Brucella melitensis 16M]
ref|NP_539708.1| ISOCITRATE DEHYDROGENASE (NADP) [Brucella melitensis 16M]
pir||AI3350 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) [imported] - Brucella melitensis (strain 16M)
(404 aa)

Score: 529 bits (1363), Expect: 6.19688e-149
Length: 412, Idn/Pos/Gap = 239/317/11 (58%/76%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+VELDGDE  R+IW  IK+KLI PYL++D+ Y+DL +  RDAT+D VT++AA
Sbjct:   2 AKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A++++   VK ATITPDEARVEEF LK+M+ SPNGT+RN+L G +FREPI+ +N+PRLV
Sbjct:  62 NAIKEYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW QPI++ RH FGDQY+A D + P    + ++ +   G  +E  +V+Q  S+    GV
Sbjct: 122 PGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGEDGQTIEH-EVYQAPSA----GV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ M+N DESIR FAR+ F + L+R  P+YLSTKNTILK YDGR++DIFQE+++ +++ +
Sbjct: 177 AMAMYNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSK 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    +WYEHRLIDDMVA ALK SGG++WACKNYDGDVQSDI+AQG+GSLGLM+SVL+TP
Sbjct: 237 FEEKKIWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ AEAAHGTVTRH+R HQ+G+ETSTNS+ASI AW RGLAHRA LD   D+  FAE 
Sbjct: 297 DGKTVEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAET 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           LE+ C++T+  G MTKDL++ + G +Q      +L+T  F+D + + L   M
Sbjct: 357 LEKVCVDTVESGFMTKDLALLI-GPDQ-----PWLSTTGFLDKIDENLQKAM 402

emb|CAE04728.1| OSJNBa0043L24.16 [Oryza sativa (japonica cultivar-group)]
ref|XP_473117.1| OSJNBa0043L24.16 [Oryza sativa (japonica cultivar-group)]
(468 aa)

Score: 529 bits (1363), Expect: 6.62464e-149
Length: 432, Idn/Pos/Gap = 262/321/9 (60%/74%/2%)

Query:  47 PKFLRRTTGRSLCANMSNVPAFS--KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNL 104
           P+ LRR      C   +        +I+V NPIVE+DGDE  RVIW +IK+KLI PYL L
Sbjct:  34 PRALRRGGASLRCYAAAAAAVAEQHRIKVHNPIVEMDGDEMTRVIWKMIKDKLIFPYLEL  93

Query: 105 DIVYFDLGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNG 164
           D+ YFDLGL  RDATDD VT+E+A A  +++ AVK ATITPDE RV+EF LK M+ SPNG
Sbjct:  94 DVKYFDLGLLNRDATDDKVTVESAEATLEYNVAVKCATITPDETRVKEFKLKSMWRSPNG 153

Query: 165 TLRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVL 224
           T+RN+LNGTVFREPIL +N+PR++ GWK+PI I RH FGDQY+A D  +    ++++ V 
Sbjct: 154 TIRNILNGTVFREPILCKNVPRILSGWKKPICIGRHAFGDQYRATDTIINGPGKLKM-VF 212

Query: 225 DAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNT 284
              G E     V+ F     G GVAL M+N DESIR FA S    AL +K P+YLSTKNT
Sbjct: 213 VPDGAEPVELNVYNF----KGPGVALSMYNVDESIRAFAESSMAMALSKKWPLYLSTKNT 268

Query: 285 ILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDG 344
           ILK YDGR++DIFQE+YE  ++E+F   ++WYEHRLIDDMVA A+KS GG++WACKNYDG
Sbjct: 269 ILKKYDGRFKDIFQEVYEEKWKEKFEENSIWYEHRLIDDMVAYAVKSEGGYVWACKNYDG 328

Query: 345 DVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIV 404
           DVQSD +AQG+GSLGLMSSVLL+ DGKTL AEAAHGTVTRHFRLHQ+G+ETSTNS+ASI 
Sbjct: 329 DVQSDFLAQGFGSLGLMSSVLLSSDGKTLEAEAAHGTVTRHFRLHQKGQETSTNSIASIF 388

Query: 405 AWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLN 464
           AW RGL HRA LD    +  F + LE +CIET+  GKMTKDL++ ++G +    RE YLN
Sbjct: 389 AWTRGLEHRAKLDKNDRLLDFTKKLESACIETVESGKMTKDLALLIHGPK--VTREFYLN 446

Query: 465 TEEFIDAVQQRL 476
           TEEFIDAV Q+L
Sbjct: 447 TEEFIDAVAQQL 458

emb|CAH02076.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
ref|XP_451683.1| unnamed protein product [Kluyveromyces lactis]
(429 aa)

Score: 529 bits (1363), Expect: 6.90686e-149
Length: 423, Idn/Pos/Gap = 250/322/11 (59%/76%/2%)

Query:  63 SNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDG 122
           S      KI+V+ P+VELDGDE  R+IW  IK+KLILPYL++D+ Y+DL +  RDAT+D 
Sbjct:  15 SAATGLRKIKVQTPVVELDGDEMTRIIWDKIKSKLILPYLDVDLKYYDLSVTNRDATNDQ  74

Query: 123 VTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVE 182
           VT+++A A++++   VK ATITPDE RV+EF+LK+M+ SPNGT+RN+L GTVFREPI++ 
Sbjct:  75 VTVDSANAIKKYGVGVKCATITPDEGRVKEFNLKKMWKSPNGTIRNILGGTVFREPIVIP 134

Query: 183 NIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASS 242
            IPRLVPGW++PIVI RH  GDQYKA DL VP   ++EL      G E +  +V+ +   
Sbjct: 135 RIPRLVPGWEKPIVIGRHAHGDQYKATDLVVPGPGKLELVYKPTDGSETKTLEVYDY--- 191

Query: 243 TDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYE 302
             G G+AL M+NTDESIR FA + F+ A+ +KL +YLSTKNTILK YDGR++DIFQE+Y+
Sbjct: 192 -KGPGIALAMYNTDESIRGFAHASFKLAITKKLNLYLSTKNTILKKYDGRFKDIFQEIYD 250

Query: 303 RDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMS 362
            +Y+  F +  +WYEHRLIDDMVAQ +KS GGF+ A KNYDGDVQSDI+AQG+GSLGLM+
Sbjct: 251 SEYKSEFEKLGIWYEHRLIDDMVAQMIKSKGGFILAFKNYDGDVQSDIVAQGFGSLGLMT 310

Query: 363 SVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDV 422
           SVL+TPDGK   +EAAHGTVTRH+R +QQGKETSTNS+ASI AW RGLA R  LD TP+V
Sbjct: 311 SVLVTPDGKAFESEAAHGTVTRHYRQYQQGKETSTNSIASIFAWTRGLAKRGELDNTPEV 370

Query: 423 AHFAEALERSCIETIL-DGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL--DVH 479
             FA  LE+S + T+  DG MTKDL++A   T+    R +Y+NT+EF+DAV++R   DV 
Sbjct: 371 VEFANLLEKSTLNTVQEDGIMTKDLALACGNTD----RSSYVNTDEFLDAVEKRFRNDVK 426

Query: 480 MLQ 482
            LQ
Sbjct: 427 SLQ 429

sp|O13294|IDH2_CANTR Isocitrate dehydrogenase [NADP] peroxisomal (Oxalosuccinate decarboxylase) (IDH) (PS-NADP-IDH) (CtIDP2)
dbj|BAA22846.1| NADP-linked isocitrate dehydrogenase [Candida tropicalis]
(411 aa)

Score: 529 bits (1363), Expect: 7.32227e-149
Length: 412, Idn/Pos/Gap = 249/314/9 (60%/76%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI V+NPIVE+DGDE  R+IW  IK+KLILPYLN+D+ Y+DLG+  RD TDD VT +AA 
Sbjct:   6 KITVKNPIVEMDGDEMTRIIWQFIKDKLILPYLNVDLKYYDLGIEYRDKTDDKVTTDAAE  65

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A+ Q+   VK ATITPDEARV+EF+LK+M+ SPNGTLRNV+ GTVFREPI+++NIPR+VP
Sbjct:  66 AILQYGVGVKCATITPDEARVKEFNLKKMWLSPNGTLRNVIGGTVFREPIVIDNIPRIVP 125

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            W++PI+I RH FGDQYKA D+ +P A  ++L      G E++   V+QF    DG GVA
Sbjct: 126 SWEKPIIIGRHAFGDQYKATDVVIPAAGDLKLVFKPKDGGEVQEFPVYQF----DGPGVA 181

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           L M+NTD SI +FA S F+ A+ RKL ++ STKNTILK YDG+++DIF+ LY   Y+ + 
Sbjct: 182 LSMYNTDASITDFAESSFQLAIERKLNLFSSTKNTILKKYDGKFKDIFEGLYASKYKTKM 241

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               +WYEHRLIDDMVAQ LKS GG++ A KNYDGDVQSDI+AQG+GSLGLM+SVL+TPD
Sbjct: 242 DELGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVQSDIVAQGFGSLGLMTSVLVTPD 301

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GK   +EAAHGTVTRH+R HQQGKETSTNS+ASI AW RGL  R  LD TP+V  FAE L
Sbjct: 302 GKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIYAWTRGLIQRGKLDDTPEVVKFAEEL 361

Query: 430 ERSCIETIL-DGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E++ IET+  D  MTKDL++    T+  + R +Y+ TEEFID V  RL+ ++
Sbjct: 362 EKAVIETVSKDNIMTKDLAL----TQGKTDRSSYVTTEEFIDGVANRLNKNL 409

gb|AAH82651.1| LOC494713 protein [Xenopus laevis]
(415 aa)

Score: 528 bits (1361), Expect: 1.13946e-148
Length: 413, Idn/Pos/Gap = 245/316/8 (59%/76%/1%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  RVIW LIK KLILPY+ LD+  +DLG+  RDATDD VT++AA A+++++ 
Sbjct:  10 VVEMQGDEMTRVIWDLIKEKLILPYVELDLHSYDLGMENRDATDDQVTVDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            +K ATITPDE RVEEF+LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GIKCATITPDEKRVEEFNLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWIKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+      G E  +  +H F    D GGVALGM+NTD
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEISFTPKDGGEAIKYVIHNFE---DCGGVALGMYNTD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SIR+FA S F+ AL +  P+Y+STKNTILK YDGR++DIFQE+YE++Y+ +F    +WY
Sbjct: 187 QSIRDFAHSSFQMALSKSWPLYMSTKNTILKRYDGRFKDIFQEIYEKEYKSQFEENKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R+HQ+G+ETSTN +ASI AW+RGL HRA LD   ++ +FA ALE  CIET
Sbjct: 307 AAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLDHRAKLDNNQELKNFATALEEVCIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQEHAAAPQ 489
           I  G MTKDL+  + G     +R +YL+T EF+D + + L + +    AA P+
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRGDYLSTFEFMDKLGENLQLKL----AAHPK 414

emb|CAG02627.1| unnamed protein product [Tetraodon nigroviridis]
(410 aa)

Score: 527 bits (1358), Expect: 2.60279e-148
Length: 412, Idn/Pos/Gap = 249/311/6 (60%/75%/1%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KIR    +VE+ GDE  RVIW LIK+KLI PYL+LD+  +DLG+  RDATDD VT+EAA
Sbjct:   3 AKIRA-GSVVEMQGDEMTRVIWELIKDKLIFPYLDLDLHSYDLGIEYRDATDDRVTVEAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            AVQ+++  +K ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+  NIPRLV
Sbjct:  62 EAVQRYNVGIKCATITPDEKRVEEFKLKQMWRSPNGTIRNILGGTVFREAIICRNIPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PI+I RH  GDQYKA D  VP   +VE+      G    +  +++F  S   GGV
Sbjct: 122 PGWTKPIIIGRHAHGDQYKATDFVVPEPGKVEMIYTPTSGTP-TKYTIYEFKGS---GGV 177

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+GM+NTD+SI++FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+YE++Y   
Sbjct: 178 AMGMYNTDKSIQDFAHSSFQLALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYEKEYISH 237

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    +WYEHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ P
Sbjct: 238 FKDRGIWYEHRLIDDMVAQAMKSDGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCP 297

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DG+T+ +EAAHGTVTRH+R HQ+GKETSTN +ASI AW RGL HRA LD   ++  F EA
Sbjct: 298 DGRTVESEAAHGTVTRHYRQHQEGKETSTNPIASIFAWTRGLLHRAKLDSNAELKSFCEA 357

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           LE  CIETI  G MTKDL+I + G    + R +YLNT EF+D + + L V +
Sbjct: 358 LEAVCIETIEGGFMTKDLAICIKGLAHVT-RADYLNTFEFLDKLAENLKVKL 408

pir||S28423 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) - alfalfa
(412 aa)

Score: 527 bits (1358), Expect: 2.9253e-148
Length: 411, Idn/Pos/Gap = 250/313/7 (60%/76%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
            F KI+V NPIVE+DGDE  R+IW  IK+KLI P++ LDI YFDLGLP RD T+D VT+E
Sbjct:   2 GFQKIKVANPIVEMDGDEMTRIIWKYIKDKLIFPFVELDIKYFDLGLPYRDETNDKVTVE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDEARV+EF LK M+ SPNGT+RN+LNGTVFREPI+ +NIPR
Sbjct:  62 SAEATLKYNVAIKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPIICKNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELR-VLDAQGMELERRQVHQFASSTDG 245
           L+PGW +PI I RH FGDQY+A D  +    +++L  V + QG E    +V+ F   T  
Sbjct: 122 LIPGWTKPICIGRHAFGDQYRATDSVIKGPGKLKLVFVPEGQG-ETTDLEVYNF---TGE 177

Query: 246 GGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDY 305
           GGVAL M+NTDESIR+FA +    AL +K P+YLSTKNTILK YDGR++DIFQE+YE  +
Sbjct: 178 GGVALAMYNTDESIRSFAEASMAVALEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEAGW 237

Query: 306 RERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVL 365
           + ++  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL
Sbjct: 238 KSKYEAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVL 297

Query: 366 LTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHF 425
           + PDGKT+ AEAAHGT+TRHFR+HQ+G ETSTNS+ASI AW RG+AH            F
Sbjct: 298 VCPDGKTIEAEAAHGTLTRHFRVHQKGGETSTNSIASIFAWTRGVAHSENWMTMLHSWIF 357

Query: 426 AEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
            E LE +CI  +  GKMTKDL++ ++G++    RE+YLNTEEFIDAV   L
Sbjct: 358 TEKLEAACIGVVESGKMTKDLALILHGSKL--SREHYLNTEEFIDAVAAEL 406

gb|AAN30118.1| isocitrate dehydrogenase, NADP-dependent [Brucella suis 1330]
ref|NP_698203.1| isocitrate dehydrogenase, NADP-dependent [Brucella suis 1330]
(404 aa)

Score: 527 bits (1357), Expect: 3.17986e-148
Length: 412, Idn/Pos/Gap = 238/317/11 (57%/76%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+VELDGDE  R+IW  IK+KLI PYL++D+ Y+DL +  RDAT+D VT++AA
Sbjct:   2 AKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDIDLKYYDLSVENRDATNDQVTIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A++++   VK ATITPDEARVEEF LK+M+ SPNGT+RN+L G +FREPI+ +N+PRLV
Sbjct:  62 NAIKEYGVGVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW QPI++ RH FGDQY+A D + P    + ++ +   G  +E  +V+Q  S+    GV
Sbjct: 122 PGWTQPIIVGRHAFGDQYRATDFKFPGKGTLTIKFVGEDGQTIEH-EVYQAPSA----GV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ M+N DESIR FAR+ F + L+R  P+YLSTKNTILK YDGR++DIFQE+++ +++ +
Sbjct: 177 AMAMYNLDESIREFARASFNYGLQRGYPVYLSTKNTILKAYDGRFKDIFQEVFDAEFKSK 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    +WYEHRLIDDMVA ALK SGG++WACKNYDGDVQSDI+AQG+GSLGLM+SVL+TP
Sbjct: 237 FEEKKIWYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ AEAAHGTVTRH+R +Q+G+ETSTNS+ASI AW RGLAHRA LD   D+  FAE 
Sbjct: 297 DGKTVEAEAAHGTVTRHYRQYQKGEETSTNSIASIFAWTRGLAHRAKLDNNADLKKFAET 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           LE+ C++T+  G MTKDL++ + G +Q      +L+T  F+D + + L   M
Sbjct: 357 LEKVCVDTVESGFMTKDLALLI-GPDQ-----PWLSTTGFLDKIDENLQKAM 402

gb|AAD38292.1| NADP-dependent isocitrate dehydrogenase [Oryza sativa (japonica cultivar-group)]
dbj|BAD81495.1| putative NADP-dependent isocitrate dehydrogenase [Oryza sativa (japonica cultivar-group)]
(414 aa)

Score: 527 bits (1357), Expect: 3.31532e-148
Length: 414, Idn/Pos/Gap = 250/312/7 (60%/75%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI V NP+VE+DGDE  RVIW  IK+KLI P+L+LDI Y+DLGLP RDAT D VT+E
Sbjct:   2 AFEKIVVANPVVEMDGDEMTRVIWKWIKDKLIFPFLDLDIKYYDLGLPNRDATGDKVTIE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDE RV+EF+L  M+ SPNGT+RN+LNGTVFREPI+ +NIPR
Sbjct:  62 SAEATLKYNVAIKCATITPDEGRVKEFNLSAMWKSPNGTIRNILNGTVFREPIICKNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQY+A D  +    +++L V D +  ++E   V  F   T  G
Sbjct: 122 LVPGWIKPICIGRHAFGDQYRATDTVIKGPGKLKL-VFDGREEQIEL-DVFNF---TGAG 176

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESI  FA +    A +++ P+YLSTKNTILK YDGR++DIFQE YE  +R
Sbjct: 177 GVALSMYNTDESIWAFAEASMNMAYQKRWPLYLSTKNTILKKYDGRFKDIFQENYETKWR 236

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            +F  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD+IAQG+GSLGLM+SVL+
Sbjct: 237 AKFDDAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDLIAQGFGSLGLMTSVLV 296

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDG+T+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW  GL HRA LD    +  F 
Sbjct: 297 CPDGRTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTTGLGHRAKLDDNKRLLDFV 356

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           + LE +C+ T+  GKMTKDL++ V+G      R+ YLNT EFIDAV + L   +
Sbjct: 357 QKLEAACVGTVESGKMTKDLALLVHGPN--VSRDKYLNTVEFIDAVAEDLRTRL 408

ref|NP_926944.1| probable isocitrate dehydrogenase [Gloeobacter violaceus PCC 7421]
dbj|BAC91939.1| gll3998 [Gloeobacter violaceus PCC 7421]
(409 aa)

Score: 526 bits (1355), Expect: 5.60809e-148
Length: 418, Idn/Pos/Gap = 250/312/10 (59%/74%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           SK+ V+  +V++DGDE  R+IW +I+ KL+ PYL + I  +DLG+  RDATDD VT+EAA
Sbjct:   2 SKLTVKTTVVDIDGDEMTRIIWEMIQQKLLRPYLEMTIERYDLGIENRDATDDRVTVEAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            AV +H   VK ATITPDEARV+EF LK+M+ SPNGT+RN+L GTVFREPI+  NIPRLV
Sbjct:  62 EAVMRHGVGVKCATITPDEARVKEFGLKKMWKSPNGTIRNILGGTVFREPIICRNIPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PIV+ARH FGDQY+A + RVP   +++L     QG E   + V  FA      GV
Sbjct: 122 PGWTRPIVVARHAFGDQYRATEYRVPGPGKLKLVFEPTQGGEPVEQTVFDFADK----GV 177

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           ALGM+N D SI  FAR+CF FAL R  P+YLSTKNTILKVYDG ++DIFQ +Y+ +++  
Sbjct: 178 ALGMYNLDVSIAGFARACFNFALTRNWPVYLSTKNTILKVYDGNFKDIFQSVYDSEFKAA 237

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    L YEHRLIDDMVA ALK SGGF+WACKNYDGDVQSD++AQG+GSLGLM+S+LLTP
Sbjct: 238 FAERGLSYEHRLIDDMVAAALKWSGGFVWACKNYDGDVQSDVVAQGFGSLGLMTSILLTP 297

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGK++  EAAHGTVTRH+RLHQQGK+TSTN +ASI AW+RGL +R   DGTP++  FAE 
Sbjct: 298 DGKSVETEAAHGTVTRHYRLHQQGKQTSTNPIASIFAWSRGLWYRGQFDGTPEICAFAEL 357

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQEHAA 486
           LE  C+ET+  G+MT+DL++ V      S  + YL T  FIDAV +RLD    +  AA
Sbjct: 358 LEHVCVETVEAGEMTRDLALLV------SPEQPYLTTGAFIDAVARRLDAAYAERFAA 409

gb|AAS50344.1| AAL022Wp [Ashbya gossypii ATCC 10895]
ref|NP_982520.1| AAL022Wp [Eremothecium gossypii]
(415 aa)

Score: 526 bits (1355), Expect: 6.09609e-148
Length: 408, Idn/Pos/Gap = 244/314/6 (59%/76%/1%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           K++V+ PIVE+DGDEQ R+IWHLIK++LI PYL++D+ Y+DL +  RDAT+D VT+E+A 
Sbjct:   3 KVKVQQPIVEMDGDEQTRIIWHLIKDQLIFPYLDVDLKYYDLSIENRDATEDRVTVESAE  62

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A  ++  AVK ATITPDEARVEEF LK M+ SPNGT+RN+L GTVFREPI++  IPRLVP
Sbjct:  63 ATLKYGVAVKCATITPDEARVEEFGLKEMWKSPNGTIRNILGGTVFREPIIIPRIPRLVP 122

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW +PI++ RH FGDQYKA D+ +P    ++L      G + +   +  F    DGG VA
Sbjct: 123 GWNEPIIVGRHAFGDQYKATDVVIPGEGTLKLVFESKDGDKSKNLDLEVFEYPKDGG-VA 181

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           + M+NT +SI  FA+S FE AL+RK+P+Y +TKNTILK YDG+++DIF+ +Y  +Y+E+F
Sbjct: 182 MTMYNTTDSITGFAKSSFELALQRKMPLYSTTKNTILKKYDGKFKDIFEGMYAAEYKEKF 241

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
             A +WYEHRLIDDMVAQ LKS GGF+ A KNYDGDVQSDI+AQG+GSLGLM+SVL++PD
Sbjct: 242 EAAGIWYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDVQSDIVAQGFGSLGLMTSVLVSPD 301

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GKT  +EAAHGTVTRH+R HQQGKETSTNS+ASI AW RG+ HR  +DGTPDV  F E L
Sbjct: 302 GKTFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGIIHRGKVDGTPDVVKFGELL 361

Query: 430 ERSCIETIL-DGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E+S ++T+  D  MTKDL++ +  T+    R +Y+ TEEFI AV  RL
Sbjct: 362 EKSTLDTVQEDNIMTKDLALILGKTD----RASYVTTEEFITAVANRL 405

gb|EAA56913.1| hypothetical protein MG07268.4 [Magnaporthe grisea 70-15]
ref|XP_367343.1| hypothetical protein MG07268.4 [Magnaporthe grisea 70-15]
(450 aa)

Score: 525 bits (1351), Expect: 1.46398e-147
Length: 416, Idn/Pos/Gap = 245/319/9 (58%/76%/2%)

Query:  62 MSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDD 121
           M  + + +KI+V+NP+VELDGDE  R+IW  IK+K I PYL++D+ Y+DLGL  RD TDD
Sbjct:  35 MRTMASQAKIKVKNPVVELDGDEMTRIIWQNIKDKFIHPYLDIDLKYYDLGLEYRDKTDD  94

Query: 122 GVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILV 181
            VTL+AA A++++   VK ATITPDEARV+EF+LK+M+ SPNGT+RN L GTVFREPI++
Sbjct:  95 KVTLDAAEAIKKYSVGVKCATITPDEARVKEFNLKQMWLSPNGTIRNALGGTVFREPIVI 154

Query: 182 ENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFAS 241
             IPRLVP W++PI+I RH FGDQY+A+D+ VP   ++ +     +G E +  QV  F  
Sbjct: 155 PRIPRLVPSWQKPIIIGRHAFGDQYRAKDMVVPGEGKLTM-TFTPKGGEPQEIQVFDF-- 211

Query: 242 STDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELY 301
             +GGGVA   +NTDESI  FA+S F+ AL + LP+Y+STKN ILK YDGR++DIF++LY
Sbjct: 212 -KNGGGVAQTQYNTDESITGFAQSSFKLALAKGLPLYMSTKNAILKKYDGRFKDIFEQLY 270

Query: 302 ERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLM 361
           +  Y+  F    +WYEHRLIDDMVAQ +KS+GG++ A KNYDGDVQSDI+AQG+GSLGLM
Sbjct: 271 QSTYKAEFEAKGIWYEHRLIDDMVAQMIKSTGGYIMALKNYDGDVQSDIVAQGFGSLGLM 330

Query: 362 SSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPD 421
           +SVL+TPDGKT  +EAAHGTVTRH+R HQ+G+ETSTN +ASI AW RGL  R  LD TPD
Sbjct: 331 TSVLITPDGKTFESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLIQRGKLDETPD 390

Query: 422 VAHFAEALERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           V  FAE LER+CIET+ +DG MTKDL++A   T     R +Y+ T E++DAV++R+
Sbjct: 391 VVAFAETLERACIETVDIDGIMTKDLALACGKT----ARSDYVTTNEYLDAVERRM 442

emb|CAE74010.1| Hypothetical protein CBG21657 [Caenorhabditis briggsae]
(436 aa)

Score: 524 bits (1350), Expect: 2.31651e-147
Length: 415, Idn/Pos/Gap = 251/318/7 (60%/76%/1%)

Query:  63 SNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDG 122
           +N  A  KI+  + IVE+ GDE  R+IW LIK KLILPY++L++ +FDLG+  RDATDD 
Sbjct:  21 TNAMAAQKIQGGD-IVEMQGDEMTRIIWDLIKEKLILPYVDLNLHFFDLGVEHRDATDDQ  79

Query: 123 VTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVE 182
           VT++AA A  +++ AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+V+
Sbjct:  80 VTIDAANATLKYNVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIIVK 139

Query: 183 NIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASS 242
           N+PRLV  W +PI+I RH   DQYKA D  VP A ++E++ + A G +  +  V  F   
Sbjct: 140 NVPRLVNTWSKPIIIGRHAHADQYKATDFVVPGAGKLEIKFVSADGTQTIQETVFDF--- 196

Query: 243 TDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYE 302
             G GV+L M+NTDESIR+FA + F++AL+RK P+YLSTKNTILK YDGR++DIF E+Y 
Sbjct: 197 -KGPGVSLSMYNTDESIRDFAHASFKYALQRKFPLYLSTKNTILKKYDGRFKDIFAEIYV 255

Query: 303 RDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMS 362
            +Y   F  A +WYEHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLGLM+
Sbjct: 256 -EYEAAFKSAGIWYEHRLIDDMVAQAMKSDGGFVWACKNYDGDVQSDSVAQGYGSLGLMT 314

Query: 363 SVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDV 422
           SVL+ PDGKT+ AEAAHGTVTRH+R+HQ+G+ETSTN +ASI AW RGL+HRATLD    +
Sbjct: 315 SVLVCPDGKTVEAEAAHGTVTRHYRMHQKGQETSTNPIASIYAWTRGLSHRATLDNNAAL 374

Query: 423 AHFAEALERSCIETILDGKMTKDLSIAVYGTEQGS-KRENYLNTEEFIDAVQQRL 476
           A FA+ LE  CIET+  G +TKDL+I V G    +  R +YLNT EF+D + + L
Sbjct: 375 ATFAQNLEAVCIETMEAGFLTKDLAICVKGGNASAVTRSDYLNTFEFLDKLAENL 429

gb|AAC43640.1| isocitrate dehydrogenase
sp|P50215|IDH_SPHYA Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
pir||JC4600 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) - Sphingomonas yanoikuyae
(406 aa)

Score: 524 bits (1350), Expect: 2.45584e-147
Length: 412, Idn/Pos/Gap = 238/317/11 (57%/76%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V+NP+VE+DGDE  R+IW  I+ +LILPYL++D+ Y+DL +  RD T D +T++AA
Sbjct:   2 AKIKVKNPVVEIDGDEMTRIIWEWIRERLILPYLDVDLKYYDLSVEKRDETSDQITIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A++++   VK ATITPDEARVEEF LK+M+ SPNGT+RN+L G VFREPI+++N+PRLV
Sbjct:  62 NAIKEYGVGVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGVVFREPIVIKNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW  PIV+ RH FGDQYKA D +VP A  + ++ +   G ELE  +V +F S+    GV
Sbjct: 122 PGWTDPIVVGRHAFGDQYKATDFKVPGAGTLTMKWVGTNGEELEY-EVFEFPSA----GV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+GM+N DESIR+FA++ F + L R  P+YLSTKNTILK YDGR++D+FQE+++ ++ ++
Sbjct: 177 AMGMYNLDESIRDFAKASFNYGLNRGWPVYLSTKNTILKAYDGRFKDLFQEVFDAEFADK 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F  A + YEHRLIDDMVA ALK SG F+WACKNYDGDVQSD +AQG+GSLGLM+SVLL+P
Sbjct: 237 FKAAGIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLSP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ AEAAHGTVTRH+R HQQGK TSTN +ASI AW +GL+ R   D TPDV  FAE 
Sbjct: 297 DGKTVEAEAAHGTVTRHYRQHQQGKATSTNPIASIFAWTQGLSFRGKFDDTPDVVKFAET 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           LE+ CI+T+  G MTKDL++ + G +Q      ++ TE+F +A++  L+  M
Sbjct: 357 LEQVCIKTVEGGAMTKDLALLI-GPDQA-----WMTTEQFFEAIRVNLEAEM 402

emb|CAA92778.1| Hypothetical protein F59B8.2 [Caenorhabditis elegans]
ref|NP_501665.1| isocitrate dehydrogenase (46.0 kD) (4K204) [Caenorhabditis elegans]
pir||T22983 hypothetical protein F59B8.2 - Caenorhabditis elegans
(412 aa)

Score: 523 bits (1348), Expect: 3.40034e-147
Length: 401, Idn/Pos/Gap = 246/310/6 (61%/77%/1%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           IVE+ GDE  R+IW LIK KLILPY++L++ +FDLG+  RDATDD VT++AA A  +++ 
Sbjct:  11 IVEMQGDEMTRIIWDLIKEKLILPYVDLNVHFFDLGIEHRDATDDQVTIDAANATLKYNV  70

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
           AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI+V+N+PRLV  W +PI+
Sbjct:  71 AVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIIVKNVPRLVNTWSKPII 130

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH   DQYKA D  VP A ++E++ + A G +  +  V  F     G GV+L M+NTD
Sbjct: 131 IGRHAHADQYKATDFVVPGAGKLEIKFVSADGTQTIQETVFDF----KGPGVSLSMYNTD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SIR+FA + F++AL+RK P+YLSTKNTILK YDGR++DIF E+Y  +Y   F  A +WY
Sbjct: 187 DSIRDFAHASFKYALQRKFPLYLSTKNTILKKYDGRFKDIFAEIYP-EYEAEFKAAGIWY 245

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLGLM+SVL+ PDGKT+ AE
Sbjct: 246 EHRLIDDMVAQAMKSDGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLVCPDGKTVEAE 305

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R+HQ+G+ETSTN +ASI AW+RGLAHRATLD    +  FA  LE  CIET
Sbjct: 306 AAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRATLDKNSALETFANNLEAVCIET 365

Query: 437 ILDGKMTKDLSIAVYGTEQGS-KRENYLNTEEFIDAVQQRL 476
           +  G +TKDL+I V G    +  R +YLNT EF+D + + L
Sbjct: 366 MEAGFLTKDLAICVKGGNASAVTRTDYLNTFEFLDKLAENL 406

gb|AAB67464.1| Idp2p: isocitrate dehydrogenase [Saccharomyces cerevisiae]
sp|P41939|IDHC_YEAST Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
pir||S51419 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) IDP2 precursor, cytosolic - yeast (Saccharomyces cerevisiae)
ref|NP_013275.1| Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose [Saccharomyces cerevisiae]
(412 aa)

Score: 523 bits (1348), Expect: 3.82167e-147
Length: 409, Idn/Pos/Gap = 242/311/8 (59%/76%/1%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NPIVE+DGDEQ R+IWHLI++KL+LPYL++D+ Y+DL +  RD T+D VT+++A
Sbjct:   2 TKIKVANPIVEMDGDEQTRIIWHLIRDKLVLPYLDVDLKYYDLSVEYRDQTNDQVTVDSA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A  ++  AVK ATITPDEARVEEFHLK+M+ SPNGT+RN+L GTVFREPI++  IPRLV
Sbjct:  62 TATLKYGVAVKCATITPDEARVEEFHLKKMWKSPNGTIRNILGGTVFREPIIIPRIPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           P W++PI+I RH FGDQYKA D+ VP    + L      G      +V  +    + GGV
Sbjct: 122 PQWEKPIIIGRHAFGDQYKATDVIVPEEGELRLVYKSKSGTHDVDLKVFDYP---EHGGV 178

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ M+NT +SI  FA++ FE A+ RKLP+Y +TKNTILK YDG+++D+F+ +Y R Y+E+
Sbjct: 179 AMMMYNTTDSIEGFAKASFELAIERKLPLYSTTKNTILKKYDGKFKDVFEAMYARSYKEK 238

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    +WYEHRLIDDMVAQ LKS GG++ A KNYDGDV+SDI+AQG+GSLGLM+SVL+TP
Sbjct: 239 FESLGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITP 298

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT  +EAAHGTVTRHFR HQQGKETSTNS+ASI AW RG+  R  LD TPDV  F + 
Sbjct: 299 DGKTFESEAAHGTVTRHFRQHQQGKETSTNSIASIFAWTRGIIQRGKLDNTPDVVKFGQI 358

Query: 429 LERSCIETIL-DGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LE + + T+  DG MTKDL++ +  +E    R  Y+ TEEFIDAV+ RL
Sbjct: 359 LESATVNTVQEDGIMTKDLALILGKSE----RSAYVTTEEFIDAVESRL 403

gb|AAD02924.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus mexicanus]
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
(414 aa)

Score: 523 bits (1347), Expect: 4.29521e-147
Length: 406, Idn/Pos/Gap = 241/309/4 (59%/76%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLILPY+ LD+  +DLG+  RDAT+D VT +AA A+++++ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+      G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITFTPKDGSQKVTYLVHSFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R+HQ+G+ETSTN +ASI AW+RGLAHRA LD   +++ FA+ALE  CIET
Sbjct: 307 AAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALEEVCIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L   + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKAKLAQ 411

gb|AAD02925.1| cytosolic NADP-dependent isocitrate dehydrogenase [Microtus ochrogaster]
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
(414 aa)

Score: 523 bits (1347), Expect: 4.74754e-147
Length: 406, Idn/Pos/Gap = 241/309/4 (59%/76%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLILPY+ LD+  +DLG+  RDAT+D VT +AA A+++++ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+      G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHSFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R+HQ+G+ETSTN +ASI AW+RGLAHRA LD   +++ FA+ALE  CIET
Sbjct: 307 AAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALEEVCIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L   + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKAKLAQ 411

ref|NP_949171.1| NADP-dependent isocitrate dehydrogenase [Rhodopseudomonas palustris CGA009]
emb|CAE29275.1| NADP-dependent isocitrate dehydrogenase [Rhodopseudomonas palustris CGA009]
(408 aa)

Score: 523 bits (1347), Expect: 5.20389e-147
Length: 418, Idn/Pos/Gap = 240/317/11 (57%/75%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V+NP+VELDGDE  R+IW +IK+KLI P+L+++++YFDLG+  RD TDD VT++AA
Sbjct:   2 AKIKVKNPVVELDGDEMTRIIWQMIKDKLITPFLDVELMYFDLGMEHRDKTDDQVTIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A++Q    VK ATITPDEARV+EF LK M+ SPNGT+RN+L G +FREPI+ +N+PRLV
Sbjct:  62 NAIKQVGVGVKCATITPDEARVKEFGLKSMWKSPNGTIRNILGGVIFREPIICKNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PIVI RH +GDQY+A D++ P    + ++ +   G  +ER           G GV
Sbjct: 122 PGWTKPIVIGRHAYGDQYRATDIKFPGPGTLTMKFVGEDGSVIERE-----VFKAPGAGV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ M+N DESI++FAR+   + L R  P+YLSTKNTI+KVYDGR++DIFQE+++ ++++ 
Sbjct: 177 AMSMYNLDESIKDFARASLNYGLMRNYPVYLSTKNTIMKVYDGRFKDIFQEIFDAEFKKE 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           +    L YEHRLIDDMVA ALK SGG++WACKNYDGDVQSD +AQGYGSLGLM+SVL+TP
Sbjct: 237 YDAKGLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ AEAAHGTVTRH+R HQ+GK TSTNS+ASI AW RGLAHRA LD   ++A FA+ 
Sbjct: 297 DGKTVEAEAAHGTVTRHYREHQKGKATSTNSIASIFAWTRGLAHRAKLDSNEELARFADL 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQEHAA 486
           LE+ C++T+  G MTKDL++ V G +Q      +L+TE F+D V Q L+  M    AA
Sbjct: 357 LEKVCVDTVEAGAMTKDLALLV-GADQ-----RWLSTEGFLDKVAQNLNKAMEDAKAA 408

gb|EAK94305.1| hypothetical protein CaO19.3733 [Candida albicans SC5314]
(412 aa)

Score: 523 bits (1346), Expect: 6.20047e-147
Length: 412, Idn/Pos/Gap = 245/314/9 (59%/76%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V+NPIVE+DGDE  R+IW  IK+KLI PYL++D+ Y+DLG+  RD TDD VT +AA 
Sbjct:   6 KIKVKNPIVEMDGDEMTRIIWQFIKDKLITPYLDVDLKYYDLGIEYRDQTDDKVTTDAAN  65

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A+ ++   VK ATITPDEARV+EF+LK+M+ SPNGTLRN+L GTVFREPI+++NIPR+VP
Sbjct:  66 AILKYGVGVKCATITPDEARVKEFNLKKMWLSPNGTLRNILGGTVFREPIVIDNIPRIVP 125

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            W++PI+I RH FGDQYKA D+ VP A  ++L      G E++   V+ F    +G GV 
Sbjct: 126 SWEKPIIIGRHAFGDQYKATDIVVPGAGELKLVFKPKDGGEIQEYPVYNF----EGPGVG 181

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           L M+NTD SI++FA S F+ A+ RKL ++ STKNTILK YDGR++DIF+ LY   Y+ + 
Sbjct: 182 LSMYNTDASIQDFAESSFQLAIERKLNLFSSTKNTILKKYDGRFKDIFEGLYASKYKTKM 241

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               +WYEHRLIDDMVAQ LKS GG++ A KNYDGDVQSDI+AQG+GSLGLM+SVL+TPD
Sbjct: 242 DELGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVQSDIVAQGFGSLGLMTSVLVTPD 301

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GK   +EAAHGTVTRH+R HQQGKETSTNS+ASI AW RGL  R  LD TP+V  FAE L
Sbjct: 302 GKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIYAWTRGLIQRGKLDETPEVVKFAEDL 361

Query: 430 ERSCIETIL-DGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E++ I+T+  D  MTKDL++    T+  + R +Y+ TEEFIDAV  RL+ ++
Sbjct: 362 EKAIIDTVSKDNIMTKDLAL----TQGKTDRSSYVTTEEFIDAVANRLNKNL 409

ref|XP_510589.1| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial [Pan troglodytes]
(458 aa)

Score: 523 bits (1346), Expect: 6.25242e-147
Length: 447, Idn/Pos/Gap = 242/313/40 (54%/70%/8%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNK------------------------------  96
           A  +I+V  P+VE+DGDE  R+IW  IK K                              
Sbjct:  10 ADKRIKVAKPVVEMDGDEMTRIIWQFIKEKVVPPPEVGSSPGGLARDCSVPQGLLDCRSL  69

Query:  97 ------LILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARV 150
                 LILP++++ + YFDLGLP RD TDD VT+++A A Q++  AVK ATITPDEARV
Sbjct:  70 GPPVVLLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARV 129

Query: 151 EEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQD 210
           EEF LK+M+ SPNGT+RN+L GTVFREPI+ +NIPRLVPGW +PI I RH  GDQYKA D
Sbjct: 130 EEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATD 189

Query: 211 LRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFA 270
                A   ++      G  ++  +V+ F +    GGV +GM+NTDESI  FA SCF++A
Sbjct: 190 FVADRAGTFKMVFTPKDGSGVKEWEVYNFPA----GGVGMGMYNTDESISGFAHSCFQYA 245

Query: 271 LRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALK 330
           +++K P+Y+STKNTILK YDGR++DIFQE++++ Y+  F +  +WYEHRLIDDMVAQ LK
Sbjct: 246 IQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLK 305

Query: 331 SSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQ 390
           SSGGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL+ PDGKT+ AEAAHGTVTRH+R HQ
Sbjct: 306 SSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQ 365

Query: 391 QGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAV 450
           +G+ TSTN +ASI AW RGL HR  LDG  D+  FA+ LE+ C+ET+  G MTKDL+  +
Sbjct: 366 KGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVESGAMTKDLAGCI 425

Query: 451 YGTEQGSKRENYLNTEEFIDAVQQRLD 477
           +G       E++LNT +F+D ++  LD
Sbjct: 426 HGLSNVKLNEHFLNTTDFLDTIKSNLD 452

ref|ZP_00376243.1| isocitrate dehydrogenase [Erythrobacter litoralis HTCC2594]
gb|EAL74973.1| isocitrate dehydrogenase [Erythrobacter litoralis HTCC2594]
(406 aa)

Score: 522 bits (1345), Expect: 8.16592e-147
Length: 411, Idn/Pos/Gap = 237/312/11 (57%/75%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V+NP+VELDGDE  ++IW  I+ +LILPYL++D+ Y+DL +  RD TDD +T++AA 
Sbjct:   3 KIQVKNPVVELDGDEMTKIIWQWIRERLILPYLDVDLRYYDLSIESRDETDDQITVDAAN  62

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A+++H   VK ATITPDEARVEEF LK+M+ SPNGT+RN+L G VFREPI+++N+PRLVP
Sbjct:  63 AIKEHGVGVKCATITPDEARVEEFDLKKMWVSPNGTIRNILGGVVFREPIVIDNVPRLVP 122

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW  PIV+ RH FGDQY+A+D  +P   ++ L    A G  ++   V +F SS    GVA
Sbjct: 123 GWTDPIVVGRHAFGDQYRAKDTLIPGPGKLRLVFEGADGENIDI-DVFEFESS----GVA 177

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           + M+N D+SIR+FAR+   + L R  P+YLSTKNTILK YDGR++D+F+E+YE +++++F
Sbjct: 178 MAMYNLDQSIRDFARASMNYGLDRGWPVYLSTKNTILKKYDGRFKDLFEEIYEAEFKDKF 237

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
            +A + YEHRLIDDMVA A+K +G F+WACKNYDGDVQSD +AQG+GSLGLM+SVL+TPD
Sbjct: 238 EKAGIHYEHRLIDDMVAAAMKWNGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPD 297

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GKT+ AEAAHGTVTRH+R HQQGK TSTN +ASI AW RGL +R   D TPDV  FAE L
Sbjct: 298 GKTVEAEAAHGTVTRHYRQHQQGKATSTNPIASIFAWTRGLMYRGKFDDTPDVVRFAETL 357

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           ER CIET+  G MTKDL++ +         +N+L TE+F +A+   L+  M
Sbjct: 358 ERVCIETVESGNMTKDLALLI------GPNQNWLTTEQFFEAIVTNLEKEM 402

ref|NP_970434.1| isocitrate dehydrogenase (NADP) [Bdellovibrio bacteriovorus HD100]
emb|CAE81088.1| isocitrate dehydrogenase (NADP) [Bdellovibrio bacteriovorus HD100]
(409 aa)

Score: 522 bits (1344), Expect: 1.02292e-146
Length: 407, Idn/Pos/Gap = 237/310/6 (58%/76%/1%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V NP+VELDGDE  R+IW  IK +LILPYL++DI Y+DLG+  RDAT+D VT++AA 
Sbjct:   3 KIKVANPVVELDGDEMTRIIWKFIKQQLILPYLDIDIKYYDLGMEHRDATNDQVTVDAAE  62

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A+++++  +K ATITPDEARV+EF+LK+M+ SPNGT+RN+L+GTVFREPI+ +N+PRLVP
Sbjct:  63 AIKKYNVGIKCATITPDEARVKEFNLKQMWKSPNGTIRNILDGTVFREPIICKNVPRLVP 122

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            W  PI I RH FGDQY+A D       ++ +      G E    +V+ F     G GVA
Sbjct: 123 NWTAPICIGRHAFGDQYRATDFVTKGKGKLTVTFQPENGGETITHEVYNF----KGDGVA 178

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           L M+NTDESI  FARSCF  AL +K P+YLSTKNTILK YDGR++DIF+E+Y+++++ +F
Sbjct: 179 LTMYNTDESITGFARSCFNQALTKKWPLYLSTKNTILKKYDGRFKDIFEEIYQKEFKAKF 238

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
             A + YEHRLIDDMVA ALK +G F+WACKNYDGDVQSD +AQG+GSLGLM+SVL+TPD
Sbjct: 239 DAAGITYEHRLIDDMVASALKWNGNFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVTPD 298

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GKT+ +EAAHGTVTRH+R HQQGK TSTN +ASI AW RGL HR  LD   ++  FA+ L
Sbjct: 299 GKTMESEAAHGTVTRHYRQHQQGKPTSTNPIASIFAWTRGLEHRGNLDNNQELVKFAQTL 358

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E+ C+ET+  G MTKDL++ +YG +  + +  Y+NTE F+  + + L
Sbjct: 359 EKVCVETVEAGFMTKDLAVCIYGDKVPADK--YMNTEPFLAKLDENL 403

gb|AAD02918.1| NADP-dependent isocitrate dehydrogenase [Homo sapiens]
(414 aa)

Score: 521 bits (1343), Expect: 1.24971e-146
Length: 406, Idn/Pos/Gap = 240/308/4 (59%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLI PY+ LD+  +DLG+  RDAT+D VT +AA A+++H+ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+    + G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK+YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKIYDGRFKDIFQEIYDKQYKSQFEAQKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW RGLAHRA LD   ++A FA ALE   IET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNLIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L + + Q
Sbjct: 367 IEAGFMTKDLAACIRGLPN-VQRSDYLNTFEFMDKLGENLKIKLAQ 411

ref|NP_217856.1| PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD1 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) [Mycobacterium tuberculosis H37Rv]
ref|NP_857016.1| PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD1 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) [Mycobacterium bovis AF2122/97]
emb|CAA17111.1| PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD1 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) [Mycobacterium tuberculosis H37Rv]
emb|CAD95494.1| PROBABLE ISOCITRATE DEHYDROGENASE [NADP] ICD1 (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) [Mycobacterium bovis AF2122/97]
gb|AAK47786.1| isocitrate dehydrogenase, NADP-dependent [Mycobacterium tuberculosis CDC1551]
ref|NP_337972.1| isocitrate dehydrogenase, NADP-dependent [Mycobacterium tuberculosis CDC1551]
pir||B70846 probable icd1 protein - Mycobacterium tuberculosis (strain H37RV)
sp|P65097|IDH_MYCTU Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
sp|P65098|IDH_MYCBO Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
(409 aa)

Score: 521 bits (1343), Expect: 1.30295e-146
Length: 416, Idn/Pos/Gap = 249/309/12 (59%/74%/2%)

Query:  62 MSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDD 121
           MSN P   KI+V  P+VELDGDE  RVIW LIK+ LILPYL++ + Y+DLG+  RDATDD
Sbjct:   1 MSNAP---KIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDD  57

Query: 122 GVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILV 181
            VT++AA A+++H   VK ATITPDEARVEEF+LK+M+ SPNGT+RN+L GT+FREPI++
Sbjct:  58 QVTIDAAYAIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVI 117

Query: 182 ENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFAS 241
            N+PRLVPGW +PIVI RH FGDQY+A + +V     V L    A G       VH+  S
Sbjct: 118 SNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFTPADG---SAPIVHEMVS 174

Query: 242 STDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELY 301
             + GGV LGM+N  ESIR+FAR+ F + L  K P+YLSTKNTILK YDG ++D F+ +Y
Sbjct: 175 IPEDGGVVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVY 234

Query: 302 ERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLM 361
           E +++ +F  A L YEHRLIDDMVA  LK  GG++WACKNYDGDVQSD +AQGYGSLGLM
Sbjct: 235 EEEFKAQFEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLM 294

Query: 362 SSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPD 421
           +SVL+T DGKT+ AEAAHGTVTRH+R +Q GK TSTN +ASI AW RGL HR  LDGTP+
Sbjct: 295 TSVLMTADGKTVEAEAAHGTVTRHYRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPE 354

Query: 422 VAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           V  FA  LE   I T+  GKMTKDL+I + G EQ     ++LN+EEF+DA+   L+
Sbjct: 355 VIDFAHKLESVVIATVESGKMTKDLAILI-GPEQ-----DWLNSEEFLDAIADNLE 404

gb|AAT06312.1| isocitrate dehydrogenase [Rhizobium leguminosarum bv. viciae]
(403 aa)

Score: 521 bits (1343), Expect: 1.40457e-146
Length: 412, Idn/Pos/Gap = 238/314/11 (57%/76%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+ +LDGDE  R+IW LIK+KLI PYL+LDI YFDL +  RDAT+D VT++AA
Sbjct:   2 NKIKVANPVADLDGDEMTRIIWQLIKDKLIHPYLDLDIDYFDLSVENRDATNDQVTVDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A++++   +K ATITPDEARV+EF+LK M+ SPNGT+RN+L G +FREPI+ +N+PRLV
Sbjct:  62 NAIKKYGVGIKCATITPDEARVKEFNLKEMWKSPNGTIRNILGGVIFREPIICKNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PIV+ RH FGDQY+A D + P   ++ ++ +   G  +E+        +  G GV
Sbjct: 122 PGWTKPIVVGRHAFGDQYRATDFKFPGKGKLTIKFVGEDGTVIEKE-----VFNAPGAGV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ M+N DESIR FAR+   + L RK P+YLSTKNTILK YDGR++DIF+E+YE +++++
Sbjct: 177 AMAMYNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVYETEFKDQ 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F  A + YEHRLIDDMVA ALK SGG++WACKNYDGDVQSD +AQG+GSLGLM+SVLLTP
Sbjct: 237 FKEAGITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ AEAAHGTVTRH+R HQ+G+ETSTNS+ASI AW RGLAHRA LD   ++A FA  
Sbjct: 297 DGKTVEAEAAHGTVTRHYRQHQKGQETSTNSIASIFAWTRGLAHRAKLDDNAELARFAST 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           LE+ C++T+  G MTKDL++ + G +Q      +L+T  F+D + Q L   M
Sbjct: 357 LEKVCVDTVESGFMTKDLALLI-GPDQ-----PWLSTTAFLDKIDQNLQKAM 402

emb|CAB66637.1| hypothetical protein [Homo sapiens]
(414 aa)

Score: 521 bits (1342), Expect: 2.01075e-146
Length: 406, Idn/Pos/Gap = 240/308/4 (59%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLI+PY+ LD+  +DLG+  RDAT+D VT +AA A+++H+ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVEPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+    + G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW RGLAHRA LD   ++A FA ALE   IET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L + + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKIKLAQ 411

ref|XP_421965.1| PREDICTED: similar to cytosolic NADP-dependent isocitrate dehydrogenase [Gallus gallus]
(480 aa)

Score: 521 bits (1341), Expect: 2.31718e-146
Length: 400, Idn/Pos/Gap = 243/304/4 (60%/76%/1%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  RVIW LIK KLI PY++LD+  +DLG+  RDAT+D VT+EAA A++++H 
Sbjct:  75 VVEMQGDEMTRVIWELIKEKLIFPYVDLDLHSYDLGIEHRDATNDKVTVEAAEAIKKYHV 134

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            +K ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PIV
Sbjct: 135 GIKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIV 194

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+      G +     VH F S    GGVA+GM+N D
Sbjct: 195 IGRHAYGDQYRATDFVVPGPGKVEMTYTPGDGGKPVTYLVHNFESC---GGVAMGMYNLD 251

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI++FA S F+ AL +  P+Y+STKNTILK YDGR++DIFQE+Y+R+Y+ +F    +WY
Sbjct: 252 QSIKDFAHSSFQMALSKGWPLYMSTKNTILKRYDGRFKDIFQEIYDREYKSQFEAKKIWY 311

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQALKS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 312 EHRLIDDMVAQALKSEGGFVWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAE 371

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R+HQ+G+ETSTN +ASI AW RGLAHRA LD    +  FA ALE  CIET
Sbjct: 372 AAHGTVTRHYRMHQKGQETSTNPIASIFAWTRGLAHRAKLDNNTSLKTFATALEEVCIET 431

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           I  G MTKDL+  + G    + R +YLNT EF+D +   L
Sbjct: 432 IESGFMTKDLAACIKGLPNVT-RSDYLNTFEFMDKLAANL 470

ref|NP_101923.1| NADP-dependent isocitrate dehydrogenase [Mesorhizobium loti MAFF303099]
dbj|BAB47709.1| NADP-dependent isocitrate dehydrogenase [Mesorhizobium loti MAFF303099]
(403 aa)

Score: 521 bits (1341), Expect: 2.3366e-146
Length: 412, Idn/Pos/Gap = 239/311/11 (58%/75%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+VELDGDE  R+IW  IK+KLI PYL+L + Y+DLG+  RDAT+D VT+++A
Sbjct:   2 AKIKVANPVVELDGDEMTRIIWQFIKDKLIHPYLDLKLEYYDLGIEHRDATNDQVTIDSA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A++++   VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GT+FREPI+++N+PRLV
Sbjct:  62 NAIKKYGVGVKCATITPDEQRVEEFKLKKMWKSPNGTIRNILGGTIFREPIIMKNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PI++ RH FGDQY+A D R P   ++ ++ +   G  +E    H    +  G GV
Sbjct: 122 PGWTKPIIVGRHAFGDQYRATDFRFPGKGKLTIKFVGEDGKVIE----HDVFDAP-GAGV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ M+N DESIR FAR+   + L R  P+YLSTKNTILK YDGR++DIFQE+YE ++   
Sbjct: 177 AMAMYNLDESIREFARASLNYGLLRNYPVYLSTKNTILKAYDGRFKDIFQEVYEAEFEAD 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    LWYEHRLIDDMVA +LK SGG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+TP
Sbjct: 237 FKSKKLWYEHRLIDDMVASSLKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ AEAAHGTVTRH+R HQ+G+ETSTNS+ASI AW RGLAHRA LD   ++  FAE 
Sbjct: 297 DGKTVEAEAAHGTVTRHYRQHQKGEETSTNSIASIFAWTRGLAHRAKLDDNAELKRFAET 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           LE+ CI+T+  G MTKDLS+ + G +Q      +L+T  F+D + + L   M
Sbjct: 357 LEKVCIQTVESGFMTKDLSLLI-GPDQ-----PWLSTTGFLDKIDENLQKAM 402

ref|NP_113698.1| isocitrate dehydrogenase 1 (NADP+), soluble [Rattus norvegicus]
pir||A54756 isocitrate dehydrogenase (NADP) (EC 1.1.1.42), cytosolic - rat
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
gb|AAA59356.1| cytosolic NADP-dependent isocitrate dehydrogenase
(414 aa)

Score: 521 bits (1341), Expect: 2.3366e-146
Length: 406, Idn/Pos/Gap = 240/308/4 (59%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLILPY+ LD+  +DLG+  RDAT+D VT +AA A+++++ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+      G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPKDGSQKVTYLVHDFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFEAQKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW+RGLAHRA LD   +++ FA ALE  CIET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALEEVCIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L   + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKAKLAQ 411

prf||2211361A isocitrate dehydrogenase
(523 aa)

Score: 521 bits (1341), Expect: 2.45655e-146
Length: 411, Idn/Pos/Gap = 239/309/5 (58%/75%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFDLGLP RD T+D VT++
Sbjct: 112 AEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTID 171

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREP + +NIPR
Sbjct: 172 SALAAQKYSMAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPSICKNIPR 231

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH  GDQYKA D  V  A   +L      G   +  +V+ F     GG
Sbjct: 232 LVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKNGSSAKEWEVYNFP----GG 287

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++++++K P+YLSTKNTILK YDGR++DIFQE++++ Y+
Sbjct: 288 GVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYK 347

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F R  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+A  +GSLGLM+SVL+
Sbjct: 348 TDFDRNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILASRFGSLGLMTSVLV 407

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TST  +ASI AW RGL HR  LDG  D+  FA
Sbjct: 408 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTKGIASIFAWTRGLEHRGKLDGNQDLIRFA 467

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           +  E+ C++T+ +G MTKDL+  ++G       E++LNT +F+D ++  LD
Sbjct: 468 QTREKVCVQTV-EGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 517

gb|AAC52473.1| isocitrate dehydrogenase
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) (ICD-M)
(523 aa)

Score: 520 bits (1340), Expect: 2.78407e-146
Length: 411, Idn/Pos/Gap = 239/309/5 (58%/75%/1%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           A  +I+V  P+VE+DGDE  R+IW  IK KLILP++++ + YFDLGLP RD T+D VT++
Sbjct: 112 AEKRIKVEKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTID 171

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A Q++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREP + +NIPR
Sbjct: 172 SALAAQKYSMAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPSICKNIPR 231

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH  GDQYKA D  V  A   +L      G   +  +V+ F     GG
Sbjct: 232 LVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKLVFTPKNGSSAKEWEVYNFP----GG 287

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GV +GM+NTDESI  FA SCF++++++K P+YLSTKNTILK YDGR++DIFQE++++ Y+
Sbjct: 288 GVGMGMYNTDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYK 347

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F R  +WYEHRLIDDMVAQ LKSSGGF+WACKNYDGDVQSDI+A  +GSLGLM+SVL+
Sbjct: 348 TDFDRNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILASRFGSLGLMTSVLV 407

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDGKT+ AEAAHGTVTRH+R HQ+G+ TST  +ASI AW RGL HR  LDG  D+  FA
Sbjct: 408 CPDGKTIEAEAAHGTVTRHYREHQKGRPTSTKGIASIFAWTRGLEHRGKLDGNQDLIRFA 467

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           +  E+ C++T+ +G MTKDL+  ++G       E++LNT +F+D ++  LD
Sbjct: 468 QTREKVCVQTV-EGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLD 517

emb|CAG38738.1| IDH1 [Homo sapiens]
(414 aa)

Score: 520 bits (1340), Expect: 2.85464e-146
Length: 406, Idn/Pos/Gap = 240/307/4 (59%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLI PY+ LD+  +DLG+  RDAT+D VT +AA A+++H+ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+    + G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEMTYTPSDGTQKVTYLVHNFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW RGLAHRA LD   ++A FA ALE   IET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L + + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKIKLAQ 411

gb|AAH12846.1| IDH1 protein [Homo sapiens]
gb|AAX93221.1| unknown [Homo sapiens]
gb|AAD29284.1| NADP+-dependent isocitrate dehydrogenase [Homo sapiens]
sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
emb|CAG46496.1| IDH1 [Homo sapiens]
pdb|1T0L|D Chain D, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent Isocitrate Dehydrogenase In Complex With Nadp, Isocitrate, And Calcium(2+)
pdb|1T0L|C Chain C, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent Isocitrate Dehydrogenase In Complex With Nadp, Isocitrate, And Calcium(2+)
pdb|1T0L|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent Isocitrate Dehydrogenase In Complex With Nadp, Isocitrate, And Calcium(2+)
pdb|1T0L|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent Isocitrate Dehydrogenase In Complex With Nadp, Isocitrate, And Calcium(2+)
pdb|1T09|B Chain B, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent Isocitrate Dehydrogenase In Complex Nadp
pdb|1T09|A Chain A, Crystal Structure Of Human Cytosolic Nadp(+)-Dependent Isocitrate Dehydrogenase In Complex Nadp
ref|NP_005887.2| isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
(414 aa)

Score: 520 bits (1340), Expect: 3.28968e-146
Length: 406, Idn/Pos/Gap = 240/307/4 (59%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLI PY+ LD+  +DLG+  RDAT+D VT +AA A+++H+ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+    + G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW RGLAHRA LD   ++A FA ALE   IET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L + + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKIKLAQ 411

ref|XP_323176.1| hypothetical protein [Neurospora crassa]
gb|EAA26614.1| hypothetical protein [Neurospora crassa]
(462 aa)

Score: 520 bits (1338), Expect: 4.82882e-146
Length: 411, Idn/Pos/Gap = 242/316/9 (58%/76%/2%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI+V+NP+VELDGDE  R+IW  IK K I P+L++D+ Y+DLGL  RD T+D VT++
Sbjct:  52 AFQKIKVKNPVVELDGDEMTRIIWQDIKEKFIYPFLDIDLKYYDLGLEYRDQTNDQVTID 111

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           AA A++++   VK ATITPDE+RVEEF LK+M+ SPNGT+RN L GTVFREPI++  +PR
Sbjct: 112 AAEAIKKYSVGVKCATITPDESRVEEFKLKQMWLSPNGTIRNALGGTVFREPIVIPRVPR 171

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGWK+PI+I RH FGDQY+A+DL  P   ++++ V   +G E    QV       +GG
Sbjct: 172 LVPGWKKPIIIGRHAFGDQYRAKDLVAPGPGKLQM-VYTPEGGE---PQVIDVFDYKNGG 227

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVA   +NTDESI  FA + F+ AL + LP+Y+STKNTILK YDGR++DIFQ++Y+  Y+
Sbjct: 228 GVAQTQYNTDESIEGFAHASFKLALDKGLPLYMSTKNTILKKYDGRFKDIFQQIYDTQYK 287

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
           E F    +WYEHRLIDDMVAQ +KSSGG++ A KNYDGDVQSDI+AQG+GSLGLM+SVL+
Sbjct: 288 EAFEAKKIWYEHRLIDDMVAQMIKSSGGYIMALKNYDGDVQSDIVAQGFGSLGLMTSVLI 347

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
           TPDGKT  +EAAHGTVTRH+R HQ+G +TSTN +ASI AW RGL  R  LD TP++  FA
Sbjct: 348 TPDGKTFESEAAHGTVTRHYREHQKGNQTSTNPIASIFAWTRGLVQRGKLDNTPELIAFA 407

Query: 427 EALERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           EALE++CI+T+ +DG MTKDL++A   T     RE+++ T E++ AV++RL
Sbjct: 408 EALEKACIDTVDIDGIMTKDLALACGKT----GREDWVTTSEYMAAVERRL 454

ref|NP_705343.1| isocitrate dehydrogenase (NADP), mitochondrial precursor [Plasmodium falciparum 3D7]
emb|CAD52580.1| isocitrate dehydrogenase (NADP), mitochondrial precursor [Plasmodium falciparum 3D7]
(468 aa)

Score: 520 bits (1338), Expect: 5.8504e-146
Length: 421, Idn/Pos/Gap = 237/317/5 (56%/75%/1%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI V NPIVELDGDE  R+IW  IK KLILPY+NL I YFDL +  RD T+D VT+EAA 
Sbjct:  32 KINVENPIVELDGDEMTRIIWKDIKEKLILPYVNLKIKYFDLSIENRDKTNDQVTIEAAE  91

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
            +++    +K ATITPD ARV+EF+LK M+ SPNGT+RN+L+GTVFR PIL++NIP+LVP
Sbjct:  92 EIKKTSVGIKCATITPDAARVKEFNLKEMWKSPNGTIRNILDGTVFRTPILIKNIPKLVP 151

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            WK+PIVI RH + DQYK + L++  + + E+        ++ R  V  F S     GV 
Sbjct: 152 NWKKPIVIGRHAYADQYKQKSLKIEKSGKFEIVFTPDDNSQVLRETVFHFKSP----GVC 207

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           LGM+NT+ESIRNFA SCF++AL  K+P+Y+STK+TILK+YDG ++DIF E+YE+ +++ F
Sbjct: 208 LGMYNTEESIRNFALSCFQYALDLKMPVYMSTKSTILKIYDGLFKDIFDEIYEKQFKKSF 267

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
            +  LWYEH+LIDDMVAQ LKS GGFLWACKNYDGD+QSD +AQGYGSLGLMSSVLL PD
Sbjct: 268 EQHNLWYEHKLIDDMVAQVLKSEGGFLWACKNYDGDIQSDAVAQGYGSLGLMSSVLLCPD 327

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           G T ++EAAHGTVTRH+R +Q+G++TSTN +ASI AW +GL HRA LD   ++  F  AL
Sbjct: 328 GVTCVSEAAHGTVTRHYRAYQKGEKTSTNPIASIFAWTKGLEHRAKLDKNDNLKQFCYAL 387

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQEHAAAPQ 489
           E++CIET+ DG M+KDL+  + G +  ++++ Y+ T++ I+A+ ++L + +LQ  +    
Sbjct: 388 EKACIETVEDGLMSKDLAGCIKGIKNVTEKD-YIFTQDLINAINEKLKLKILQNQSKNDP 446

Query: 490 Q 490
           Q
Sbjct: 447 Q 447

gb|AAH93020.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens]
(414 aa)

Score: 519 bits (1337), Expect: 7.45197e-146
Length: 406, Idn/Pos/Gap = 239/307/4 (58%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLI PY+ LD+  +DLG+  RDAT+D VT +AA A+++H+ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+    + G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           +AHGTVTRH+R++Q+G+ETSTN +ASI AW RGLAHRA LD   ++A FA ALE   IET
Sbjct: 307 SAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L + + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKIKLAQ 411

ref|ZP_00304182.1| COG0538: Isocitrate dehydrogenases [Novosphingobium aromaticivorans DSM 12444]
(407 aa)

Score: 519 bits (1337), Expect: 7.64085e-146
Length: 413, Idn/Pos/Gap = 238/315/12 (57%/76%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V+NP+VE+DGDE  R+IW  I+ +LILPYL++D+ Y+DL +  RD T+D +T+++A
Sbjct:   2 AKIKVKNPVVEIDGDEMTRIIWEWIRERLILPYLDIDLKYYDLSVQKRDETNDQITIDSA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A++Q+   VK ATITPDEARVEEF+LK M+ SPNGT+RN+L G VFREPI+++N+PRLV
Sbjct:  62 NAIKQYGVGVKCATITPDEARVEEFNLKSMWKSPNGTIRNILGGVVFREPIVIQNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW  PIV+ RH FGDQY+A D  VP   ++ L V +    E   R+V  + S    GGV
Sbjct: 122 PGWTDPIVVGRHAFGDQYRATDFVVPGPGKLRL-VWEGDNGETIDREVFNYPS----GGV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERD-YRE 307
           A+ M+N D+SIR+FAR+ F + L    P+YLSTKNTILK YDGR++D+FQE+++ + ++E
Sbjct: 177 AMAMYNLDDSIRDFARASFNYGLGLGWPVYLSTKNTILKAYDGRFKDLFQEVFDTEGFKE 236

Query: 308 RFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLT 367
           +F  A + YEHRLIDDMVA ALK SG F+WACKNYDGDVQSD +AQG+GSLGLM+SVL+T
Sbjct: 237 KFAAAGIVYEHRLIDDMVASALKWSGKFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMT 296

Query: 368 PDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAE 427
           PDGKT+ AEAAHGTVTRH+R HQQGK+TSTN +ASI AW RGL +R   D TP+V  FAE
Sbjct: 297 PDGKTVEAEAAHGTVTRHYRQHQQGKQTSTNPIASIFAWTRGLIYRGKFDETPEVVKFAE 356

Query: 428 ALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
            LER CIET+  GKMTKDL++ + G +Q      ++ TE+F +A+ + L+  M
Sbjct: 357 TLERVCIETVESGKMTKDLALLI-GPDQA-----WMTTEKFFEAIVENLETEM 403

gb|AAS45361.1| similar to Rattus norvegicus (Rat). Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) [Dictyostelium discoideum]
gb|EAL71256.1| isocitrate dehydrogenase (NADP+) [Dictyostelium discoideum]
(412 aa)

Score: 519 bits (1336), Expect: 9.89634e-146
Length: 407, Idn/Pos/Gap = 245/306/5 (60%/75%/1%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI V NP+  L GDEQ RVIW LI+ KLI P+L+L +  +DLG+  RD T+D VT++AA 
Sbjct:   4 KIIVSNPVANLLGDEQTRVIWDLIEKKLIFPFLDLKVETYDLGIEYRDKTNDQVTIDAAN  63

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A+++    +K ATITPDEARV EF LK M+ SPNGT+RN L GT+FREPI+ +N+PRLV 
Sbjct:  64 AIKRLKVGIKCATITPDEARVTEFGLKEMWKSPNGTIRNTLGGTLFREPIVCKNVPRLVT 123

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            W + IVI RH FGDQY+A D  V  A ++EL    A G   ++ QV  F S    GGVA
Sbjct: 124 CWNKSIVIGRHAFGDQYRATDFVVKGAGKLELTYTPADGSAPQKFQVFDFPSD---GGVA 180

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           LGM+NTD SI+ FA +CF F+L +K P+YLSTKNTILK YDGR++DIFQE+YER+Y+ +F
Sbjct: 181 LGMYNTDASIKEFAYACFNFSLDKKWPLYLSTKNTILKRYDGRFKDIFQEIYEREYKVKF 240

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
             A +WYEHRLIDDMVA A+KS GGF+WACKNYDGDVQSD +AQGYGSLGLM+SVLL+ D
Sbjct: 241 DTAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDAVAQGYGSLGLMTSVLLSAD 300

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
             +L+AEA+HGTVTRHFR HQ+G+ETSTNS+ASI AW RGL +RA LD    +  F  AL
Sbjct: 301 --SLVAEASHGTVTRHFREHQKGRETSTNSIASIFAWTRGLEYRAKLDNNDKLLKFCHAL 358

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E SCI+ +  G MTKDL+I V G+ +  KR +YLNTEE+I+ V + L
Sbjct: 359 EASCIDAVESGFMTKDLAICVKGSVENVKRTDYLNTEEYINKVAELL 405

gb|AAT44354.1| isocitrate dehydrogenase [Crassostrea gigas]
(449 aa)

Score: 519 bits (1336), Expect: 1.04044e-145
Length: 405, Idn/Pos/Gap = 238/310/5 (58%/76%/1%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           +I+V NP+VE+DGDE  R+IW  IK  LILPY+++D+ Y+DLGLP RD TDD VT++AA 
Sbjct:  45 RIKVANPVVEMDGDEMTRIIWEKIKETLILPYVDVDLKYYDLGLPYRDQTDDQVTIDAAP 104

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A ++++ AVK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFREPI+ + +PRLVP
Sbjct: 105 ATKKYNVAVKCATITPDEERVEEFKLKKMWLSPNGTIRNILGGTVFREPIICQKVPRLVP 164

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW +PIVI RH  GDQYKA D+ +P   ++EL +   +G+  + R         D   V 
Sbjct: 165 GWTRPIVIGRHAHGDQYKATDMVIPGNGKLEL-IYTPEGVRSKERPCSTSKMVVD---VP 220

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
               NTDESI  FA +CF++A+ +K P+Y+STKNTILK YDGR++DIF+E+Y++ Y+ +F
Sbjct: 221 WPCHNTDESITAFAHTCFQYAIMKKWPLYMSTKNTILKRYDGRFKDIFEEVYQQGYKAKF 280

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               +WYEHRLIDDMVAQALKS GGF+WACKNYDGDVQSD++AQGYGSLGLM+SVL  PD
Sbjct: 281 DELKIWYEHRLIDDMVAQALKSDGGFVWACKNYDGDVQSDVVAQGYGSLGLMTSVLXCPD 340

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GKT+ +EAAHGTVTRH+R HQ+G  TSTN VASI AW RGL HR  LDG  D+  F++ L
Sbjct: 341 GKTVESEAAHGTVTRHYREHQKGNPTSTNPVASIYAWTRGLEHRGKLDGNNDLITFSQKL 400

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQ 474
           E++C++TI  GKMTKDL+  +YG  +  K E+YLNT +F+ A+++
Sbjct: 401 EKACVDTIDSGKMTKDLAGCIYGL-KNVKPEHYLNTMDFLQAIRE 444

emb|CAD97653.1| hypothetical protein [Homo sapiens]
(414 aa)

Score: 518 bits (1335), Expect: 1.17916e-145
Length: 406, Idn/Pos/Gap = 240/307/4 (59%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLI PY+ LD+  +DLG+  RDAT+D VT +AA A+++H+ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+    + G +     VH   +S  GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVH---NSEGGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW RGLAHRA LD   ++A FA ALE   IET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L + + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKIKLAQ 411

emb|CAG38553.1| IDH1 [Homo sapiens]
(414 aa)

Score: 518 bits (1334), Expect: 1.59229e-145
Length: 406, Idn/Pos/Gap = 239/307/4 (58%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLI+PY+ LD+  +DLG+  RDAT+D VT +AA A+++H+ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLIIPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVEPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+    + G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW RGLAHRA LD   ++A FA ALE   IET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTK L+  + G     +R +YLNT EF+D + + L + + Q
Sbjct: 367 IEAGFMTKGLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKIKLAQ 411

ref|NP_001009276.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
gb|AAP41947.1| cytosolic NADP-isocitrate dehydrogenase [Ovis aries]
(414 aa)

Score: 518 bits (1333), Expect: 2.15017e-145
Length: 406, Idn/Pos/Gap = 239/308/4 (58%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLI PY++LD+  +DL +  RDAT+D VT +AA A+++++ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLIFPYVDLDLHSYDLSIENRDATNDQVTKDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+    + G       VH F   T+ GGVA+GMFN D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEICYTPSDGSPKTVYLVHNF---TESGGVAMGMFNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQNIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW RGLAHRA LD   +++ FA+ALE  CIET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L + + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLQLKLAQ 411

gb|AAD34457.1| cytosolic NADP+-dependent isocitrate dehydrogenase [Bos taurus]
ref|NP_851355.1| isocitrate dehydrogenase 1 (NADP+), soluble [Bos taurus]
(414 aa)

Score: 516 bits (1329), Expect: 6.1014e-145
Length: 406, Idn/Pos/Gap = 238/306/4 (58%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLI PY+ LD+  +DLG+  RDAT+D VT +AA A+++++ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+    + G       VH F   T+ GGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEISYTPSDGSPKTVYLVHNF---TESGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+  F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKNWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSEFEAQNIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ET TN +ASI AW RGLAHRA LD   +++ FA+ALE  CIET
Sbjct: 307 AAHGTVTRHYRMYQKGQETLTNPIASIFAWTRGLAHRAKLDNNKELSFFAKALEEVCIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L + + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLQLKLAQ 411

ref|NP_772387.1| isocitrate dehydrogenase [NADP] [Bradyrhizobium japonicum USDA 110]
dbj|BAC51012.1| isocitrate dehydrogenase [NADP] [Bradyrhizobium japonicum USDA 110]
(404 aa)

Score: 516 bits (1328), Expect: 8.23911e-145
Length: 412, Idn/Pos/Gap = 236/312/11 (57%/75%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+VELDGDE  R+IW  IK+KLI P+L+++++YFDLG+  RD T+D VT++AA
Sbjct:   2 AKIKVSNPVVELDGDEMTRIIWQYIKDKLITPFLDVELMYFDLGMEYRDHTNDQVTIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A+++    VK ATITPDEARV+EF+LK+M+ SPNGT+RN+L G +FREPI+ +N+PRLV
Sbjct:  62 EAIKKVGVGVKCATITPDEARVKEFNLKQMWKSPNGTIRNILGGVIFREPIICKNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PI+I RH +GDQY+A D + P    + ++ +   G  +E+           G GV
Sbjct: 122 PGWTKPIIIGRHAYGDQYRATDFKFPGKGTLSMKFVGEDGTVIEKE-----VFKAPGAGV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ M+N D+SI +FAR+   + L R  P+YLSTKNTILKVYDGR++DIFQ++Y+R++++ 
Sbjct: 177 AMEMYNLDDSIIDFARASLNYGLLRNYPVYLSTKNTILKVYDGRFKDIFQDIYDREFKKE 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    L YEHRLIDDMVA ALK SGG++WACKNYDGDVQSD +AQGYGSLGLM+SVLLTP
Sbjct: 237 FEAKGLTYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLLTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT+ AEAAHGTVTRH+R HQ+GKETSTNS+ASI AW RGLAHRA LD   ++A FA  
Sbjct: 297 DGKTVEAEAAHGTVTRHYREHQKGKETSTNSIASIFAWTRGLAHRAKLDNNAELAKFANT 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           LE+ C++T+  G MTKDL++ V G +Q      +L+T  F+D V + L   M
Sbjct: 357 LEKVCVDTVEAGYMTKDLALLV-GADQ-----RWLSTTGFLDKVAENLTKAM 402

dbj|BAC39792.1| unnamed protein product [Mus musculus]
(422 aa)

Score: 516 bits (1328), Expect: 8.30815e-145
Length: 406, Idn/Pos/Gap = 239/308/4 (58%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLILPY+ LD+  +DLG+  RDAT+D VT +AA A+++++ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+      G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    + Y
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQKICY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW+RGLAHRA LD   +++ FA+ALE  CIET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L   + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKAKLAQ 411

gb|AAD02919.1| NADP-dependent isocitrate dehydrogenase [Mus musculus]
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
(414 aa)

Score: 515 bits (1327), Expect: 1.04946e-144
Length: 406, Idn/Pos/Gap = 239/308/4 (58%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLILPY+ LD+  +DLG+  RDAT+D VT +AA A+++++ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+      G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    + Y
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQNICY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW+RGLAHRA LD   +++ FA+ALE  CIET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L   + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKAKLAQ 411

ref|NP_034627.2| isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus]
gb|AAH88986.1| Isocitrate dehydrogenase 1 (NADP+), soluble [Mus musculus]
(414 aa)

Score: 515 bits (1326), Expect: 1.38212e-144
Length: 406, Idn/Pos/Gap = 239/308/4 (58%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLILPY+ LD+  +DLG+  RDAT+D VT +AA A+++++ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEALKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+      G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    + Y
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQKICY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW+RGLAHRA LD   +++ FA+ALE  CIET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L   + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKAKLAQ 411

emb|CAB11294.1| SPAC6G10.08 [Schizosaccharomyces pombe]
ref|NP_594105.1| isocitrate dehydrogenase [nadp] [Schizosaccharomyces pombe]
sp|O14254|IDHP_SCHPO Probable isocitrate dehydrogenase [NADP], mitochondrial precursor (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
pir||T39058 probable isocitrate dehydrogenase (NADP) (EC 1.1.1.42) - fission yeast (Schizosaccharomyces pombe)
(418 aa)

Score: 514 bits (1325), Expect: 1.54047e-144
Length: 422, Idn/Pos/Gap = 234/316/13 (55%/74%/3%)

Query:  62 MSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDD 121
           M++  +F KI V+NP+VE+DGDE  RVIW +I+ KL+LPY+++ + Y+DLG+  RD T+D
Sbjct:   5 MASSKSFQKITVKNPVVEMDGDEMTRVIWKIIREKLVLPYMDIKLDYYDLGIEARDKTND  64

Query: 122 GVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILV 181
            +T++AA+A+ ++   +K ATITPDEARV+E++LK+M+ SPNGT+RN+LNGTVFREPIL+
Sbjct:  65 QITVDAAKAILKNDVGIKCATITPDEARVKEYNLKKMWKSPNGTIRNILNGTVFREPILI 124

Query: 182 ENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVL-DAQGMELERRQVHQFA 240
           +NIP+ +PGW  PI I RH FGDQYK+ DL      ++EL           E   V++F 
Sbjct: 125 KNIPKYIPGWTNPICIGRHAFGDQYKSTDLVASGPGKLELSFTPKGNPSAKETYNVYEF- 183

Query: 241 SSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQEL 300
              +G GVA+ M+NTD+SIR FA S F+ AL++K+P+YLSTKNTILK YDGR++D FQE+
Sbjct: 184 ---NGSGVAMSMYNTDDSIRGFAHSSFQMALQKKMPLYLSTKNTILKKYDGRFKDTFQEV 240

Query: 301 YERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGL 360
           YE DY+++F    LWY+HRLIDDMVAQA+KS+GGF+WACKNYDGDV SD++AQ YGSLGL
Sbjct: 241 YESDYKQKFEELGLWYQHRLIDDMVAQAIKSNGGFVWACKNYDGDVMSDVVAQAYGSLGL 300

Query: 361 MSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTP 420
           M+SVL+ P+G+T  +EAAHGTV RH+  + +GK+TSTNS+ASI AW RGLAHR  LDG  
Sbjct: 301 MTSVLIHPNGRTFESEAAHGTVQRHYMQYLKGKKTSTNSIASIFAWTRGLAHRGRLDGNE 360

Query: 421 DVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKREN-YLNTEEFIDAVQQRLDVH 479
            +  FA ALE +C+  +  G MTKDL +        SK  N Y++T EF+DAV+  LD  
Sbjct: 361 RLVKFANALEHACVRCVEKGIMTKDLYLL-------SKSPNGYVDTFEFLDAVKSELDSE 413

Query: 480 ML 481
           ++
Sbjct: 414 LV 415

ref|NP_354851.1| hypothetical protein AGR_C_3429 [Agrobacterium tumefaciens str. C58]
ref|NP_532550.1| isocitrate dehydrogenase [NADP] [Agrobacterium tumefaciens str. C58]
gb|AAL42866.1| isocitrate dehydrogenase [NADP] [Agrobacterium tumefaciens str. C58]
gb|AAK87636.1| AGR_C_3429p [Agrobacterium tumefaciens str. C58]
pir||C97585 NADp-dependent isocitrate dehydrogenase (AF268076) [imported] - Agrobacterium tumefaciens (strain C58, Cereon)
pir||AD2806 isocitrate dehydrogenase [NADP] icdA [imported] - Agrobacterium tumefaciens (strain C58, Dupont)
(455 aa)

Score: 514 bits (1325), Expect: 1.61956e-144
Length: 412, Idn/Pos/Gap = 236/310/11 (57%/75%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+V+LDGDE  R+IW LIK+KLILPYL+LDI Y+DL +  RDAT+D VT++AA
Sbjct:  53 AKIKVANPVVDLDGDEMTRIIWQLIKDKLILPYLDLDIEYYDLSVENRDATNDQVTVDAA 112

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A+++H   +K ATITPDE RVEEF LK+M+ SPNGT+RN+L G +FREPI+ +N+PRLV
Sbjct: 113 HAIKKHGVGIKCATITPDEQRVEEFGLKQMWKSPNGTIRNILGGVIFREPIICKNVPRLV 172

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PIV+ RH FGDQYKA D + P   ++ ++ +   G  +E+             GV
Sbjct: 173 PGWTKPIVVGRHAFGDQYKATDFKFPGKGKLTIKFVGEDGTVIEKD-----VFDAPSAGV 227

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           AL M+N DESIR FAR+   + L RK P+YLSTKNTILK YDGR++DIF+E+Y+ +++ +
Sbjct: 228 ALAMYNLDESIREFARASMMYGLMRKWPVYLSTKNTILKAYDGRFKDIFEEVYQTEFKAK 287

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    + YEHRLIDDMVA ALK SGG++WACKNYDGDVQSD +AQG+GSLGLM+SVLL+P
Sbjct: 288 FDEVGITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLSP 347

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DG+T+ AEAAHGTVTRH+R HQ+G+ETSTNS+ASI AW RGLAHRA LD   ++A FA  
Sbjct: 348 DGRTVEAEAAHGTVTRHYRQHQKGQETSTNSIASIFAWTRGLAHRAKLDDNAELAKFATT 407

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           LE  C++T+  G MTKDL++ + G +Q      +L+T  F+D + + L   M
Sbjct: 408 LETVCVDTVESGFMTKDLALLI-GPDQ-----PWLSTTAFLDKIDENLKTAM 453

ref|ZP_00007720.1| COG0538: Isocitrate dehydrogenases [Rhodobacter sphaeroides 2.4.1]
(404 aa)

Score: 514 bits (1325), Expect: 1.64681e-144
Length: 409, Idn/Pos/Gap = 239/305/11 (58%/74%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           SKI+V NP+VELDGDE  R+IW  IK KLILPYL++D+ Y+DLG+  RD T+D +T++AA
Sbjct:   2 SKIKVANPVVELDGDEMTRIIWDFIKQKLILPYLDIDLHYYDLGIEERDRTEDKITVDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A++QH   VK ATITPDEARVEEF LK M+ SPNGT+RN+L G +FR+PI+  N+PRLV
Sbjct:  62 HAIKQHGVGVKCATITPDEARVEEFGLKSMWKSPNGTIRNILGGVIFRQPIICRNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PIV+ RH FGDQY+A D R P   ++ L+ +   G  +ER           G GV
Sbjct: 122 PGWTKPIVVGRHAFGDQYRATDFRFPGKGKLTLKFVGEDGAVIERE-----VFDAPGSGV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
            + M+N D+SI +FAR+   + L    P+YLSTKNTILK YDGR++D+FQ++YE ++ E+
Sbjct: 177 TMAMYNLDQSIIDFARASMNYGLNLGWPVYLSTKNTILKAYDGRFKDLFQQVYEEEFAEK 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F  A + YEHRLIDDMVA ALK SGG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+TP
Sbjct: 237 FKAAGITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DG+T+ AEAAHGTVTRHFR HQ GKETSTNS+ASI AW  GL HRA LDG  D+A FAE 
Sbjct: 297 DGQTVEAEAAHGTVTRHFRQHQAGKETSTNSIASIYAWTGGLKHRAKLDGNADLARFAET 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           LER  ++T+ DG MTKDL++ V G +Q      +L T  +++ V + LD
Sbjct: 357 LERVTVQTVEDGFMTKDLALLV-GPDQ-----KWLTTIGYLEKVDEYLD 399

gb|EAA17070.1| isocitrate dehydrogenase, NADP-dependent [Plasmodium yoelii yoelii]
(469 aa)

Score: 514 bits (1324), Expect: 2.28016e-144
Length: 430, Idn/Pos/Gap = 234/321/5 (54%/74%/1%)

Query:  52 RTTGRSLCANMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDL 111
           R T R +    S      K++V NPIVELDGDE  +VIW  IK KLILPYL+L+I YFDL
Sbjct:  15 RITKRYVSNGQSAFNLSGKVKVENPIVELDGDEMTKVIWKDIKEKLILPYLDLNIKYFDL  74

Query: 112 GLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLN 171
            +  RD T+D +TL+AA+ ++++   +K ATITPD ARV+EF+LK M+ SPNGT+RN+L+
Sbjct:  75 SIENRDKTNDQITLDAAQEIKKYSVGIKCATITPDSARVKEFNLKEMWKSPNGTIRNILD 134

Query: 172 GTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMEL 231
           GTVFR PIL++NIP+L+  WK+PIVI RH + DQYK + L+V  + + E+         +
Sbjct: 135 GTVFRAPILIKNIPKLISNWKKPIVIGRHAYADQYKQKSLKVTKSGKFEIVFTPDDNSPV 194

Query: 232 ERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDG 291
            R  +  F S     GV LGM+NT+ESI+NFA SCF++AL  K+P+Y STK+TILK+YDG
Sbjct: 195 VRETIFNFKSP----GVCLGMYNTEESIKNFALSCFQYALDLKMPVYFSTKSTILKIYDG 250

Query: 292 RWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDII 351
            ++DIFQ++YE+ +++ F +  LWYEH+LIDDMVAQ LKS GGF+WACKNYDGD+QSD +
Sbjct: 251 LFKDIFQDIYEQKFKKIFEQNNLWYEHKLIDDMVAQVLKSEGGFVWACKNYDGDIQSDAV 310

Query: 352 AQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLA 411
           AQGYGSLGLMSS+L+ PDG T ++EAAHGTVT+H+R +Q+G++TSTN +ASI AW RGL 
Sbjct: 311 AQGYGSLGLMSSILMCPDGVTCISEAAHGTVTKHYRAYQRGEKTSTNPIASIFAWTRGLQ 370

Query: 412 HRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDA 471
           HRA LD   ++  F  ALE++CIET+ +G M KDL+I + G +  ++++ YL T++FIDA
Sbjct: 371 HRAKLDQNKNLQQFCYALEKACIETVENGLMPKDLAICIKGIKNVTEKD-YLCTDDFIDA 429

Query: 472 VQQRLDVHML 481
           + + L + +L
Sbjct: 430 INENLKLKLL 439

dbj|BAA19074.1| NADP-dependent isocitrate dehydrogenase precursor [Aspergillus niger]
sp|P79089|IDHP_ASPNG Isocitrate dehydrogenase [NADP], mitochondrial precursor (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
dbj|BAA19073.1| NADP-dependent isocitrate dehydrogenase precursor [Aspergillus niger]
(498 aa)

Score: 514 bits (1323), Expect: 2.78569e-144
Length: 412, Idn/Pos/Gap = 247/311/10 (59%/75%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V+NP+VELDGDE  R+IW  I+ KLILPYL++D+ Y+DLGL  RD TDD VT+EAA 
Sbjct:  92 KIKVKNPVVELDGDEMTRIIWQEIREKLILPYLDVDLKYYDLGLEYRDQTDDQVTVEAAE 151

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   VK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI++  IPRLVP
Sbjct: 152 AIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILGGTVFREPIIIPAIPRLVP 211

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW +PI+I RH FGDQY+A D  +P   ++EL      G E E  +V+ F     GGG+A
Sbjct: 212 GWNKPIIIGRHAFGDQYRATDRVIPGPGKLELVYTPVNG-EPETVKVYDF----QGGGIA 266

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
              +NTDESIR FA + F+ AL + LP+Y+STKNTILK YDGR++DIFQE+YE  Y++ F
Sbjct: 267 QTQYNTDESIRGFAHASFQMALLKGLPLYMSTKNTILKRYDGRFKDIFQEIYESTYQKDF 326

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               LWYEHRLIDDMVAQ +KS GGF+ A KNYDGDVQSDI+AQG+GSLGLM+S L+TP 
Sbjct: 327 EAKNLWYEHRLIDDMVAQMIKSEGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSTLVTPT 386

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           G+   +EAAHGTVTRH+R HQ+G+ETSTN +ASI AW RGL  R  LD TPDV  FAE L
Sbjct: 387 GEAFESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLIQRGKLDETPDVVTFAEEL 446

Query: 430 ERSCIETILD-GKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           ER+CIE + D G MTKDL++A    E    RE ++ T E++ AV++RL  ++
Sbjct: 447 ERACIEVVNDEGIMTKDLALACGRKE----REAWVTTREYMAAVERRLKANL 494

emb|CAH91635.1| hypothetical protein [Pongo pygmaeus]
(414 aa)

Score: 513 bits (1322), Expect: 4.29895e-144
Length: 406, Idn/Pos/Gap = 236/305/4 (58%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLI PY+ LD+  +DLG+  RDAT+D VT +AA A+++++ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+    + G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++D FQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDTFQEIYDKQYKSQFEARKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN + SI AW RGLAHRA LD   ++A FA ALE   +ET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIVSIFAWTRGLAHRAKLDNNKELAFFANALEEVSVET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           I  G MTKDL+  + G     +R +YLNT EF+D + + L + + Q
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKIKLAQ 411

gb|AAK76731.1| peroxisomal NADP-dependent isocitrate dehydrogenase [Aspergillus nidulans]
(413 aa)

Score: 513 bits (1321), Expect: 5.16514e-144
Length: 412, Idn/Pos/Gap = 241/312/10 (58%/75%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V+NP+VELDGDE  R+IW  I+ KLILP+L++D+ Y+DLGL  RD TDD VT E+A 
Sbjct:   7 KIKVKNPVVELDGDEMTRIIWKEIREKLILPFLDIDLKYYDLGLEYRDQTDDKVTTESAE  66

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   VK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI++  IPRLVP
Sbjct:  67 AIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILGGTVFREPIVIPRIPRLVP 126

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW +PI+I RH FGDQY+A D  +P   ++EL V   +G + E  +V  F     GGGV 
Sbjct: 127 GWTKPIIIGRHAFGDQYRATDRVIPGPGKLEL-VYTPEGGQPEAIKVFDFP----GGGVT 181

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
              +NTDESIR FA + F+ AL + LP+Y+STKNTILK YDGR++DIFQE++E DY++ F
Sbjct: 182 QTQYNTDESIRGFAHASFKLALTKGLPLYMSTKNTILKKYDGRFKDIFQEIFESDYKKEF 241

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               +WYEHRLIDDMVAQ +KS GGF+ A KNYDGDVQSDI+AQG+GSLGLM+S L+TPD
Sbjct: 242 DAKGIWYEHRLIDDMVAQMIKSEGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSTLITPD 301

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           G+   +EAAHGTVTRH+R HQ+G+ETSTN +ASI AW RGL  R  LD TPDV  FAE L
Sbjct: 302 GQAFESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLIQRGKLDETPDVVKFAEEL 361

Query: 430 ERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           ER+CI+ +  +G MTKDL+++    E    R+ ++ T E++ AV++RL  ++
Sbjct: 362 ERACIDVVNEEGIMTKDLALSCGRKE----RDAWVTTREYMAAVERRLRANL 409

gb|EAA11493.2| ENSANGP00000020939 [Anopheles gambiae str. PEST]
ref|XP_316694.2| ENSANGP00000020939 [Anopheles gambiae str. PEST]
(413 aa)

Score: 513 bits (1321), Expect: 5.52168e-144
Length: 414, Idn/Pos/Gap = 237/315/6 (57%/76%/1%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           SKI+   P+V++ GDE  R+IW  IK KLILP+L++++  +DLG+  RDAT+D VT++ A
Sbjct:   3 SKIKA-GPVVDILGDEMTRIIWDSIKEKLILPFLDIELHTYDLGIEHRDATNDQVTIDCA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            AV++++  +K ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +N+PRLV
Sbjct:  62 EAVKRYNVGIKCATITPDEARVEEFKLKQMWRSPNGTIRNILGGTVFREAIICKNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW++PI+I RH  GDQYKA D  VP   ++E++   A G E     V+++ S+    GV
Sbjct: 122 PGWEKPIIIGRHAHGDQYKATDFVVPVPGKLEMKFTPADGSEPTTYVVNEYKSA----GV 177

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+GM+N D+SI +FA S F+ AL RK P+YLSTKNTILK YDGR++DIFQE+Y++DY+++
Sbjct: 178 AMGMYNLDDSICDFAHSSFKVALDRKFPLYLSTKNTILKKYDGRFKDIFQEIYDKDYKKQ 237

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    +WYEHRLIDDMVA  +K+ GGF+WACKNYDGDVQSD +AQG+GSLGLM+SVL+ P
Sbjct: 238 FEALGIWYEHRLIDDMVAYCMKAEGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLVCP 297

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DG+T+ +EAAHGTVTRH+R HQQGKETSTN +ASI AW RGL HRA LD   ++  FAE 
Sbjct: 298 DGRTVESEAAHGTVTRHYRQHQQGKETSTNPIASIFAWTRGLLHRAKLDDNAELKRFAET 357

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           LE+ CI+TI  G MTKDL+I + G     KR +Y+ T EF++ + + L   + Q
Sbjct: 358 LEKVCIDTIESGFMTKDLAICIKGMAN-VKRTDYMETFEFMNKLGENLQAALTQ 410

emb|CAH89719.1| hypothetical protein [Pongo pygmaeus]
(414 aa)

Score: 513 bits (1321), Expect: 5.70908e-144
Length: 404, Idn/Pos/Gap = 236/305/4 (58%/75%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW  IK KLI PY+ LD+  +DLG+  RDAT+D VT +AA A+++++ 
Sbjct:  10 VVEMQGDEMTRIIWEQIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+    + G +     VH F    +GGGVA+GM+N D
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFE---EGGGVAMGMYNQD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SI +FA S F+ AL +  P+YLSTKNTILK YDGR++DIFQE+Y++ Y+ +F    +WY
Sbjct: 187 KSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEARKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AE
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAE 306

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
           AAHGTVTRH+R++Q+G+ETSTN +ASI AW RGLAHRA LD   ++A FA ALE   +ET
Sbjct: 307 AAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSVET 366

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           I  G MTKDL+  + G     +R +YLNT EF+D + + L + +
Sbjct: 367 IEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGENLKIKL 409

ref|YP_062774.1| isocitrate dehydrogenase [Leifsonia xyli subsp. xyli str. CTCB07]
gb|AAT89669.1| isocitrate dehydrogenase [Leifsonia xyli subsp. xyli str. CTCB07]
(404 aa)

Score: 513 bits (1320), Expect: 6.52446e-144
Length: 407, Idn/Pos/Gap = 239/301/10 (58%/73%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V   +VELDGDE  R+IW  IK+ LI PYL++D+ Y+DLG+  RD TDD +T++AA 
Sbjct:   3 KIKVEGTVVELDGDEMTRIIWKAIKDSLIHPYLDIDLEYYDLGIQKRDETDDQITIDAAH  62

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A+Q+H   VK ATITPDEARVEEF LK+M+ SPNGT+RN+L G VFREPI++ NIPRLVP
Sbjct:  63 AIQKHGVGVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGVVFREPIIISNIPRLVP 122

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW +PI+I RH FGDQY+A D        + L    + G E +  +V+Q      G GVA
Sbjct: 123 GWNKPIIIGRHAFGDQYRATDFTFDGPGTLTLSFQPSDGGEAKSVEVYQ----APGAGVA 178

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           L M+N DESIR+FAR+ F + L R+ P+YLSTKNTILK YDGR++D+FQE+++ +Y+E+F
Sbjct: 179 LAMYNQDESIRDFARASFTYGLDRQYPVYLSTKNTILKAYDGRFKDLFQEVFDTEYKEKF 238

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
             A L YEHRLIDDMVA +LK  GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL TPD
Sbjct: 239 DAAGLTYEHRLIDDMVASSLKWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLTTPD 298

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GK + AEAAHGTVTRH+R HQQGK TSTN +ASI AW RGLAHR  LDG   +  F   L
Sbjct: 299 GKVVEAEAAHGTVTRHYRQHQQGKPTSTNPIASIFAWTRGLAHRGKLDGNQQLIDFTHTL 358

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E   ++T+  GKMTKDL++ V G EQ      +L TEEF++A+   L
Sbjct: 359 EDVVVKTVEQGKMTKDLALLV-GPEQA-----FLTTEEFLEAISANL 399

emb|CAG58084.1| unnamed protein product [Candida glabrata CBS138]
ref|XP_445184.1| unnamed protein product [Candida glabrata]
(411 aa)

Score: 513 bits (1320), Expect: 7.27197e-144
Length: 409, Idn/Pos/Gap = 240/307/8 (58%/75%/1%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           SK++V NPIVE+DGDEQ R+IWHLI+ KLILP+L++D+ Y+DL +  RD T+D VT ++A
Sbjct:   2 SKVKVVNPIVEMDGDEQTRIIWHLIREKLILPFLDVDLKYYDLSIEYRDETNDKVTEDSA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A  ++  AVK ATITPDEARVEEF+LK M+ SPNGT+RN+L GTVFREPI++  IP+LV
Sbjct:  62 LATLKYGVAVKCATITPDEARVEEFNLKEMWKSPNGTIRNILGGTVFREPIVIPRIPKLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           P WK+PI+I RH FGDQY+A D+ +P    V L      G       V+ F      GGV
Sbjct: 122 PQWKEPIIIGRHAFGDQYRATDVVIPDEGEVRLVYKSKDGKTDIDIPVYNFPKE---GGV 178

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ M+NT ESIR FAR+ F  AL  ++P+Y +TKNTILK YDG+++D F+ +YE +Y+E+
Sbjct: 179 AMMMYNTTESIRGFARASFNMALEHEMPLYSTTKNTILKKYDGKFKDTFESMYEAEYKEQ 238

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    +WYEHRLIDDMVAQ LKS GGF+ A KNYDGDV+SDI+AQG+GSLGLM+SVL++P
Sbjct: 239 FEAKGIWYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDVESDIVAQGFGSLGLMTSVLISP 298

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT  +EAAHGTVTRH+R HQQGKETSTNS+ASI AW RG+  R  LD T DV  F E 
Sbjct: 299 DGKTFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGIIQRGKLDETADVVKFGEL 358

Query: 429 LERSCIETIL-DGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LER+ ++T+  DG MTKDL++ +  T+    R  Y+ TEEFIDAV+ R+
Sbjct: 359 LERATVDTVQEDGIMTKDLALILGKTD----RSAYVTTEEFIDAVENRI 403

gb|AAS45362.1| similar to Sus scrofa (Pig). Isocitrate dehydrogenase [NADP], mitochondrial precursor (EC 1.1.1.42) (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) (ICD-M) (Fragment) [Dictyostelium discoideum]
gb|EAL71257.1| isocitrate dehydrogenase (NADP+) [Dictyostelium discoideum]
(428 aa)

Score: 512 bits (1319), Expect: 7.97098e-144
Length: 405, Idn/Pos/Gap = 238/306/8 (58%/75%/1%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           +I+V  P+VE+DGDEQ R++W  IK+KLI PY+++   Y+DLGLP RDAT+D VT++AA 
Sbjct:  26 RIKVTGPVVEMDGDEQTRIMWESIKSKLIFPYVDITPEYYDLGLPNRDATNDQVTIDAAN  85

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A+++    VK ATITPDEARV+EF LK M+ SPNGT+RN+L+GTVFR PI+ +N+P LVP
Sbjct:  86 AIKRAKIGVKCATITPDEARVKEFGLKEMWKSPNGTIRNILDGTVFRGPIICKNLPLLVP 145

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GWK+PI+I RH  GDQYKA D  V    ++E+    +QG E  ++ ++ F     G GVA
Sbjct: 146 GWKKPIIIGRHAHGDQYKATDFVVNGPGKLEMIFTPSQG-EPIKKVIYDF----KGSGVA 200

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           +GM+NT  SI  FA SCF++A+ +K P+YLSTKNTILK YDG+++DIFQE+YER+Y  +F
Sbjct: 201 MGMYNTTSSITAFAHSCFQYAIDKKYPLYLSTKNTILKKYDGQFKDIFQEIYEREYSTKF 260

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               +WYEHRLIDDMVA ALKS GGF+WACKNYDGDVQSDI+AQGYGSLGLM+SVL   D
Sbjct: 261 GELGIWYEHRLIDDMVAFALKSEGGFVWACKNYDGDVQSDIVAQGYGSLGLMTSVLTNAD 320

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           G    +EA+HGTVTRHFR HQ+G ETSTNSVASI AW   L  R  LD   D+  FA+ +
Sbjct: 321 G-VFASEASHGTVTRHFREHQKGNETSTNSVASIFAWTSALGQRGKLDNNKDLVKFAQDM 379

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQ 474
           E++C+E+I  G MTKDL+I + G +   KR NYLNTEE+I+ V +
Sbjct: 380 EKACVESIESGFMTKDLAICIKGNQ--VKRSNYLNTEEYINKVAE 422

ref|NP_696658.1| isocitrate dehydrogenase [NADP] [Bifidobacterium longum NCC2705]
gb|AAN25294.1| isocitrate dehydrogenase [NADP] [Bifidobacterium longum NCC2705]
(406 aa)

Score: 512 bits (1319), Expect: 8.73719e-144
Length: 408, Idn/Pos/Gap = 234/314/9 (57%/76%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V   +VELDGDE  RVIW  IK++LILPYL++++ Y+DLG+  RD TDD VT++AA
Sbjct:   2 AKIKVEGTVVELDGDEMTRVIWKDIKDRLILPYLDVNLDYYDLGIEHRDETDDQVTIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A+Q+HH  VK ATITPDEARV+EF LK+M+ SPNGT+RN+L GT+FREPI++ N+PRLV
Sbjct:  62 HAIQKHHVGVKCATITPDEARVKEFGLKKMWKSPNGTIRNILGGTIFREPIVMSNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PIV+ARH FGDQYKA D +VP A ++ +      G E  +  V+ +    + GGV
Sbjct: 122 PGWTKPIVVARHAFGDQYKATDFKVPGAGQLTVTFTPDDGSEPIQHVVYNYG---EDGGV 178

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A   +N ++SIR FAR+CF + L R  P+YLSTKNTILK YDG+++DIF E++E +Y++R
Sbjct: 179 AQVQYNVNDSIRGFARACFNYGLMRHYPVYLSTKNTILKAYDGQFKDIFAEVFETEYKDR 238

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           +  A L YEHRLIDDMVA +LK  GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+TP
Sbjct: 239 YAEAGLTYEHRLIDDMVASSLKWHGGYIWACKNYDGDVQSDSVAQGFGSLGLMTSVLMTP 298

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DG+T+ AEAAHGTVTRH+R  Q+G++TSTN +ASI AW  GL HRA LDGTP+V HFA+ 
Sbjct: 299 DGQTVEAEAAHGTVTRHYRRWQKGEKTSTNPIASIFAWTGGLKHRADLDGTPEVRHFAKT 358

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LE+  ++T+  G+MTKDL++ +         E +L+T+ F++A+ + L
Sbjct: 359 LEKVIVDTVEGGQMTKDLAMLI------GPDEPWLDTDGFMNALDENL 400

ref|NP_962389.1| Icd1 [Mycobacterium avium subsp. paratuberculosis str. k10]
gb|AAS06005.1| Icd1 [Mycobacterium avium subsp. paratuberculosis str. k10]
(412 aa)

Score: 512 bits (1318), Expect: 1.2301e-143
Length: 415, Idn/Pos/Gap = 242/308/9 (58%/74%/2%)

Query:  62 MSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDD 121
           MSN    SKI+V+  +VELDGDE  RVIW +IK  LILPYL++D+ Y+DLG+  RD TDD
Sbjct:   1 MSNPANTSKIKVKGRVVELDGDEMTRVIWKMIKENLILPYLDIDLDYYDLGIEHRDRTDD  60

Query: 122 GVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILV 181
            VT++AA A+++H   VK ATITPDEARV EF+LKRM+ SPNGT+RN+L GT+FREPI++
Sbjct:  61 QVTIDAAYAIKKHGVGVKCATITPDEARVREFNLKRMWLSPNGTIRNILGGTIFREPIVI 120

Query: 182 ENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFAS 241
            N+PRLVPGW +PIVI RH FGDQY++ + +V     V +    A G E     VH+  S
Sbjct: 121 SNVPRLVPGWTKPIVIGRHAFGDQYRSTNFKVDKPGTVAITFTPADGSE---PIVHEMVS 177

Query: 242 STDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELY 301
             + GGV +GM+N  ESIR+FAR+ F++ L  K P+YLSTKNTILK YDG ++D FQ +Y
Sbjct: 178 IPEDGGVVMGMYNFRESIRDFARASFKYGLNAKWPVYLSTKNTILKAYDGMFKDEFQRIY 237

Query: 302 ERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLM 361
           + +++E+F    L YEHRLIDDMVA  LK  GG++WACKNYDGDVQSD IAQGYGSLGLM
Sbjct: 238 DEEFKEQFEAEGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDAIAQGYGSLGLM 297

Query: 362 SSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPD 421
           +SVL+T DGKT+ AEAAHGTVTRHFR +Q GK TSTN +ASI AW RGLAHR  LD TP+
Sbjct: 298 TSVLMTADGKTVEAEAAHGTVTRHFRQYQAGKPTSTNPIASIFAWTRGLAHRGKLDDTPE 357

Query: 422 VAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           V  FA+ LER  + T+  GKMTKDL+I + G +Q      +  +EEF++++ + L
Sbjct: 358 VVEFAQTLERVVVSTVESGKMTKDLAILI-GPDQ-----KWQQSEEFLNSIAENL 406

gb|AAS52745.1| AER061Cp [Ashbya gossypii ATCC 10895]
ref|NP_984921.1| AER061Cp [Eremothecium gossypii]
(425 aa)

Score: 512 bits (1318), Expect: 1.26128e-143
Length: 426, Idn/Pos/Gap = 253/315/12 (59%/73%/2%)

Query:  52 RTTGRSLCANMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDL 111
           R  GR L    S   A ++IRV+ P+VELDGDE  R+IW  IK +L+LP++++++ Y+DL
Sbjct:   6 RMLGRRL---FSGSRAAARIRVKTPVVELDGDEMTRIIWERIKQQLVLPHVDVELKYYDL  62

Query: 112 GLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLN 171
            +  RDAT D VT++AA A++Q+   VK ATITPDEARV EF LK+M+ SPNGT+RN+L 
Sbjct:  63 SITSRDATSDQVTVDAAHAIKQYGVGVKCATITPDEARVREFGLKKMWRSPNGTIRNILG 122

Query: 172 GTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMEL 231
           GTVFREPI++  IPRLVPGW++PI+I RH  GDQYKA D  VP A  ++L    A G   
Sbjct: 123 GTVFREPIVIPRIPRLVPGWEKPIIIGRHAHGDQYKATDAVVPGAGTLDLVFRPADGSAP 182

Query: 232 ERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDG 291
               V+ FA    G GVAL M+NT+ESIR FA + F  AL ++L ++LSTKNTILK YDG
Sbjct: 183 TSLHVYDFA----GPGVALAMYNTEESIRGFAHASFRLALAKQLNLFLSTKNTILKQYDG 238

Query: 292 RWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDII 351
           R++D+F+ELY+  Y+  F R  ++YEHRLIDDMVAQ +KS GGF+ A KNYDGDVQSDI+
Sbjct: 239 RFKDVFEELYQAQYKAEFERLGIYYEHRLIDDMVAQMVKSKGGFIMALKNYDGDVQSDIV 298

Query: 352 AQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLA 411
           AQG+GSLGLM+SVL+TPDGKT  +EAAHGTVTRHFR HQ GKETSTNS+ASI AW RGLA
Sbjct: 299 AQGFGSLGLMTSVLVTPDGKTFESEAAHGTVTRHFRQHQAGKETSTNSIASIFAWTRGLA 358

Query: 412 HRATLDGTPDVAHFAEALERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFID 470
            R  LD TPDV +FA ALE +   T+ LDG MTKDL++A       S R  Y+NT EFID
Sbjct: 359 KRGELDNTPDVVNFAHALEAATTNTVQLDGIMTKDLALAC----GRSDRSAYVNTNEFID 414

Query: 471 AVQQRL 476
           AV+ RL
Sbjct: 415 AVEARL 420

ref|ZP_00293814.1| COG0538: Isocitrate dehydrogenases [Thermobifida fusca]
(406 aa)

Score: 511 bits (1317), Expect: 1.29325e-143
Length: 408, Idn/Pos/Gap = 238/303/9 (58%/74%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+VELDGDE  R+IW  IK +LILPYL++D+ Y+DLG+  RD T+D VT++AA
Sbjct:   2 AKIKVENPVVELDGDEMTRIIWSFIKERLILPYLDIDLKYYDLGIEERDRTEDQVTIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A++++   VK ATITPDEARVEEF LK+M+ SPNGT+RN+L G VFREPI+  N+PRLV
Sbjct:  62 HAIKKYGVGVKCATITPDEARVEEFGLKKMWRSPNGTIRNILGGVVFREPIICSNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PI+I RH  GDQYKA D +VP    V +      G E    +V +F    +GGGV
Sbjct: 122 PGWTKPIIIGRHAHGDQYKASDFKVPGPGTVTITYTPENGGEPIEMEVAKFP---EGGGV 178

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           ALGM+N  +SI +FAR+CF + L R  P+YLSTKNTILK YDG ++D+F E+YE +++E+
Sbjct: 179 ALGMYNFRKSIEDFARACFNYGLDRNYPVYLSTKNTILKAYDGMFKDVFAEIYENEFKEK 238

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F +A L YEHRLIDDMVA ALK  GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL T 
Sbjct: 239 FEKAGLTYEHRLIDDMVAAALKWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLRTS 298

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DG+ + AEAAHGTVTRH+R HQQGK TSTN +ASI AW RGL HR  LD TP V  FA  
Sbjct: 299 DGRVVEAEAAHGTVTRHYRQHQQGKPTSTNPIASIFAWTRGLEHRGKLDNTPAVIEFART 358

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LE   I+T+  G+MTKDL+I + G +Q      +L TE+F+  + + L
Sbjct: 359 LEDVVIKTVESGQMTKDLAILI-GPDQ-----EWLTTEQFLAVLDENL 400

ref|ZP_00206729.1| COG0538: Isocitrate dehydrogenases [Bifidobacterium longum DJO10A]
(406 aa)

Score: 511 bits (1317), Expect: 1.59321e-143
Length: 408, Idn/Pos/Gap = 233/314/9 (57%/76%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V   +VELDGDE  RVIW  IK++LILPYL++++ Y+DLG+  RD TDD VT++AA
Sbjct:   2 AKIKVEGTVVELDGDEMTRVIWKDIKDRLILPYLDVNLDYYDLGIEHRDETDDQVTIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A+Q+HH  VK ATITPDEARV+EF LK+M+ SPNGT+RN+L GT+FREPI++ N+PRLV
Sbjct:  62 HAIQKHHVGVKCATITPDEARVKEFGLKKMWKSPNGTIRNILGGTIFREPIVMSNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PIV+ARH FGDQYKA D +VP A ++ +      G E  +  V+ +    + GGV
Sbjct: 122 PGWTKPIVVARHAFGDQYKATDFKVPGAGQLTVTFTPDDGSEPIQHVVYNYG---EDGGV 178

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A   +N ++SIR FAR+CF + L R  P+YLSTKNTILK YDG+++DIF E++E +Y+++
Sbjct: 179 AQVQYNVNDSIRGFARACFNYGLMRHYPVYLSTKNTILKAYDGQFKDIFAEVFETEYKDK 238

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           +  A L YEHRLIDDMVA +LK  GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+TP
Sbjct: 239 YAEAGLTYEHRLIDDMVASSLKWHGGYIWACKNYDGDVQSDSVAQGFGSLGLMTSVLMTP 298

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DG+T+ AEAAHGTVTRH+R  Q+G++TSTN +ASI AW  GL HRA LDGTP+V HFA+ 
Sbjct: 299 DGQTVEAEAAHGTVTRHYRRWQKGEKTSTNPIASIFAWTGGLKHRADLDGTPEVRHFAKT 358

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LE+  ++T+  G+MTKDL++ +         E +L+T+ F++A+ + L
Sbjct: 359 LEKVIVDTVEGGQMTKDLAMLI------GPDEPWLDTDGFMNALDENL 400

ref|ZP_00005933.1| COG0538: Isocitrate dehydrogenases [Rhodobacter sphaeroides 2.4.1]
(404 aa)

Score: 510 bits (1313), Expect: 3.76279e-143
Length: 409, Idn/Pos/Gap = 237/305/11 (57%/74%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           SKI+V NP+VELDGDE  R+IW  IK KLILPYL++D+ Y+DLG+  RD T+D +T++AA
Sbjct:   2 SKIKVANPVVELDGDEMTRIIWDFIKQKLILPYLDIDLHYYDLGIEERDRTEDRITVDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A++Q+   VK ATITPDEARV+EF LK M+ SPNGT+RN+L G +FR+PI+  N+PRLV
Sbjct:  62 HAIKQYGVGVKCATITPDEARVDEFGLKSMWKSPNGTIRNILGGVIFRQPIICRNVPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PIV+ RH FGDQY+A D R P   ++ L+ +   G  +ER           G GV
Sbjct: 122 PGWTKPIVVGRHAFGDQYRATDFRFPGKGKLTLKFVGEDGAVIERE-----VFDAPGSGV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
            + M+N D+SI +FAR+   + L    P+YLSTKNTILK YDGR++D+FQ++YE ++ E+
Sbjct: 177 TMAMYNLDQSIIDFARASMNYGLNLGWPVYLSTKNTILKAYDGRFKDLFQQVYEEEFAEK 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F  A + YEHRLIDDMVA ALK SGG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+TP
Sbjct: 237 FKAAGITYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DG+T+ AEAAHGTVTRHFR HQ GKETSTNS+ASI AW  GL HRA LDG  D+A FAE 
Sbjct: 297 DGQTVEAEAAHGTVTRHFRQHQAGKETSTNSIASIYAWTGGLKHRAKLDGNADLARFAET 356

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           LER  ++T+ DG MTKDL++ V G +Q      +L T  +++ V + LD
Sbjct: 357 LERVTVQTVEDGFMTKDLALLV-GPDQ-----KWLTTMGYLERVDEYLD 399

gb|EAK86993.1| hypothetical protein UM06111.1 [Ustilago maydis 521]
ref|XP_403726.1| hypothetical protein UM06111.1 [Ustilago maydis 521]
(429 aa)

Score: 510 bits (1313), Expect: 3.95596e-143
Length: 408, Idn/Pos/Gap = 236/307/5 (57%/75%/1%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NP+VELDGDE  R+IWH I+  LILP+L++++ Y+DLG+  RDATDD VT+EAA
Sbjct:  13 AKIKVSNPVVELDGDEMTRIIWHKIREDLILPFLDIELKYYDLGMEHRDATDDQVTVEAA  72

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A++++   VK ATITPDEARV+EF LK+M+ SPNGT+RN+L GTVFR PI+++++PR V
Sbjct:  73 EAIKKYKVGVKCATITPDEARVKEFGLKKMWLSPNGTIRNILGGTVFRAPIVLDDLPRPV 132

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PIVI RH FGDQY+ Q+  V  A +  +    + G + ++ +V  +    +GGG 
Sbjct: 133 PGWTKPIVIGRHAFGDQYRCQNFAVDKAGKFTMEFTPSDGSQGQKWEVFNYP---EGGGS 189

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
            L M+NT ESI  FA S F+ AL + +P+Y+STKNTILK YDGR++DIFQ LY+  Y++ 
Sbjct: 190 GLAMYNTTESITGFAHSSFKMALEKNIPLYMSTKNTILKAYDGRFKDIFQHLYDTIYKKD 249

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    LWYEHRLIDDMVAQ +KS GGFL A KNYDGDV SDI AQG+GSLG+M+S L+TP
Sbjct: 250 FEAKGLWYEHRLIDDMVAQMIKSDGGFLMALKNYDGDVISDITAQGFGSLGMMTSELITP 309

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DG  + AEAAHGTVTRH+R HQ+G ETSTNSVASI AW RGLA R  LD   D+ +FA A
Sbjct: 310 DGDIMEAEAAHGTVTRHYREHQKGNETSTNSVASIYAWTRGLAFRGKLDKNDDLIYFANA 369

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LE +C++ I  GKMTKDL++  +G  +G KRE+Y+ T E+ID V + L
Sbjct: 370 LEEACLDAISAGKMTKDLALIYHG--KGMKREHYVTTMEYIDEVAKLL 415

gb|EAL29840.1| GA20156-PA [Drosophila pseudoobscura]
(448 aa)

Score: 509 bits (1312), Expect: 4.87352e-143
Length: 408, Idn/Pos/Gap = 236/310/6 (57%/75%/1%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KIR   P+V++ GDE  R+IW  IK+KLILP+L++++  FDLG+  RD T+D VT++ A 
Sbjct:  36 KIRA-GPVVDVLGDEMTRIIWQSIKDKLILPFLDIELHTFDLGIEYRDQTEDKVTIDCAE  94

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A+++++  +K ATITPDE RVEEF+LK+M+ SPNGT+RN+L GTVFRE I+ +N+PRLV 
Sbjct:  95 AIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVS 154

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW++PIVI RH   DQYKA D  VP   ++ L      G     + + +  +   G GVA
Sbjct: 155 GWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGNDG-----QVIDEVINDFKGPGVA 209

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           LGMFNTD+SI +FA + F+FAL RKLP+Y+STKNTILK YDGR++DIF+++Y ++Y++++
Sbjct: 210 LGMFNTDDSIVDFAHASFKFALDRKLPLYMSTKNTILKKYDGRFKDIFEDIYNKEYKKQY 269

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
             A +WYEHRLIDDMVA A+KS GGF+WACKNYDGDVQSD +AQGYGSLGLM+SVLL PD
Sbjct: 270 EAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPD 329

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GKT+ AEAAHGTVTRHFR +QQGKETSTN +ASI AW RGL HRA LD    +  FAE L
Sbjct: 330 GKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDDNVPLQQFAETL 389

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           E+ CI+TI  G MTKDL+I + G+    +R++Y  T EF+D + + L+
Sbjct: 390 EQVCIDTIEGGAMTKDLAICIKGSISAVERKDYQETFEFMDTLAKNLE 437

emb|CAG58358.1| unnamed protein product [Candida glabrata CBS138]
ref|XP_445447.1| unnamed protein product [Candida glabrata]
(423 aa)

Score: 508 bits (1309), Expect: 1.23046e-142
Length: 415, Idn/Pos/Gap = 238/315/10 (57%/75%/2%)

Query:  68 FSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEA 127
            +KI+V+ P+VELDGDE  R+IW  IK +LILP+L++D+ Y+DL +  RD T D +T ++
Sbjct:  13 LAKIKVKTPVVELDGDEMTRIIWDKIKKQLILPFLDVDLKYYDLSIQSRDKTKDQITHDS  72

Query: 128 ARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRL 187
           A A++++   VK ATITPDEARV+EF+L +M+ SPNGT+RN+L GTVFREPI++  +PRL
Sbjct:  73 AEAIKKYGVGVKCATITPDEARVKEFNLTKMWKSPNGTIRNILGGTVFREPIVIPRVPRL 132

Query: 188 VPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVL-DAQGMELERRQVHQFASSTDGG 246
           VPGW++PI+I RH  GDQYKA D  +P   ++EL    +    + E  +V+ +     G 
Sbjct: 133 VPGWEKPIIIGRHAHGDQYKATDAVIPGQGKLELVYKPNGDASKAEVMEVYDY----KGP 188

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESIR FA S F+ AL++KL ++LSTKNTILK YDGR++DIFQE+Y+ +Y+
Sbjct: 189 GVALAMYNTDESIRGFAHSSFKLALQKKLNLFLSTKNTILKKYDGRFKDIFQEVYDSEYK 248

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
           ++F    + YEHRLIDDMVAQ +KS GGF+ A KNYDGDVQSDI+AQG+GSLGLM+S+L+
Sbjct: 249 QKFAELNITYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILI 308

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
           TPDGKT  +EAAHGTVTRH+R HQQG+ETSTNS+ASI AW RGLA R  LDGTPDV  FA
Sbjct: 309 TPDGKTFESEAAHGTVTRHYRKHQQGEETSTNSIASIFAWTRGLAKRGELDGTPDVVRFA 368

Query: 427 EALERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
             LE + + T+  DG MTKDL++A   T+    R +Y+ T EF+DAV++RL   +
Sbjct: 369 NILESATLNTVQQDGIMTKDLALACGKTD----RASYVTTTEFLDAVEKRLQTEI 419

gb|AAK76730.1| mitochondrial NADP-dependent isocitrate dehydrogenase [Aspergillus nidulans]
(493 aa)

Score: 508 bits (1308), Expect: 1.4661e-142
Length: 412, Idn/Pos/Gap = 241/312/10 (58%/75%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V+NP+VELDGDE  R+IW  I+ KLILP+L++D+ Y+DLGL  RD TDD VT E+A 
Sbjct:  87 KIKVKNPVVELDGDEMTRIIWKEIREKLILPFLDIDLKYYDLGLEYRDQTDDKVTTESAE 146

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   VK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI++  IPRLVP
Sbjct: 147 AIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILGGTVFREPIVIPRIPRLVP 206

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW +PI+I RH FGDQY+A D  +P   ++EL V   +G + E  +V  F     GGGV 
Sbjct: 207 GWTKPIIIGRHAFGDQYRATDRVIPGPGKLEL-VYTPEGGQPEAIKVFDFP----GGGVT 261

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
              +NTDESIR FA + F+ AL + LP+Y+STKNTILK YDGR++DIFQE++E DY++ F
Sbjct: 262 QTQYNTDESIRGFAHASFKLALTKGLPLYMSTKNTILKKYDGRFKDIFQEIFESDYKKEF 321

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               +WYEHRLIDDMVAQ +KS GGF+ A KNYDGDVQSDI+AQG+GSLGLM+S L+TPD
Sbjct: 322 DAKGIWYEHRLIDDMVAQMIKSEGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSTLITPD 381

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           G+   +EAAHGTVTRH+R HQ+G+ETSTN +ASI AW RGL  R  LD TPDV  FAE L
Sbjct: 382 GQAFESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLIQRGKLDETPDVVKFAEEL 441

Query: 430 ERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           ER+CI+ +  +G MTKDL+++    E    R+ ++ T E++ AV++RL  ++
Sbjct: 442 ERACIDVVNEEGIMTKDLALSCGRKE----RDAWVTTREYMAAVERRLRANL 489

emb|CAI05037.1| isocitrate dehydrogenase (NADP), mitochondrial precursor, putative [Plasmodium berghei]
(468 aa)

Score: 507 bits (1305), Expect: 3.34892e-142
Length: 430, Idn/Pos/Gap = 232/320/6 (53%/74%/1%)

Query:  52 RTTGRSLCANMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDL 111
           R T R +    S      K++V NPIVELDGDE  +VIW  IK KLILPYL+L+I YFDL
Sbjct:  15 RITKRYISNGHSAFNLSGKVKVENPIVELDGDEMTKVIWKDIKEKLILPYLDLNIKYFDL  74

Query: 112 GLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLN 171
            +  RD T+D +TLEAA+ ++++   +K ATITPD ARV+EF+LK M+ SPNGT+RN+L+
Sbjct:  75 SIENRDKTNDQITLEAAQEIKKYGVGIKCATITPDAARVKEFNLKEMWKSPNGTIRNILD 134

Query: 172 GTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMEL 231
           GTVFR PIL++N+P+L+  WK+PI+I RH + DQYK + L+V  + + E+         +
Sbjct: 135 GTVFRAPILIKNVPKLISNWKKPIIIGRHAYADQYKQKSLKVTKSGKFEIVFTPDDNSPV 194

Query: 232 ERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDG 291
            R  +  F S     GV LGM+NT+ESI+NFA SCF++AL  K+P+Y ST +TILK+YDG
Sbjct: 195 VRETIFNFKSP----GVCLGMYNTEESIKNFALSCFQYALDLKMPVYFST-STILKIYDG 249

Query: 292 RWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDII 351
            ++DIFQ++YE+ +++ + +  LWYEH+LIDDMVAQ LKS GGF+WACKNYDGD+QSD +
Sbjct: 250 LFKDIFQDIYEQKFKKIYEQNNLWYEHKLIDDMVAQVLKSEGGFVWACKNYDGDIQSDAV 309

Query: 352 AQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLA 411
           AQGYGSLGLMSS+L+ PDG T ++EAAHGTVT+H+R +Q+G++TSTN +ASI AW RGL 
Sbjct: 310 AQGYGSLGLMSSILMCPDGVTCISEAAHGTVTKHYRAYQRGEKTSTNPIASIFAWTRGLQ 369

Query: 412 HRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDA 471
           HRA LD   ++  F  ALE++CIET+ +G M KDL+I + G +  ++++ YL TE+FIDA
Sbjct: 370 HRAKLDQNKNLQQFCYALEKACIETVENGLMPKDLAICIKGIKNVTEKD-YLFTEDFIDA 428

Query: 472 VQQRLDVHML 481
           + + L + +L
Sbjct: 429 INENLKLKLL 438

gb|EAL22716.1| hypothetical protein CNBB1650 [Cryptococcus neoformans var. neoformans B-3501A]
gb|AAW41927.1| isocitrate dehydrogenase (NADP+), putative [Cryptococcus neoformans var. neoformans JEC21]
ref|XP_569234.1| isocitrate dehydrogenase (NADP+), putative [Cryptococcus neoformans var. neoformans JEC21]
(452 aa)

Score: 506 bits (1304), Expect: 5.29914e-142
Length: 458, Idn/Pos/Gap = 242/329/24 (52%/71%/5%)

Query:  46 FPKFLRRTTGRSLCA---------------NMSNVPA-FSKIRVRNPIVELDGDEQARVI  89
           FP+  R TT  +  +               N ++ PA   +I+V+NP+VE+DGDE  R+I
Sbjct:   2 FPQLARSTTAFTRSSLLRSTRPLAFAMASRNYASTPAGIDRIKVKNPVVEIDGDEMTRII  61

Query:  90 WHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEAR 149
           W  I+ +LILPY+++D+ Y+DLG+  RDAT+D +T+++A A++++   VK ATITPDEAR
Sbjct:  62 WKKIREELILPYVDVDLKYYDLGMESRDATNDQITIDSAEAIKKYSVGVKCATITPDEAR 121

Query: 150 VEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQ 209
           V+EF LK M+ SPNGT+RN+L GTVFREPI+++ IP+ VPGW +PI I RH FGDQY++ 
Sbjct: 122 VKEFKLKEMWRSPNGTIRNILGGTVFREPIILDKIPKPVPGWTKPICIGRHAFGDQYRST 181

Query: 210 DLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEF 269
           D   P   ++ L    A+G       V+ F     G GVAL M+NTDESI  FA + F+ 
Sbjct: 182 DFIAPGPGKLTLTYTPAEGGAPTELNVYDF----KGKGVALAMYNTDESIYGFAHASFKM 237

Query: 270 ALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQAL 329
           AL +K+P+++STKNTILK YDGR++DIFQE+YE  Y+  F +  ++YEHRLIDDMVAQA+
Sbjct: 238 ALSKKMPLFMSTKNTILKKYDGRFKDIFQEVYESTYKAEFEKLGVYYEHRLIDDMVAQAI 297

Query: 330 KSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLH 389
           KSSGGF+WACKNYDGDV SDI+AQG+GSLG+M+S L+TPDGKT+ +EAAHGTVTRH+R +
Sbjct: 298 KSSGGFVWACKNYDGDVMSDILAQGFGSLGMMTSELITPDGKTMESEAAHGTVTRHYRQY 357

Query: 390 QQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI-LDGKMTKDLSI 448
           Q G ETSTN VASI AW RGLA RA LD TP +  FA+ LE +C+E I  DG MTKDL++
Sbjct: 358 QAGHETSTNPVASIFAWTRGLAFRAKLDETPALEAFAKDLEAACVEVIDKDGIMTKDLAL 417

Query: 449 AVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQEHAA 486
           A+ G +    R++++ T+ ++  V +RL V  L+  +A
Sbjct: 418 AMKGKDM--TRDDWVTTDVYMKKVNERL-VEKLKARSA 452

gb|EAL22717.1| hypothetical protein CNBB1650 [Cryptococcus neoformans var. neoformans B-3501A]
gb|AAW41926.1| isocitrate dehydrogenase (NADP+), putative [Cryptococcus neoformans var. neoformans JEC21]
ref|XP_569233.1| isocitrate dehydrogenase (NADP+), putative [Cryptococcus neoformans var. neoformans JEC21]
(449 aa)

Score: 506 bits (1303), Expect: 5.80852e-142
Length: 428, Idn/Pos/Gap = 237/321/9 (55%/75%/2%)

Query:  61 NMSNVPA-FSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDAT 119
           N ++ PA   +I+V+NP+VE+DGDE  R+IW  I+ +LILPY+++D+ Y+DLG+  RDAT
Sbjct:  29 NYASTPAGIDRIKVKNPVVEIDGDEMTRIIWKKIREELILPYVDVDLKYYDLGMESRDAT  88

Query: 120 DDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPI 179
           +D +T+++A A++++   VK ATITPDEARV+EF LK M+ SPNGT+RN+L GTVFREPI
Sbjct:  89 NDQITIDSAEAIKKYSVGVKCATITPDEARVKEFKLKEMWRSPNGTIRNILGGTVFREPI 148

Query: 180 LVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQF 239
           +++ IP+ VPGW +PI I RH FGDQY++ D   P   ++ L    A+G       V+ F
Sbjct: 149 ILDKIPKPVPGWTKPICIGRHAFGDQYRSTDFIAPGPGKLTLTYTPAEGGAPTELNVYDF 208

Query: 240 ASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQE 299
                G GVAL M+NTDESI  FA + F+ AL +K+P+++STKNTILK YDGR++DIFQE
Sbjct: 209 ----KGKGVALAMYNTDESIYGFAHASFKMALSKKMPLFMSTKNTILKKYDGRFKDIFQE 264

Query: 300 LYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLG 359
           +YE  Y+  F +  ++YEHRLIDDMVAQA+KSSGGF+WACKNYDGDV SDI+AQG+GSLG
Sbjct: 265 VYESTYKAEFEKLGVYYEHRLIDDMVAQAIKSSGGFVWACKNYDGDVMSDILAQGFGSLG 324

Query: 360 LMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGT 419
           +M+S L+TPDGKT+ +EAAHGTVTRH+R +Q G ETSTN VASI AW RGLA RA LD T
Sbjct: 325 MMTSELITPDGKTMESEAAHGTVTRHYRQYQAGHETSTNPVASIFAWTRGLAFRAKLDET 384

Query: 420 PDVAHFAEALERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDV 478
           P +  FA+ LE +C+E I  DG MTKDL++A+ G +    R++++ T+ ++  V +RL V
Sbjct: 385 PALEAFAKDLEAACVEVIDKDGIMTKDLALAMKGKDM--TRDDWVTTDVYMKKVNERL-V 441

Query: 479 HMLQEHAA 486
             L+  +A
Sbjct: 442 EKLKARSA 449

ref|YP_117132.1| putative isocitrate/isopropylmalate dehydrogenase [Nocardia farcinica IFM 10152]
dbj|BAD55768.1| putative isocitrate/isopropylmalate dehydrogenase [Nocardia farcinica IFM 10152]
(405 aa)

Score: 505 bits (1301), Expect: 1.11355e-141
Length: 408, Idn/Pos/Gap = 235/302/9 (57%/74%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           SKI+V   +VELDGDE  R+IW  IK+KLI PYL++++ Y+DLG+  RD TDD VT++AA
Sbjct:   2 SKIKVEGTVVELDGDEMTRIIWQFIKDKLIHPYLDVNLEYYDLGIEYRDKTDDQVTVDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A+++H   VK ATITPDEARV+EF LK+M+ SPNGT+RN+L GT+FR PI++ NIPRLV
Sbjct:  62 EAIKRHGVGVKCATITPDEARVKEFGLKKMWRSPNGTIRNILGGTIFRAPIIISNIPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           PGW +PI+I RH FGDQY+A D +V     V L      G E     VH+     + GGV
Sbjct: 122 PGWTKPIIIGRHAFGDQYRATDFKVFQGGTVTLTFTPDDGSE---PIVHEVVKMPEDGGV 178

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
            +GM+N  +SI +FAR+ F + L++  P+Y+STKNTILK YDG ++D FQE+++ +++ +
Sbjct: 179 VMGMYNFKKSIEDFARASFNYGLQQNYPVYMSTKNTILKAYDGMFKDTFQEIFDTEFKSQ 238

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F  A L YEHRLIDDMVA ++K  GG++WACKNYDGDVQSD +AQG+GSLGLM+SVLLTP
Sbjct: 239 FDAAGLTYEHRLIDDMVASSMKWEGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLLTP 298

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT  AEAAHGTVTRH+R HQQGK TSTN +ASI AW RGL HR  LD TP+V  FA+ 
Sbjct: 299 DGKTCEAEAAHGTVTRHYRQHQQGKPTSTNPIASIFAWTRGLEHRGKLDNTPEVIGFAQT 358

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LE   I+T+  G+MTKDL++ V G +QG     YL TEEF+ A+   L
Sbjct: 359 LEDVVIKTVEGGQMTKDLALLV-GGDQG-----YLTTEEFLGALDTNL 400

emb|CAA95869.1| unnamed protein product [Saccharomyces cerevisiae]
gb|AAT93173.1| YNL009W [Saccharomyces cerevisiae]
ref|NP_014389.1| Idp3p [Saccharomyces cerevisiae]
pir||S62921 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) IDP3 - yeast  (Saccharomyces cerevisiae)
sp|P53982|IDHH_YEAST Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
(420 aa)

Score: 505 bits (1300), Expect: 1.30484e-141
Length: 417, Idn/Pos/Gap = 236/316/8 (56%/75%/1%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           SKI+V +PIVE+DGDEQ RVIW LIK KLILPYL++D+ Y+DL +  RD T+D VT +++
Sbjct:   2 SKIKVVHPIVEMDGDEQTRVIWKLIKEKLILPYLDVDLKYYDLSIQERDRTNDQVTKDSS  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A  ++  AVK ATITPDEAR++EF+LK M+ SPNGT+RN+L GTVFREPI++  IPRLV
Sbjct:  62 YATLKYGVAVKCATITPDEARMKEFNLKEMWKSPNGTIRNILGGTVFREPIIIPKIPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           P W++PI+I RH FGDQY+A D+++  A ++ L+     G E    +V++F  S   GG+
Sbjct: 122 PHWEKPIIIGRHAFGDQYRATDIKIKKAGKLRLQFSSDDGKENIDLKVYEFPKS---GGI 178

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ MFNT++SI+ FA++ FE AL+RKLP++ +TKNTILK YD +++ IF  L++++Y+E+
Sbjct: 179 AMAMFNTNDSIKGFAKASFELALKRKLPLFFTTKNTILKNYDNQFKQIFDNLFDKEYKEK 238

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    + YEHRLIDDMVAQ LKS GGF+ A KNYDGDVQSDI+AQG+GSLGLM+S+L+TP
Sbjct: 239 FQALKITYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDVQSDIVAQGFGSLGLMTSILITP 298

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT  +EAAHGTVTRHFR HQ+G+ETSTNS+ASI AW R +  R  LD T DV  F   
Sbjct: 299 DGKTFESEAAHGTVTRHFRKHQRGEETSTNSIASIFAWTRAIIQRGKLDNTDDVIKFGNL 358

Query: 429 LERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQEH 484
           LE++ ++T+ + GKMTKDL++ +  T     R +Y+ TEEFID V +RL   ML  +
Sbjct: 359 LEKATLDTVQVGGKMTKDLALMLGKT----NRSSYVTTEEFIDEVAKRLQNMMLSSN 411

gb|AAX78964.1| isocitrate dehydrogenase [NADP], mitochondrial precursor, putative [Trypanosoma brucei]
(437 aa)

Score: 504 bits (1299), Expect: 1.64824e-141
Length: 411, Idn/Pos/Gap = 238/308/6 (57%/74%/1%)

Query:  66 PAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTL 125
           P+  +I+V   +V++DGDE  R+IW LIK KLILP++++ I Y+DL +  RDA++D VT 
Sbjct:  27 PSLGRIKVSGTVVDMDGDEMTRIIWALIKEKLILPHVDVPIEYYDLSITSRDASNDKVTE  86

Query: 126 EAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIP 185
           +AA A+Q+H+  +K ATITPDEARV+EF+LK+M+ SPNGT+RN+L GTVFREPI+V+N+P
Sbjct:  87 QAAEAIQRHNVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGTVFREPIIVKNVP 146

Query: 186 RLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDG 245
           R+VP W +PI++ RH +GDQYKA +   PP  R+EL    A G   +  +V  F     G
Sbjct: 147 RVVPQWSEPIIVGRHAYGDQYKATESLFPPG-RLELVHTPANGGSPQVLEVFNF----KG 201

Query: 246 GGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDY 305
            GV L M+NT ES+  FA SCFE+A+ R+ P+ LSTKNTILK YDG + + FQ +Y+  Y
Sbjct: 202 EGVGLAMYNTRESVEAFAESCFEYAIMRRYPLVLSTKNTILKKYDGLFLETFQRMYDTKY 261

Query: 306 RERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVL 365
           RE+F R  L Y HRLIDD VAQ +K +GGF+WACKNYDGDVQSDI+AQG+GSLGLM+SVL
Sbjct: 262 REQFERLNLTYVHRLIDDQVAQMIKGNGGFVWACKNYDGDVQSDIVAQGFGSLGLMTSVL 321

Query: 366 LTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHF 425
           L PDGKT+ +EAAHGTVTRH+R HQ+GKETSTNSVASI AW RGLAHR  LDG   +  F
Sbjct: 322 LCPDGKTIESEAAHGTVTRHYREHQKGKETSTNSVASIFAWTRGLAHRGKLDGNAPLVEF 381

Query: 426 AEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           A +LER+ I+TI  G MTKDL++ V+G     +R +Y  TE FID+V + L
Sbjct: 382 ASSLERATIKTIEGGHMTKDLALCVHGA-AALQRSHYETTEVFIDSVAEEL 431

emb|CAA98631.1| IDP1 [Saccharomyces cerevisiae]
sp|P21954|IDHP_YEAST Isocitrate dehydrogenase [NADP], mitochondrial precursor (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
ref|NP_010217.1| Idp1p [Saccharomyces cerevisiae]
gb|AAA34703.1| NADPH-specific isocitrate dehydrogenase
(428 aa)

Score: 503 bits (1294), Expect: 6.9809e-141
Length: 417, Idn/Pos/Gap = 238/312/11 (57%/74%/2%)

Query:  63 SNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDG 122
           S + AFSKI+V+ P+VELDGDE  R+IW  IK KLILPYL++D+ Y+DL +  RDAT D 
Sbjct:  12 SRLAAFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDK  71

Query: 123 VTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVE 182
           +T +AA A++++   +K ATITPDEARV+EF+L +M+ SPNGT+RN+L GTVFREPI++ 
Sbjct:  72 ITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIP 131

Query: 183 NIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVEL--RVLDAQGMELERRQVHQFA 240
            IPRLVP W++PI+I RH  GDQYKA D  +P    +EL  +  D    + +  +V+ + 
Sbjct: 132 RIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDY- 190

Query: 241 SSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQEL 300
               G GVA+ M+NTDESI  FA S F+ A+ +KL ++LSTKNTILK YDGR++DIFQE+
Sbjct: 191 ---KGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEV 247

Query: 301 YERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGL 360
           YE  Y+ +F +  + YEHRLIDDMVAQ +KS GGF+ A KNYDGDVQSDI+AQG+GSLGL
Sbjct: 248 YEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGL 307

Query: 361 MSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTP 420
           M+S+L+TPDGKT  +EAAHGTVTRH+R +Q+G+ETSTNS+ASI AW+RGL  R  LD TP
Sbjct: 308 MTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTP 367

Query: 421 DVAHFAEALERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
            +  FA  LE + + T+  DG MTKDL++A    E    R  Y+ TEEF+DAV++RL
Sbjct: 368 ALCKFANILESATLNTVQQDGIMTKDLALACGNNE----RSAYVTTEEFLDAVEKRL 420

emb|CAG98346.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
ref|XP_455638.1| unnamed protein product [Kluyveromyces lactis]
(415 aa)

Score: 502 bits (1293), Expect: 9.50574e-141
Length: 412, Idn/Pos/Gap = 239/309/9 (58%/75%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           SKI V+ PIVE+DGDEQ R+IW LIK+ LI PYL++D+ Y+DL +  RD TDD VT ++A
Sbjct:   2 SKISVKTPIVEMDGDEQTRIIWKLIKDHLIHPYLDIDLKYYDLSIENRDLTDDKVTEQSA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
           +A  ++  AVK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI++  IP+LV
Sbjct:  62 QATLKYGVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIVIPRIPKLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQ--VHQFASSTDGG 246
             W++PI+I RH FGDQY+A D+ +P A +++L V ++     E  +  V+ F   + GG
Sbjct: 122 TNWEKPIIIGRHAFGDQYRATDVVIPGAGKLKL-VFESDDSNTENIELSVYDFDEESKGG 180

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
            VA+ M+NT ESI  FA + F+ AL R LP+Y +TKNTILK YDG+++D+F+ LYE  Y+
Sbjct: 181 -VAMAMYNTLESITGFAHASFKMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYK 239

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
             F    +WYEHRLIDDMVAQ LKS GG++ A KNYDGDV+SDI+AQG+GSLGLM+SVL+
Sbjct: 240 SAFEAKGIWYEHRLIDDMVAQMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLI 299

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
           TPDGK   +EAAHGTVTRH+R HQQGKETSTNS+ASI AW RGL  R  LD TPDV  FA
Sbjct: 300 TPDGKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFA 359

Query: 427 EALERSCIETIL-DGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           E +E + + T+  D  MTKDL++ +  T+    R +Y+ TEEFI+AV +RLD
Sbjct: 360 ELVESATVNTVQEDEIMTKDLALILGKTD----RSSYVTTEEFIEAVHKRLD 407

ref|NP_913674.1| putative NADP-isocitrate dehydrogenase [Oryza sativa (japonica cultivar-group)]
(408 aa)

Score: 502 bits (1293), Expect: 9.74669e-141
Length: 414, Idn/Pos/Gap = 242/303/13 (58%/73%/3%)

Query:  67 AFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLE 126
           AF KI V NP+VE+DGDE  RVIW  IK+KLI P+L+LDI Y+DLGLP RDAT D VT+E
Sbjct:   2 AFEKIVVANPVVEMDGDEMTRVIWKWIKDKLIFPFLDLDIKYYDLGLPNRDATGDKVTIE  61

Query: 127 AARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPR 186
           +A A  +++ A+K ATITPDE RV+EF+L  M+ SPNGT+RN+LNGTVFREPI+ +NIPR
Sbjct:  62 SAEATLKYNVAIKCATITPDEGRVKEFNLSAMWKSPNGTIRNILNGTVFREPIICKNIPR 121

Query: 187 LVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGG 246
           LVPGW +PI I RH FGDQY+A D  +    +++L V D +  ++E   V  F   T  G
Sbjct: 122 LVPGWIKPICIGRHAFGDQYRATDTVIKGPGKLKL-VFDGREEQIE-LDVFNF---TGAG 176

Query: 247 GVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYR 306
           GVAL M+NTDESI  FA +    A +++ P+YLSTKNTILK YDGR++DIFQE YE  +R
Sbjct: 177 GVALSMYNTDESIWAFAEASMNMAYQKRWPLYLSTKNTILKKYDGRFKDIFQENYETKWR 236

Query: 307 ERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
            +F  A +WYEHRLIDDMVA ALKS GG++WACKNYDGDVQSD+IAQG+  L       +
Sbjct: 237 AKFDDAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDLIAQGFCLL------YV 290

Query: 367 TPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFA 426
            PDG+T+ AEAAHGTVTRH+R+HQ+G ETSTNS+ASI AW  GL HRA LD    +  F 
Sbjct: 291 CPDGRTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTTGLGHRAKLDDNKRLLDFV 350

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           + LE +C+ T+  GKMTKDL++ V+G      R+ YLNT EFIDAV + L   +
Sbjct: 351 QKLEAACVGTVESGKMTKDLALLVHGPN--VSRDKYLNTVEFIDAVAEDLRTRL 402

ref|NP_729367.1| CG7176-PD, isoform D [Drosophila melanogaster]
gb|AAN12002.1| CG7176-PD, isoform D [Drosophila melanogaster]
(437 aa)

Score: 502 bits (1292), Expect: 1.18087e-140
Length: 412, Idn/Pos/Gap = 231/306/5 (56%/74%/1%)

Query:  76 PIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHH 135
           P+V++ GDE  R+IW  IK++LILP+L++++  +DLG+  RD T+D VT++ A A+++++
Sbjct:  30 PVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYN  89

Query: 136 AAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPI 195
             +K ATITPDE RVEEF+LK+M+ SPNGT+RN+L GTVFRE I+ +N+PRLV GW++PI
Sbjct:  90 VGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPI 149

Query: 196 VIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNT 255
           VI RH   DQYKA D  VP   ++ L      G     + + +  +   G G+ALGMFNT
Sbjct: 150 VIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDG-----QVIDEVINDFKGPGIALGMFNT 204

Query: 256 DESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALW 315
           D+SI +FA + F++AL RKLP+Y+STKNTILK YDGR++DIF++LY + Y++ +  A +W
Sbjct: 205 DDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIW 264

Query: 316 YEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLA 375
           YEHRLIDDMVA A+KS GGF+WACKNYDGDVQSD +AQGYGSLGLM+SVLL PDGKT+ A
Sbjct: 265 YEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEA 324

Query: 376 EAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIE 435
           EAAHGTVTRHFR +QQGKETSTN +ASI AW RGL HRA LD    +  FA+ LE+ CI+
Sbjct: 325 EAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCID 384

Query: 436 TILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQEHAAA 487
           TI  G MTKDL+I + G      R +Y  T EFI+ + + L+  + +   AA
Sbjct: 385 TIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLEGALAKNAVAA 436

ref|NP_729369.1| CG7176-PE, isoform E [Drosophila melanogaster]
ref|NP_729368.1| CG7176-PA, isoform A [Drosophila melanogaster]
ref|NP_729370.1| CG7176-PF, isoform F [Drosophila melanogaster]
gb|AAN12004.1| CG7176-PF, isoform F [Drosophila melanogaster]
gb|AAN12003.1| CG7176-PE, isoform E [Drosophila melanogaster]
gb|AAF50435.1| CG7176-PA, isoform A [Drosophila melanogaster]
(416 aa)

Score: 502 bits (1292), Expect: 1.18087e-140
Length: 412, Idn/Pos/Gap = 231/306/5 (56%/74%/1%)

Query:  76 PIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHH 135
           P+V++ GDE  R+IW  IK++LILP+L++++  +DLG+  RD T+D VT++ A A+++++
Sbjct:   9 PVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTEDQVTIDCAEAIKKYN  68

Query: 136 AAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPI 195
             +K ATITPDE RVEEF+LK+M+ SPNGT+RN+L GTVFRE I+ +N+PRLV GW++PI
Sbjct:  69 VGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIICKNVPRLVTGWQKPI 128

Query: 196 VIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNT 255
           VI RH   DQYKA D  VP   ++ L      G     + + +  +   G G+ALGMFNT
Sbjct: 129 VIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDG-----QVIDEVINDFKGPGIALGMFNT 183

Query: 256 DESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALW 315
           D+SI +FA + F++AL RKLP+Y+STKNTILK YDGR++DIF++LY + Y++ +  A +W
Sbjct: 184 DDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLYNKQYKKEYEAAGIW 243

Query: 316 YEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLA 375
           YEHRLIDDMVA A+KS GGF+WACKNYDGDVQSD +AQGYGSLGLM+SVLL PDGKT+ A
Sbjct: 244 YEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLLCPDGKTVEA 303

Query: 376 EAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIE 435
           EAAHGTVTRHFR +QQGKETSTN +ASI AW RGL HRA LD    +  FA+ LE+ CI+
Sbjct: 304 EAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEPLKQFADTLEQVCID 363

Query: 436 TILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQEHAAA 487
           TI  G MTKDL+I + G      R +Y  T EFI+ + + L+  + +   AA
Sbjct: 364 TIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLEGALAKNAVAA 415

ref|NP_652044.1| CG7176-PC, isoform C [Drosophila melanogaster]
gb|AAF50434.1| CG7176-PC, isoform C [Drosophila melanogaster]
(469 aa)

Score: 502 bits (1292), Expect: 1.23117e-140
Length: 426, Idn/Pos/Gap = 234/311/5 (54%/73%/1%)

Query:  62 MSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDD 121
           MS V   ++     P+V++ GDE  R+IW  IK++LILP+L++++  +DLG+  RD T+D
Sbjct:  48 MSAVSEMAQKIKAGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKTED 107

Query: 122 GVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILV 181
            VT++ A A+++++  +K ATITPDE RVEEF+LK+M+ SPNGT+RN+L GTVFRE I+ 
Sbjct: 108 QVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAIIC 167

Query: 182 ENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFAS 241
           +N+PRLV GW++PIVI RH   DQYKA D  VP   ++ L      G     + + +  +
Sbjct: 168 KNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDG-----QVIDEVIN 222

Query: 242 STDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELY 301
              G G+ALGMFNTD+SI +FA + F++AL RKLP+Y+STKNTILK YDGR++DIF++LY
Sbjct: 223 DFKGPGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFEDLY 282

Query: 302 ERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLM 361
            + Y++ +  A +WYEHRLIDDMVA A+KS GGF+WACKNYDGDVQSD +AQGYGSLGLM
Sbjct: 283 NKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLGLM 342

Query: 362 SSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPD 421
           +SVLL PDGKT+ AEAAHGTVTRHFR +QQGKETSTN +ASI AW RGL HRA LD    
Sbjct: 343 TSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNNEP 402

Query: 422 VAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHML 481
           +  FA+ LE+ CI+TI  G MTKDL+I + G      R +Y  T EFI+ + + L+  + 
Sbjct: 403 LKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLEGALA 462

Query: 482 QEHAAA 487
           +   AA
Sbjct: 463 KNAVAA 468

ref|NP_729366.1| CG7176-PB, isoform B [Drosophila melanogaster]
ref|NP_788476.1| CG7176-PG, isoform G [Drosophila melanogaster]
gb|AAO41266.1| CG7176-PG, isoform G [Drosophila melanogaster]
gb|AAF50433.1| CG7176-PB, isoform B [Drosophila melanogaster]
gb|AAK77237.1| GH01524p [Drosophila melanogaster]
(450 aa)

Score: 501 bits (1291), Expect: 1.33831e-140
Length: 428, Idn/Pos/Gap = 234/312/5 (54%/72%/1%)

Query:  60 ANMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDAT 119
           AN +   A ++     P+V++ GDE  R+IW  IK++LILP+L++++  +DLG+  RD T
Sbjct:  27 ANFAISAAMAQKIKAGPVVDVLGDEMTRIIWDSIKSQLILPFLDIELHTYDLGIENRDKT  86

Query: 120 DDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPI 179
           +D VT++ A A+++++  +K ATITPDE RVEEF+LK+M+ SPNGT+RN+L GTVFRE I
Sbjct:  87 EDQVTIDCAEAIKKYNVGIKCATITPDEKRVEEFNLKKMWKSPNGTIRNILGGTVFREAI 146

Query: 180 LVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQF 239
           + +N+PRLV GW++PIVI RH   DQYKA D  VP   ++ L      G     + + + 
Sbjct: 147 ICKNVPRLVTGWQKPIVIGRHAHADQYKAVDYVVPGPGKLTLTWKGTDG-----QVIDEV 201

Query: 240 ASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQE 299
            +   G G+ALGMFNTD+SI +FA + F++AL RKLP+Y+STKNTILK YDGR++DIF++
Sbjct: 202 INDFKGPGIALGMFNTDDSIVDFAHASFKYALDRKLPLYMSTKNTILKKYDGRFKDIFED 261

Query: 300 LYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLG 359
           LY + Y++ +  A +WYEHRLIDDMVA A+KS GGF+WACKNYDGDVQSD +AQGYGSLG
Sbjct: 262 LYNKQYKKEYEAAGIWYEHRLIDDMVAYAMKSEGGFVWACKNYDGDVQSDSVAQGYGSLG 321

Query: 360 LMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGT 419
           LM+SVLL PDGKT+ AEAAHGTVTRHFR +QQGKETSTN +ASI AW RGL HRA LD  
Sbjct: 322 LMTSVLLCPDGKTVEAEAAHGTVTRHFRFYQQGKETSTNPIASIFAWTRGLLHRAKLDNN 381

Query: 420 PDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVH 479
             +  FA+ LE+ CI+TI  G MTKDL+I + G      R +Y  T EFI+ + + L+  
Sbjct: 382 EPLKQFADTLEQVCIDTIESGAMTKDLAICIKGNINAVTRRDYQETFEFINTLAKNLEGA 441

Query: 480 MLQEHAAA 487
           + +   AA
Sbjct: 442 LAKNAVAA 449

ref|YP_033790.1| NADP-dependent isocitrate dehydrogenase [Bartonella henselae str. Houston-1]
emb|CAF27796.1| NADP-dependent isocitrate dehydrogenase [Bartonella henselae str. Houston-1]
(404 aa)

Score: 501 bits (1289), Expect: 2.67496e-140
Length: 411, Idn/Pos/Gap = 227/311/11 (55%/75%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V NPIVE+DGDE  R+IW  IK+KLI PYL++++ Y+DL +  RDAT+D VT+++A 
Sbjct:   3 KIKVENPIVEIDGDEMTRIIWKYIKDKLIHPYLDIELKYYDLSVENRDATNDQVTIDSAN  62

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   +K ATITPDE+RV+EF+LK+M+ SPNGT+RN+L G +FREPI+ +N+PRLVP
Sbjct:  63 AIKKYGVGIKCATITPDESRVKEFNLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLVP 122

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            W +PI+I RH FGDQYKA D + P   ++ ++ +      +E    H    +   G +A
Sbjct: 123 NWTKPIIIGRHAFGDQYKATDFKFPGKGKLSIKFVGDDNQVIE----HDVFDAPSAG-IA 177

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           + M+N DESIR+FAR+ F + L+R LP+YLSTKNTILK YDGR++DIFQE+++ +++  F
Sbjct: 178 MAMYNLDESIRDFARASFNYGLQRNLPVYLSTKNTILKTYDGRFKDIFQEIFDAEFKAEF 237

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               L+YEHRLIDDMVA ALK SGG++WACKNYDGDVQSDI+AQG+GSLGLM+SVL+TPD
Sbjct: 238 ENRKLYYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPD 297

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GK + AEAAHGTVTRH+R +Q+ +ETSTNS+ASI AW RGL HRA LD    + +FA  L
Sbjct: 298 GKIVEAEAAHGTVTRHYRQYQKNEETSTNSIASIFAWTRGLTHRAKLDNNEKLKNFATTL 357

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E  CI+T+ +G MTKDL++ +     GSK++ +L+T  F+D + + L   M
Sbjct: 358 ESVCIKTVEEGFMTKDLALLI-----GSKQK-WLSTTGFLDKIDENLKKAM 402

emb|CAG59886.1| unnamed protein product [Candida glabrata CBS138]
ref|XP_446953.1| unnamed protein product [Candida glabrata]
(418 aa)

Score: 496 bits (1278), Expect: 5.52969e-139
Length: 409, Idn/Pos/Gap = 242/316/10 (59%/77%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V+NPIVE+DGDE  RVIW ++K+KLI PYL++D+ Y+DL +  RD T+D VT++AA 
Sbjct:   4 KIKVKNPIVEMDGDEMTRVIWGMVKDKLIYPYLDVDLKYYDLSIQHRDETEDRVTVDAAE  63

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A  +H  A+K ATITPDEAR++EFHLK+M+ SPNGT+RN+L GTVFREPI++  IPR+VP
Sbjct:  64 ATLKHGVAIKCATITPDEARMKEFHLKKMWKSPNGTIRNILGGTVFREPIIIPRIPRIVP 123

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERR-QVHQFASSTDGGGV 248
            W +PI+I RH FGDQYKA D  +    ++EL    A G    +  +V+ + S     GV
Sbjct: 124 TWNKPIIIGRHAFGDQYKASDAVIKEPGKLELVFTPASGQGNPKTIKVYDYKSP----GV 179

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           AL M+NTDESI  FAR+ FE A++RKLP++ +TKNTILK YDGR++DIFQ++Y+ DY+ +
Sbjct: 180 ALAMYNTDESITGFARASFELAIKRKLPLFFTTKNTILKKYDGRFKDIFQKMYDEDYKGK 239

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    + YEHRLIDDMVAQ +KS GGF+ A KNYDGDVQSDI+AQG+GSLGLM+S LLTP
Sbjct: 240 FKELGISYEHRLIDDMVAQMIKSKGGFIIAMKNYDGDVQSDIVAQGFGSLGLMTSTLLTP 299

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGK   +EAAHGTVTRH+R +Q+GKETSTNS+A+I AW++G+ HR  +D TPDV  F E 
Sbjct: 300 DGKIFESEAAHGTVTRHYRQYQKGKETSTNSIATIFAWSQGIIHRGKVDQTPDVRLFGEI 359

Query: 429 LERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LERS I+T+ +DG MTKDL++ +  TE    R++Y +TEEFIDAV +RL
Sbjct: 360 LERSTIDTVQIDGIMTKDLALILGKTE----RKDYASTEEFIDAVARRL 404

ref|YP_032403.1| NADP-dependent isocitrate dehydrogenase [Bartonella quintana str. Toulouse]
emb|CAF26261.1| NADP-dependent isocitrate dehydrogenase [Bartonella quintana str. Toulouse]
(404 aa)

Score: 494 bits (1273), Expect: 1.69149e-138
Length: 411, Idn/Pos/Gap = 224/306/11 (54%/74%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V+NPIVE+DGDE  R+IW  IK+KLI PYL++D+ Y+DL +  RD T+D VT+++A 
Sbjct:   3 KIKVQNPIVEIDGDEMTRIIWKYIKDKLIHPYLDIDLKYYDLSVENRDTTNDQVTIDSAN  62

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   +K ATITPDEARV+EF+LK+M+ SPNGT+RN+L G +FREPI+ +N+PRLVP
Sbjct:  63 AIKKYGVGIKCATITPDEARVKEFNLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLVP 122

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            W +PI+I RH FGDQYKA D + P   ++ ++ +      +E    H    +   G VA
Sbjct: 123 NWTKPIIIGRHAFGDQYKATDFKFPGKGKLSIKFVGDDNQVIE----HDVFDAPSAG-VA 177

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           + M+N DESI +FAR+ F + L+R +P+YLSTKNTILK YDGR++DIFQE+++ +++  F
Sbjct: 178 MAMYNLDESICDFARASFNYGLQRNVPVYLSTKNTILKSYDGRFKDIFQEIFDAEFKAEF 237

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               L YEHRLIDDMVA ALK SGG++WACKNYDGDVQSDI+AQG+GSLGLM+SVL+TPD
Sbjct: 238 ENRKLHYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPD 297

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GK + AEAAHGTVTRH+R +Q+ +ETSTNS+ASI AW RGL HRA LD    + +FA  L
Sbjct: 298 GKIVEAEAAHGTVTRHYRQYQKNEETSTNSIASIFAWTRGLTHRAKLDNNEKLKNFATTL 357

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E  CI+T+ +G MTKDL++ +        ++ +L+T  F+D + + L   M
Sbjct: 358 EEVCIKTVEEGFMTKDLALLI------GPKQKWLSTTGFLDKIHENLKKAM 402

gb|EAA63570.1| IDHP_ASPNG ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL PRECURSOR (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) [Aspergillus nidulans FGSC A4]
ref|XP_407136.1| IDHP_ASPNG ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL PRECURSOR (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) [Aspergillus nidulans FGSC A4]
(491 aa)

Score: 494 bits (1272), Expect: 2.50369e-138
Length: 412, Idn/Pos/Gap = 237/308/12 (57%/74%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V+NP+VELDGDE  R+IW  I+ K    +L++D+ Y+DLGL  RD TDD VT E+A 
Sbjct:  87 KIKVKNPVVELDGDEMTRIIWKEIREKA--SFLDIDLKYYDLGLEYRDQTDDKVTTESAE 144

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   VK ATITPDEARVEEF LK+M+ SPNGT+RN+L GTVFREPI++  IPRLVP
Sbjct: 145 AIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILGGTVFREPIVIPRIPRLVP 204

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
           GW +PI+I RH FGDQY+A D  +P   ++EL V   +G + E  +V  F     GGGV 
Sbjct: 205 GWTKPIIIGRHAFGDQYRATDRVIPGPGKLEL-VYTPEGGQPEAIKVFDFP----GGGVT 259

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
              +NTDESIR FA + F+ AL + LP+Y+STKNTILK YDGR++DIFQE++E DY++ F
Sbjct: 260 QTQYNTDESIRGFAHASFKLALTKGLPLYMSTKNTILKKYDGRFKDIFQEIFESDYKKEF 319

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
               +WYEHRLIDDMVAQ +KS GGF+ A KNYDGDVQSDI+AQG+GSLGLM+S L+TPD
Sbjct: 320 DAKGIWYEHRLIDDMVAQMIKSEGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSTLITPD 379

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           G+   +EAAHGTVTRH+R HQ+G+ETSTN +ASI AW RGL  R  LD TPDV  FAE L
Sbjct: 380 GQAFESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLIQRGKLDETPDVVKFAEEL 439

Query: 430 ERSCIETI-LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           ER+CI+ +  +G MTKDL+++    E    R+ ++ T E++ AV++RL  ++
Sbjct: 440 ERACIDVVNEEGIMTKDLALSCGRKE----RDAWVTTREYMAAVERRLRANL 487

gb|AAC50455.1| isocitrate dehydrogenase
(419 aa)

Score: 490 bits (1262), Expect: 3.27087e-137
Length: 376, Idn/Pos/Gap = 222/286/4 (59%/76%/1%)

Query: 102 LNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPS 161
           L++ + YFDLGLP RD TDD VT+++A A Q++  AVK ATITPDEARVEEF LK+M+ S
Sbjct:  42 LDVQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKS 101

Query: 162 PNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVEL 221
           PNGT+RN+  GTVFREPI+ +NIPRLVPGW +PI I RH  GDQYKA D     A   ++
Sbjct: 102 PNGTIRNIHGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKM 161

Query: 222 RVLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLST 281
                 G  ++  +V+ F +    GGV +GM+NTDESI  FA SCF++A+++K P+Y+ST
Sbjct: 162 VFTPKDGSGVKEWEVYNFPA----GGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMST 217

Query: 282 KNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKN 341
           KNTILK YDGR++DIFQE++++ Y+  F +  +WYEHRLIDDMVAQ LKSSGGF+WACKN
Sbjct: 218 KNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKN 277

Query: 342 YDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVA 401
           YDGDVQSDI+AQG+GSLGLM+SVL+ PDGKT+ AEAAHGTVTRH+R HQ+G+ TSTN +A
Sbjct: 278 YDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIA 337

Query: 402 SIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKREN 461
           SI AW RGL HR  LDG  D+  FA+ LE+ C+ET+  G MTKDL+  ++G       E+
Sbjct: 338 SIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEH 397

Query: 462 YLNTEEFIDAVQQRLD 477
           +LNT +F+D ++  LD
Sbjct: 398 FLNTTDFLDTIKSNLD 413

gb|AAA64516.1| isocitrate dehydrogenase
(411 aa)

Score: 484 bits (1246), Expect: 2.72392e-135
Length: 409, Idn/Pos/Gap = 226/298/8 (55%/72%/1%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V NPIVE+DGDEQ R+IW   ++KL+LPYL++D+ Y+DL +  RD T+D VT+++A
Sbjct:   2 TKIKVANPIVEMDGDEQTRIIWSFNQDKLVLPYLDVDLKYYDLSVEYRDQTNDQVTVDSA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A  ++  AVK ATITPDEARVEEFHLK+M+ SPNGT+RN+L GTVFREPI++  IPRLV
Sbjct:  62 TATLKYRVAVKCATITPDEARVEEFHLKKMWKSPNGTIRNILGGTVFREPIIIPRIPRLV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
           P W++PI+I RH FGDQYKA D+ VP    + L      G      +V  +    + GGV
Sbjct: 122 PQWEKPIIIGRHAFGDQYKATDVIVPEEGELRLVYKSKSGTHDVDLKVFDYP---EHGGV 178

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           A+ M+N  +SI  FA++ FE A+ RKLP+Y +TKNTILK YDG+++D+F+ +Y    +  
Sbjct: 179 AMMMYNNTDSIEGFAKASFELAIERKLPLYSTTKNTILKKYDGKFKDVFEAMYLEVIKRS 238

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
                +WYEHRLIDDMVAQ LKS GG++ A KNYDGDV+SDI+AQG+GSLGLM+SVL+TP
Sbjct: 239 LESLGIWYEHRLIDDMVAQMLKSKGGYIMAMKNYDGDVESDIVAQGFGSLGLMTSVLITP 298

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGKT  ++ AHGTVTRH   + +G+ETSTNS+ASI AW RG+  R  LD TPDV  F + 
Sbjct: 299 DGKTFESDRAHGTVTRHLTDYDKGRETSTNSIASIFAWTRGIIQRGKLDNTPDVVKFGQI 358

Query: 429 LERSCIETIL-DGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LE + + T+  DG MTKDL++ +  +E    R  Y+ TEEFIDAV+ RL
Sbjct: 359 LESATVNTVQEDGIMTKDLALILGKSE----RSAYVTTEEFIDAVESRL 403

ref|ZP_00314344.1| COG0538: Isocitrate dehydrogenases [Clostridium thermocellum ATCC 27405]
(402 aa)

Score: 435 bits (1118), Expect: 1.83294e-120
Length: 409, Idn/Pos/Gap = 208/292/11 (50%/71%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           SKI+++ P+VE+DGDE  R+IW LIK  L+ PY+ L+  Y+DLGL  RD T+D VT++AA
Sbjct:   2 SKIKMKVPLVEMDGDEMTRIIWRLIKENLLEPYIELNTEYYDLGLENRDKTEDQVTIDAA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
           RA+Q++   VK ATITP+  RVEE++LK+M+ SPNGT+R +L+GTVFR PI+V +I   V
Sbjct:  62 RAIQKYGVGVKCATITPNAQRVEEYNLKKMWKSPNGTIRAILDGTVFRAPIVVNSIKPFV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
            GWK+PI IARH +GD YK  +  VP A + EL V  ++  E+ R+ +H+F    DG GV
Sbjct: 122 KGWKKPISIARHAYGDVYKNVEYYVPSAGKAEL-VFTSENGEVSRQTIHEF----DGPGV 176

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
            +GM NTD+SIR+FAR+CF +AL     ++ STK+TI K YD R++DIFQE+YE +Y+E+
Sbjct: 177 IMGMHNTDKSIRSFARACFNYALDMNQDLWFSTKDTISKTYDHRFKDIFQEIYENEYKEK 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
           F    L Y + LIDD VA+ ++S GG +WACKNYDGDV SD++A  +GSL +M+SVL++P
Sbjct: 237 FEAKNLQYFYTLIDDAVARIIRSEGGMVWACKNYDGDVMSDMVASAFGSLAMMTSVLVSP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGK    EAAHGTVTRH+  H +G+ETSTNS+A+I AW   L  R  LDG  ++  FA  
Sbjct: 297 DGKYEF-EAAHGTVTRHYYKHLKGEETSTNSMATIFAWTGALKKRGELDGIKELVDFATK 355

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           LE++ ++TI +G MTKDL+     +E   K+   +NTE+F+  +++  +
Sbjct: 356 LEQASVQTIENGVMTKDLASL---SEVPEKK--IVNTEDFLKEIRKTFE 399

ref|NP_622070.1| Isocitrate dehydrogenases [Thermoanaerobacter tengcongensis MB4]
gb|AAM23674.1| Isocitrate dehydrogenases [Thermoanaerobacter tengcongensis MB4]
(403 aa)

Score: 421 bits (1081), Expect: 3.60718e-116
Length: 408, Idn/Pos/Gap = 203/287/11 (49%/70%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI ++ PIVE+DGDE  R+IW LIK  LI PY++L   Y+DLG+  RD T+D VT++AA 
Sbjct:   4 KIEMKVPIVEMDGDEMTRIIWKLIKEMLIKPYVDLKTEYYDLGIKNRDETEDQVTVDAAY  63

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   VK ATITP+  RV+E++LK M+ SPN T+R++L+GTVFR PILVE I  LV 
Sbjct:  64 AIKKYGVGVKCATITPNAERVKEYNLKNMWKSPNATIRSILDGTVFRTPILVEGIKPLVR 123

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            WK+PI IARH +GD YK  + R+P   + EL     +G E+ R  +H+F +     GV 
Sbjct: 124 TWKKPITIARHAYGDIYKGVEYRIPEKGKAELVFTSEKGEEI-RYAIHEFETP----GVI 178

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           LGM NTDESI++FAR+CF +AL  K  ++ +TK+TI K+YD R++DIFQE+YE +Y+E+F
Sbjct: 179 LGMHNTDESIKSFARACFNYALDTKQDLWFATKDTISKIYDHRFKDIFQEIYENEYKEKF 238

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
             A + Y + LIDD VA+ ++S GG +WACKNYDGDV SD++A  +GSL +M+SVL++PD
Sbjct: 239 EEAGIEYFYTLIDDAVARIVRSEGGMIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPD 298

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           GK    EAAHGTVTRH+  + +G+ETSTN +A+I AW   L  R  LDG  D+  FA+ L
Sbjct: 299 GKYEF-EAAHGTVTRHYYKYLKGEETSTNPIATIFAWTGALKKRGELDGIKDLVDFADKL 357

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           E++ ++T+  G MTKDL+     +E  +K    +NTE F+  +++ L+
Sbjct: 358 EKASLKTVEKGIMTKDLAAL---SELPNK--TVVNTETFLIEIKKTLE 400

ref|YP_003151.1| isocitrate dehydrogenase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
ref|NP_714247.1| Isocitrate dehydrogenases [Leptospira interrogans serovar Lai str. 56601]
gb|AAN51265.1| Isocitrate dehydrogenases [Leptospira interrogans serovar lai str. 56601]
gb|AAS71788.1| isocitrate dehydrogenase [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
(398 aa)

Score: 419 bits (1078), Expect: 8.17117e-116
Length: 408, Idn/Pos/Gap = 204/288/11 (50%/70%/2%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +KI+V+ P+VELDGDE  R+IW  IK++ I PYL++++ Y+DLG+  RD TDD VT+++A
Sbjct:   2 AKIKVKTPLVELDGDEMTRIIWKEIKDRFIHPYLDIELDYYDLGVEYRDKTDDKVTVDSA  61

Query: 129 RAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLV 188
            A+Q++   VK ATITP++ RV+E++LK+ + SPNGT+R++L+GTVFR+PI+V+NIP  V
Sbjct:  62 HAIQKYGVGVKCATITPNQDRVKEYNLKQEWKSPNGTIRSILDGTVFRKPIIVKNIPPAV 121

Query: 189 PGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGV 248
             WK+PI + RH +GD YK  +L +P A +VEL      G E +R  +H F    +G GV
Sbjct: 122 RSWKKPITVGRHAYGDLYKDTELYIPEAGKVELVYTGKDGKEKQRALIHDF----EGAGV 177

Query: 249 ALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
            +G  N D+SI +FA++CF +A+  K+ ++ +TK+TI K Y  R+R IF E   +     
Sbjct: 178 IMGQHNLDKSILSFAQACFNYAISEKIDLWFATKDTISKKYHARFRAIFDE-LAKAKAAD 236

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTP 368
             +A + Y + LIDD VAQ +K+ GG LWA  NYDGDV SD++A G+GSLGLM+SVL++P
Sbjct: 237 LKKAGIEYSYYLIDDAVAQLMKNEGGMLWALMNYDGDVMSDMVASGFGSLGLMTSVLVSP 296

Query: 369 DGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEA 428
           DGK    EAAHGTVTRH+R +QQG+ TSTNSVASI AW   L  R  LDGTPDV  F   
Sbjct: 297 DGK-FEYEAAHGTVTRHYRKYQQGETTSTNSVASIFAWTGALIKRGELDGTPDVVAFGHK 355

Query: 429 LERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           LE++ I+TI  G+MTKDL++    T+  +K    L+T +F++A+Q+RL
Sbjct: 356 LEKAVIDTIESGEMTKDLTLLC--TDSNAKA---LDTFQFMEAIQKRL 398

ref|NP_228954.1| isocitrate dehydrogenase [Thermotoga maritima MSB8]
gb|AAD36224.1| isocitrate dehydrogenase [Thermotoga maritima MSB8]
pir||H72288 isocitrate dehydrogenase - Thermotoga maritima (strain MSB8)
(399 aa)

Score: 414 bits (1063), Expect: 3.76303e-114
Length: 408, Idn/Pos/Gap = 204/284/14 (50%/69%/3%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           K++V+NPIVELDGDE ARV+W +IK KLILPYL++ +VYFDLG+  RD TDD +T+EAA+
Sbjct:   3 KVKVKNPIVELDGDEMARVMWKMIKEKLILPYLDIQLVYFDLGIKKRDETDDQITIEAAK  62

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   VK ATITPD  RV+E++LK+ + SPN T+R  L+GTVFR+PI+V+N+P LV 
Sbjct:  63 AIKKYGVGVKCATITPDAERVKEYNLKKAWKSPNATIRAYLDGTVFRKPIMVKNVPPLVK 122

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            WK+PI+I RH +GD Y A + +V     VEL V + +   L    VH+F    +G GV 
Sbjct: 123 RWKKPIIIGRHAYGDIYNAVEAKVEGPAEVELVVRNKENKTL---LVHKF----EGNGVV 175

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           + M N ++SIR+FA+SC  +A+  K+ ++ +TK+TI KVY   ++DIFQE  ++  +E  
Sbjct: 176 MAMHNLEKSIRSFAQSCINYAISEKVDIWFATKDTISKVYHAYFKDIFQEEVDKR-KEEL 234

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
            +A + Y + LIDD  AQ L+S GG LWAC NY+GD+ SD+IA G+GSLGLM+SVL++PD
Sbjct: 235 EKAGVNYRYMLIDDAAAQILRSEGGMLWACMNYEGDIMSDMIASGFGSLGLMTSVLVSPD 294

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           G     EAAHGTV RH+  + +G++TSTN  ASI AW   +  R  LDGTP+V  FA+ L
Sbjct: 295 G-VYEFEAAHGTVRRHYYRYLKGEKTSTNPTASIFAWTGAIRKRGELDGTPEVCEFADKL 353

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           E++ I TI  G +TKDL      TE     + Y+  EEFID V++ L+
Sbjct: 354 EKAVINTIESGVITKDLQPF---TE--PPIDKYVTLEEFIDEVKKNLE 396

ref|ZP_00097880.2| COG0538: Isocitrate dehydrogenases [Desulfitobacterium hafniense DCB-2]
(398 aa)

Score: 405 bits (1041), Expect: 1.50423e-111
Length: 404, Idn/Pos/Gap = 198/278/15 (49%/68%/3%)

Query:  76 PIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHH 135
           P+VE+DGDE  R+IW  IK  L+ PY+ L   Y+DLGL  RD TDD +T++AA A +++ 
Sbjct:   4 PLVEMDGDEMTRIIWDYIKEILLYPYIELKTEYYDLGLQKRDETDDQITVDAALATKKYG  63

Query: 136 AAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPI 195
            AVK ATITP+  RVEE++LK+M+ SPNGT+R +L+GTVFR P+LVE I  LV  WK+PI
Sbjct:  64 VAVKCATITPNAQRVEEYNLKQMWKSPNGTIRALLDGTVFRAPVLVEGIKPLVTTWKKPI 123

Query: 196 VIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNT 255
            IARH +GD YK  + RV    + EL V   +  E  R+ +  F    +G G+ +GM N 
Sbjct: 124 TIARHAYGDIYKNVEYRVGGPGKAEL-VFSGEHGEESRQTICNF----EGKGILMGMHNL 178

Query: 256 DESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALW 315
           D SI +FAR+CF +AL  K  ++ +TK+T+ K YD  ++DIFQE+Y+++Y+ERF  A L 
Sbjct: 179 DSSIESFARACFNYALDVKQDVWFATKDTVSKQYDHTFKDIFQEVYDKEYKERFAAAQLE 238

Query: 316 YEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLA 375
           Y + LIDD VA+ ++S GG++WACKNYDGDV SD++A  +GSL +M+SVL++P+G     
Sbjct: 239 YFYTLIDDAVARVIRSEGGYIWACKNYDGDVMSDMVATAFGSLAMMTSVLVSPEG-NFEY 297

Query: 376 EAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIE 435
           EAAHGTVTRH+  H +G+ETSTN +A+I AW   L  R  LDG PD+A FA  LE + ++
Sbjct: 298 EAAHGTVTRHYYQHLKGEETSTNPIATIFAWTGALKKRGELDGLPDLADFAAQLEEASLK 357

Query: 436 TILDGKMTKDLSIAVYGTEQGSKRENY--LNTEEFIDAVQQRLD 477
           TI  G MTKDL++        S+  N   +NT++F++ +++ LD
Sbjct: 358 TIEAGIMTKDLALI-------SELPNIKTVNTKDFLEEIKKTLD 394

ref|ZP_00049780.2| COG0538: Isocitrate dehydrogenases [Magnetospirillum magnetotacticum MS-1]
(328 aa)

Score: 384 bits (987), Expect: 2.81736e-105
Length: 298, Idn/Pos/Gap = 176/230/6 (59%/77%/2%)

Query: 158 MYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPAC 217
           M+ SPNGT+RN+L G +FREPI+  N+PRLVPGW QP VI RH +GDQY+A D +VP   
Sbjct:   1 MWRSPNGTIRNILGGVIFREPIICSNVPRLVPGWTQPFVIGRHAYGDQYRATDFKVPGKG  60

Query: 218 RVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPM 277
           R+ ++     G  +E+ +V +F  +    GVA+ M+N D+SI +FAR+ F + L RK P+
Sbjct:  61 RLTIKFEGDDGTVIEK-EVFKFPDA----GVAMSMYNLDQSIIDFARASFNYGLARKYPV 115

Query: 278 YLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLW 337
           YLSTKNTILKVYDGR++D+FQ++++ +++ +F    L YEHRLIDDMVA  LK SGG++W
Sbjct: 116 YLSTKNTILKVYDGRFKDLFQKVFDEEFKSKFQSLGLVYEHRLIDDMVASCLKWSGGYVW 175

Query: 338 ACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETST 397
           ACKNYDGDVQSD  AQG+GSLGLM+SVL+TPDG+T+ AEAAHGTVTRH+R HQ+GK TST
Sbjct: 176 ACKNYDGDVQSDTAAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYREHQKGKATST 235

Query: 398 NSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQ 455
           NS+ASI AW RGLAHRA LDG  ++A FA  LE+ C++T+  G MTKDL++ V G +Q
Sbjct: 236 NSIASIFAWTRGLAHRAKLDGNAELATFASTLEKVCVDTVESGFMTKDLALLV-GPDQ 292

emb|CAA76364.1| isocitrate dehydrogenase (NADP+) [Piromyces sp. E2]
(287 aa)

Score: 383 bits (983), Expect: 8.12916e-105
Length: 287, Idn/Pos/Gap = 167/223/4 (58%/77%/1%)

Query:  87 RVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPD 146
           R+IW +IK +LI PY++L+I Y+DL +  RD T+D +T+++A A ++   A+K ATITPD
Sbjct:   3 RIIWKMIKEQLIFPYVDLNIQYYDLSIQKRDETNDQITIDSAEATKKCGVAIKCATITPD  62

Query: 147 EARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQY 206
           EARV+EF+LK+M+ SPNGT+RN+L GTVFR PI+++ +PRLVPGW +PI I RH FGDQY
Sbjct:  63 EARVKEFNLKKMWKSPNGTIRNILGGTVFRAPIVLKRVPRLVPGWTKPITIGRHAFGDQY 122

Query: 207 KAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSC 266
           +A D   P   + ++ +    G +     V  +     G GV +GM+NTDESIR FA+SC
Sbjct: 123 RATDFVTPGPGKFQIVLTPEDGSDPITYDVFNY----KGTGVGMGMYNTDESIRGFAQSC 178

Query: 267 FEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVA 326
           F+ AL +K P+YLSTKNTILK YDGR++DIFQE+YE++Y+  F +  +WYEHRLIDDMVA
Sbjct: 179 FQMALSKKQPLYLSTKNTILKAYDGRFKDIFQEIYEKEYKAEFEKLGIWYEHRLIDDMVA 238

Query: 327 QALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTL 373
           Q +KS GGF+WA KNYDGDVQSDI+AQG+GSLGLM+S+L+TPDGKT+
Sbjct: 239 QTIKSEGGFVWATKNYDGDVQSDILAQGFGSLGLMTSILVTPDGKTV 285

gb|AAH74702.1| MGC69225 protein [Xenopus tropicalis]
ref|NP_001004863.1| MGC69225 protein [Xenopus tropicalis]
(284 aa)

Score: 383 bits (983), Expect: 8.76312e-105
Length: 278, Idn/Pos/Gap = 171/217/3 (61%/78%/1%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  RVIW LIK KLILPY+ LD+  +DLG+  RDATDD VT++AA A+++++ 
Sbjct:  10 VVEMQGDEMTRVIWDLIKEKLILPYVELDLHCYDLGIENRDATDDQVTVDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            +K ATITPDE RVEEF+LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GIKCATITPDEKRVEEFNLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 197 IARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
           I RH +GDQY+A D  VP   +VE+      G E  +  +H F    D GGVALGM+NTD
Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEISFTPKDGGEAIKYVIHNF---EDCGGVALGMYNTD 186

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           +SIR+FA S F+ AL +  P+Y+STKNTILK YDGR++DIFQE+YE+DY+ +F    +WY
Sbjct: 187 QSIRDFAHSSFQMALSKSWPLYMSTKNTILKKYDGRFKDIFQEIYEKDYKSQFEEKKIWY 246

Query: 317 EHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQG 354
           EHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQG
Sbjct: 247 EHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQG 284

emb|CAG35507.1| probable isocitrate dehydrogenase [Desulfotalea psychrophila LSv54]
ref|YP_064514.1| isocitrate dehydrogenase [Desulfotalea psychrophila LSv54]
(402 aa)

Score: 382 bits (980), Expect: 1.78102e-104
Length: 407, Idn/Pos/Gap = 188/274/11 (46%/67%/2%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+++ P+VELDGDE  RV+W LIK+KL+LP+++L   Y+DLG+  RD T+D +T++AA 
Sbjct:   2 KIQMKTPLVELDGDEMTRVLWPLIKDKLLLPFIDLQTEYYDLGIEERDRTNDQITIDAAE  61

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A++++   VK ATITP++ RVEE+ LK  + SPN T+R +L+GTVFR+PI+V+NI   V 
Sbjct:  62 AIKKYGVGVKNATITPNQDRVEEYGLKEQWKSPNATVRAMLDGTVFRKPIMVKNIKPSVR 121

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            W++PIV+ RH +GD YK  ++      ++E+ V D  G     ++  Q     D   + 
Sbjct: 122 SWQKPIVVGRHAYGDFYKNAEIFAEAGGKLEIVVTDKNG-----KETRQTIMEVDEPAIV 176

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
            G+ NT  SI +FAR+CFE++L +K+  + +TK+TI K YD R++ IF+E++ ++Y+E+F
Sbjct: 177 QGIHNTVASIGHFARACFEYSLDQKIDCWFATKDTISKQYDQRFKIIFEEIFAQEYKEKF 236

Query: 310 TRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
             A + Y + LIDD+VA+ +K+ GG LWACKNYDGDV SD++A  +GSL +MSSVL++P 
Sbjct: 237 AAAGIEYFYTLIDDVVARMMKTEGGMLWACKNYDGDVMSDMVASAFGSLAMMSSVLVSPY 296

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           G     EAAHGTV RH+  H +G+ TSTN VA I AW   L  R  LDGTPD+  F ++L
Sbjct: 297 G-YFEYEAAHGTVQRHYYQHLKGERTSTNPVALIYAWTGALRKRGELDGTPDLCAFCDSL 355

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           E   IE I  G MT DL+      E  + +   L++ EFID + +RL
Sbjct: 356 EAITIECIESGYMTGDLARIC---EPAAIK--VLDSIEFIDELGKRL 397

gb|EAA21953.1| isocitrate dehydrogenase, NADP-dependent, putative [Plasmodium yoelii yoelii]
(371 aa)

Score: 373 bits (958), Expect: 6.3876e-102
Length: 304, Idn/Pos/Gap = 168/225/4 (55%/74%/1%)

Query:  52 RTTGRSLCANMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDL 111
           R T R +    S      K++V NPIVELDGDE  +VIW  IK KLILPYL+L+I YFDL
Sbjct:  70 RITKRYVSNGQSAFNLSGKVKVENPIVELDGDEMTKVIWKDIKEKLILPYLDLNIKYFDL 129

Query: 112 GLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLN 171
            +  RD T+D +TL+AA+ ++++   +K ATITPD ARV+EF+LK M+ SPNGT+RN+L+
Sbjct: 130 SIENRDKTNDQITLDAAQEIKKYSVGIKCATITPDSARVKEFNLKEMWKSPNGTIRNILD 189

Query: 172 GTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMEL 231
           GTVFR PIL++NIP+L+  WK+PIVI RH + DQYK + L+V  + + E+         +
Sbjct: 190 GTVFRAPILIKNIPKLISNWKKPIVIGRHAYADQYKQKSLKVTKSGKFEIVFTPDDNSPV 249

Query: 232 ERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDG 291
            R  +  F S     GV LGM+NT+ESI+NFA SCF++AL  K+P+Y STK+TILK+YDG
Sbjct: 250 VRETIFNFKSP----GVCLGMYNTEESIKNFALSCFQYALDLKMPVYFSTKSTILKIYDG 305

Query: 292 RWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDII 351
            ++DIFQ++YE+ +++ F +  LWYEH+LIDDMVAQ LKS GGF+WACKNYDGD+QSD +
Sbjct: 306 LFKDIFQDIYEQKFKKIFEQNNLWYEHKLIDDMVAQVLKSEGGFVWACKNYDGDIQSDAV 365

Query: 352 AQGY 355
           AQGY
Sbjct: 366 AQGY 369

emb|CAH74916.1| isocitrate dehydrogenase (NADP), mitochondrial precursor, putative [Plasmodium chabaudi]
(298 aa)

Score: 318 bits (814), Expect: 3.23847e-85
Length: 273, Idn/Pos/Gap = 143/204/5 (52%/74%/1%)

Query: 209 QDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFE 268
           + L++  + + E+         + R  +  F S     GV LGM+NT+ESI+NFA SCF+
Sbjct:   1 KSLKITKSGKFEIVFTPDDNSSVVRETIFDFKSP----GVCLGMYNTEESIKNFALSCFQ  56

Query: 269 FALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQA 328
           +AL  K+P+Y STK+TILK+YDG ++DIFQ++YE+ +++ F +  LWYEH+LIDDMVAQ 
Sbjct:  57 YALDLKMPVYFSTKSTILKIYDGLFKDIFQDIYEQKFKKVFEQNNLWYEHKLIDDMVAQV 116

Query: 329 LKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRL 388
           LKS GGF+WACKNYDGD+QSD +AQGYGSLGLMSS+L+ PDG T ++EAAHGTVT+H+R 
Sbjct: 117 LKSEGGFVWACKNYDGDIQSDAVAQGYGSLGLMSSILMCPDGVTCISEAAHGTVTKHYRA 176

Query: 389 HQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSI 448
           +Q+G++TSTN +ASI AW RGL HRA LD   ++  F  ALE++CIET+ +G M KDL++
Sbjct: 177 YQRGEKTSTNPIASIFAWTRGLQHRAKLDQNKNLQQFCYALEKACIETVENGLMPKDLAV 236

Query: 449 AVYGTEQGSKRENYLNTEEFIDAVQQRLDVHML 481
            + G +  ++++ YL T++FIDA+ + L + +L
Sbjct: 237 CIKGIKNVTEKD-YLFTDDFIDAINENLKLKLL 268

gb|EAK94343.1| hypothetical protein CaO19.11218 [Candida albicans SC5314]
(270 aa)

Score: 305 bits (781), Expect: 2.15419e-81
Length: 260, Idn/Pos/Gap = 142/191/4 (54%/73%/1%)

Query:  70 KIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAAR 129
           KI+V+NPIVE+DGDE  R+IW  IK+KLI PYL++D+ Y+DLG+  RD TDD VT +AA 
Sbjct:   6 KIKVKNPIVEMDGDEMTRIIWQFIKDKLITPYLDVDLKYYDLGIEYRDQTDDKVTTDAAN  65

Query: 130 AVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVP 189
           A+ ++   VK ATITPDEARV+EF+LK+M+ SPNGTLRN+L GTVFREPI+++NIPR+VP
Sbjct:  66 AILKYGVGVKCATITPDEARVKEFNLKKMWLSPNGTLRNILGGTVFREPIVIDNIPRIVP 125

Query: 190 GWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVA 249
            W++PI+I RH FGDQYKA D+ VP A  ++L      G E++   V+ F    +G GV 
Sbjct: 126 SWEKPIIIGRHAFGDQYKATDIVVPGAGELKLVFRPKDGGEIQEYPVYNF----EGPGVG 181

Query: 250 LGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERF 309
           L M+NTD SI++FA S F+ A+ RKL ++ STKNTILK YDGR +   ++    + R ++
Sbjct: 182 LSMYNTDASIQDFAESSFQLAIERKLNLFSSTKNTILKKYDGRLKIFSKDYMPVNTRLKW 241

Query: 310 TRAALWYEHRLIDDMVAQAL 329
            + A   +HR+IDDMVAQ L
Sbjct: 242 VKWAFCTKHRIIDDMVAQML 261

emb|CAA65773.1| isocitrate dehydrogenase (NADP+) [Eucalyptus globulus subsp. bicostata]
(219 aa)

Score: 301 bits (771), Expect: 2.98354e-80
Length: 211, Idn/Pos/Gap = 138/171/2 (65%/81%/0%)

Query: 270 ALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQAL 329
           A ++K P+YLSTKNTILK YDGR++DIFQE+YE +++ +F  A +WYEHRLIDDMVA AL
Sbjct:   5 AYQKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKSKFEAAGIWYEHRLIDDMVAYAL  64

Query: 330 KSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLH 389
           KS GG++WACKNYDGDVQSD +AQG+GSLGLM+SVL+ PDGKT+ AEAAHGTVTRH+R+H
Sbjct:  65 KSDGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRVH 124

Query: 390 QQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIA 449
           Q+G ETSTNS+ASI AW+RGLAHRA LD    +  FAE LE +CI T+  GKMTKDL++ 
Sbjct: 125 QKGGETSTNSIASIFAWSRGLAHRAKLDNNAKLLDFAEKLEAACIGTVESGKMTKDLALL 184

Query: 450 VYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           ++G +    R+ YLNTEEFIDAV   L   +
Sbjct: 185 IHGPK--FTRDQYLNTEEFIDAVAVELKARL 213

gb|AAD55056.1| isocitrate dehydrogenase [Beta vulgaris]
(239 aa)

Score: 297 bits (761), Expect: 4.88263e-79
Length: 243, Idn/Pos/Gap = 139/181/5 (57%/74%/2%)

Query:  78 VELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHAA 137
           VE+DGDE  RV W  IK KLI P+L LDI YFDLGLP RDAT+D VT+E+A A  +++ A
Sbjct:   1 VEMDGDEMTRVFWKSIKEKLIYPFLELDIKYFDLGLPNRDATNDKVTIESAEATLKYNVA  60

Query: 138 VKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIVI 197
           +K ATITPDE RV+EF+LK+M+ SPNGT+RN+LNGTVFREPI+  N+P+LVPGW +PI I
Sbjct:  61 IKCATITPDEGRVKEFNLKQMWRSPNGTIRNILNGTVFREPIICRNVPKLVPGWTKPICI 120

Query: 198 ARHGFGDQYKAQDLRVPPACRVELR-VLDAQGMELERRQVHQFASSTDGGGVALGMFNTD 256
            RH FGDQY+A +  +  A  +++  V D QG   E  +V++F      GGVA+ M+NTD
Sbjct: 121 GRHAFGDQYRASEEIIRGAGTLKMVFVPDGQGGNTE-LEVYRFKHP---GGVAMSMYNTD 176

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           ESI+ FA +    AL++K P+YLSTKNTILK YDGR++DIFQE+YE  ++ +F    +WY
Sbjct: 177 ESIQAFAEASMNTALQKKWPLYLSTKNTILKKYDGRFKDIFQEVYESKWKSKFEAIGIWY 236

Query: 317 EHR 319
           EHR
Sbjct: 237 EHR 239

emb|CAC29022.1| isocitrate dehydrogenase [Kluyveromyces lactis]
(217 aa)

Score: 282 bits (722), Expect: 1.57205e-74
Length: 212, Idn/Pos/Gap = 132/163/5 (62%/76%/2%)

Query: 267 FEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVA 326
           FE AL R LP+Y +TKNTILK YDG+++D+F+ LYE  Y+  F    +WYEHRLIDDMVA
Sbjct:   2 FEMALERGLPLYSTTKNTILKKYDGKFKDVFESLYESQYKSAFEAKGIWYEHRLIDDMVA  61

Query: 327 QALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHF 386
           Q LKS GG++ A KNYDGDV+SDI+AQG+GSLGLM+SVL+TPDGK   +EAAHGTVTRH+
Sbjct:  62 QMLKSKGGYIIAMKNYDGDVESDIVAQGFGSLGLMTSVLITPDGKAFESEAAHGTVTRHY 121

Query: 387 RLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETIL-DGKMTKD 445
           R HQQGKETSTNS+ASI AW RGL  R  LD TPDV  FAE +E + + T+  D  MTKD
Sbjct: 122 RQHQQGKETSTNSIASIFAWTRGLIQRGKLDSTPDVVKFAELVESATVNTVQEDEIMTKD 181

Query: 446 LSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
           L++ +  T+    R +Y+ TEEFI+AV +RLD
Sbjct: 182 LALILGKTD----RSSYVTTEEFIEAVHKRLD 209

emb|CAH86836.1| hypothetical protein PC302184.00.0 [Plasmodium chabaudi]
(218 aa)

Score: 268 bits (686), Expect: 2.23442e-70
Length: 222, Idn/Pos/Gap = 121/165/4 (54%/74%/1%)

Query:  76 PIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHH 135
           PIVELDGDE  ++IW  IK KLILPYL+L+I YFDL +  RD T+D +TLEAA+ ++++ 
Sbjct:   1 PIVELDGDEMTKIIWKDIKEKLILPYLDLNIKYFDLSIENRDKTNDQITLEAAQEIKKYG  60

Query: 136 AAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPI 195
             +K ATITPD ARV+EF+LK M+ SPNGT+RN+L+GTVFR PIL++NIP+L+  WK+PI
Sbjct:  61 VGIKCATITPDAARVKEFNLKEMWKSPNGTIRNILDGTVFRAPILIKNIPKLISNWKKPI 120

Query: 196 VIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNT 255
           VI RH + DQYK + L++  + + E+         + R  +  F S     GV LGM+NT
Sbjct: 121 VIGRHAYADQYKQKSLKITKSGKFEIVFTPDDNSSVVRETIFDFKSP----GVCLGMYNT 176

Query: 256 DESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIF 297
           +ESI+NFA SCF++AL  K+P+Y STK+TILK+YDG ++DIF
Sbjct: 177 EESIKNFALSCFQYALDLKMPVYFSTKSTILKIYDGLFKDIF 218

ref|XP_536047.1| PREDICTED: similar to cytosolic NADP+-dependent isocitrate dehydrogenase [Canis familiaris]
(354 aa)

Score: 251 bits (641), Expect: 3.54074e-65
Length: 188, Idn/Pos/Gap = 113/147/1 (60%/78%/0%)

Query: 295 DIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQG 354
           D   E+Y++ Y+ +F    +WYEHRLIDDMVAQA+KS GGF+WACKNYDGDVQSD +AQG
Sbjct: 165 DHSSEIYDKQYKSQFEAQNIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQG 224

Query: 355 YGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRA 414
           YGSLG+M+SVL+ PDGKT+ AEAAHGTVTRH+R++Q+G+ETSTN +ASI AW RGLAHRA
Sbjct: 225 YGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRA 284

Query: 415 TLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQ 474
            LD   +++ FA+ALE  C+ETI  G MTKDL+  + G     +R +YLNT EF+D + +
Sbjct: 285 KLDNNKELSFFAKALEEVCVETIEAGFMTKDLAACIKGLPN-VQRSDYLNTFEFMDKLGE 343

Query: 475 RLDVHMLQ 482
            L++ + Q
Sbjct: 344 NLNIKLAQ 351


Score: 181 bits (460), Expect: 3.27719e-44
Length: 129, Idn/Pos/Gap = 79/102/0 (61%/79%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHA 136
           +VE+ GDE  R+IW LIK KLI PY+ LD+  +DLG+  RDAT+D VT +AA A+++++ 
Sbjct:  10 VVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNV  69

Query: 137 AVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIV 196
            VK ATITPDE RVEEF LK+M+ SPNGT+RN+L GTVFRE I+ +NIPRLV GW +PI+
Sbjct:  70 GVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPII 129

Query: 197 IARHGFGDQ 205
           I RH +GDQ
Sbjct: 130 IGRHAYGDQ 138

ref|ZP_00049098.1| COG0538: Isocitrate dehydrogenases [Magnetospirillum magnetotacticum MS-1]
(193 aa)

Score: 243 bits (619), Expect: 1.28052e-62
Length: 192, Idn/Pos/Gap = 114/145/6 (59%/75%/3%)

Query: 289 YDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGFLWACKNYDGDVQS 348
           YD  ++DIFQE+++ ++ E F    L YEHRLIDDMVA A+K  GG++WACKNYDGDVQS
Sbjct:   7 YDVAFKDIFQEVFDAEFAEAFDAKGLTYEHRLIDDMVASAMKWEGGYVWACKNYDGDVQS  66

Query: 349 DIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWAR 408
           D +AQG+GSLGLM+SVL+TPDG+T+ AEAAHGTVTRH+R HQQGK TSTN +ASI AW R
Sbjct:  67 DTVAQGFGSLGLMTSVLMTPDGQTVEAEAAHGTVTRHYRQHQQGKPTSTNPIASIFAWTR 126

Query: 409 GLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEF 468
           GL HR  LDGTP+V  FA+ LE   I+T+  GKMTKDL++ + G +Q      +L TEEF
Sbjct: 127 GLMHRGKLDGTPEVTEFAQTLEDVVIKTVESGKMTKDLALLI-GPDQ-----EWLTTEEF 180

Query: 469 IDAVQQRLDVHM 480
           + A+ + L   +
Sbjct: 181 LAALDENLKARL 192

gb|AAX26279.1| unknown [Schistosoma japonicum]
(156 aa)

Score: 216 bits (550), Expect: 1.44253e-54
Length: 153, Idn/Pos/Gap = 99/122/1 (64%/79%/0%)

Query: 324 MVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVT 383
           MVAQALKS GGF+WACKNYDGDVQSDIIAQGYGSLGLM+SVL+ PDGKT+ AEAAHGTVT
Sbjct:   1 MVAQALKSDGGFVWACKNYDGDVQSDIIAQGYGSLGLMTSVLMCPDGKTIEAEAAHGTVT  60

Query: 384 RHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMT 443
           RH+R HQ+G  TSTN +ASI AW RGL HR  LDG   +  F   LE++CI+T+  GKMT
Sbjct:  61 RHYREHQKGLPTSTNPIASIFAWTRGLEHRGKLDGNNSLIRFCSNLEKACIDTVESGKMT 120

Query: 444 KDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           KDL+I ++G+ +  K ++Y+ T +F+DA+  RL
Sbjct: 121 KDLAICIHGS-KNVKSKDYMTTMDFLDAIVDRL 152

ref|XP_527228.1| PREDICTED: similar to Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) [Pan troglodytes]
(229 aa)

Score: 192 bits (489), Expect: 1.58441e-47
Length: 163, Idn/Pos/Gap = 92/121/1 (56%/74%/0%)

Query: 320 LIDDMVAQALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAH 379
           L DDM A+A+KS GGF+WACKNYDGD+QSD +AQGYGSLG+M+S+L+ P GKT+ AEAAH
Sbjct:  65 LADDMWARAMKSEGGFIWACKNYDGDMQSDSVAQGYGSLGMMTSMLVCPHGKTVEAEAAH 124

Query: 380 GTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILD 439
            TVTRH+ ++Q+G+E STN +ASI AW RGLA +A  D   ++A FA ALE  CIETI  
Sbjct: 125 WTVTRHYCMYQKGQEISTNPIASIFAWTRGLALQAKTDNNKELAFFANALEEVCIETIEA 184

Query: 440 GKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
           G MTKDL+  + G    ++  +YLNT EF+D + + L + + Q
Sbjct: 185 GFMTKDLAACIKGLPS-AQCSDYLNTFEFMDKLGENLKIKLAQ 226


Score: 54 bits (129), Expect: 8.50663e-06
Length: 52, Idn/Pos/Gap = 26/34/0 (50%/65%/0%)

Query:  77 IVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAA 128
           +VE+  DE  ++ W LIK KLI PY  LD   +DLG+   DAT+D VT +AA
Sbjct:  10 VVEMQRDEMTQITWELIKEKLIFPYGELDKHSYDLGIENCDATNDQVTKDAA  61

gb|AAB17375.1| putative cytosolic NADP-dependent isocitrate dehydrogenase [Homo sapiens]
(154 aa)

Score: 191 bits (485), Expect: 4.34838e-47
Length: 157, Idn/Pos/Gap = 85/112/3 (54%/71%/1%)

Query: 167 RNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDA 226
           RN+L GTVF E I+ +NIPRLV GW +PI+I RH +GDQY+A D  VP   +VE+    +
Sbjct:   1 RNILGGTVFXEAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPS  60

Query: 227 QGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTIL 286
            G +     VH F    +GGGVA+GM+N D+SI +FA S F+ AL +  P+YLSTKNTIL
Sbjct:  61 DGTQKVTYLVHNFE---EGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTIL 117

Query: 287 KVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDD 323
           K YDGR++DIFQE+Y++ Y+ +F    +WYEHRLIDD
Sbjct: 118 KKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDD 154

gb|AAD36990.1| NADP-dependent isocitrate dehydrogenase [Periplaneta americana]
(138 aa)

Score: 182 bits (462), Expect: 1.98647e-44
Length: 134, Idn/Pos/Gap = 85/102/1 (63%/76%/0%)

Query: 337 WACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETS 396
           W CKNYDGDVQSD +AQGYGSLG+M+SVL+ PDGKT+ AEAAHGTVTRH+R +Q GKETS
Sbjct:   1 WGCKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRFYQDGKETS  60

Query: 397 TNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQG 456
           TN +ASI AW RGL+HRA LD    + +FAE LE  C+ETI  G MTKDL+I + G    
Sbjct:  61 TNPIASIFAWTRGLSHRAKLDNNKQLENFAEKLEAVCVETIESGFMTKDLAICIKGMAN- 119

Query: 457 SKRENYLNTEEFID 470
            +R +YL T  F+D
Sbjct: 120 VQRSDYLETFSFMD 133

gb|EAK94342.1| hypothetical protein CaO19.11217 [Candida albicans SC5314]
(142 aa)

Score: 182 bits (462), Expect: 2.27018e-44
Length: 142, Idn/Pos/Gap = 89/110/5 (62%/77%/3%)

Query: 340 KNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNS 399
           KNYDGDVQSDI+AQG+GSLGLM+SVL+TPDGK   +EAAHGTVTRH+R HQQGK TSTNS
Sbjct:   2 KNYDGDVQSDIVAQGFGSLGLMTSVLVTPDGKAFESEAAHGTVTRHYRQHQQGKATSTNS  61

Query: 400 VASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI-LDGKMTKDLSIAVYGTEQGSK 458
           +ASI AW RGL  R  LD TP+V  FAE LE++ I+T+  D  MTKDL++    T+  + 
Sbjct:  62 IASIYAWTRGLIQRGKLDETPEVVKFAEDLEKAIIDTVGKDNIMTKDLAL----TQGKTD 117

Query: 459 RENYLNTEEFIDAVQQRLDVHM 480
           R +Y+ TEEFIDAV  RL+ ++
Sbjct: 118 RSSYVTTEEFIDAVANRLNKNL 139

gb|AAS78670.1| NADP-dependent isocitrate dehydrogenase [Capsicum annuum]
(139 aa)

Score: 169 bits (427), Expect: 2.40952e-40
Length: 142, Idn/Pos/Gap = 78/101/3 (54%/71%/2%)

Query: 202 FGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRN 261
           FGDQY+A D  +  A +++L  +     E    +V+ F   T  GGVAL M+NTDESIR 
Sbjct:   1 FGDQYRATDAVIQGAGKLKLVFVPEGSDEKTEYEVYNF---TGAGGVALSMYNTDESIRA  57

Query: 262 FARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLI 321
           FA +    A ++K P+YLSTKNTILK YDGR++DIFQE+YE  ++ ++  A +WYEHRLI
Sbjct:  58 FADASMNMAYQKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWKSKYEEAGIWYEHRLI 117

Query: 322 DDMVAQALKSSGGFLWACKNYD 343
           DDMVA ALKS GG++WACKNYD
Sbjct: 118 DDMVAYALKSEGGYVWACKNYD 139

emb|CAH81026.1| hypothetical protein PC000375.04.0 [Plasmodium chabaudi]
(148 aa)

Score: 166 bits (419), Expect: 2.0741e-39
Length: 134, Idn/Pos/Gap = 76/99/0 (56%/73%/0%)

Query:  52 RTTGRSLCANMSNVPAFSKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDL 111
           R T R      S      K++V NPIVELDGDE  ++IW  IK KLILPYL+L+I YFDL
Sbjct:  15 RVTKRYASNGQSAFNLSGKVKVENPIVELDGDEMTKIIWKDIKEKLILPYLDLNIKYFDL  74

Query: 112 GLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLN 171
            +  RD T+D +TLEAA+ ++++   +K ATITPD ARV+EF+LK M+ SPNGT+RN+L+
Sbjct:  75 SIENRDKTNDQITLEAAQEIKKYGVGIKCATITPDAARVKEFNLKEMWKSPNGTIRNILD 134

Query: 172 GTVFREPILVENIP 185
           GTVFR PIL++NIP
Sbjct: 135 GTVFRAPILIKNIP 148

gb|AAL16965.1| NADP-dependent isocitrate dehydrogenase [Prunus persica]
(132 aa)

Score: 130 bits (327), Expect: 9.73787e-29
Length: 127, Idn/Pos/Gap = 62/83/3 (48%/65%/2%)

Query: 188 VPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGG 247
           VPGW +PI I RH FGDQY+A D  +    ++++  +     E    +V+ F   T  GG
Sbjct:   1 VPGWSKPICIGRHAFGDQYRATDAIIEGPGKLKMVFVPDGPNEKTEWEVYNF---TGAGG  57

Query: 248 VALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRE 307
           +AL M+NTDESIR FA +    A ++K P+YLSTKNTILK YDGR++DIFQE+YE  +R 
Sbjct:  58 IALSMYNTDESIRAFAEASMNTAYQKKWPLYLSTKNTILKKYDGRFKDIFQEVYEAHWRS 117

Query: 308 RFTRAAL 314
           RF  A +
Sbjct: 118 RFEAAGI 124

ref|XP_545573.1| PREDICTED: similar to cytosolic NADP+-dependent isocitrate dehydrogenase [Canis familiaris]
(145 aa)

Score: 115 bits (288), Expect: 3.13529e-24
Length: 128, Idn/Pos/Gap = 59/81/0 (46%/63%/0%)

Query:  78 VELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHAA 137
           V++ GDE  R+   LIK KLI PY+ L++  ++LG    DAT+D VT  AA A + ++  
Sbjct:  11 VDILGDEVTRITGELIKEKLIFPYVELELHSYELGTENHDATNDRVTQVAAGATKNYNVG  70

Query: 138 VKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIPRLVPGWKQPIVI 197
           VK A ITP + RVEEF+  +     NGT+ N+L GTVFRE I+ +NI   V G  +PI+I
Sbjct:  71 VKWAPITPKDKRVEEFNXNKCGNHQNGTICNILGGTVFREVIICKNIHWFVSGRIKPIII 130

Query: 198 ARHGFGDQ 205
             H +GDQ
Sbjct: 131 GHHAYGDQ 138

dbj|BAD94180.1| NADP specific isocitrate dehydrogenase like protein [Arabidopsis thaliana]
(90 aa)

Score: 98 bits (245), Expect: 3.30103e-19
Length: 85, Idn/Pos/Gap = 48/60/2 (56%/70%/2%)

Query: 392 GKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVY 451
           G ETSTNS+ASI AW RGLAHRA LD    +  F E LE +C+ T+  GKMTKDL++ ++
Sbjct:   2 GGETSTNSIASIFAWTRGLAHRAKLDDNAKLLDFTEKLEAACVGTVESGKMTKDLALIIH  61

Query: 452 GTEQGSKRENYLNTEEFIDAVQQRL 476
           G++    R+ YLNTEEFIDAV   L
Sbjct:  62 GSKL--SRDTYLNTEEFIDAVAAEL  84

ref|ZP_00187819.1| COG0473: Isocitrate/isopropylmalate dehydrogenase [Rubrobacter xylanophilus DSM 9941]
(358 aa)

Score: 92 bits (228), Expect: 2.57153e-17
Length: 388, Idn/Pos/Gap = 110/161/78 (28%/41%/20%)

Query: 102 LNLDIVYFDLGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPS 161
           L L+   FDL L  R  T++ V  EAA A+++    +KAATITP+ A            S
Sbjct:  33 LELEFRRFDLSLENRRRTENRVVHEAAAAMRECGYGIKAATITPERAG--------DVGS  84

Query: 162 PNGTLRNVLNGTVFREPILVENIPRL--VPGWKQPIVIARHGFGDQYKAQDLRVPPACRV 219
           PN  LR  +NGTV         IP +  +PG   PI + R    D Y A++ R       
Sbjct:  85 PNALLRKDINGTVIVRT--GRRIPGVNPLPGVHAPISVVRMAVDDAYGAEEWR------- 135

Query: 220 ELRVLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFAL----RRKL 275
                                   +G G     + T++  R   R   EFA     R + 
Sbjct: 136 ------------------------EGEGPDEVAYRTEKISRRVCRGVAEFAFIHARRMRA 171

Query: 276 PMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGG- 334
            ++   K T+  VY+G  ++      E++   R       YE +LID   A  L + G  
Sbjct: 172 KVFGGPKWTVSPVYEGMLKEEMDRAAEKNPDVR-------YEPQLIDATYALLLSTYGEP 224

Query: 335 FLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG----KTLLAEAAHGTVTRHFRLHQ 390
            +    N DGD  SD++ Q +GS+    S+L+  D     +T++AEA HGT         
Sbjct: 225 LVIPTLNRDGDCLSDMVLQMFGSIAGAESLLIALDEEERPQTVMAEAPHGTAPS-----L 279

Query: 391 QGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAV 450
           +GK  + N +A I+A A  L               + A+  S  ET+LDG  T DL  + 
Sbjct: 280 EGKNIA-NPMAMILAGAALLGFFE----DEQAGRVSRAIYESTFETVLDGVKTADLGGSA 334

Query: 451 YGTEQGSKRENYLNTEEFIDAVQQRLDV 478
             TE          T+E I  V+ +L+V
Sbjct: 335 TTTE---------FTDEVIRHVRNKLEV 353

ref|YP_075775.1| 3-isopropylmalate dehydrogenase [Symbiobacterium thermophilum IAM 14863]
dbj|BAD40931.1| 3-isopropylmalate dehydrogenase [Symbiobacterium thermophilum IAM 14863]
(357 aa)

Score: 85 bits (210), Expect: 3.59244e-15
Length: 422, Idn/Pos/Gap = 119/179/94 (28%/42%/22%)

Query:  77 IVELDGDEQARVIWHLIKN--KLILP---YLNLDIVYFDLGLPVRDATDDGVTLEAARAV 131
           IV L+GD+  +    L++   +L+ P    L L +V +DL L  R AT + V  EAA A+
Sbjct:   7 IVVLEGDQTGQ---ELLEEAVRLLSPDVIGLPLHLVRYDLSLENRRATSNRVVYEAAAAM  63

Query: 132 QQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIP----RL 187
           ++H   +KAATITP E R +         SPN  LR  ++GTV    IL    P      
Sbjct:  64 REHGYGLKAATITP-EGRGD-------VGSPNAILRREIDGTV----ILRTGRPLPGVET 111

Query: 188 VPGWKQPIVIARHGFGDQYKAQDLRVPPACRVELRVLDAQGMELERRQVHQFASSTDGGG 247
           + G   PI + R    D Y+A++ R            + +G E ER              
Sbjct: 112 IGGITAPIAVVRMATEDAYEAKEWR------------EGEGDE-ER-------------- 144

Query: 248 VALGMFNTDESIRNFARSCFEFALRRKLPM----YLSTKNTILKVYDGRWRDIFQELYER 303
                  T  S RN  R+  EFA R    M    +   K T+   Y+G  ++   E   R
Sbjct: 145 ---AFRTTYISARN-CRATAEFAFRLARQMGALVFGGPKWTVSPTYEGLLKEAMDEAARR 200

Query: 304 DYRERFTRAALWYEHRLIDDMVAQAL-KSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMS 362
           +         + Y+ +LID   A  + +++   +  C N DGD+ SD++   YGS+    
Sbjct: 201 N-------PDVPYDPQLIDAAYALLIARATRPLVIPCLNRDGDILSDLVLALYGSIAGSE 253

Query: 363 SVLLTPDG----KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDG 418
           S+L+  D     + ++AEA HGT         QGK  +          A  LA  A L  
Sbjct: 254 SLLIAFDEQFNPRVVMAEAPHGTAPS-----LQGKNLAN-------PLAMQLAAGALLKQ 301

Query: 419 TPDVAH--FAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
            PD  +     A++ +C++ +  G  T DL      TE          T+E I  V+++L
Sbjct: 302 MPDPEYQRAGAAIQEACLQAVAQGVRTADLGGTARTTE---------FTDEVIRRVKEKL 352

Query: 477 DV 478
            V
Sbjct: 353 AV 354

gb|AAG43470.1| NADP+-specific isocitrate dehydrogenase [Homo sapiens]
(127 aa)

Score: 81 bits (199), Expect: 7.12285e-14
Length: 90, Idn/Pos/Gap = 42/57/1 (46%/63%/1%)

Query: 393 KETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYG 452
           +E STN +ASI AW RGLA RA  D   ++A FA ALE  CIETI  G MTKDL+  + G
Sbjct:   1 QEISTNPIASIFAWTRGLALRAKTDNNKELAFFANALEEVCIETIEAGFMTKDLAACIKG  60

Query: 453 TEQGSKRENYLNTEEFIDAVQQRLDVHMLQ 482
               ++  +YLNT EF++ + + L + + Q
Sbjct:  61 LPS-AQCSDYLNTFEFMEKLGENLKIKLAQ  89

ref|ZP_00048673.1| COG0538: Isocitrate dehydrogenases [Magnetospirillum magnetotacticum MS-1]
(76 aa)

Score: 62 bits (151), Expect: 2.39173e-08
Length: 56, Idn/Pos/Gap = 37/46/0 (66%/82%/0%)

Query:  69 SKIRVRNPIVELDGDEQARVIWHLIKNKLILPYLNLDIVYFDLGLPVRDATDDGVT 124
           +KI+V NP+VELDGDE  R+IW  IKNKLI PYL+LD+ Y+DLG+  RDAT+D VT
Sbjct:   2 AKIKVANPVVELDGDEMTRIIWAEIKNKLIHPYLDLDLDYYDLGVEHRDATNDQVT  57

emb|CAC80860.2| NADP-isocitrate dehydrogenase [Haloferax volcanii]
(419 aa)

Score: 57 bits (138), Expect: 8.57542e-07
Length: 396, Idn/Pos/Gap = 97/149/82 (24%/37%/20%)

Query: 112 GLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLN 171
           G   RD  D+ +  +   A++ H  A+K    TP  A          + S N  LR  L+
Sbjct:  71 GSSARDKYDENLPEDTVSAIRNHRVAIKGPLTTPVGAG---------FRSLNVALRKKLD 121

Query: 172 GTVFREPIL-VENIPRLVPGWKQP----IVIARHGFGDQYKAQDLRVPPACRVELRVLDA 226
                 P   ++ +P  V   K P    +V  R    D Y                 ++ 
Sbjct: 122 LYANVRPTYHLDGVPSPV---KNPSAMDMVTFRENTEDVYAG---------------IEW 163

Query: 227 QGMELERRQVHQFASSTDG-------GGVALGMFNTDE-SIRNFARSCFEFALRRKLP-M 277
           +    E ++V +F     G       G V +G+    E   +   R   E+AL    P +
Sbjct: 164 EAGTDEVQKVKEFVEEEMGADGVIHDGPVGIGIKPITEFGTKRLVREAIEYALENDRPSV 223

Query: 278 YLSTKNTILKVYDGRWRDIFQELYERDYRE-RFTRAALWYEH-------------RLIDD 323
            L  K  I+K  +G +RD   EL E ++ +   T   LW E+             R+ D+
Sbjct: 224 TLVHKGNIMKFTEGAFRDWGYELAEEEFGDVTITEDELWEEYDGKRPEDKVVVKDRIADN 283

Query: 324 MVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTL-LAEAAHGT 381
           M+ Q L  +  + + A  N +GD  SD      G LG+         G+ L LAE  HG+
Sbjct: 284 MLQQLLTRTANYDVIATMNLNGDYMSDAAGAQIGGLGIAPGANF---GEGLCLAEPVHGS 340

Query: 382 VTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIE-TILDG 440
             ++      GK+   N  A I++      +    D        A  L R  +E TI DG
Sbjct: 341 APKY-----AGKD-KVNPTAMILSGRLMFEYMGWKD--------AGKLIRDTVEKTISDG 386

Query: 441 KMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
            +T DL   + G        N L T E+ D V + +
Sbjct: 387 DVTYDLERQIEGG-------NKLATSEYADKVVENI 415

ref|NP_767054.1| 3-isopropylmalate dehydrogenase [Bradyrhizobium japonicum USDA 110]
dbj|BAC45679.1| 3-isopropylmalate dehydrogenase [Bradyrhizobium japonicum USDA 110]
(388 aa)

Score: 57 bits (137), Expect: 1.01328e-06
Length: 245, Idn/Pos/Gap = 70/106/41 (28%/43%/16%)

Query: 253 FNTDE----SIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRER 308
           FNT +     IR  AR+ FE A  RK  +    K  +L+     WR+    L+E ++ + 
Sbjct: 173 FNTQQYTTSQIRRVARTAFELARTRKGRVCSVDKANVLET-SVLWREEVTALHEAEFSD- 230

Query: 309 FTRAALWYEHRLIDDMVAQALKSSGGF--LWACKNYDGDVQSDIIAQGYGSLGLMSSVLL 366
                +   H  +D+   Q +++   F  +  C N  GD+ SD  A   GSLG++ SV L
Sbjct: 231 -----VELTHLYVDNAAMQIVRAPSQFDVMVTC-NIFGDILSDCAAMASGSLGMLPSVSL 284

Query: 367 TPDG----KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDV 422
            P      +  L E  HG+      +  +G      S+ S+    R   HR      P+ 
Sbjct: 285 GPPDRLGRRKALYEPVHGSAP---DIAGKGIANPLGSILSVAMMLRITLHR------PED 335

Query: 423 AHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLD--VHM 480
           A     LE++    +  G  T D++      E G+KR   L+T+E  DAV   LD  V  
Sbjct: 336 AAL---LEKAVDTALAAGARTADIA------EPGAKR---LSTQEMGDAVLNALDKVVGK 383

Query: 481 LQEHA 485
            +EHA
Sbjct: 384 EREHA 388

ref|NP_439150.1| 3-isopropylmalate dehydrogenase (beta-IPM dehydrogenase) [Haemophilus influenzae Rd KW20]
gb|AAC22648.1| 3-isopropylmalate dehydrogenase (beta-IPM dehydrogenase) (leuB) [Haemophilus influenzae Rd KW20]
sp|P43860|LEU3_HAEIN 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(358 aa)

Score: 55 bits (133), Expect: 2.9978e-06
Length: 222, Idn/Pos/Gap = 64/98/29 (28%/44%/13%)

Query: 244 DGGGVALGMFNTD----ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQE 299
           +G GV    F+T+      I   AR+ FE A++R   +    K  +L+     WR+   E
Sbjct: 152 EGDGVQTKAFDTEVYYKYEIERIARAAFEAAMKRNKKVTSVDKANVLQS-SILWRETVTE 210

Query: 300 LYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSL 358
           +  +DY E      +  EH  ID+   Q +KS   F +  C N  GD+ SD  A   GS+
Sbjct: 211 M-AKDYPE------VTLEHIYIDNATMQLIKSPESFDVLLCSNIFGDIISDEAAMITGSM 263

Query: 359 GLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDG 418
           G++ S  L  +G  L  E A G+          GK  + N +A I++ A  L +   L+ 
Sbjct: 264 GMLPSASLNEEGFGLY-EPAGGSAP-----DIAGKGIA-NPIAQILSAAMMLRYSFNLNE 316

Query: 419 TPDVAHFAEALERSCIETILDGKMTKDL---SIAVYGTEQGS 457
                  A+A+E +  + +  G  T DL   S  V   E G+
Sbjct: 317 A------ADAIESAVQKVLASGHRTADLADDSTPVSTAEMGT 352

ref|YP_008782.1| probable isocitrate dehydrogenase (NADP) [Parachlamydia sp. UWE25]
emb|CAF24507.1| probable isocitrate dehydrogenase (NADP) [Parachlamydia sp. UWE25]
(483 aa)

Score: 54 bits (130), Expect: 6.5133e-06
Length: 217, Idn/Pos/Gap = 60/103/35 (27%/47%/16%)

Query: 264 RSCFEFAL---RRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRL 320
           R  FE+A    R+K+  +  TK+ ILK+ DG +  IF E+   +Y +      +  EH +
Sbjct: 158 RYAFEYAQIYHRKKVTCF--TKDNILKLTDGLFHKIFDEI-GAEYPQ------IEKEHWI 208

Query: 321 IDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAH 379
           +D   A+   +   F +    N  GD+ SD+ AQ  GS+GL  S  +   G   + EA H
Sbjct: 209 VDIGAAKLADTPTAFDVIVMPNLYGDILSDVAAQIAGSVGLAGSANIGNSGA--MFEAIH 266

Query: 380 GTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILD 439
           G+  R      +  +   N    ++A  + L H        + ++ AE +  + ++T+ +
Sbjct: 267 GSAPR------RAGQNLANPSGLLLAAIQMLVHL-------EQSNLAELIHNAWLKTLEE 313

Query: 440 GKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           G  T D+       E+ SK++  + T+EF +AV  RL
Sbjct: 314 GIHTYDIF-----KEKTSKQK--VGTKEFANAVTARL 343

gb|AAV48099.1| isocitrate dehydrogenase [Haloarcula marismortui ATCC 43049]
ref|YP_137805.1| isocitrate dehydrogenase [Haloarcula marismortui ATCC 43049]
(420 aa)

Score: 54 bits (129), Expect: 8.79533e-06
Length: 391, Idn/Pos/Gap = 95/147/70 (24%/37%/17%)

Query: 112 GLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLN 171
           G   RD  D+ +  +   A+++ + A+K    TP  A          + S N  LR  L+
Sbjct:  72 GQSARDKYDENLPDDTVEAIKEFNVAIKGPLTTPVGAG---------FRSLNVALRKTLD 122

Query: 172 GTVFREPIL-VENIPRLVPGWKQP----IVIARHGFGDQYKAQDLRVPPACRVELRVLDA 226
                 P   +E +P  V   K P    +V  R    D Y   +         E++    
Sbjct: 123 LYANVRPTYHIEGVPSPV---KDPEEMDMVTFRENTEDVYAGIEWEAGTDEVEEVKEFVE 179

Query: 227 QGMELERRQVHQFASSTDGGGVALGMFNTDE-SIRNFARSCFEFALRR-KLPMYLSTKNT 284
             M         F  +   G V +G+    E   +   R   ++AL   +  + L  K  
Sbjct: 180 DEM--------NFDETIHDGPVGIGVKPITEFGTKRLVREAIDYALEEDRDSVTLVHKGN 231

Query: 285 ILKVYDGRWRDIFQELYERDYRER-FTRAALWYEH-------------RLIDDMVAQALK 330
           I+K  +G +RD   E+ E +Y E   T   LW E+             R+ D+M+ Q L 
Sbjct: 232 IMKFTEGAFRDWGYEVAEEEYGEHVITEDELWDEYDGEAPEDSLVVNDRIADNMLQQLLT 291

Query: 331 SSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLH 389
            +  + + A  N +GD  SD      G LG+             LAE  HG+  ++    
Sbjct: 292 RTDEYDVIATMNLNGDYMSDAAGAQIGGLGIAPGANF--GSARCLAEPVHGSAPKY---- 345

Query: 390 QQGKETSTNSVASIVAWARGLAHRATLD--GTPDVAHFA-EALERSCIETILDGKMTKDL 446
               E   N  A I      L+ R  L+  G  D      +A+E    ETI  G +T DL
Sbjct: 346 --AGEDKVNPTAMI------LSGRLMLEYMGWKDAGQLVRDAVE----ETISSGNVTYDL 393

Query: 447 SIAVYGTEQGSKRENYLNTEEFIDAVQQRLD 477
              + G   G+K    L T EF + V + ++
Sbjct: 394 ERQIEG---GTK----LATSEFAEKVVENIE 417

ref|YP_128652.1| putative Isocitrate/isopropylmalatedehydrogenase [Photobacterium profundum SS9]
emb|CAG18850.1| putative Isocitrate/isopropylmalatedehydrogenase [Photobacterium profundum SS9]
(362 aa)

Score: 53 bits (126), Expect: 1.9594e-05
Length: 209, Idn/Pos/Gap = 61/97/25 (29%/46%/11%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEH 318
           I   AR  FE A+ R+  +Y   K  +L+     WR++ +E+  +DY E      +   H
Sbjct: 172 IERIARIAFESAMLREKNVYSIDKANVLQS-SILWREVVEEV-AKDYPE------VTLNH 223

Query: 319 RLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEA 377
             ID+   Q +K    F +  C N  GD+ SD  A   GS+G++ S  L  + K  + E 
Sbjct: 224 MYIDNATMQLIKDPSQFDVMLCSNIFGDIISDECAMITGSMGMLPSASLNQE-KFGMYEP 282

Query: 378 AHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI 437
           A G+          GK  + N VA I++ A  L  R +LD        A A+E++  + +
Sbjct: 283 AGGSAP-----DIAGKNIA-NPVAQILSAA--LMLRYSLDEEKA----ARAIEQAVSQAL 330

Query: 438 LDGKMTKDLS---IAVYGTEQGSKRENYL 463
             G++T DL+    A+  +E G K   Y+
Sbjct: 331 EAGELTADLAGKGAALSTSEMGDKIAAYI 359

ref|ZP_00155721.2| COG0473: Isocitrate/isopropylmalate dehydrogenase [Haemophilus influenzae R2846]
(358 aa)

Score: 52 bits (124), Expect: 3.45565e-05
Length: 203, Idn/Pos/Gap = 58/92/25 (28%/45%/12%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEH 318
           I   AR+ FE A++R   +    K  +L+     WR+   E+  +DY E      +  EH
Sbjct: 171 IERIARAAFEAAMKRNKKVTSVDKANVLQS-SILWRETVTEI-AKDYPE------VTLEH 222

Query: 319 RLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEA 377
             ID+   Q +K+   F +  C N  GD+ SD  A   GS+G++ S  L  +G  L  E 
Sbjct: 223 IYIDNATMQLIKAPESFDVLLCSNIFGDIISDEAAMITGSMGMLPSASLNEEGFGLY-EP 281

Query: 378 AHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI 437
           A G+          GK  + N +A I++ A  L +   L+        A+A+E +  + +
Sbjct: 282 AGGSAP-----DIAGKGIA-NPIAQILSAAMMLRYSFNLNEA------ADAIESAVQKVL 329

Query: 438 LDGKMTKDL---SIAVYGTEQGS 457
            +G  T DL   S  V  +E G+
Sbjct: 330 ANGHRTADLADDSTPVSTSEMGT 352

ref|ZP_00303122.1| COG0473: Isocitrate/isopropylmalate dehydrogenase [Novosphingobium aromaticivorans DSM 12444]
(352 aa)

Score: 51 bits (122), Expect: 5.0303e-05
Length: 210, Idn/Pos/Gap = 57/95/25 (27%/45%/11%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           M  ++  +R  A   F  A+ RK  +    K  +L+     WRD+  E+  +DY E    
Sbjct: 156 MSYSESEVRRIAHVAFRAAMGRKKRLCSVDKANVLETSQ-LWRDVMLEV-AKDYPE---- 209

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
            AL  EH  +D+   Q +++ G F +    N  GD+ SD  +   GS+GL++S  L    
Sbjct: 210 VAL--EHMYVDNAAMQLVRAPGNFDVVVTGNLFGDILSDQASMCVGSIGLLASASLGE-- 265

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETS----TNSVASIVAWARGLAHRATLDGTPDVAHFA 426
                E  +GT   +  +H    + +     N +A+I++ A  L H   L    +VA  A
Sbjct: 266 ----RETEYGTFGLYEPIHGSAPDIAGKGLANPMATILSAAMLLRHSLGL----EVA--A 315

Query: 427 EALERSCIETILDGKMTKDLSIAVYGTEQG 456
           + +E +  + + DG + +DL      TE G
Sbjct: 316 DRIEAAVAKALADGVLGRDLGGTAGTTEIG 345

ref|ZP_00322241.1| COG0473: Isocitrate/isopropylmalate dehydrogenase [Haemophilus influenzae 86-028NP]
(358 aa)

Score: 50 bits (119), Expect: 0.000107484
Length: 222, Idn/Pos/Gap = 62/96/29 (27%/43%/13%)

Query: 244 DGGGVALGMFNTD----ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQE 299
           +G G     F+T+      I   AR+ FE A++R   +    K  +L+     WR+   E
Sbjct: 152 EGEGSQTKAFDTEVYYKYEIERIARAAFEAAMKRNKKVTSVDKANVLQS-SILWRETVTE 210

Query: 300 LYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSL 358
           +  +DY E      +  EH  ID+   Q +K+   F +  C N  GD+ SD  A   GS+
Sbjct: 211 M-AKDYPE------VTLEHIYIDNATMQLIKAPESFDVLLCSNIFGDIISDEAAMITGSM 263

Query: 359 GLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDG 418
           G++ S  L   G  L  E A G+          GK  + N +A I++ A  L +   L+ 
Sbjct: 264 GMLPSASLNEAGFGLY-EPAGGSAP-----DIAGKGIA-NPIAQILSAAMMLRYSFNLNE 316

Query: 419 TPDVAHFAEALERSCIETILDGKMTKDL---SIAVYGTEQGS 457
                  A+A+E +  + +  G  T DL   S  V   E G+
Sbjct: 317 A------ADAIESAVQKVLASGHRTADLADDSTPVSTAEMGT 352

ref|ZP_00005979.2| COG0473: Isocitrate/isopropylmalate dehydrogenase [Rhodobacter sphaeroides 2.4.1]
(369 aa)

Score: 50 bits (119), Expect: 0.000135771
Length: 232, Idn/Pos/Gap = 67/104/34 (28%/44%/14%)

Query: 255 TDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAAL 314
           T E IR  ARS FE A RR   +    K  +++     WR+  Q +++ +Y +      +
Sbjct: 166 TTEEIRRVARSAFELARRRNNRVCSMEKANVMES-GILWREEVQWVHDNEYPD------V 218

Query: 315 WYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLL---TPDG 370
              H   D+   Q ++    F +    N  GD+ SD  A   GSLG++ S  L     +G
Sbjct: 219 ELSHMYADNGAMQLVRWPRQFDVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAPMANG 278

Query: 371 K-TLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           +   L E  HG+      +  QGK    N +A I+++A  L +      + D+   A  L
Sbjct: 279 RPKALYEPVHGSAP---DIAGQGK---ANPIACILSFAMALRY------SFDMGEEATRL 326

Query: 430 ERSCIETIL-DGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E++ +ET+L DG  T DL     G E G+     ++T    DAV   LD  +
Sbjct: 327 EKA-VETVLADGVRTADL----MGPEGGTP----VSTSGMGDAVLAALDASL 369

ref|NP_213167.1| 3-isopropylmalate dehydrogenase [Aquifex aeolicus VF5]
gb|AAC06564.1| 3-isopropylmalate dehydrogenase [Aquifex aeolicus VF5]
pir||C70322 3-isopropylmalate dehydrogenase (EC 1.1.1.85) - Aquifex aeolicus
sp|O66607|LEU3_AQUAE 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(364 aa)

Score: 50 bits (118), Expect: 0.000150069
Length: 196, Idn/Pos/Gap = 53/86/23 (27%/43%/11%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           M  T++ IR   R  FE A +R+  +    K  +L+V    WR I +E      +E +  
Sbjct: 162 MKYTEDEIRRIVRKGFEIARKRRKKLTSVDKANVLEV-SALWRQIVEE-----EKENYPD 215

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
             L  EH  ID+   Q ++    F +    N  GD+ SD      GSLG++ S  +    
Sbjct: 216 VEL--EHLYIDNCAMQLVRRPTSFDVIVTGNIFGDILSDEAGVVVGSLGMLPSASI--GD 271

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALE 430
           +  L E  HG+          GK  + N +A+I++ A  L +   +D   D+      +E
Sbjct: 272 RYALYEPVHGSAP-----DIAGKGIA-NPIATILSAAMMLKYSFNMDKAHDL------IE 319

Query: 431 RSCIETILDGKMTKDL 446
           ++  ET+  G  T D+
Sbjct: 320 KAIEETLNQGYRTPDI 335

ref|NP_578669.1| 3-isopropylmalate dehydrogenase 2 [Pyrococcus furiosus DSM 3638]
gb|AAL81064.1| 3-isopropylmalate dehydrogenase 2; (leuB) [Pyrococcus furiosus DSM 3638]
(355 aa)

Score: 50 bits (118), Expect: 0.000167263
Length: 209, Idn/Pos/Gap = 56/97/23 (26%/46%/11%)

Query: 252 MFNTDESIRNFARSCFEFA-LRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFT 310
           M NT   +    R  FE+A  + +  + L  K  +L      W+ +F+E+   +Y+E  T
Sbjct: 153 MINTRFGVERTIRFAFEYAKTKGRKKVTLVDKANVLTYAHDLWQRVFKEV-ASEYQEIET 211

Query: 311 RAALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPD 369
                 +H  +D M  + ++S   F +    N  GD+ +D+ A+  G LGL +S  + P 
Sbjct: 212 ------DHYYVDAMAMKMIRSPEIFEVVVTPNMFGDILTDLGAEIVGGLGLAASGNINPR 265

Query: 370 GKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           G ++  E  HG+          GK  + N +A+I+  A  L H   LD        A  +
Sbjct: 266 GVSMF-EPVHGSAP-----DIAGKGIA-NPLAAILTAALMLEHLG-LDRE------ASLV 311

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSK 458
           E++  +TI + K+T DL   +  +E G++
Sbjct: 312 EKAVAKTIEENKVTPDLGGELKTSEVGNE 340

ref|YP_087790.1| LeuB protein [Mannheimia succiniciproducens MBEL55E]
gb|AAU37205.1| LeuB protein [Mannheimia succiniciproducens MBEL55E]
(358 aa)

Score: 49 bits (117), Expect: 0.000206058
Length: 222, Idn/Pos/Gap = 61/98/29 (27%/44%/13%)

Query: 244 DGGGVALGMFNTD----ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQE 299
           DG G     F+T+      I   AR+ F+ A++R+  +    K  +L+     WR+   E
Sbjct: 152 DGEGSDTRAFDTEVYYKYEIERIARAAFDAAMKRRKQVTSVDKANVLQS-SILWRETVAE 210

Query: 300 LYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSL 358
           +  ++Y E      +  E+  ID+   Q +K+   F +  C N  GD+ SD  A   GS+
Sbjct: 211 I-AKEYPE------VQVENMYIDNATMQLIKAPESFDVLLCSNIFGDIISDEAAMITGSM 263

Query: 359 GLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDG 418
           G++ S  L  +G  L  E A G+          GK  + N +A I++ A  L +   L+ 
Sbjct: 264 GMLPSASLNEEGFGLY-EPAGGSAP-----DIAGKGIA-NPIAQILSAAMMLRYSFNLNE 316

Query: 419 TPDVAHFAEALERSCIETILDGKMTKDL---SIAVYGTEQGS 457
                  A A+E +  + + DG  T DL   S  V   E G+
Sbjct: 317 A------ATAIENAVQKVLADGHRTGDLADNSTPVSTAEMGT 352

dbj|BAB06776.1| 3-isopropylmalate dehydrogenase [Bacillus halodurans C-125]
sp|Q9K8E9|LEU3_BACHD 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
ref|NP_243923.1| 3-isopropylmalate dehydrogenase [Bacillus halodurans C-125]
(363 aa)

Score: 49 bits (117), Expect: 0.000213051
Length: 228, Idn/Pos/Gap = 60/97/27 (26%/42%/11%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           +  T   +R   R  FE A+ R   +    K  +L+     WR++  E+      + F  
Sbjct: 161 LLYTRGEMRRIIRKAFELAMVRNKHVTSVDKANVLES-SRMWREVANEV-----AQEFPE 214

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
             L  EH L+D+   Q ++    F +   +N  GD+ SD  +   GSLG++ S  LT DG
Sbjct: 215 VTL--EHMLVDNAAMQLIRRPKQFDVLVTENLFGDILSDEASMVTGSLGMLPSASLTSDG 272

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALE 430
             L  E  HG+          GK  + N +A+I + A  L +   L         A+ +E
Sbjct: 273 PGLY-EPIHGSAP-----DIAGKGVA-NPLATIASCAMMLKYSFGLHEE------AKTIE 319

Query: 431 RSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDV 478
            +    +  G  T D  IA  G E  S +     T+  ++A+Q  +D+
Sbjct: 320 DAIEAVLKQGYRTAD--IAKPGEESSSTKA---ITDAVVEAIQASVDI 362

ref|XP_428608.1| PREDICTED: similar to isocitrate dehydrogenase 2 (NADP+), mitochondrial, partial [Gallus gallus]
(99 aa)

Score: 49 bits (117), Expect: 0.000233531
Length: 61, Idn/Pos/Gap = 24/39/8 (39%/63%/13%)

Query: 425 FAEALERSCIETILDGKMTKDLSIAVYGTEQ-------GSK-RENYLNTEEFIDAVQQRL 476
           FA+ LE+ C+ET+  G MTKDL+  ++G  +       G K  E+++NT +F+DA++  L
Sbjct:  34 FAQTLEKVCVETVESGTMTKDLAGCIHGLAKYVWLRGGGVKLNEHFVNTTDFLDAIKNNL  93

Query: 477 D 477
           D
Sbjct:  94 D  94


Score: 46 bits (108), Expect: 0.00209586
Length: 29, Idn/Pos/Gap = 17/24/0 (58%/82%/0%)

Query: 70 KIRVRNPIVELDGDEQARVIWHLIKNKLI 98
          +I+V NP+VE+DGDE+ R+IW  IK KL+
Sbjct:  4 RIKVANPVVEMDGDERTRIIWAFIKEKLL 32

ref|ZP_00370694.1| 3-isopropylmalate dehydrogenase [Campylobacter coli RM2228]
gb|EAL56171.1| 3-isopropylmalate dehydrogenase [Campylobacter coli RM2228]
(358 aa)

Score: 49 bits (116), Expect: 0.000241457
Length: 233, Idn/Pos/Gap = 65/101/42 (27%/43%/18%)

Query: 255 TDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAAL 314
           T   I    R  FE A  R   ++L  K  +L      WRD+  ++  ++Y +      +
Sbjct: 162 TKAEIERITRLAFESARIRNKKVHLIDKANVL-ASSILWRDVVGQI-AKEYED------I 213

Query: 315 WYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTL 373
             E+  +D+   Q +K+   F +  C N  GD+ SD +A   GSLGL+ S  L   G  L
Sbjct: 214 KLEYMYVDNAAMQIIKNPSTFDVMLCSNLFGDILSDELAAISGSLGLLCSASLNDKGFGL 273

Query: 374 LAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLD-GTPDVAH-FAEALER 431
             E A G+      L+        N +A I++ A  L +    +    D+ +  A ALER
Sbjct: 274 Y-EPAGGSAPDIAHLN------IANPIAQILSAALMLKYSFKEEKAARDIENAIAIALER 326

Query: 432 SCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHMLQEH 484
                   GKMTKDL+             +YL+T+E  D +     V +L+E+
Sbjct: 327 --------GKMTKDLNA-----------NSYLSTDEMGDCI-----VEILKEN 355

gb|AAV93535.1| 3-isopropylmalate dehydrogenase [Silicibacter pomeroyi DSS-3]
ref|YP_165479.1| 3-isopropylmalate dehydrogenase [Silicibacter pomeroyi DSS-3]
(367 aa)

Score: 49 bits (116), Expect: 0.000253852
Length: 231, Idn/Pos/Gap = 63/103/33 (27%/44%/14%)

Query: 255 TDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAAL 314
           T+  I   ARS FE A+RR   +    K  +++     WR++   +  +DY E      +
Sbjct: 165 TESEIERVARSAFELAMRRSKKLCSMEKANVMES-GILWREVVTRV-AKDYPE------V 216

Query: 315 WYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLL---TPDG 370
              H   D+   Q +++   F +    N  GD+ SD  A   GSLG++ S  L     +G
Sbjct: 217 ELSHMYADNGAMQLVRAPKQFDVILTDNLFGDILSDCAAMLTGSLGMLPSASLGAPMANG 276

Query: 371 K-TLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           +   L E  HG+      +  QGK    N +A I+++A  +A R + D   +    A+ L
Sbjct: 277 RPKALYEPVHGSAP---DIAGQGK---ANPIACILSFA--MALRYSFDQGAE----ADRL 324

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E +  + + DG  T DL     GTE  +     ++T E   A+  +LD  +
Sbjct: 325 EAAVEQVLADGVRTADL----LGTEGVTP----VSTTEMGAAILAKLDASL 367

ref|ZP_00340064.1| COG0473: Isocitrate/isopropylmalate dehydrogenase [Rickettsia akari str. Hartford]
(483 aa)

Score: 49 bits (116), Expect: 0.000260287
Length: 253, Idn/Pos/Gap = 66/109/49 (26%/43%/19%)

Query: 231 LERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALR--RKLPMYLSTKNTILKV 288
           +E RQ H    S     + L      E I  +A   FE+A++  RK    LS K+ I+K 
Sbjct: 131 IEYRQTHNIYES-----IKLISHTGCEKIIRYA---FEYAVKNNRKKVTCLS-KDNIMKF 181

Query: 289 YDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQ 347
            DG +  +F E+  ++Y +      +  EH +ID   A+       F +    N  GD+ 
Sbjct: 182 SDGVFHKVFNEI-AKEYPQ------ISNEHYIIDIGTARLSTKPEIFDVIVTSNLYGDII 234

Query: 348 SDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWA 407
           SD+ A+  GS+GL                A    + +H+ + +    ++ N     +A  
Sbjct: 235 SDVAAEISGSVGL----------------AGSANIGQHYAMFEAVHGSAPNIAGKDIANP 278

Query: 408 RGLAHRATLD----GTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYL 463
            GL + A +     G  D+A     +E +  +TI DG  T D    +Y  +  SK+   +
Sbjct: 279 SGLLNAAIMMLVHIGQGDIATL---IENAWKKTIEDGVHTAD----IYNQQNSSKK---V 328

Query: 464 NTEEFIDAVQQRL 476
            T+EF + V +RL
Sbjct: 329 GTKEFAEEVTKRL 341

ref|NP_419012.1| 3-isopropylmalate dehydrogenase [Caulobacter crescentus CB15]
gb|AAK22180.1| 3-isopropylmalate dehydrogenase [Caulobacter crescentus CB15]
pir||H87272 3-isopropylmalate dehydrogenase [imported] - Caulobacter crescentus
sp|Q9ABN3|LEU3_CAUCR 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(350 aa)

Score: 49 bits (116), Expect: 0.000271375
Length: 128, Idn/Pos/Gap = 37/59/8 (28%/46%/6%)

Query: 255 TDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAAL 314
           T   I    R  FE A  R   ++ + K+ +++     W+ +  EL+ R+Y +      +
Sbjct: 160 TTSEIERVGRVAFELARGRTNKVHSAEKSNVMES-GLLWKQVITELHAREYPD------V 212

Query: 315 WYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTL 373
             EH L D+   Q +++   F +    N  GD+ SD  A   GSLG++ S  L   GK  
Sbjct: 213 QLEHILADNCAMQLVRAPKQFDVIVTDNLFGDILSDAAAMLTGSLGMLPSAALGAPGKPG 272

Query: 374 LAEAAHGT 381
           L E  HG+
Sbjct: 273 LYEPIHGS 280

gb|EAK86173.1| hypothetical protein UM04873.1 [Ustilago maydis 521]
ref|XP_402488.1| hypothetical protein UM04873.1 [Ustilago maydis 521]
(377 aa)

Score: 48 bits (115), Expect: 0.000345665
Length: 166, Idn/Pos/Gap = 49/73/27 (29%/43%/16%)

Query: 255 TDESIRNFARSCFEFALRRK------LPMYLST-----KNTILKVYDGRWRDIFQELYER 303
           T+++     +  FE AL RK       P Y+ T     K+ +L V DG +R   + +YE+
Sbjct: 165 TEKASTRIGKKAFEVALARKELRKTTQPSYVPTVTICHKSNVLSVTDGLFRTSVRGIYEQ 224

Query: 304 DYRE-----RFTRAALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGS 357
           D +      R+    L    +L+D MV +  +    F +    N  GD+ SD  A   GS
Sbjct: 225 DQKANGGAGRYEEVKL--NEQLVDSMVYRLFREPEVFDVVVAPNLYGDIVSDAAAALVGS 282

Query: 358 LGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASI 403
           LGL+ SV         + E  HG+      +  QGK    N +ASI
Sbjct: 283 LGLVPSV--NAGDSFFMGEPVHGSAP---DIAGQGK---ANPIASI 320

ref|ZP_00156846.1| COG0473: Isocitrate/isopropylmalate dehydrogenase [Haemophilus influenzae R2866]
(358 aa)

Score: 48 bits (115), Expect: 0.000351482
Length: 209, Idn/Pos/Gap = 56/93/26 (26%/44%/12%)

Query: 244 DGGGVALGMFNTD----ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQE 299
           +G G     F+T+      I   AR+ F+ A++R   +    K  +L+     WR+   E
Sbjct: 152 EGEGAQTKAFDTEVYYKYEIERIARAAFDAAMKRNKKVTSVDKANVLQS-SILWRETVTE 210

Query: 300 LYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSL 358
           +  ++Y E      +  EH  ID+   Q +K+   F +  C N  GD+ SD  A   GS+
Sbjct: 211 V-AKEYPE------VTLEHIYIDNATMQLIKAPESFDVLLCSNIFGDIISDEAAMITGSM 263

Query: 359 GLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDG 418
           G++ S  L  +G  L  E A G+          GK  + N +A I++ A  L +   L+ 
Sbjct: 264 GMLPSASLNEEGFGLY-EPAGGSAP-----DIAGKGIA-NPIAQILSAAMMLRYSFNLNE 316

Query: 419 TPDVAHFAEALERSCIETILDGKMTKDLS 447
                  A+A+E +  + +  G  T DL+
Sbjct: 317 A------ADAIENAVQKVLASGHRTADLA 339

ref|ZP_00337660.1| COG0473: Isocitrate/isopropylmalate dehydrogenase [Silicibacter sp. TM1040]
(367 aa)

Score: 47 bits (112), Expect: 0.000776514
Length: 231, Idn/Pos/Gap = 62/99/33 (26%/42%/14%)

Query: 255 TDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAAL 314
           T+  I   ARS FE A+RR   +    K  +++     WR++  E+  +DY E      +
Sbjct: 165 TESEIERVARSAFELAMRRGKKLCSMEKANVMES-GILWREVVTEV-SKDYPE------V 216

Query: 315 WYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLL---TPDG 370
              H   D    Q  +    F +    N  GD+ SD  A   GSLG++ S  L     +G
Sbjct: 217 ELSHMYADAGAMQLCRWPKQFDVIVTDNLFGDLLSDAAAMLTGSLGMLPSASLGAPMANG 276

Query: 371 K-TLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEAL 429
           +   L E  HG+      +  QGK    N +A I+++A  L +      + D+   A+ L
Sbjct: 277 RPKALYEPVHGSAP---DIAGQGK---ANPIACILSFAMALRY------SFDMGTEADRL 324

Query: 430 ERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRLDVHM 480
           E +  + + DG  T DL         G +    ++T E  DAV + L+  +
Sbjct: 325 EAAVEKVLADGVRTADL--------LGEEGVTPVSTSEMGDAVVEALNASL 367

ref|ZP_00188064.2| COG0473: Isocitrate/isopropylmalate dehydrogenase [Rubrobacter xylanophilus DSM 9941]
(336 aa)

Score: 47 bits (111), Expect: 0.000948674
Length: 135, Idn/Pos/Gap = 39/63/13 (28%/46%/9%)

Query: 255 TDESIRNFARSCFEFAL---RRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           T E      R  FE++    RR + +    K  I+K  DG +R++F E+  RDY + F  
Sbjct: 143 TREGTERICRMAFEYSRDQGRRHVTVV--HKANIMKYTDGLFREVFYEV-ARDYEDDFEE 199

Query: 312 AALWYEHRLIDDMVAQ-ALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
                + R++D+M  Q  +K +   +  C N  GD+ SD+ A   G LG+     +  D 
Sbjct: 200 I----DERIVDNMAMQLVMKPNLYDVLVCPNLYGDILSDLCAGLTGGLGVAPGANIGED- 254

Query: 371 KTLLAEAAHGTVTRH 385
              L E  HG+  ++
Sbjct: 255 -IALFEPVHGSAPKY 268

ref|NP_246900.1| LeuB [Pasteurella multocida subsp. multocida str. Pm70]
gb|AAK04045.1| LeuB [Pasteurella multocida subsp. multocida str. Pm70]
sp|Q9CJN6|LEU3_PASMU 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(359 aa)

Score: 47 bits (111), Expect: 0.000997376
Length: 209, Idn/Pos/Gap = 57/90/26 (27%/43%/12%)

Query: 244 DGGGVALGMFNTD----ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQE 299
           +G G     F+T+      I   AR  FE A++R   +    K  +L +    WR++  +
Sbjct: 152 EGEGANEKAFDTEVYHRYEIERIARVAFETAMKRSKHVTSVDKANVL-ISSVLWREVVCD 210

Query: 300 LYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSL 358
           +  +DY E      +  +H  ID+   Q +K    F +  C N  GD+ SD  A   GS+
Sbjct: 211 V-AKDYPE------VTLDHIYIDNATMQLIKQPEFFDVLLCSNIFGDIISDECAMITGSM 263

Query: 359 GLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDG 418
           G++ S  L   G  L  E A G+          GK  + N +A I++ A  L H   L+ 
Sbjct: 264 GMLPSASLNEKGFGLY-EPAGGSAP-----DIAGKGIA-NPIAQILSAAMMLRHSFNLND 316

Query: 419 TPDVAHFAEALERSCIETILDGKMTKDLS 447
                  A A+E +    + +G  T DL+
Sbjct: 317 A------ATAIENAVKNVLAEGHRTADLA 339

gb|AAS51706.1| ADL214Cp [Ashbya gossypii ATCC 10895]
ref|NP_983882.1| ADL214Cp [Eremothecium gossypii]
(367 aa)

Score: 47 bits (111), Expect: 0.00101416
Length: 225, Idn/Pos/Gap = 53/97/17 (23%/43%/7%)

Query: 166 LRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPAC--RVELRV 223
           LR    G +F     V++    V G+  PIV  R   G     + ++        V+L +
Sbjct:  81 LRERCQGALFGA---VQSPTTKVEGYSSPIVALRRQLGLYANIRPVKSVSGTGQPVDLVI 137

Query: 224 LDAQGMELERRQVHQFASSTDGGGVALGMFNTDE-SIRNFARSCFEFALRRKL-----PM 277
           +     +L  +Q   +  +  G  VA  +    E +    A      AL+R+       +
Sbjct: 138 VRENTEDLYVQQERTYVDAATGKRVAEAIKRISEPATERIAEISLRLALQRQRMGGRGAL 197

Query: 278 YLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGF-L 336
            ++ K+ +L   DG ++++ +E+YE + +   +  ++ Y  +++D MV +  K    F +
Sbjct: 198 TVTHKSNVLSQTDGLFKEVCREVYEANKK---SYGSIEYNEQIVDSMVYRLFKEPHCFDV 254

Query: 337 WACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGT 381
               N  GD+ SD  A   GSLGL+ SV        ++ E  HG+
Sbjct: 255 VVAPNLYGDLLSDGAAALVGSLGLVPSV--NVGNNIIIGEPCHGS 297

ref|YP_076373.1| isocitrate dehydrogenase [Symbiobacterium thermophilum IAM 14863]
dbj|BAD41529.1| isocitrate dehydrogenase [Symbiobacterium thermophilum IAM 14863]
(421 aa)

Score: 47 bits (111), Expect: 0.00114937
Length: 288, Idn/Pos/Gap = 62/111/51 (21%/38%/17%)

Query: 126 EAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNVLNGTVFREPILVENIP 185
           +   A++++  A+K    TP    +          S N TLR VL+      P+      
Sbjct:  86 DTVEAIREYRVAIKGPLTTPVGGGIR---------SLNVTLRQVLDLYACVRPV------ 130

Query: 186 RLVPGWKQPI--------VIARHGFGDQYKAQDLR--VPPACRVELRVLDAQGMELERRQ 235
           R  PG   P+        VI R    D Y   + +   P A +V+  + +  G+      
Sbjct: 131 RWFPGVPSPVKEPHKTDVVIFRENTEDIYAGIEWKAGTPEARKVQALLAEEMGV------ 184

Query: 236 VHQFASSTDGGGVALGMFNTDE-SIRNFARSCFEFAL-RRKLPMYLSTKNTILKVYDGRW 293
             +F +S     + +G+    E   +   R+  ++A+  ++  + L  K  I K  +G +
Sbjct: 185 --KFPNSDKSDMIGVGIKPVSEFGSKRLVRAAIQYAIDNKRKSVTLVHKGNIQKFTEGAF 242

Query: 294 RD---------------IFQELYERDYRERFTRAALWYEHRLIDDMVAQAL-KSSGGFLW 337
           RD                 +EL+  +Y+ +     +    R+ D    Q L +     + 
Sbjct: 243 RDWGYQVALEEFRPYVITEEELWSDEYKGKMPEGKILIRDRIADITFQQLLLRPEEWDVI 302

Query: 338 ACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRH 385
           A  N +GD  SD +A   G +G+     ++  G   L EA HGT  ++
Sbjct: 303 ATLNLNGDYLSDHVAAIVGGIGIAPGANISYSGGYGLFEATHGTAPKY 350

ref|YP_092518.1| LeuB [Bacillus licheniformis ATCC 14580]
gb|AAU41825.1| LeuB [Bacillus licheniformis DSM 13]
(373 aa)

Score: 46 bits (110), Expect: 0.00124939
Length: 197, Idn/Pos/Gap = 51/84/22 (25%/42%/11%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           +F     +    R  F+ A  RK  +    K  +L+     WR   +E+      + F  
Sbjct: 165 LFYKKSEMERVIREAFQMAQSRKGKVTSVDKANVLES-SKLWRKTAEEV-----AKEFPD 218

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
             L  EH L+D+   Q + + G F +   +N  GD+ SD  +   GSLG++ S  L+  G
Sbjct: 219 VKL--EHMLVDNAAMQLIYAPGQFDIIVTENMFGDILSDEASMLTGSLGMLPSASLSSSG 276

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALE 430
             L  E  HG+            +   N +A+I++ A  L     L+        A+A+E
Sbjct: 277 LHLY-EPVHGSAP------DIAGQNIANPLAAILSAAMMLRTSFGLEAE------AQAVE 323

Query: 431 RSCIETILDGKMTKDLS 447
            +  + +  GK TKDL+
Sbjct: 324 HAVDQVLRAGKRTKDLA 340

gb|AAU24463.1| 3-isopropylmalate dehydrogenase [Bacillus licheniformis ATCC 14580]
ref|YP_080101.1| 3-isopropylmalate dehydrogenase [Bacillus licheniformis ATCC 14580]
(370 aa)

Score: 46 bits (110), Expect: 0.00133563
Length: 197, Idn/Pos/Gap = 51/84/22 (25%/42%/11%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           +F     +    R  F+ A  RK  +    K  +L+     WR   +E+      + F  
Sbjct: 162 LFYKKSEMERVIREAFQMAQSRKGKVTSVDKANVLES-SKLWRKTAEEV-----AKEFPD 215

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
             L  EH L+D+   Q + + G F +   +N  GD+ SD  +   GSLG++ S  L+  G
Sbjct: 216 VKL--EHMLVDNAAMQLIYAPGQFDIIVTENMFGDILSDEASMLTGSLGMLPSASLSSSG 273

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALE 430
             L  E  HG+            +   N +A+I++ A  L     L+        A+A+E
Sbjct: 274 LHLY-EPVHGSAP------DIAGQNIANPLAAILSAAMMLRTSFGLEAE------AQAVE 320

Query: 431 RSCIETILDGKMTKDLS 447
            +  + +  GK TKDL+
Sbjct: 321 HAVDQVLRAGKRTKDLA 337

emb|CAA86700.1| unnamed protein product [Saccharomyces cerevisiae]
sp|P40495|YIJ4_YEAST Hypothetical 40.1 kDa protein in SGA1-KTR7 intergenic region
ref|NP_012172.1| Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate [Saccharomyces cerevisiae]
(371 aa)

Score: 46 bits (109), Expect: 0.00157819
Length: 130, Idn/Pos/Gap = 34/68/11 (26%/52%/8%)

Query: 258 SIRNFARSCFEFALRR-----KLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRA 312
           + R  A    + AL+R     +  + ++ K+ +L   DG +R+I +E+YE + ++++ + 
Sbjct: 177 ATRRIATIALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESN-KDKYGQ- 234

Query: 313 ALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGK 371
            + Y  +++D MV +  +    F +    N  GD+ SD  A   GSLG++ S  + P+  
Sbjct: 235 -IKYNEQIVDSMVYRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE-- 291

Query: 372 TLLAEAAHGT 381
            ++ E  HG+
Sbjct: 292 IVIGEPCHGS 301

ref|NP_719762.1| 3-isopropylmalate dehydrogenase [Shewanella oneidensis MR-1]
gb|AAN57206.1| 3-isopropylmalate dehydrogenase [Shewanella oneidensis MR-1]
sp|Q8E9N3|LEU3_SHEON 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(364 aa)

Score: 46 bits (109), Expect: 0.00163175
Length: 224, Idn/Pos/Gap = 62/97/27 (27%/43%/12%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           M  +   I   AR  FE A  R+  +    K  +L      WR + +E+   D+ +    
Sbjct: 163 MRYSRREISRIARIAFEAARGRRKKVTSVDKANVLAC-SVLWRQVVEEV-AVDFPD---- 216

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
             +  EH  ID+   Q L+    F +  C N  GD+ SD IA   GS+GL+SS  +   G
Sbjct: 217 --VELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDILSDEIAMLTGSMGLLSSASMNSTG 274

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALE 430
             L  E A G+          GK  + N +A I++ A  L H    +        A A+E
Sbjct: 275 FGLF-EPAGGSAP-----DIAGKGIA-NPIAQILSAALMLRHSLKQEEA------ASAIE 321

Query: 431 RSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFI-DAVQ 473
           R+  + +  G +T +L      ++Q  K +  +   +FI DAV+
Sbjct: 322 RAVTKALNSGYLTGEL----LSSDQRHKAKTTVQMGDFIADAVK 361

ref|ZP_00153401.1| COG0473: Isocitrate/isopropylmalate dehydrogenase [Rickettsia rickettsii]
(483 aa)

Score: 46 bits (109), Expect: 0.0018187
Length: 220, Idn/Pos/Gap = 58/98/41 (26%/44%/18%)

Query: 264 RSCFEFALR--RKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLI 321
           R  FE+A++  RK  M LS K+ I+K  DG    +F E+  ++Y +      +   H +I
Sbjct: 156 RYAFEYAVKNNRKKVMCLS-KDNIMKFSDGVLHKVFNEI-AKEYPQ------INNAHYII 207

Query: 322 DDMVAQ-ALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHG 380
           D   A+ A K     +    N  GD+ SD+ A+  GS+GL                A   
Sbjct: 208 DIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVGL----------------AGSA 251

Query: 381 TVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLD----GTPDVAHFAEALERSCIET 436
            + +H+ + +    ++ +     +A   GL + A +     G  D+A     +E +  +T
Sbjct: 252 NIGQHYAMFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQGDIATL---IENAWKKT 308

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           I DG  T D    +Y  +  SK+   + T+EF + V +RL
Sbjct: 309 IEDGVHTAD----IYNEQSSSKK---VGTKEFAEEVTKRL 341

ref|NP_359990.1| isocitrate dehydrogenase [EC:1.1.1.42] [Rickettsia conorii str. Malish 7]
gb|AAL02891.1| isocitrate dehydrogenase [EC:1.1.1.42] [Rickettsia conorii str. Malish 7]
sp|Q92IR7|IDH_RICCN Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
pir||A97744 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) - Rickettsia conorii (strain Malish 7)
(483 aa)

Score: 46 bits (109), Expect: 0.0018187
Length: 220, Idn/Pos/Gap = 58/98/41 (26%/44%/18%)

Query: 264 RSCFEFALR--RKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLI 321
           R  FE+A++  RK  M LS K+ I+K  DG    +F E+  ++Y +      +   H +I
Sbjct: 156 RYAFEYAVKNNRKKVMCLS-KDNIMKFSDGVLHKVFNEI-AKEYPQ------INNAHYII 207

Query: 322 DDMVAQ-ALKSSGGFLWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHG 380
           D   A+ A K     +    N  GD+ SD+ A+  GS+GL                A   
Sbjct: 208 DIGTARLATKPEIFDVIVTSNLYGDIISDVAAEISGSVGL----------------AGSA 251

Query: 381 TVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLD----GTPDVAHFAEALERSCIET 436
            + +H+ + +    ++ +     +A   GL + A +     G  D+A     +E +  +T
Sbjct: 252 NIGQHYAMFEAVHGSAPDIAGKDIANPSGLLNAAIMMLVHIGQGDIATL---IENAWKKT 308

Query: 437 ILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           I DG  T D    +Y  +  SK+   + T+EF + V +RL
Sbjct: 309 IEDGVHTAD----IYNEQSSSKK---VGTKEFAEEVTKRL 341

emb|CAG59402.1| unnamed protein product [Candida glabrata CBS138]
ref|XP_446475.1| unnamed protein product [Candida glabrata]
(372 aa)

Score: 46 bits (109), Expect: 0.00194424
Length: 247, Idn/Pos/Gap = 53/104/25 (21%/42%/10%)

Query: 188 VPGWKQPIVIARHGFGDQYKAQDLRVPPACR---VELRVLDAQGMELERRQVHQFASSTD 244
           V G+  PIV  R   G     + ++         V++ ++     +L  +    +     
Sbjct: 104 VEGYSSPIVALRKAMGLFANVRPVKAVEGTNDRPVDMVIVRENTEDLYIKIEKTYTDPAT 163

Query: 245 GGGVALGMFNTDE-SIRNFARSCFEFALRR-----KLPMYLSTKNTILKVYDGRWRDIFQ 298
           G  VA       E + R  A    + AL+R        + ++ K+ +L   DG +R+I +
Sbjct: 164 GTRVAEATKRISEVATRRIATIALDIALQRLQSRGHATLTVTHKSNVLSQSDGLFREICK 223

Query: 299 ELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGS 357
           ++YE + ++++ +  + Y  +++D MV +  +    F +    N  GD+ SD  A   GS
Sbjct: 224 DVYESN-KDKYGK--IQYNEQIVDSMVYRMFREPECFDVVVAPNLYGDILSDGAAALVGS 280

Query: 358 LGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLD 417
           LG++ S  + P+   ++ E  HG+            + +   +A+ +A  R  A      
Sbjct: 281 LGVVPSANVGPE--IVIGEPCHGS----------APDIAGRGIANPIATIRSTALMLEFL 328

Query: 418 GTPDVAH 424
           G P+ A 
Sbjct: 329 GYPEAAQ 335

sp|Q59985|IDH_STRSL Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
gb|AAA98355.1| isocitrate dehydrogenase
(391 aa)

Score: 46 bits (109), Expect: 0.00197696
Length: 127, Idn/Pos/Gap = 35/56/2 (27%/44%/1%)

Query: 257 ESIRNFARSCFEFALRRKLP-MYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALW 315
           E  +   RS  ++AL+  L  + L  K  I K  +G +R    E+ + DY+E      L 
Sbjct: 193 EGSKRLIRSAIDYALKNNLKKVTLVHKGNIQKFTEGGFRKWGYEVAQEDYKEELLAGRLE 252

Query: 316 YEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLL 374
               + D+ + Q L +   F + A  N +GD  SD +A   G +G+     +       +
Sbjct: 253 INDIIADNFLQQILLNPEKFDVVALTNLNGDYASDALAAQVGGIGISPGANINYQTGHAI 312

Query: 375 AEAAHGT 381
            EA HGT
Sbjct: 313 FEATHGT 319

emb|CAA72702.1| 3-isopropylmalate dehydrogenase [Buchnera aphidicola]
sp|O31292|LEU3_BUCTS 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(364 aa)

Score: 46 bits (108), Expect: 0.00206118
Length: 219, Idn/Pos/Gap = 57/90/31 (26%/41%/14%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEH 318
           I+  A+  F+ A  RK  +    K  +LK     WRD   ++       +F    L  EH
Sbjct: 172 IKRIAKIAFQIAQSRKKKIVSIDKANVLKS-SILWRDTVNKM-----AYKFPNVKL--EH 223

Query: 319 RLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEA 377
             ID+   + +K+   F +  C N  GD+ SD  A   GS+GL+ S  L   G  L  E 
Sbjct: 224 MYIDNATMELIKNPSSFDVILCSNLFGDIISDECAAIIGSIGLLPSASLNKSGFGLY-EP 282

Query: 378 AHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI 437
           A G+       +  GK T  N +A I++ +  L +   L         +  ++ +  E +
Sbjct: 283 AGGSAP-----NIAGK-TIANPIAQILSLSMLLKYSLHL------PFLSSCIDEAVHEAL 330

Query: 438 LDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
           +   MT D+S            +N+L T E  D +   L
Sbjct: 331 VKKYMTMDIS---------KNPQNFLKTNEIGDKISDLL 360

emb|CAG99413.1| unnamed protein product [Kluyveromyces lactis NRRL Y-1140]
ref|XP_454326.1| unnamed protein product [Kluyveromyces lactis]
(369 aa)

Score: 46 bits (108), Expect: 0.00213113
Length: 292, Idn/Pos/Gap = 63/124/32 (21%/42%/10%)

Query: 166 LRNVLNGTVFREPILVENIPRLVPGWKQPIVIARHGFGDQYKAQDLRVPPACR---VELR 222
           L+N   G +F     V++    V G+  PIV  R   G     + ++     +   V+L 
Sbjct:  81 LKNQCEGALFGA---VQSPTTKVEGYSSPIVALRKNLGLFANVRPVKSVDGTKDRKVDLV 137

Query: 223 VLDAQGMELERRQVHQFASSTDGGGVALGMFNTDE-SIRNFARSCFEFALRR-----KLP 276
           ++     +L  +    +     G  VA       E + +N A    + A +R        
Sbjct: 138 IVRENTEDLYIKLEKSYIDEATGTRVADATKRITEIATKNIATIALQIAQQRLEQNGHAT 197

Query: 277 MYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGF- 335
           + ++ K+ +L   DG +R++ +E YE + ++++    + Y  +++D MV +  +    F 
Sbjct: 198 LTVTHKSNVLSQSDGLFREVCRETYEAN-KDKY--GGVQYNEQIVDSMVYRMFREPECFD 254

Query: 336 LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKET 395
           +    N  GD+ SD  A   GSLG++ S  + P+   ++ E  HG+            + 
Sbjct: 255 VVVAPNLYGDILSDGAAALVGSLGVVPSANVGPN--IVIGEPCHGS----------APDI 302

Query: 396 STNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGK-MTKDL 446
           +   +++ +A  R  A      G P+    A+ + ++    I +GK +T DL
Sbjct: 303 AGKGISNPIATIRSTALMLEFLGYPEP---AKDIHKAVDANIREGKYLTPDL 351

gb|AAW70955.1| Isocitrate/isopropylmalate dehydrogenase, LeuB [Wolbachia endosymbiont strain TRS of Brugia malayi]
ref|YP_198197.1| Isocitrate/isopropylmalate dehydrogenase, LeuB [Wolbachia endosymbiont strain TRS of Brugia malayi]
(475 aa)

Score: 46 bits (108), Expect: 0.0023753
Length: 212, Idn/Pos/Gap = 57/95/33 (26%/44%/15%)

Query: 264 RSCFEFALR--RKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLI 321
           R  F +A R  RK    L TK+ I+K+ DG +   F  +  ++Y +      +  EH ++
Sbjct: 154 RYAFNYAKRHNRKKVTCL-TKDNIMKMTDGIFHTAFDSI-AKEYPD------IKAEHYIV 205

Query: 322 DDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHG 380
           D  +A+       F +   +N  GD+ SDI+AQ  GS+GL  S  +    +  + EA HG
Sbjct: 206 DIGMARVATEPENFDVIVTENLYGDILSDIVAQTSGSVGLAGSSNI--GSEYAMFEAVHG 263

Query: 381 TVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDG 440
           +              +  ++A+         H     G  DVA     +  + ++T+ DG
Sbjct: 264 S----------APNIAGKNIANPSGLLNAAVHMLIYIGQADVAKL---VHDAWLKTLEDG 310

Query: 441 KMTKDLSIAVYGTEQGSKRENYLNTEEFIDAV 472
             T DL       E+ SK++  + T+EF +AV
Sbjct: 311 IHTADLY-----KEKKSKQK--VGTKEFAEAV 335

ref|ZP_00317100.1| COG0473: Isocitrate/isopropylmalate dehydrogenase [Microbulbifer degradans 2-40]
(357 aa)

Score: 46 bits (108), Expect: 0.00258199
Length: 127, Idn/Pos/Gap = 35/58/10 (27%/45%/7%)

Query: 256 DESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALW 315
           +  I    R+ FE A++R   +    K  +L+     WR++ Q +  +DY E      + 
Sbjct: 166 EHEIERIGRTAFEMAMKRDKKVCSVDKANVLEA-TVLWREVIQSI-SKDYPE------VE 217

Query: 316 YEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLL 374
             H  +D+   Q +++   F +    N  GD+ SD  A   GS+G++ S  L  D K L 
Sbjct: 218 LSHMYVDNAAMQLVRAPKQFDVVVTGNMFGDILSDTAAMLTGSIGMLPSASLNQDSKGLY 277

Query: 375 AEAAHGT 381
            E  HG+
Sbjct: 278 -EPVHGS 283

pdb|1V5B|H Chain H, The Structure Of The Mutant, S225a And E251l, Of 3- Isopropylmalate Dehydrogenase From Bacillus Coagulans
pdb|1V5B|G Chain G, The Structure Of The Mutant, S225a And E251l, Of 3- Isopropylmalate Dehydrogenase From Bacillus Coagulans
pdb|1V5B|F Chain F, The Structure Of The Mutant, S225a And E251l, Of 3- Isopropylmalate Dehydrogenase From Bacillus Coagulans
pdb|1V5B|E Chain E, The Structure Of The Mutant, S225a And E251l, Of 3- Isopropylmalate Dehydrogenase From Bacillus Coagulans
pdb|1V5B|D Chain D, The Structure Of The Mutant, S225a And E251l, Of 3- Isopropylmalate Dehydrogenase From Bacillus Coagulans
pdb|1V5B|C Chain C, The Structure Of The Mutant, S225a And E251l, Of 3- Isopropylmalate Dehydrogenase From Bacillus Coagulans
pdb|1V5B|B Chain B, The Structure Of The Mutant, S225a And E251l, Of 3- Isopropylmalate Dehydrogenase From Bacillus Coagulans
pdb|1V5B|A Chain A, The Structure Of The Mutant, S225a And E251l, Of 3- Isopropylmalate Dehydrogenase From Bacillus Coagulans
(366 aa)

Score: 45 bits (107), Expect: 0.00264743
Length: 196, Idn/Pos/Gap = 50/87/22 (25%/44%/11%)

Query: 255 TDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAAL 314
           T E I       F+ A  R+  +    K  +L+     WR+I +E       +++    L
Sbjct: 163 TREEIERIIEKAFQLAQIRRKKLASVDKANVLES-SRMWREIAEET-----AKKYPDVEL 216

Query: 315 WYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTL 373
              H L+D    Q + + G F +   +N  GD+ SD+ +   GSLG++ S  L  D +  
Sbjct: 217 --SHMLVDSTAMQLIANPGQFDVIVTENMFGDILSDLASVITGSLGMLPSASLRSD-RFG 273

Query: 374 LAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSC 433
           + E  HG+      +  QGK    N + ++++ A  L +   L+        A A+E++ 
Sbjct: 274 MYEPVHGSAP---DIAGQGK---ANPLGTVLSAALMLRYSFGLEKE------AAAIEKAV 321

Query: 434 IETILDGKMTKDLSIA 449
            + + DG  T DL +A
Sbjct: 322 DDVLQDGYCTGDLQVA 337

ref|YP_176137.1| 3-isopropylmalate dehydrogenase [Bacillus clausii KSM-K16]
dbj|BAD65176.1| 3-isopropylmalate dehydrogenase [Bacillus clausii KSM-K16]
(364 aa)

Score: 45 bits (107), Expect: 0.00305089
Length: 250, Idn/Pos/Gap = 63/103/37 (25%/41%/14%)

Query: 228 GMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILK 287
           G   ERRQ++    + D       +  T   I       F+FA  RK  +    K  +L+
Sbjct: 143 GEPRERRQINGEDGAVDT------LLYTRGEIERIVHQAFQFARTRKKRVVSVDKANVLE 196

Query: 288 VYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDV 346
                WR+I  E+  R+Y +      +   H L+D+   Q ++    F +   +N  GD+
Sbjct: 197 S-SRLWREIADEV-AREYPD------VTLSHMLVDNAAMQLIRDPRQFDVIVTENLFGDI 248

Query: 347 QSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAW 406
            SD  +   GSLGL+ S  +    K  L E  HG+              + N +A+I++ 
Sbjct: 249 LSDEASMITGSLGLLPSASMN-TSKVGLFEPVHGSAP------DIAGTGAANPLATILSA 301

Query: 407 ARGLAHRATLDGTPDVAHFAEALERSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTE 466
           A  L +   L      A  A+A+E +    +  G  TKD++ A          EN ++T 
Sbjct: 302 AMMLQYSFGL------ADEAKAIEVAVDRVLAQGVRTKDIAKA---------SENAVSTT 346

Query: 467 EFIDAVQQRL 476
              +AV + L
Sbjct: 347 AITNAVMEAL 356

gb|AAO09167.1| Isocitrate/isopropylmalate dehydrogenase [Vibrio vulnificus CMCP6]
ref|NP_759640.1| Isocitrate/isopropylmalate dehydrogenase [Vibrio vulnificus CMCP6]
sp|Q8DEE0|LEU3_VIBVU 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(363 aa)

Score: 45 bits (107), Expect: 0.00315444
Length: 210, Idn/Pos/Gap = 58/91/27 (27%/43%/12%)

Query: 259 IRNFARSCFEFA-LRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYE 317
           I   A+  FE A LRRK    +   N +       WR++ +EL  +DY +      +   
Sbjct: 173 IERIAKIAFESARLRRKKVCSIDKANVLQSSI--LWREVVEEL-AKDYPD------VELS 223

Query: 318 HRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           H  ID+   Q +K    F +  C N  GD+ SD  A   GS+G++ S  L  + K  L E
Sbjct: 224 HMYIDNATMQLIKDPAQFDVMLCSNIFGDIISDECAMITGSMGMLPSASLN-ESKFGLYE 282

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
            A G+          GK  + N VA I++ A  L +    +        A+ +E +  + 
Sbjct: 283 PAGGSAP-----DIAGKNIA-NPVAQILSAALMLRYSLGEEAA------AQDIENAVSQA 330

Query: 437 ILDGKMTKDLS---IAVYGTEQGSKRENYL 463
           +  G++T DL+    A+   E G K   Y+
Sbjct: 331 LAAGELTADLAGDKPALSTAEMGDKIAQYI 360

gb|EAL21189.1| hypothetical protein CNBD2460 [Cryptococcus neoformans var. neoformans B-3501A]
(370 aa)

Score: 45 bits (106), Expect: 0.00340044
Length: 320, Idn/Pos/Gap = 76/129/42 (23%/40%/13%)

Query: 111 LGLPVRDATDDGVTLEAARAVQQHHAAVKAATITPDEARVEEFHLKRMYPSPNGTLRNV- 169
           LG+   D     V   A R ++   +++   T  P  A  EEF+ K     P+ T+  + 
Sbjct:  12 LGMIPADGIGKEVLPAAQRVIEALGSSIPKTTFVPLVAGWEEFN-KNGKALPDDTVSALR  70

Query: 170 -LNGTVFREPILVENIPRLVPGWKQPIVIARHG---FGDQYKAQDLRVP--PACR-VELR 222
             +G +F     V +    V G+  PIV  R     + +      + +P  P+ + V+L 
Sbjct:  71 ECDGAMFGA---VSSPSHKVAGYSSPIVALRKHLDLYANVRPVSSVPIPGQPSAKAVDLV 127

Query: 223 VLDAQGMELERRQVHQFASSTDGGGVALGMFNTDESIRNFARSCFEFALRR--------- 273
           ++      L  +Q        D   +A    +   S R   R  FE ALRR         
Sbjct: 128 IVRENTECLYIKQEEISGEGEDRVALATRKISAKASSR-IGRMAFEIALRRGQEREAARA 186

Query: 274 ---------KLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLIDDM 324
                    +  + +  K+ +L V DG +R+  + + E    E++  A +  E +++D M
Sbjct: 187 AGKDVWWKGEPKVTIVHKSNVLSVTDGLFRETVRAVKEGKGGEKY--AGVKLEEQIVDSM 244

Query: 325 VAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGTVT 383
           V +  +    F +    N  GD+ SD  A   GSLGL+ S+        ++ E  HG+  
Sbjct: 245 VYRMFREPEFFDVCVAPNLYGDIISDGAAALVGSLGLVPSI--NAGDNFIMGEPVHGSAP 302

Query: 384 RHFRLHQQGKETSTNSVASI 403
                  +GK  + N +ASI
Sbjct: 303 -----DIEGKNIA-NPIASI 316

sp|Q7M886|LEU3_WOLSU 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(358 aa)

Score: 45 bits (106), Expect: 0.00360496
Length: 217, Idn/Pos/Gap = 58/92/42 (26%/42%/19%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY-- 316
           I   A   F+ A+RR+  +    K  +L V              + +RE  TR A  Y  
Sbjct: 165 IERIAHVAFKAAMRRQKRVCSVDKANVLDV-------------SQLWRETVTRIAKEYPE 211

Query: 317 ---EHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKT 372
               H  ID+   Q +++   F +    N  GD+ SD  +   GS+GL+ S  +   GK 
Sbjct: 212 VELSHMYIDNAAMQLIRNPKQFDVILTGNLFGDILSDEASMLSGSIGLLPSASI--GGKA 269

Query: 373 LLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERS 432
            L E  HG+      +  QG     N +A+I + +  L H      +      A+A++++
Sbjct: 270 ALYEPIHGSAP---DIAGQG---IANPIATIASASMMLRH------SLGEVEAADAIDKA 317

Query: 433 CIETILDGKMTKDLSIAVYGT-------EQGSKRENY 462
            ++T+ +G  TKD  IA +G        E GS   NY
Sbjct: 318 IVKTLKEGYRTKD--IAAFGAKEICTTDEMGSIIANY 352

ref|NP_907929.1| ISOPROPYLMALATE DEHYDROGENASE [Wolinella succinogenes DSM 1740]
emb|CAE10829.1| ISOPROPYLMALATE DEHYDROGENASE [Wolinella succinogenes]
(377 aa)

Score: 45 bits (106), Expect: 0.00360496
Length: 217, Idn/Pos/Gap = 58/92/42 (26%/42%/19%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY-- 316
           I   A   F+ A+RR+  +    K  +L V              + +RE  TR A  Y  
Sbjct: 184 IERIAHVAFKAAMRRQKRVCSVDKANVLDV-------------SQLWRETVTRIAKEYPE 230

Query: 317 ---EHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKT 372
               H  ID+   Q +++   F +    N  GD+ SD  +   GS+GL+ S  +   GK 
Sbjct: 231 VELSHMYIDNAAMQLIRNPKQFDVILTGNLFGDILSDEASMLSGSIGLLPSASI--GGKA 288

Query: 373 LLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERS 432
            L E  HG+      +  QG     N +A+I + +  L H      +      A+A++++
Sbjct: 289 ALYEPIHGSAP---DIAGQG---IANPIATIASASMMLRH------SLGEVEAADAIDKA 336

Query: 433 CIETILDGKMTKDLSIAVYGT-------EQGSKRENY 462
            ++T+ +G  TKD  IA +G        E GS   NY
Sbjct: 337 IVKTLKEGYRTKD--IAAFGAKEICTTDEMGSIIANY 371

ref|YP_148510.1| 3-isopropylmalate dehydrogenase [Geobacillus kaustophilus HTA426]
dbj|BAD76942.1| 3-isopropylmalate dehydrogenase [Geobacillus kaustophilus HTA426]
(371 aa)

Score: 45 bits (105), Expect: 0.00444111
Length: 192, Idn/Pos/Gap = 51/87/22 (26%/45%/11%)

Query: 257 ESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWY 316
           E I    R  F  A  RK  +    K  +L      WR++ +E+      ++F    L  
Sbjct: 167 EEIERIVRMAFILARGRKKKVTSVDKANVLSS-SRLWREVAEEV-----AKQFPDVTL-- 218

Query: 317 EHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLA 375
           EH L+D+   Q +++   F +   +N  GD+ SD  +   GSLG++ S  L+  G +L  
Sbjct: 219 EHMLVDNAAMQLIRAPKQFDVIVTENMFGDILSDEASMLSGSLGMLPSASLSASGPSLY- 277

Query: 376 EAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIE 435
           E  HG+      +++       N +A+I++ A  L  R +   T +    AEA+E +  +
Sbjct: 278 EPVHGSAPDIAGMNK------ANPIAAILSAAMML--RLSFGLTAE----AEAVEHAVRQ 325

Query: 436 TILDGKMTKDLS 447
            +  G  T DL+
Sbjct: 326 ALDQGLRTADLA 337

pir||S43888 3-isopropylmalate dehydrogenase (EC 1.1.1.85) - Neisseria lactamica (fragment)
sp|P50180|LEU3_NEILA 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
gb|AAA53239.1| isopropylmalate dehydrogenase
(313 aa)

Score: 45 bits (105), Expect: 0.00455368
Length: 131, Idn/Pos/Gap = 37/65/10 (28%/49%/7%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           M  ++  IR  A   F+ A +R   +    K  +L+  +  WR+IF+E+  ++Y +    
Sbjct: 161 MKYSESEIRRIAHVAFQSAQKRSKKVCSVGKANVLETTE-LWREIFEEI-GKEYPD---- 214

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
             +   H  +D+   Q +++   F + A  N  GD+ SD  +   GSLG++ S  L  +G
Sbjct: 215 --VELSHMYVDNAAMQLVRAPKQFDVIATGNIFGDILSDEASMLTGSLGMLPSASLDENG 272

Query: 371 KTLLAEAAHGT 381
           K L  E +HG+
Sbjct: 273 KGLY-EPSHGS 282

emb|CAA50616.1| isopropylmalate dehydrogenase [Buchnera aphidicola]
sp|P48572|LEU3_BUCRP 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(363 aa)

Score: 45 bits (105), Expect: 0.00490879
Length: 222, Idn/Pos/Gap = 56/93/32 (25%/41%/14%)

Query: 256 DESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALW 315
           D  I+  A   FE A  R+  +    K+ +L      WR+I +E+  ++Y        + 
Sbjct: 169 DFEIKRIAHLAFELASSRRCKVCSIDKSNVL-ASSILWREIVEEV-SKNY------PNII 220

Query: 316 YEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLL 374
             H  ID+   Q +K+   F +  C N  GD+ SD  A   GS+G++ S  L    K  L
Sbjct: 221 LSHLYIDNACMQIIKNPSQFDVLLCSNIFGDIISDECAMITGSIGMLPSASLNSK-KFGL 279

Query: 375 AEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCI 434
            E A G+         +GK  + N +A I++ +  + H   L+        A+ ++ S  
Sbjct: 280 YEPAGGSAP-----DIEGKNIA-NPIAQILSLSMLIRHSMNLN------EIADKIDSSVY 327

Query: 435 ETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
             +  G  T D+S            +NY+ T E  D + + L
Sbjct: 328 RALKAGYRTLDISDG----------KNYIKTNEMGDIIAKFL 359

ref|ZP_00290277.1| COG0473: Isocitrate/isopropylmalate dehydrogenase [Magnetococcus sp. MC-1]
(359 aa)

Score: 45 bits (105), Expect: 0.00503322
Length: 197, Idn/Pos/Gap = 54/91/25 (27%/46%/12%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           ++ TDE I   AR  FE A +R   +    K  +L+  +  WR++  +L++R+Y      
Sbjct: 162 VYTTDE-IERIARKAFEAARKRSNRVCSVDKANVLESTE-LWREVVSDLHKREY------ 213

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
           A +   H  +D+   Q +++   F +    N  GD+ SD  +   GS+G++ S  L    
Sbjct: 214 ADVELSHMYVDNAAMQLIRNPRQFDVIVTTNMFGDILSDAASMLTGSIGMLPSASL--GD 271

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALE 430
           +  L E  HG+          GK  + N +A+I++ A  L +   L   P +A   EA  
Sbjct: 272 QFALYEPIHGSAP-----DIAGKGIA-NPLATILSVAMMLRYSLEL---PQLADGVEA-- 320

Query: 431 RSCIETILD-GKMTKDL 446
              + T+LD G  T D+
Sbjct: 321 --AVVTVLDQGLRTADI 335

ref|ZP_00332422.1| COG0538: Isocitrate dehydrogenases [Streptococcus suis 89/1591]
(393 aa)

Score: 45 bits (105), Expect: 0.00507539
Length: 129, Idn/Pos/Gap = 34/56/2 (26%/43%/1%)

Query: 255 TDESIRNFARSCFEFALRRKLPMY-LSTKNTILKVYDGRWRDIFQELYERDYRERFTRAA 313
           ++E  +   RS  E+AL  +L +  L  K  I K  +G +R    EL + ++        
Sbjct: 191 SEEGSKRLIRSAIEYALEHQLKIVTLVHKGNIQKFTEGGFRKWGYELAKEEFATELAEGT 250

Query: 314 LWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKT 372
           L     + D+ + Q L +   F + A  N +GD  SD +A   G +G+     +      
Sbjct: 251 LVVNDIIADNFLQQILLAPENFQVVALTNLNGDYASDALAAQVGGIGISPGANINYQTGH 310

Query: 373 LLAEAAHGT 381
            + EA HGT
Sbjct: 311 AIFEATHGT 319

gb|AAF41430.1| 3-isopropylmalate dehydrogenase [Neisseria meningitidis MC58]
pir||E81130 3-isopropylmalate dehydrogenase NMB1031 [imported] - Neisseria meningitidis (strain MC58 serogroup B)
sp|Q9JZI9|LEU3_NEIMB 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
ref|NP_274065.1| 3-isopropylmalate dehydrogenase [Neisseria meningitidis MC58]
(356 aa)

Score: 45 bits (105), Expect: 0.00533594
Length: 222, Idn/Pos/Gap = 57/103/31 (25%/46%/13%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           M  ++  IR  A   F+ A +R   +    K  +L+  +  WR+IF+E+  ++Y +    
Sbjct: 161 MKYSESEIRRIAHVAFQSAQKRSKKVCSVGKANVLETTE-LWREIFEEI-GKEYPD---- 214

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
             +   H  +D+   Q +++   F + A  N  GD+ SD  +   GS+G++ S  L  +G
Sbjct: 215 --VELSHMYVDNAAMQLVRAPKQFDVIATGNIFGDILSDEASMLTGSIGMLPSASLDENG 272

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALE 430
           K L  E +HG+            +   N +A+I++ A  L  R +L+   D A  A+ +E
Sbjct: 273 KGLY-EPSHGSAP------DIAGQNKANPLATILSLAMLL--RYSLN---DEAR-AQQVE 319

Query: 431 RSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAV 472
            +  + +  G  T D+       E+G+K    ++  E  DAV
Sbjct: 320 NAVQKVLQQGLRTSDI------YEEGTK---LVSCSEMGDAV 352

ref|NP_796723.1| 3-isopropylmalate dehydrogenase [Vibrio parahaemolyticus RIMD 2210633]
dbj|BAC58607.1| 3-isopropylmalate dehydrogenase [Vibrio parahaemolyticus RIMD 2210633]
sp|Q87SS8|LEU3_VIBPA 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(363 aa)

Score: 45 bits (105), Expect: 0.00551704
Length: 229, Idn/Pos/Gap = 61/99/31 (26%/43%/13%)

Query: 244 DGGGVALGMFNTD----ESIRNFARSCFEFA-LRRKLPMYLSTKNTILKVYDGRWRDIFQ 298
           +G G     F+T+      I   A+  FE A LRRK    +   N +       WR++ +
Sbjct: 154 EGEGANEKAFDTEVYHRYEIERIAKIAFESARLRRKKVCSIDKANVLQSSI--LWREVVE 211

Query: 299 ELYERDYRERFTRAALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGS 357
           E+  +DY +      +   H  ID+   Q +K    F +  C N  GD+ SD  A   GS
Sbjct: 212 EI-AKDYPD------VELSHMYIDNATMQLIKDPAQFDVMLCSNIFGDIISDECAMITGS 264

Query: 358 LGLMSSVLLTPDGKTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLD 417
           +G++ S  L  + K  L E A G+          GK  + N VA I++ A  L +    +
Sbjct: 265 MGMLPSASLN-ESKFGLYEPAGGSAP-----DIAGKNIA-NPVAQILSAALMLRYSLGEE 317

Query: 418 GTPDVAHFAEALERSCIETILDGKMTKDLSI---AVYGTEQGSKRENYL 463
                   A+ +E +  + +  G++T DL+    A+  +E G K   Y+
Sbjct: 318 AA------AQDIESAVSKALSAGELTADLASDKPALTTSEMGDKIAEYI 360

ref|NP_884205.1| 3-isopropylmalate dehydrogenase [Bordetella parapertussis 12822]
emb|CAE37244.1| 3-isopropylmalate dehydrogenase [Bordetella parapertussis]
(367 aa)

Score: 45 bits (105), Expect: 0.00560987
Length: 226, Idn/Pos/Gap = 60/102/31 (26%/45%/13%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           M   +  +R  AR  FE A +R   +    K  +L+     WRD+  E+  RDY +    
Sbjct: 171 MRYAESEVRRIARIGFESARKRNKKLCSVDKANVLETSQ-FWRDLVIEV-SRDYPD---- 224

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
             +   H  +D+   Q +++   F +    N  GD+ SD  A   GS+G++ S  L   G
Sbjct: 225 --VELSHMYVDNAAMQLVRNPRQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLNAAG 282

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALE 430
           + L  E +HG+      +  QG     N +A+I++ A  L  R +L+  P     A+ +E
Sbjct: 283 QGLY-EPSHGSAP---DIAGQG---IANPLATILSAAMLL--RYSLNLAPQ----ADRVE 329

Query: 431 RSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
            +  + + DG  T D+       E G+ +   ++T +  DAV + L
Sbjct: 330 AAVRKVLADGLRTADIH------EAGTTK---VSTSQMGDAVLKAL 366

gb|AAU90861.1| isocitrate dehydrogenase, NAD-dependent, putative [Methylococcus capsulatus str. Bath]
ref|YP_115458.1| isocitrate dehydrogenase, NAD-dependent, putative [Methylococcus capsulatus str. Bath]
(340 aa)

Score: 45 bits (105), Expect: 0.00565688
Length: 187, Idn/Pos/Gap = 54/84/25 (28%/44%/13%)

Query: 264 RSCFEFALR-RKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEHRLID 322
           R  F++A R R+  + L  K  ILK   G + +I +E+  ++Y +      + ++ R++D
Sbjct: 155 RYAFDYARRARRKKVTLVHKANILKCTSGLFLEIGREI-AKEYPD------IEFDDRIVD 207

Query: 323 DMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEAAHGT 381
               Q +     F +    N  GD+ SD+ A   G LGL +   +  D    L EA HG+
Sbjct: 208 ACSMQMVMQPQRFDVLVTTNLFGDILSDLAAGLIGGLGLTAGANIGTDAA--LFEAVHGS 265

Query: 382 VTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETILDGK 441
                       +   N  A I+A A  L H     G PD    A  +ER+  E I DG+
Sbjct: 266 AP------DIADKGIANPTAMIMAGAMMLEHI----GEPDA---ARRIERAVREVIEDGR 312

Query: 442 -MTKDLS 447
            +T DL+
Sbjct: 313 SVTPDLA 319

ref|YP_207813.1| LeuB [Neisseria gonorrhoeae FA 1090]
gb|AAW89401.1| putative 3-isopropylmalate dehydrogenase [Neisseria gonorrhoeae FA 1090]
(356 aa)

Score: 45 bits (105), Expect: 0.00575207
Length: 222, Idn/Pos/Gap = 58/102/31 (26%/45%/13%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           M  ++  IR  A   F+ A +R   +    K  +L+  +  WR+IF+E+  + Y +    
Sbjct: 161 MKYSESEIRRIAHVAFQSAQKRSKKVCSVGKANVLETTE-LWREIFEEI-GKQYPD---- 214

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
             +   H  +D+   Q +++   F + A  N  GD+ SD  +   GS+G++ S  L  +G
Sbjct: 215 --VELSHMYVDNAAMQLVRAPKQFDVIATGNIFGDILSDEASMLTGSIGMLPSASLDENG 272

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALE 430
           K L  E +HG+            +   N +A+I++ A  L  R +L+   D A  A+ +E
Sbjct: 273 KGLY-EPSHGSAP------DIAGQNKANPLATILSLAMLL--RYSLN---DEAR-AQQVE 319

Query: 431 RSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAV 472
            S  + +  G  T D+       E+G+K    ++  E  DAV
Sbjct: 320 NSVQKVLQQGLRTGDI------YEEGTK---LVSCSEMGDAV 352

ref|NP_933279.1| 3-isopropylmalate dehydrogenase [Vibrio vulnificus YJ016]
sp|Q7MP78|LEU3_VIBVY 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
dbj|BAC93250.1| 3-isopropylmalate dehydrogenase [Vibrio vulnificus YJ016]
(363 aa)

Score: 44 bits (104), Expect: 0.00599711
Length: 210, Idn/Pos/Gap = 57/91/27 (27%/43%/12%)

Query: 259 IRNFARSCFEFA-LRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYE 317
           I   A+  FE A LRRK    +   N +       WR++ +E+  +DY +      +   
Sbjct: 173 IERIAKIAFESARLRRKKVCSIDKANVLQSSI--LWREVVEEI-AKDYPD------VELS 223

Query: 318 HRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAE 376
           H  ID+   Q +K    F +  C N  GD+ SD  A   GS+G++ S  L  + K  L E
Sbjct: 224 HMYIDNATMQLIKDPAQFDVMLCSNIFGDIISDECAMITGSMGMLPSASLN-ESKFGLYE 282

Query: 377 AAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIET 436
            A G+          GK  + N VA I++ A  L +    +        A+ +E +  + 
Sbjct: 283 PAGGSAP-----DIAGKNIA-NPVAQILSAALMLRYSLGEEAA------AQDIENAVSQA 330

Query: 437 ILDGKMTKDLS---IAVYGTEQGSKRENYL 463
           +  G++T DL+    A+   E G K   Y+
Sbjct: 331 LAAGELTADLAGDKPALSTAEMGDKIAQYI 360

emb|CAE32628.1| 3-isopropylmalate dehydrogenase [Bordetella bronchiseptica RB50]
ref|NP_888675.1| 3-isopropylmalate dehydrogenase [Bordetella bronchiseptica RB50]
sp|Q7WKH4|LEU3_BORBR 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
sp|Q7W929|LEU3_BORPA 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(358 aa)

Score: 44 bits (104), Expect: 0.00604736
Length: 226, Idn/Pos/Gap = 60/102/31 (26%/45%/13%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           M   +  +R  AR  FE A +R   +    K  +L+     WRD+  E+  RDY +    
Sbjct: 162 MRYAESEVRRIARIGFESARKRNKKLCSVDKANVLETSQ-FWRDLVIEV-SRDYPD---- 215

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
             +   H  +D+   Q +++   F +    N  GD+ SD  A   GS+G++ S  L   G
Sbjct: 216 --VELSHMYVDNAAMQLVRNPRQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLNAAG 273

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALE 430
           + L  E +HG+      +  QG     N +A+I++ A  L  R +L+  P     A+ +E
Sbjct: 274 QGLY-EPSHGSAP---DIAGQG---IANPLATILSAAMLL--RYSLNLAPQ----ADRVE 320

Query: 431 RSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
            +  + + DG  T D+       E G+ +   ++T +  DAV + L
Sbjct: 321 AAVRKVLADGLRTADIH------EAGTTK---VSTSQMGDAVLKAL 357

emb|CAE41772.1| 3-isopropylmalate dehydrogenase [Bordetella pertussis Tohama I]
ref|NP_880220.1| 3-isopropylmalate dehydrogenase [Bordetella pertussis Tohama I]
sp|Q7VY73|LEU3_BORPE 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(358 aa)

Score: 44 bits (104), Expect: 0.00609803
Length: 226, Idn/Pos/Gap = 60/102/31 (26%/45%/13%)

Query: 252 MFNTDESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTR 311
           M   +  +R  AR  FE A +R   +    K  +L+     WRD+  E+  RDY +    
Sbjct: 162 MRYAESEVRRIARIGFESARKRNKKLCSVDKANVLETSQ-FWRDLVIEV-SRDYLD---- 215

Query: 312 AALWYEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDG 370
             +   H  +D+   Q +++   F +    N  GD+ SD  A   GS+G++ S  L   G
Sbjct: 216 --VELSHMYVDNAAMQLVRNPRQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLNAAG 273

Query: 371 KTLLAEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALE 430
           + L  E +HG+      +  QG     N +A+I++ A  L  R +L+  P     A+ +E
Sbjct: 274 QGLY-EPSHGSAP---DIAGQG---IANPLATILSAAMLL--RYSLNLAPQ----ADRVE 320

Query: 431 RSCIETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
            +  + + DG  T D+       E G+ +   ++T +  DAV + L
Sbjct: 321 AAVRKVLADGLRTADIH------EAGTTK---VSTSQMGDAVLKAL 357

ref|YP_215095.1| 3-isopropylmalate dehydrogenase [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67]
gb|AAX64014.1| 3-isopropylmalate dehydrogenase [Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67]
gb|AAL19076.1| 3-isopropylmalate dehydrogenase [Salmonella typhimurium LT2]
gb|AAB60185.1| 3-isopropylmalate dehydrogenase
ref|NP_459117.1| 3-isopropylmalate dehydrogenase [Salmonella typhimurium LT2]
sp|P37412|LEU3_SALTY 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
pdb|1CNZ|B Chain B, 3-Isopropylmalate Dehydrogenase (Ipmdh) From Salmonella Typhimurium
pdb|1CNZ|A Chain A, 3-Isopropylmalate Dehydrogenase (Ipmdh) From Salmonella Typhimurium
(363 aa)

Score: 44 bits (104), Expect: 0.00662867
Length: 206, Idn/Pos/Gap = 55/86/19 (26%/41%/9%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEH 318
           I   AR  FE A +R+  +    K  +L+     WR+I  ++ +       T   +   H
Sbjct: 172 IERIARIAFESARKRRRKVTSIDKANVLQS-SILWREIVNDVAK-------TYPDVELAH 223

Query: 319 RLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEA 377
             ID+   Q +K    F +  C N  GD+ SD  A   GS+G++ S  L   G  L  E 
Sbjct: 224 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY-EP 282

Query: 378 AHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI 437
           A G+          GK  + N +A I++ A  L  R +LD         +A+ R+  E +
Sbjct: 283 AGGSAP-----DIAGKNIA-NPIAQILSLA--LLLRYSLDANDAATAIEQAINRALEEGV 334

Query: 438 LDGKMTKDLSIAVYGTEQGSKRENYL 463
             G + +  + AV   E G     Y+
Sbjct: 335 RTGDLARG-AAAVSTDEMGDIIARYV 359

ref|YP_149459.1| 3-isopropylmalate dehydrogenase [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]
gb|AAV76147.1| 3-isopropylmalate dehydrogenase [Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150]
(363 aa)

Score: 44 bits (104), Expect: 0.00691105
Length: 206, Idn/Pos/Gap = 55/86/19 (26%/41%/9%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEH 318
           I   AR  FE A +R+  +    K  +L+     WR+I  ++ +       T   +   H
Sbjct: 172 IERIARIAFESARKRRRKVTSIDKANVLQS-SILWREIVNDVAK-------TYPDVELAH 223

Query: 319 RLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEA 377
             ID+   Q +K    F +  C N  GD+ SD  A   GS+G++ S  L   G  L  E 
Sbjct: 224 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY-EP 282

Query: 378 AHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI 437
           A G+          GK  + N +A I++ A  L  R +LD         +A+ R+  E +
Sbjct: 283 AGGSAP-----DIAGKNIA-NPIAQILSLA--LLLRYSLDANDAATAIEQAINRALEEGV 334

Query: 438 LDGKMTKDLSIAVYGTEQGSKRENYL 463
             G + +  + AV   E G     Y+
Sbjct: 335 RTGDLARG-AAAVSTDEMGDIIARYV 359

sp|Q8FL76|LEU3_ECOL6 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(363 aa)

Score: 44 bits (104), Expect: 0.00708623
Length: 206, Idn/Pos/Gap = 57/84/19 (27%/40%/9%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEH 318
           I   AR  FE A +R+  +    K  +L+     WR+I  E+         T       H
Sbjct: 172 IERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEIATEYPDVELT-------H 223

Query: 319 RLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEA 377
             ID+   Q +K    F +  C N  GD+ SD  A   GS+G++ S  L   G  L  E 
Sbjct: 224 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY-EP 282

Query: 378 AHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI 437
           A G+          GK  + N +A I++ A  L  R +LD     +    A+ R+  E I
Sbjct: 283 AGGSAP-----DIAGKNIA-NPIAQILSLA--LLLRYSLDADDAASAIERAINRALEEGI 334

Query: 438 LDGKMTKDLSIAVYGTEQGSKRENYL 463
             G + +  + AV   E G     Y+
Sbjct: 335 RTGDLARG-AAAVSTDEMGDIIARYV 359

ref|NP_752042.1| 3-isopropylmalate dehydrogenase [Escherichia coli CFT073]
gb|AAN78586.1| 3-isopropylmalate dehydrogenase [Escherichia coli CFT073]
(364 aa)

Score: 44 bits (104), Expect: 0.00708623
Length: 206, Idn/Pos/Gap = 57/84/19 (27%/40%/9%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEH 318
           I   AR  FE A +R+  +    K  +L+     WR+I  E+         T       H
Sbjct: 173 IERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEIATEYPDVELT-------H 224

Query: 319 RLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEA 377
             ID+   Q +K    F +  C N  GD+ SD  A   GS+G++ S  L   G  L  E 
Sbjct: 225 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY-EP 283

Query: 378 AHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI 437
           A G+          GK  + N +A I++ A  L  R +LD     +    A+ R+  E I
Sbjct: 284 AGGSAP-----DIAGKNIA-NPIAQILSLA--LLLRYSLDADDAASAIERAINRALEEGI 335

Query: 438 LDGKMTKDLSIAVYGTEQGSKRENYL 463
             G + +  + AV   E G     Y+
Sbjct: 336 RTGDLARG-AAAVSTDEMGDIIARYV 360

ref|NP_308104.2| 3-isopropylmalate dehydrogenase [Escherichia coli O157:H7]
sp|Q8X9Z9|LEU3_ECO57 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(363 aa)

Score: 44 bits (104), Expect: 0.00720547
Length: 206, Idn/Pos/Gap = 57/87/19 (27%/42%/9%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEH 318
           I   AR  FE A +R+  +    K  +L+     WR+I  E+   +Y +      +   H
Sbjct: 172 IERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEI-ATEYPD------IELAH 223

Query: 319 RLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEA 377
             ID+   Q +K    F +  C N  GD+ SD  A   GS+G++ S  L   G  L  E 
Sbjct: 224 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY-EP 282

Query: 378 AHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI 437
           A G+          GK  + N +A I++ A  L  R +LD     +    A+ R+  E I
Sbjct: 283 AGGSAP-----DIAGKNIA-NPIAQILSLA--LLLRYSLDADDAASAIERAINRALEEGI 334

Query: 438 LDGKMTKDLSIAVYGTEQGSKRENYL 463
             G + +  + AV   E G     Y+
Sbjct: 335 RTGDLARG-AAAVSTDEMGDIIARYV 359

gb|AAG54377.1| 3-isopropylmalate dehydrogenase [Escherichia coli O157:H7 EDL933]
dbj|BAB33500.1| 3-isopropylmalate dehydrogenase [Escherichia coli O157:H7]
pir||E90638 3-isopropylmalate dehydrogenase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952)
pir||E85489 3-isopropylmalate dehydrogenase [imported] - Escherichia coli (strain O157:H7, substrain EDL933)
ref|NP_285769.1| 3-isopropylmalate dehydrogenase [Escherichia coli O157:H7 EDL933]
(364 aa)

Score: 44 bits (104), Expect: 0.00720547
Length: 206, Idn/Pos/Gap = 57/87/19 (27%/42%/9%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEH 318
           I   AR  FE A +R+  +    K  +L+     WR+I  E+   +Y +      +   H
Sbjct: 173 IERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEI-ATEYPD------IELAH 224

Query: 319 RLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEA 377
             ID+   Q +K    F +  C N  GD+ SD  A   GS+G++ S  L   G  L  E 
Sbjct: 225 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY-EP 283

Query: 378 AHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI 437
           A G+          GK  + N +A I++ A  L  R +LD     +    A+ R+  E I
Sbjct: 284 AGGSAP-----DIAGKNIA-NPIAQILSLA--LLLRYSLDADDAASAIERAINRALEEGI 335

Query: 438 LDGKMTKDLSIAVYGTEQGSKRENYL 463
             G + +  + AV   E G     Y+
Sbjct: 336 RTGDLARG-AAAVSTDEMGDIIARYV 360

ref|NP_706026.1| 3-isopropylmalate dehydrogenase [Shigella flexneri 2a str. 301]
gb|AAN41733.1| 3-isopropylmalate dehydrogenase [Shigella flexneri 2a str. 301]
ref|NP_835809.1| 3-isopropylmalate dehydrogenase [Shigella flexneri 2a str. 2457T]
gb|AAP15614.1| 3-isopropylmalate dehydrogenase [Shigella flexneri 2a str. 2457T]
(364 aa)

Score: 44 bits (103), Expect: 0.00887674
Length: 206, Idn/Pos/Gap = 57/87/19 (27%/42%/9%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEH 318
           I   AR  FE A +R+  +    K  +L+     WR+I  E+   +Y +      +   H
Sbjct: 173 IERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEI-ATEYPD------VELAH 224

Query: 319 RLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEA 377
             ID+   Q +K    F +  C N  GD+ SD  A   GS+G++ S  L   G  L  E 
Sbjct: 225 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY-EP 283

Query: 378 AHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI 437
           A G+          GK  + N +A I++ A  L  R +LD     +    A+ R+  E I
Sbjct: 284 AGGSAP-----DIAGKNIA-NPIAQILSLA--LLLRYSLDADDAASAIERAINRALEEGI 335

Query: 438 LDGKMTKDLSIAVYGTEQGSKRENYL 463
             G + +  + AV   E G     Y+
Sbjct: 336 RTGDLARG-AAAVSTDEMGDIIARYV 360

gb|AAG31390.1| 3-isopropylmaltate dehydrogenase [Buchnera aphidicola]
sp|Q9EVH5|LEU3_BUCUE 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(364 aa)

Score: 44 bits (103), Expect: 0.00910174
Length: 222, Idn/Pos/Gap = 55/92/31 (24%/41%/13%)

Query: 256 DESIRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALW 315
           D  I   A   F+ A  RK  +    K+ +LK     W++I +++  ++Y +      + 
Sbjct: 169 DYEISRIAHLAFQLARNRKKKVCSLDKSNVLKS-SILWKEIVEKI-SKNYPD------VH 220

Query: 316 YEHRLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLL 374
             H  ID+ + Q +K    F +  C N  GD+ SD  A   GS+G++ S  L  +    L
Sbjct: 221 LSHLYIDNAIMQIIKDPSQFDVILCSNLFGDIVSDECAAITGSIGMLPSASLN-EKNFGL 279

Query: 375 AEAAHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCI 434
            E A G+          GK  + N +A I++ +  + H   L         A+ ++ S +
Sbjct: 280 YEPAGGSAP-----DIAGKNIA-NPIAQILSVSMLVRHGMNLK------KIADKIDESVV 327

Query: 435 ETILDGKMTKDLSIAVYGTEQGSKRENYLNTEEFIDAVQQRL 476
             +  G  T D+S         +   NYL T E  D +   L
Sbjct: 328 SVLKQGYRTADIS---------NNSHNYLKTSEMGDIIANFL 360

sp|Q83SP1|LEU3_SHIFL 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)
(363 aa)

Score: 44 bits (103), Expect: 0.0092549
Length: 206, Idn/Pos/Gap = 57/87/19 (27%/42%/9%)

Query: 259 IRNFARSCFEFALRRKLPMYLSTKNTILKVYDGRWRDIFQELYERDYRERFTRAALWYEH 318
           I   AR  FE A +R+  +    K  +L+     WR+I  E+   +Y +      +   H
Sbjct: 172 IERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEI-ATEYPD------VELAH 223

Query: 319 RLIDDMVAQALKSSGGF-LWACKNYDGDVQSDIIAQGYGSLGLMSSVLLTPDGKTLLAEA 377
             ID+   Q +K    F +  C N  GD+ SD  A   GS+G++ S  L   G  L  E 
Sbjct: 224 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY-EP 282

Query: 378 AHGTVTRHFRLHQQGKETSTNSVASIVAWARGLAHRATLDGTPDVAHFAEALERSCIETI 437
           A G+          GK  + N +A I++ A  L  R +LD     +    A+ R+  E I
Sbjct: 283 AGGSAP-----DIAGKNIA-NPIAQILSLA--LLLRYSLDADDAASAIERAINRALEEGI 334

Query: 438 LDGKMTKDLSIAVYGTEQGSKRENYL 463
             G + +  + AV   E G     Y+
Sbjct: 335 RTGDLARG-AAAVSTDEMGDIIARYV 359